Hedgehog/Smoothened
A via de sinalização Hedgehog/Smoothened é uma via crucial relacionada aos GPCRs, envolvida no desenvolvimento embrionário, regeneração de tecidos e manutenção de células-tronco. Smoothened (SMO) é uma proteína transmembrana chave que transduz sinais dos ligantes Hedgehog (Hh) para ativar cascatas de sinalização a jusante. A desregulação da via Hedgehog/Smoothened está implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um alvo significativo para intervenção terapêutica. Na CymitQuimica, oferecemos uma gama de moduladores de alta qualidade para a via Hedgehog/Smoothened para apoiar sua pesquisa em biologia do desenvolvimento, oncologia e medicina regenerativa.
Foram encontrados 49 produtos de "Hedgehog/Smoothened"
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MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Fórmula:C31H29N3O5SPureza:99.72%Cor e Forma:SolidPeso molecular:555.64SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Cor e Forma:SolidPeso molecular:490.06Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:98.54% - 99.57%Cor e Forma:SolidPeso molecular:358.18HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Fórmula:C27H29NO6Pureza:97.6%Cor e Forma:SolidPeso molecular:463.52Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.01%Cor e Forma:SolidPeso molecular:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Fórmula:C22H27N5O2Pureza:98.01%Cor e Forma:SolidPeso molecular:393.48MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Fórmula:C21H16BrN3OCor e Forma:SolidPeso molecular:406.28SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Fórmula:C16H24BrClN2OPureza:99.81%Cor e Forma:SolidPeso molecular:375.733-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFórmula:C27H44OCor e Forma:SolidPeso molecular:384.64RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Fórmula:C20H29Cl2N3OSCor e Forma:SolidPeso molecular:430.43Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Fórmula:C23H15ClF4N4O2Cor e Forma:SolidPeso molecular:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Fórmula:C27H25F4N3O2Cor e Forma:SolidPeso molecular:499.5RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Fórmula:C20H27N3OSCor e Forma:SolidPeso molecular:357.51SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Fórmula:C23H20ClN3O4Cor e Forma:SolidPeso molecular:437.88Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Fórmula:C18H13ClF3N5OCor e Forma:SolidPeso molecular:407.78M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Fórmula:C23H29N3O2Cor e Forma:SolidPeso molecular:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Fórmula:C27H29N5OCor e Forma:SolidPeso molecular:439.55SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Fórmula:C25H25F4N5O2Pureza:98.64%Cor e Forma:SolidPeso molecular:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Fórmula:C25H24N4O2Pureza:99.96%Cor e Forma:SolidPeso molecular:412.48Hedgehog IN-2
CAS:Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.46
