Receptor de Canabinóides
Os receptores de canabinoides são GPCRs que mediam os efeitos dos canabinoides endógenos (endocanabinoides) e dos fitocanabinoides, como aqueles encontrados na cannabis. Os dois principais tipos de receptores de canabinoides, CB1 e CB2, estão envolvidos na regulação de uma ampla gama de processos fisiológicos, incluindo percepção da dor, apetite, humor e função imunológica. Moduladores de receptores de canabinoides têm potencial terapêutico no tratamento de condições como dor crônica, epilepsia e esclerose múltipla. Na CymitQuimica, oferecemos uma ampla gama de moduladores de receptores de canabinoides de alta qualidade para apoiar sua pesquisa em neurofarmacologia, manejo da dor e imunologia.
Foram encontrados 217 produtos de "Receptor de Canabinóides"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CB2R PAM
CAS:CB2R PAM, an oral drug, boosts CB2 receptor response to specific agonists, showing potential in neuropathic pain relief.Fórmula:C21H24BrFN2O2Pureza:99.09%Cor e Forma:SolidPeso molecular:435.33SCH-336
CAS:SCH-336: potent, selective CB2 agonist (Ki=1.8 nM, EC50=2 nM), orally active, 100x CB2 vs. CB1 preference, reduces leukocyte migration and eosinophilia.Fórmula:C23H25NO8S3Pureza:97.00%Cor e Forma:SolidPeso molecular:539.64Ref: TM-T24771
5mg49,00€10mg73,00€25mg152,00€50mg213,00€100mg309,00€200mg444,00€1mL*10mM (DMSO)60,00€PSB-CB5
CAS:PSB-CB5 (GPR18-IN-32)2 is a GRP18 antagonist with anti-inflammatory activity and can be used to study obesity and metabolic disorders.Fórmula:C20H17ClN2O2SPureza:99.26%Cor e Forma:SolidPeso molecular:384.88AZD1940
CAS:AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.Fórmula:C20H29F2N3O2SPureza:98.68%Cor e Forma:SolidPeso molecular:413.52Ref: TM-T30252
1mg130,00€5mg311,00€10mg535,00€25mg847,00€50mg1.169,00€100mg1.586,00€1mL*10mM (DMSO)344,00€JTE-907
CAS:JTE-907 是一种具有高度选择性和口服活性的 CB2 受体反向激动剂。JTE-907在体内展现出抗炎活性。Fórmula:C24H26N2O6Pureza:99.93%Cor e Forma:SolidPeso molecular:438.47Ref: TM-T19705
1mg52,00€5mg119,00€10mg177,00€25mg313,00€50mg465,00€100mg662,00€1mL*10mM (DMSO)142,00€AM-1235
CAS:AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.Fórmula:C24H21FN2O3Pureza:99.92%Cor e Forma:SolidPeso molecular:404.43O-2050
CAS:O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.Fórmula:C23H31NO4SPureza:98%Cor e Forma:SolidPeso molecular:417.56Heptadecanoyl ethanolamide
CAS:Heptadecanoyl ethanolamide, an endogenous cannabinoid, serves as a synthetic analog of PEA, featuring an odd-numbered (17-carbon) fatty acid chain [1].Fórmula:C19H39NO2Cor e Forma:SolidPeso molecular:313.52COR659
CAS:COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Fórmula:C16H16ClNO3SPureza:99.75%Cor e Forma:SolidPeso molecular:337.82Ref: TM-T36520
1mg38,00€5mg86,00€10mg123,00€25mg215,00€50mg299,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)94,00€PF-03550096
CAS:PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].Fórmula:C19H28N4O4Cor e Forma:SolidPeso molecular:376.45URB447
CAS:URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].Fórmula:C25H21ClN2OCor e Forma:SolidPeso molecular:400.9Tedalinab
CAS:Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Fórmula:C19H21F2N3OPureza:98%Cor e Forma:SolidPeso molecular:345.39GW405833 hydrochloride
CAS:GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Fórmula:C23H25Cl3N2O3Cor e Forma:SolidPeso molecular:483.822-Linoleoyl Glycerol
CAS:2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Fórmula:C21H38O4Cor e Forma:SolidPeso molecular:354.531GSK494581A
CAS:GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Fórmula:C27H28F2N2O4SPureza:98%Cor e Forma:SolidPeso molecular:514.58PF 514273
CAS:PF 514273 is a CB1 receptor antagonist.Fórmula:C21H17Cl2F2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:452.28PSNCBAM-1
CAS:PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Fórmula:C22H21ClN4OPureza:99.86%Cor e Forma:SolidPeso molecular:392.88Hemopressin(rat) TFA
CAS:Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.Fórmula:C55H78F3N13O14Cor e Forma:SolidPeso molecular:1202.2811(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS:11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Fórmula:C22H41NO2Cor e Forma:SolidPeso molecular:351.57SAD-448
CAS:SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Fórmula:C24H28N4O8SCor e Forma:SolidPeso molecular:532.57O-2545 hydrochloride
CAS:O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Fórmula:C26H36N2O2HClCor e Forma:SolidPeso molecular:445Tricosanoyl Ethanolamide
CAS:Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Fórmula:C25H51NO2Cor e Forma:SolidPeso molecular:397.688Isopropyl dodec-11-enylfluorophosphonate
CAS:Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibitsFórmula:C15H30FO2PPureza:98%Cor e Forma:SolidPeso molecular:292.37MCHB-1
CAS:MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.Fórmula:C28H37N3O2Cor e Forma:SolidPeso molecular:447.623CB1 antagonist 1
CAS:CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, andFórmula:C26H22Cl2N4Pureza:98%Cor e Forma:SolidPeso molecular:461.39Amauromine
CAS:Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.Fórmula:C32H36N4O2Cor e Forma:SolidPeso molecular:508.65γ-Linolenoyl monoethanolamide
CAS:γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].Fórmula:C20H35NO2Cor e Forma:SolidPeso molecular:321.505CB 65
CAS:CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.Fórmula:C22H28ClN3O3Pureza:99.53%Cor e Forma:SolidPeso molecular:417.93(R)-Monlunabant
CAS:(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].Fórmula:C26H22ClF3N6O3SPureza:98%Cor e Forma:SolidPeso molecular:591CB1 inverse agonist 1
CAS:MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.Fórmula:C25H18Cl3N3O3Pureza:99.92%Cor e Forma:SolidPeso molecular:514.79Ref: TM-T10694
1mg50,00€5mg105,00€10mg155,00€25mg224,00€50mg314,00€100mg427,00€200mg577,00€1mL*10mM (DMSO)129,00€AM841
CAS:AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Fórmula:C26H39NO3SPureza:98%Cor e Forma:SolidPeso molecular:445.66Prostaglandin E2-1-glyceryl ester
CAS:Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].Fórmula:C23H38O7Cor e Forma:SolidPeso molecular:426.55PSB-SB1202
CAS:PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].Fórmula:C23H26O4Cor e Forma:SolidPeso molecular:366.45CB2R-IN-1
CAS:CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).Fórmula:C23H27F3N4O6S3Pureza:98%Cor e Forma:SolidPeso molecular:608.67CB-25
CAS:CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFórmula:C25H41NO3Pureza:98%Cor e Forma:SolidPeso molecular:403.6CB-52
CAS:CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].Fórmula:C26H43NO3Cor e Forma:SolidPeso molecular:417.62OMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Fórmula:C26H44N2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:432.64Ref: TM-T12306
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)210,00€O-Arachidonoyl glycidol
CAS:O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Fórmula:C23H36O3Cor e Forma:SolidPeso molecular:360.53GSK-554418A
CAS:GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model.Fórmula:C19H19ClN4O2Cor e Forma:SolidPeso molecular:370.83CAY10508
CAS:CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Fórmula:C21H14Br2N2O2Cor e Forma:SolidPeso molecular:486.2GP 1a
CAS:GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.
Fórmula:C23H22Cl2N4OPureza:99.79%Cor e Forma:SolidPeso molecular:441.35GW 833972A
CAS:GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Fórmula:C18H14Cl2F3N5OPureza:99.93%Cor e Forma:SoildPeso molecular:444.24Bzo-poxizid
CAS:Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.40BAY 38-7271
CAS:BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Fórmula:C20H21F3O5SPureza:98%Cor e Forma:SolidPeso molecular:430.44AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Fórmula:C25H33NO3Cor e Forma:SolidPeso molecular:395.53CBR Agonist-2
CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.Fórmula:C27H27FN4OCor e Forma:SolidPeso molecular:442.53PSB-KK1415
CAS:PSB-KK1415 is a selective agonist for the human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM.Fórmula:C24H23ClN6O2Peso molecular:462.93Cannabigerovarin
CAS:Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.Fórmula:C19H28O2Peso molecular:288.42Ac-Atovaquone
CAS:Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Fórmula:C24H21ClO4Cor e Forma:SolidPeso molecular:408.87CBR Agonist-1
CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.Fórmula:C27H27FN4OCor e Forma:SolidPeso molecular:442.53
