Hedgehog/Smoothened
A via de sinalização Hedgehog/Smoothened é uma via crucial relacionada aos GPCRs, envolvida no desenvolvimento embrionário, regeneração de tecidos e manutenção de células-tronco. Smoothened (SMO) é uma proteína transmembrana chave que transduz sinais dos ligantes Hedgehog (Hh) para ativar cascatas de sinalização a jusante. A desregulação da via Hedgehog/Smoothened está implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um alvo significativo para intervenção terapêutica. Na CymitQuimica, oferecemos uma gama de moduladores de alta qualidade para a via Hedgehog/Smoothened para apoiar sua pesquisa em biologia do desenvolvimento, oncologia e medicina regenerativa.
Foram encontrados 44 produtos de "Hedgehog/Smoothened"
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Sonidegib
CAS:<p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Cor e Forma:SolidPeso molecular:485.5MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Fórmula:C24H23N3O5SPureza:99.73%Cor e Forma:SolidPeso molecular:465.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Fórmula:C23H27N5Pureza:99.98% - >99.99%Cor e Forma:SolidPeso molecular:373.49Neurodazine
CAS:<p>Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.</p>Fórmula:C27H21ClN2O3Pureza:98.01%Cor e Forma:SolidPeso molecular:456.92RUSKI-201
CAS:<p>RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.</p>Fórmula:C20H27N3OSCor e Forma:SolidPeso molecular:357.51SANT-2
CAS:<p>SANT-2 is a potent inhibitor of Shh signaling pathway.</p>Fórmula:C23H20ClN3O4Cor e Forma:SolidPeso molecular:437.88Hedgehog Antagonist VIII
CAS:<p>Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.</p>Fórmula:C23H15ClF4N4O2Cor e Forma:SolidPeso molecular:490.84RUSKI-201 dihydrochloride
CAS:<p>RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.</p>Fórmula:C20H29Cl2N3OSCor e Forma:SolidPeso molecular:430.43SMANT hydrochloride
CAS:<p>SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.</p>Fórmula:C16H24BrClN2OPureza:99.81%Cor e Forma:SolidPeso molecular:375.733-epi-Vitamin D3
CAS:<p>3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in</p>Fórmula:C27H44OCor e Forma:SolidPeso molecular:384.64SMO-IN-3
CAS:<p>SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.</p>Fórmula:C27H25F4N3O2Cor e Forma:SolidPeso molecular:499.5MS-0022
CAS:<p>MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.</p>Fórmula:C21H16BrN3OCor e Forma:SolidPeso molecular:406.28Hedgehog IN-3
CAS:<p>Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].</p>Fórmula:C18H13ClF3N5OCor e Forma:SolidPeso molecular:407.78AZD8542
CAS:<p>AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.</p>Fórmula:C25H24N4O2Pureza:99.96%Cor e Forma:SolidPeso molecular:412.48SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Fórmula:C25H25F4N5O2Pureza:98.64%Cor e Forma:SolidPeso molecular:503.49GSA-10
CAS:<p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>Fórmula:C26H30N2O5Pureza:99.71%Cor e Forma:SolidPeso molecular:450.53Robotnikinin
CAS:<p>Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.</p>Fórmula:C25H27ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:454.95Hh-Ag1.5
CAS:<p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>Fórmula:C28H26ClF2N3OSPureza:99.8%Cor e Forma:SolidPeso molecular:526.04Hedgehog IN-2
CAS:<p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].</p>Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.46TAK-441
CAS:<p>TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.</p>Fórmula:C28H31F3N4O6Pureza:99.82%Cor e Forma:SolidPeso molecular:576.56
