GRK
As cinases de receptores acoplados à proteína G (GRKs) são uma família de enzimas que fosforilam GPCRs ativados, levando à dessensibilização dos receptores e à regulação da sinalização dos receptores. As GRKs desempenham papéis críticos no controle da intensidade e duração da sinalização dos GPCRs, sendo importantes na regulação de vários processos fisiológicos, incluindo função cardiovascular, resposta imunológica e neurotransmissão. Inibidores e ativadores de GRK são estudados por suas potenciais aplicações terapêuticas em insuficiência cardíaca, câncer e distúrbios neurológicos. Na CymitQuimica, oferecemos uma gama de moduladores de GRK de alta qualidade para apoiar sua pesquisa em transdução de sinal, regulação de receptores e desenvolvimento terapêutico.
Foram encontrados 31 produtos de "GRK"
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CMPD101
CAS:<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Cor e Forma:SolidPeso molecular:466.46Corazonin
CAS:<p>Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.</p>Fórmula:C62H83N17O19Cor e Forma:SolidPeso molecular:1370.42CCG258208 hydrochloride
<p>GRKs-IN-1 HCl (14as) strongly inhibits GRK2 (IC50=130nM) & GRK5 (IC50=7.1μM), is a paroxetine derivative with 100x cardiac boost.</p>Cor e Forma:SolidGRL018-21
<p>GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].</p>Cor e Forma:Odour SolidGSK270822A
CAS:<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Fórmula:C24H20N4O2Pureza:98.64% - 99.78%Cor e Forma:SolidPeso molecular:396.44GRK-IN-1
CAS:<p>4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.</p>Fórmula:C6H10Br3N3Cor e Forma:SolidPeso molecular:363.879Endothelin-3, human, mouse, rabbit, rat
CAS:<p>Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.</p>Fórmula:C121H168N26O33S4Pureza:98%Cor e Forma:SolidPeso molecular:2643.04GRK2i
CAS:<p>GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.</p>Fórmula:C153H256N50O41SPureza:98%Cor e Forma:SolidPeso molecular:3484.08GRK2-IN-1 hydrochloride (2055990-90-2 free base)
<p>GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Fórmula:C24H26ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:488.94GRL093-22
<p>GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.</p>Fórmula:C33H29FN6O3Cor e Forma:SolidPeso molecular:576.62GSK180736A
CAS:<p>GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).</p>Fórmula:C19H16FN5O2Pureza:98.38% - 98.98%Cor e Forma:SolidPeso molecular:365.36CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Cor e Forma:SolidPeso molecular:499.51-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:<p>1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.</p>Fórmula:C13H13NO5Pureza:99.55%Cor e Forma:SolidPeso molecular:263.25Takeda103A
CAS:<p>Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.</p>Fórmula:C24H23F2N7OPureza:97.17%Cor e Forma:SolidPeso molecular:463.48GRK6-IN-2
CAS:<p>GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.</p>Fórmula:C21H21FN6Pureza:98.94%Cor e Forma:SolidPeso molecular:376.43KR-39038
CAS:<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Fórmula:C24H32ClFN6OCor e Forma:SolidPeso molecular:475.00GRK5-IN-3
CAS:<p>GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).</p>Fórmula:C23H21N7O3Cor e Forma:SolidPeso molecular:443.46GSK317354A
CAS:<p>GSK317354A is a GRK2 inhibitor.</p>Fórmula:C25H18F4N6OCor e Forma:SolidPeso molecular:494.44CCG-271423
CAS:<p>CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.</p>Fórmula:C28H26N4O3Cor e Forma:SolidPeso molecular:466.53GRK5-IN-4
CAS:<p>GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.</p>Fórmula:C26H25N7O3Cor e Forma:SolidPeso molecular:483.52CCG-224406
CAS:<p>CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.</p>Fórmula:C29H27FN6O5Cor e Forma:SolidPeso molecular:558.56CCG-273463
CAS:<p>CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.</p>Fórmula:C26H25BrN4O3Cor e Forma:SolidPeso molecular:521.41CCG-273220
CAS:<p>CCG-273220 covalently inhibits GRK5 at Cys474 with 220 nM IC50; more selective over GRK2.</p>Fórmula:C26H24ClFN4O3Cor e Forma:SolidPeso molecular:494.95GSK466317A
CAS:<p>GSK466317A is a GRK2 inhibitor.</p>Fórmula:C21H16ClF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:448.83GSK299115A
CAS:<p>GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.</p>Fórmula:C20H16Cl2N4O2Pureza:99.81%Cor e Forma:SolidPeso molecular:415.27GSK2163632A
CAS:<p>GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.</p>Fórmula:C27H32N8O3SCor e Forma:SolidPeso molecular:548.66GRK2 Inhibitor 2
CAS:<p>GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293</p>Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.36Ro 32-0432 hydrochloride
CAS:<p>Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.</p>Fórmula:C28H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:452.55CCG258208
CAS:<p>GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Fórmula:C24H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:452.48GRK6-IN-5
CAS:<p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C23H21N3O2Cor e Forma:SolidPeso molecular:371.432GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Fórmula:C15H15N5Cor e Forma:SolidPeso molecular:265.313
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