
HIV Protease
Os inibidores da protease do HIV são uma classe de medicamentos antirretrovirais que têm como alvo específico a enzima protease do vírus da imunodeficiência humana (HIV). Ao inibir esta enzima, esses compostos impedem o vírus de processar suas poliproteínas em proteínas maduras e funcionais, bloqueando assim a produção de novos virions infecciosos. Os inibidores da protease do HIV são um pilar da terapia antirretroviral altamente ativa (HAART) utilizada para o tratamento do HIV/AIDS. Na CymitQuimica, oferecemos uma variedade de inibidores da protease do HIV para apoiar sua pesquisa em tratamento do HIV, resistência a medicamentos e virologia.
Foram encontrados 447 produtos de "HIV Protease"
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Methyl piperazine-2-carboxylate
CAS:<p>Methyl piperazine-2-carboxylate (compound 4) is a potent activator of METTL3/METTL14/WTAP. It enhances the production of HIV-1p24 viral particles and increases the level of N6-methyladenosine in the viral RNA genome.</p>Fórmula:C6H12N2O2Cor e Forma:SolidPeso molecular:144.172BI-2540
CAS:<p>BI-2540 is a HIV non-nucleoside reverse transcriptase ( NNRT ) inhibitor .</p>Fórmula:C24H15ClF5NO5Cor e Forma:SolidPeso molecular:527.83Desthiazolylmethyl ritonavir
CAS:<p>Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir.</p>Fórmula:C33H43N5O4SCor e Forma:SolidPeso molecular:605.791HIV-1 protease-IN-6
<p>HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.</p>Fórmula:C27H31FN2O6SCor e Forma:SolidPeso molecular:530.61NBD-14189
CAS:<p>NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 <200 nM).</p>Fórmula:C18H16F4N4O2SCor e Forma:SolidPeso molecular:428.40BI 224436
CAS:<p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>Fórmula:C27H26N2O4Cor e Forma:SolidPeso molecular:442.51BRD-K98645985
CAS:<p>BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.</p>Fórmula:C33H43N5O4Pureza:98%Cor e Forma:SolidPeso molecular:573.73PD 134922
CAS:<p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>Fórmula:C37H61N5O7SPureza:98%Cor e Forma:SolidPeso molecular:719.97MIV-150
CAS:<p>MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).</p>Fórmula:C19H17FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:368.36ZK-316
CAS:<p>ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 range of 0.99 to 75.1 nM. It is applicable for HIV research.</p>Fórmula:C27H22D6N6O3S2Cor e Forma:SolidPeso molecular:554.72BMIM-TFSI
CAS:<p>BMIM-TFSI (compound8) is an HIV-1 integrase inhibitor that effectively suppresses both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration process. It is applicable in HIV-1 research.</p>Fórmula:C10H15F6N3O4S2Cor e Forma:SolidPeso molecular:419.364HIV-1 inhibitor-44
<p>HIV-1 inhibitor-44 (compound 11l) is an HIV-1 reverse transcriptase inhibitor that exhibits activity against wild-type HIV-1 strains (EC50: 0.209 μM).</p>Fórmula:C23H26N2O4SCor e Forma:SolidPeso molecular:426.53A 76889
CAS:<p>A 76889 is an inhibitor of HIV-1 protease.</p>Fórmula:C44H58N8O6Pureza:98%Cor e Forma:SolidPeso molecular:794.98BRN3OMe
CAS:<p>BRN3OMe is an effective inhibitor of HIV-1 reverse transcriptase (HIV-1 reverse transcriptase), showing potential for antiviral drug research.</p>Fórmula:C7H13N3O4Cor e Forma:SolidPeso molecular:203.196Telinavir
CAS:<p>Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.</p>Fórmula:C33H44N6O5Cor e Forma:SolidPeso molecular:604.74GSK3739936
CAS:<p>GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 >24.3 μM), rapid absorption, moderate clearance, high oral availability.</p>Fórmula:C34H43FN2O4Cor e Forma:SolidPeso molecular:562.71HIV-1 inhibitor-40
<p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>Fórmula:C25H18N6O2Cor e Forma:SolidPeso molecular:434.45Lentiginosine
CAS:<p>Lentiginosine is a selective amyloglucosidase inhibitor.</p>Fórmula:C8H15NO2Cor e Forma:SolidPeso molecular:157.21L-697639
CAS:<p>L-697639 inhibits of HIV-1 reverse transcriptase and HIV-1 replication.</p>Fórmula:C18H21N3O2Cor e Forma:SolidPeso molecular:311.38GS-9822
CAS:<p>GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.</p>Fórmula:C36H39ClN4O4SCor e Forma:SolidPeso molecular:659.24Gardiquimod hydrochloride
CAS:<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Fórmula:C17H24ClN5OCor e Forma:SolidPeso molecular:349.858Fipravirimat
CAS:<p>Fipravirimat is a potent inhibitor of HIV-1 with potential applications in HIV and AIDS research.</p>Fórmula:C43H67FN2O4SCor e Forma:SolidPeso molecular:727.07Integrase-LEDGF/p75 allosteric inhibitor 1
CAS:<p>Oral HIV-1 allosteric integrase inhibitor, blocks DNA integration, antiviral, potent against NL432 (EC50: 3.9 nM).</p>Fórmula:C33H41NO6SCor e Forma:SolidPeso molecular:579.75HIV-1 inhibitor-52
CAS:<p>HIV-1 inhibitor-52: potent, broad-spectrum with EC50s 1.6-6.4 nM against various HIV-1 strains.</p>Fórmula:C46H72FNO5SCor e Forma:SolidPeso molecular:770.13(S)-Batylalcohol
CAS:<p>(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is an analogue of phosphonoformic acid (PFA) and demonstrates higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) compared to PFA. This compound is applicable in antiretroviral research.</p>Fórmula:C21H44O3Cor e Forma:SolidPeso molecular:344.5724'-Ethynyl-2'-deoxyadenosine
CAS:<p>4'-E-dA is a potent nucleoside RT inhibitor for drug-resistant HIV (EC50: 98 nM in MT-4 cells).</p>Fórmula:C12H13N5O3Pureza:98%Cor e Forma:SolidPeso molecular:275.26BMS-818251
CAS:<p>BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the conserved β20-β21 hairpin.</p>Fórmula:C29H26N6O5SCor e Forma:SolidPeso molecular:570.619ZLM-66
<p>ZLM-66: Doravirine analog, HIV-1 NNRTI inhibitor, IC50: 41nM, EC50: HIV-1 13nM, cIAP1 0.32nM; useful in AIDS research.</p>Cor e Forma:SolidHIV-IN-3
<p>HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.</p>Fórmula:C21H32ClN7O3Cor e Forma:SolidPeso molecular:465.98Lamivudine, (+/-)-trans-
CAS:<p>Lamivudine, a drug for HIV-1 and HBV, inhibits reverse transcriptase and resembles zalcitabine.</p>Fórmula:C8H11N3O3SPureza:98%Cor e Forma:SolidPeso molecular:229.26NBD-10007
CAS:<p>NBD-10007 is an inhibitor of HIV-1 entry.</p>Fórmula:C20H25ClN4O3SPureza:98%Cor e Forma:SolidPeso molecular:436.96Saphenamycin
CAS:<p>Saphenamycin is an antibiotic from a strain of Streptomyces.</p>Fórmula:C23H18N2O5Pureza:98%Cor e Forma:SolidPeso molecular:402.40Emtricitabine triphosphate
CAS:<p>Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.</p>Fórmula:C8H13FN3O12P3SCor e Forma:SolidPeso molecular:487.19L 702007
CAS:<p>L 702007 is an inhibitor of HIV-1 reverse transcriptase.</p>Fórmula:C18H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:315.41HIV-1 inhibitor-41
<p>HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.</p>Fórmula:C16H15F2N3OSCor e Forma:SolidPeso molecular:335.37HIV-1 inhibitor-14
<p>HIV-1 inhibitor-14: potent, broad HIV-1 RT inhibitor. IC50=0.14μM. Effective against wild-type and resistant strains, EC50=5.79-28.3nM.</p>Fórmula:C29H32N6O4SCor e Forma:SolidPeso molecular:560.67HIV-1 inhibitor-18
<p>HIV-1 inhibitor-18 blocks HIV-1 capsid, effective on NL4-3 strain (EC50: 5.14 μM), slightly toxic (MT-4CC50>9.51).</p>Fórmula:C27H31N3O6SCor e Forma:SolidPeso molecular:525.62HIV-1 inhibitor-13
<p>HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).</p>Fórmula:C30H32N6O3Cor e Forma:SolidPeso molecular:524.61HIV-1 inhibitor-8
<p>HIV-1 inhibitor-8: potent oral NNRTI, low toxicity, IC50: 0.081 μM, effective on multiple strains, EC50: 4.44-54.5 nM.</p>Fórmula:C25H21N5OSCor e Forma:SolidPeso molecular:439.53HIV-1 inhibitor-61
CAS:<p>HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].</p>Fórmula:C24H24F2N2O2SCor e Forma:SolidPeso molecular:442.52Aurothioglucose
CAS:<p>Aurothioglucose is a active-site TrxR1 inhibitor.</p>Fórmula:C6H11AuO5SPureza:98%Cor e Forma:Yellow Crystals SolidPeso molecular:392.18BMS-378806
<p>BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.</p>Fórmula:C22H22N4O4Pureza:98%Cor e Forma:SolidPeso molecular:406.43Cyclotriazadisulfonamide
CAS:<p>Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4 by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through a signal peptide (SP)-dependent mechanism.</p>Fórmula:C31H39N3O4S2Cor e Forma:SolidPeso molecular:581.793-Deazaadenosine
CAS:<p>3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.</p>Fórmula:C11H14N4O4Pureza:98%Cor e Forma:SolidPeso molecular:266.25Loviride
CAS:<p>Loviride, a reverse transcriptase inhibitor with IC50 of 0.3 μM, blocks HIV-1/2 and SIV in MT-4 cells.</p>Fórmula:C17H16Cl2N2O2Cor e Forma:SolidPeso molecular:351.23Ref: TM-T15776
Produto descontinuadoOxindole
CAS:<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Fórmula:C8H7NOPureza:99.34%Cor e Forma:Off-White Crystalline PowderPeso molecular:133.15HIV-1 integrase inhibitor
CAS:<p>Hiv-1 integrase inhibitor is an effective anti-HIV drug.</p>Fórmula:C11H9N3O4Pureza:98%Cor e Forma:SolidPeso molecular:247.21

