Síntese de DNA/RNA

FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin …

Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.

Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad …

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the …

Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 …

Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse …

S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the salt of a mixture of diastereoisomers of …

dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage …

L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I …

Pseudouridine, prevalent in non-coding RNAs, boosts tRNA and rRNA function by RNA stabilization.

Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including …

NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not …

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of …

Isoindigotin is used in the therapy of Y.

Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.

Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product

O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) …

dCTP is a nucleotide used in DNA synthesis, PCR, cDNA creation, and sequencing.

GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free …

Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).

TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: …

PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for …

NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-

Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial …

SR 11302 is an inhibitor of activator protein-1 (AP-1).

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 …

SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) is enzyme inhibition, antiproliferative effects and antifungal activity.

360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 …

PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.

6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.

MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits …

5-Fluoroorotic acid is an inhibitor of thymidylate synthase.

RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR …

AT-130 is a HBV virus inhibitor with improved potency (IC50 = 0.13 μM) and reduced …

CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell …

Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat …

Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.

Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early …

Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.

Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.

Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.

Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.

Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that …

3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase and melanoma growth, varying with tyrosinase activity.

DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits …

Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.

NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis …