PAFR
O receptor do fator ativador de plaquetas (PAFR) é um GPCR que se liga ao fator ativador de plaquetas (PAF), um potente mediador fosfolipídico envolvido na inflamação, trombose e respostas alérgicas. A sinalização do PAFR desempenha um papel crucial nas respostas imunológicas, na saúde cardiovascular e na patogênese de doenças inflamatórias. A modulação da atividade do PAFR é de interesse no desenvolvimento de terapias anti-inflamatórias e antitrombóticas. Na CymitQuimica, oferecemos uma variedade de moduladores de PAFR de alta qualidade para apoiar sua pesquisa em imunologia, biologia cardiovascular e inflamação.
Foram encontrados 14 produtos de "PAFR"
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Kadsurenin C
CAS:Kadsurenin C (compound 1), a neolignan isolated from the aerial parts of Piper kadsura, exhibits anti-inflammatory properties and significant PAF (Platelet Activating Factor) antagonistic activity, with an IC50 value of 5.1 μM [1].Fórmula:C21H26O5Peso molecular:358.43Oxopurpureine
CAS:Oxopurpureine, classified as an oxoaporphine compound, functions to inhibit plant pathogens.Fórmula:C21H19NO6Peso molecular:381.38PAF C-18
CAS:PAF C-18 is a natural phospholipid molecule belonging to the platelet-activating factor (PAF) family,, involved in hemostasis and thrombosis by binding to PAFR.Fórmula:C28H58NO7PPureza:>99.99%Cor e Forma:SolidPeso molecular:551.74α-Bulnesene
CAS:α-Bulnesene, a novel PAF (platelet-activating factor) receptor antagonist, exhibits an IC50 of 17.62 μM. It can be isolated from patchouli. α-Bulnesene inhibits both PAF and arachidonic acid-induced aggregation of rabbit platelets.Fórmula:C15H24Cor e Forma:SolidPeso molecular:204.35PAF-AN-1
CAS:PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.Fórmula:C28H28N2O3Pureza:98.06%Cor e Forma:SolidPeso molecular:440.532-Acetylbenzoic acid
CAS:2-Acetylbenzoic acid outperforms 2-propionyloxybenzoic in hindering platelet function and PG synthesis; both similar in blocking PGI2 creation.Fórmula:C9H8O3Pureza:99.62%Cor e Forma:Off-White SolidPeso molecular:164.16Tulopafant
CAS:Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.Fórmula:C25H19N3O2SPureza:99.38%Cor e Forma:SolidPeso molecular:425.5Methylcarbamyl PAF C-16
CAS:Methylcarbamyl PAF C-16 (Carbamyl-PAF) is a PAF analog with PAF agonistic properties, activating inflammation in pregnancy tissues and promoting preterm birth.Fórmula:C26H55N2O7PCor e Forma:SolidPeso molecular:538.7Rocepafant
CAS:Rocepafant (LAU8080), a PAF antagonist, reduces neonatal rat brain damage and inhibits TNF-α toxicity in L929 cells.Fórmula:C26H23ClN6OS2Pureza:97.31% - 98.95%Cor e Forma:SolidPeso molecular:535.08SDZ-62-434
CAS:SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity and may be used in the study of leukemia.Fórmula:C23H27Cl2N3Pureza:98.38%Cor e Forma:SolidPeso molecular:416.3948740 RP
CAS:48740 RP (RP 55779) is an antagonist of platelet-activating factor.Fórmula:C12H11N3OSPureza:99.79%Cor e Forma:SolidPeso molecular:245.3Ref: TM-T10159
1mg356,00€5mg567,00€10mg907,00€25mg1.339,00€50mg1.815,00€100mg2.432,00€1mL*10mM (DMSO)567,00€Foropafant
CAS:Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM).Fórmula:C28H40N4SPureza:99.67%Cor e Forma:SolidPeso molecular:464.71Apafant
CAS:Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.Fórmula:C22H22ClN5O2SPureza:99.56%Cor e Forma:SolidPeso molecular:455.96ST-899
CAS:ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Fórmula:C22H29BrClNO6Cor e Forma:SolidPeso molecular:518.83
