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HIV Protease

HIV Protease

Os inibidores da protease do HIV são uma classe de medicamentos antirretrovirais que têm como alvo específico a enzima protease do vírus da imunodeficiência humana (HIV). Ao inibir esta enzima, esses compostos impedem o vírus de processar suas poliproteínas em proteínas maduras e funcionais, bloqueando assim a produção de novos virions infecciosos. Os inibidores da protease do HIV são um pilar da terapia antirretroviral altamente ativa (HAART) utilizada para o tratamento do HIV/AIDS. Na CymitQuimica, oferecemos uma variedade de inibidores da protease do HIV para apoiar sua pesquisa em tratamento do HIV, resistência a medicamentos e virologia.

Foram encontrados 447 produtos de "HIV Protease"

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  • Methyl piperazine-2-carboxylate

    CAS:
    <p>Methyl piperazine-2-carboxylate (compound 4) is a potent activator of METTL3/METTL14/WTAP. It enhances the production of HIV-1p24 viral particles and increases the level of N6-methyladenosine in the viral RNA genome.</p>
    Fórmula:C6H12N2O2
    Cor e Forma:Solid
    Peso molecular:144.172
  • BI-2540

    CAS:
    <p>BI-2540 is a HIV non-nucleoside reverse transcriptase ( NNRT ) inhibitor .</p>
    Fórmula:C24H15ClF5NO5
    Cor e Forma:Solid
    Peso molecular:527.83
  • Desthiazolylmethyl ritonavir

    CAS:
    <p>Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir.</p>
    Fórmula:C33H43N5O4S
    Cor e Forma:Solid
    Peso molecular:605.791
  • HIV-1 protease-IN-6


    <p>HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.</p>
    Fórmula:C27H31FN2O6S
    Cor e Forma:Solid
    Peso molecular:530.61
  • NBD-14189

    CAS:
    <p>NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 &lt;200 nM).</p>
    Fórmula:C18H16F4N4O2S
    Cor e Forma:Solid
    Peso molecular:428.40
  • BI 224436

    CAS:
    <p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>
    Fórmula:C27H26N2O4
    Cor e Forma:Solid
    Peso molecular:442.51
  • BRD-K98645985

    CAS:
    <p>BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.</p>
    Fórmula:C33H43N5O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:573.73
  • PD 134922

    CAS:
    <p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>
    Fórmula:C37H61N5O7S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:719.97
  • MIV-150

    CAS:
    <p>MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50&lt;1 nM against HIV-1/HIV-2MN).</p>
    Fórmula:C19H17FN4O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:368.36
  • ZK-316

    CAS:
    <p>ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 range of 0.99 to 75.1 nM. It is applicable for HIV research.</p>
    Fórmula:C27H22D6N6O3S2
    Cor e Forma:Solid
    Peso molecular:554.72
  • BMIM-TFSI

    CAS:
    <p>BMIM-TFSI (compound8) is an HIV-1 integrase inhibitor that effectively suppresses both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration process. It is applicable in HIV-1 research.</p>
    Fórmula:C10H15F6N3O4S2
    Cor e Forma:Solid
    Peso molecular:419.364
  • HIV-1 inhibitor-44


    <p>HIV-1 inhibitor-44 (compound 11l) is an HIV-1 reverse transcriptase inhibitor that exhibits activity against wild-type HIV-1 strains (EC50: 0.209 μM).</p>
    Fórmula:C23H26N2O4S
    Cor e Forma:Solid
    Peso molecular:426.53
  • A 76889

    CAS:
    <p>A 76889 is an inhibitor of HIV-1 protease.</p>
    Fórmula:C44H58N8O6
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:794.98
  • BRN3OMe

    CAS:
    <p>BRN3OMe is an effective inhibitor of HIV-1 reverse transcriptase (HIV-1 reverse transcriptase), showing potential for antiviral drug research.</p>
    Fórmula:C7H13N3O4
    Cor e Forma:Solid
    Peso molecular:203.196
  • Telinavir

    CAS:
    <p>Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.</p>
    Fórmula:C33H44N6O5
    Cor e Forma:Solid
    Peso molecular:604.74
  • GSK3739936

    CAS:
    <p>GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 &gt;24.3 μM), rapid absorption, moderate clearance, high oral availability.</p>
    Fórmula:C34H43FN2O4
    Cor e Forma:Solid
    Peso molecular:562.71
  • HIV-1 inhibitor-40


    <p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>
    Fórmula:C25H18N6O2
    Cor e Forma:Solid
    Peso molecular:434.45
  • Lentiginosine

    CAS:
    <p>Lentiginosine is a selective amyloglucosidase inhibitor.</p>
    Fórmula:C8H15NO2
    Cor e Forma:Solid
    Peso molecular:157.21
  • L-697639

    CAS:
    <p>L-697639 inhibits of HIV-1 reverse transcriptase and HIV-1 replication.</p>
    Fórmula:C18H21N3O2
    Cor e Forma:Solid
    Peso molecular:311.38
  • GS-9822

    CAS:
    <p>GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.</p>
    Fórmula:C36H39ClN4O4S
    Cor e Forma:Solid
    Peso molecular:659.24
  • Gardiquimod hydrochloride

    CAS:
    <p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>
    Fórmula:C17H24ClN5O
    Cor e Forma:Solid
    Peso molecular:349.858
  • Fipravirimat

    CAS:
    <p>Fipravirimat is a potent inhibitor of HIV-1 with potential applications in HIV and AIDS research.</p>
    Fórmula:C43H67FN2O4S
    Cor e Forma:Solid
    Peso molecular:727.07
  • Integrase-LEDGF/p75 allosteric inhibitor 1

    CAS:
    <p>Oral HIV-1 allosteric integrase inhibitor, blocks DNA integration, antiviral, potent against NL432 (EC50: 3.9 nM).</p>
    Fórmula:C33H41NO6S
    Cor e Forma:Solid
    Peso molecular:579.75
  • HIV-1 inhibitor-52

    CAS:
    <p>HIV-1 inhibitor-52: potent, broad-spectrum with EC50s 1.6-6.4 nM against various HIV-1 strains.</p>
    Fórmula:C46H72FNO5S
    Cor e Forma:Solid
    Peso molecular:770.13
  • (S)-Batylalcohol

    CAS:
    <p>(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is an analogue of phosphonoformic acid (PFA) and demonstrates higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) compared to PFA. This compound is applicable in antiretroviral research.</p>
    Fórmula:C21H44O3
    Cor e Forma:Solid
    Peso molecular:344.572
  • 4'-Ethynyl-2'-deoxyadenosine

    CAS:
    <p>4'-E-dA is a potent nucleoside RT inhibitor for drug-resistant HIV (EC50: 98 nM in MT-4 cells).</p>
    Fórmula:C12H13N5O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:275.26
  • BMS-818251

    CAS:
    <p>BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the conserved β20-β21 hairpin.</p>
    Fórmula:C29H26N6O5S
    Cor e Forma:Solid
    Peso molecular:570.619
  • ZLM-66


    <p>ZLM-66: Doravirine analog, HIV-1 NNRTI inhibitor, IC50: 41nM, EC50: HIV-1 13nM, cIAP1 0.32nM; useful in AIDS research.</p>
    Cor e Forma:Solid
  • HIV-IN-3


    <p>HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.</p>
    Fórmula:C21H32ClN7O3
    Cor e Forma:Solid
    Peso molecular:465.98
  • Lamivudine, (+/-)-trans-

    CAS:
    <p>Lamivudine, a drug for HIV-1 and HBV, inhibits reverse transcriptase and resembles zalcitabine.</p>
    Fórmula:C8H11N3O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:229.26
  • NBD-10007

    CAS:
    <p>NBD-10007 is an inhibitor of HIV-1 entry.</p>
    Fórmula:C20H25ClN4O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:436.96
  • Saphenamycin

    CAS:
    <p>Saphenamycin is an antibiotic from a strain of Streptomyces.</p>
    Fórmula:C23H18N2O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:402.40
  • Emtricitabine triphosphate

    CAS:
    <p>Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.</p>
    Fórmula:C8H13FN3O12P3S
    Cor e Forma:Solid
    Peso molecular:487.19
  • L 702007

    CAS:
    <p>L 702007 is an inhibitor of HIV-1 reverse transcriptase.</p>
    Fórmula:C18H25N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:315.41
  • HIV-1 inhibitor-41


    <p>HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.</p>
    Fórmula:C16H15F2N3OS
    Cor e Forma:Solid
    Peso molecular:335.37
  • HIV-1 inhibitor-14


    <p>HIV-1 inhibitor-14: potent, broad HIV-1 RT inhibitor. IC50=0.14μM. Effective against wild-type and resistant strains, EC50=5.79-28.3nM.</p>
    Fórmula:C29H32N6O4S
    Cor e Forma:Solid
    Peso molecular:560.67
  • HIV-1 inhibitor-18


    <p>HIV-1 inhibitor-18 blocks HIV-1 capsid, effective on NL4-3 strain (EC50: 5.14 μM), slightly toxic (MT-4CC50&gt;9.51).</p>
    Fórmula:C27H31N3O6S
    Cor e Forma:Solid
    Peso molecular:525.62
  • HIV-1 inhibitor-13


    <p>HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).</p>
    Fórmula:C30H32N6O3
    Cor e Forma:Solid
    Peso molecular:524.61
  • HIV-1 inhibitor-8


    <p>HIV-1 inhibitor-8: potent oral NNRTI, low toxicity, IC50: 0.081 μM, effective on multiple strains, EC50: 4.44-54.5 nM.</p>
    Fórmula:C25H21N5OS
    Cor e Forma:Solid
    Peso molecular:439.53
  • HIV-1 inhibitor-61

    CAS:
    <p>HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].</p>
    Fórmula:C24H24F2N2O2S
    Cor e Forma:Solid
    Peso molecular:442.52
  • Aurothioglucose

    CAS:
    <p>Aurothioglucose is a active-site TrxR1 inhibitor.</p>
    Fórmula:C6H11AuO5S
    Pureza:98%
    Cor e Forma:Yellow Crystals Solid
    Peso molecular:392.18

    Ref: TM-T14351

    100mg
    Descontinuado
    Produto descontinuado
  • BMS-378806


    <p>BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.</p>
    Fórmula:C22H22N4O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:406.43

    Ref: TM-T22609

    1mg
    Descontinuado
    2mg
    Descontinuado
    Produto descontinuado
  • Cyclotriazadisulfonamide

    CAS:
    <p>Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4 by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through a signal peptide (SP)-dependent mechanism.</p>
    Fórmula:C31H39N3O4S2
    Cor e Forma:Solid
    Peso molecular:581.79

    Ref: TM-T39264

    Produto descontinuado
  • 3-Deazaadenosine

    CAS:
    <p>3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.</p>
    Fórmula:C11H14N4O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:266.25

    Ref: TM-T10111L

    5mg
    Descontinuado
    Produto descontinuado
  • Loviride

    CAS:
    <p>Loviride, a reverse transcriptase inhibitor with IC50 of 0.3 μM, blocks HIV-1/2 and SIV in MT-4 cells.</p>
    Fórmula:C17H16Cl2N2O2
    Cor e Forma:Solid
    Peso molecular:351.23

    Ref: TM-T15776

    1mg
    Descontinuado
    2mg
    Descontinuado
    1ml*10 (DMSO)
    Descontinuado
    1mL*10mM (DMSO)_old
    Descontinuado
    Produto descontinuado
  • Oxindole

    CAS:
    <p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>
    Fórmula:C8H7NO
    Pureza:99.34%
    Cor e Forma:Off-White Crystalline Powder
    Peso molecular:133.15

    Ref: TM-FR16741

    10g
    Descontinuado
    Produto descontinuado
  • HIV-1 integrase inhibitor

    CAS:
    <p>Hiv-1 integrase inhibitor is an effective anti-HIV drug.</p>
    Fórmula:C11H9N3O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:247.21

    Ref: TM-T11566

    50mg
    Descontinuado
    100mg
    Descontinuado
    Produto descontinuado