Síntese de DNA/RNA
Os inibidores da síntese de DNA e RNA são compostos que interferem nos processos de replicação e transcrição nas células, impedindo a produção de material genético essencial. Esses inibidores podem atingir várias enzimas e proteínas envolvidas na síntese de ácidos nucleicos, tornando-os ferramentas valiosas para estudar os mecanismos de replicação, transcrição e tradução. Eles também são usados no desenvolvimento de tratamentos para infecções e câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores da síntese de DNA/RNA para apoiar sua pesquisa em biologia molecular, virologia e desenvolvimento terapêutico.
Foram encontrados 710 produtos de "Síntese de DNA/RNA"
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SMN-C3
CAS:<p>SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).</p>Fórmula:C24H28N6OPureza:99.01% - 99.05%Cor e Forma:SolidPeso molecular:416.52DHX9-IN-2
CAS:<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Fórmula:C18H16ClN3O3S2Pureza:98%Cor e Forma:SolidPeso molecular:421.92CeMMEC1
CAS:CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Fórmula:C19H16N2O4Pureza:98.9% - 99.92%Cor e Forma:SolidPeso molecular:336.34Sorivudine
CAS:<p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>Fórmula:C11H13BrN2O6Pureza:99.74%Cor e Forma:SolidPeso molecular:349.13Lomibuvir
CAS:<p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>Fórmula:C25H35NO4SPureza:99.83%Cor e Forma:SolidPeso molecular:445.61NRTT-IN-1
CAS:<p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>Fórmula:C28H24FN5O5Cor e Forma:SolidPeso molecular:529.519N-Nitrosonornicotine
CAS:<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Fórmula:C9H11N3OCor e Forma:SolidPeso molecular:177.24,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Fórmula:C21H19NO7SCor e Forma:SolidPeso molecular:429.44D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Fórmula:C19H22N4O3Cor e Forma:SolidPeso molecular:354.403Adafosbuvir
CAS:<p>Adafosbuvir has antiviral activity.</p>Fórmula:C22H29FN3O10PCor e Forma:SolidPeso molecular:545.457TREX1-IN-4
CAS:<p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898PCNA-IN-1
CAS:<p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>Fórmula:C19H18I3NO3Cor e Forma:SolidPeso molecular:689.065WRN inhibitor 7
CAS:<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Fórmula:C27H23N3O6Cor e Forma:SolidPeso molecular:485.49RAD51-IN-5
CAS:<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Fórmula:C26H38N4O5S2Cor e Forma:SolidPeso molecular:550.73EFdA-TP tetrasodium
CAS:<p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>Fórmula:C12H11FN5Na4O12P3Pureza:98%Cor e Forma:SolidPeso molecular:621.12ddCTP trisodium
<p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>Fórmula:C9H13N3Na3O12P3Cor e Forma:SolidPeso molecular:517.1HPH-15
CAS:<p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>Fórmula:C19H31N3S4Cor e Forma:SolidPeso molecular:429.73TREX1-IN-3
CAS:<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898Antitumor agent-74
<p>Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.</p>Fórmula:C26H23FN6Cor e Forma:SolidPeso molecular:438.5KWR095
CAS:<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105
