HIV Protease
Os inibidores da protease do HIV são uma classe de medicamentos antirretrovirais que têm como alvo específico a enzima protease do vírus da imunodeficiência humana (HIV). Ao inibir esta enzima, esses compostos impedem o vírus de processar suas poliproteínas em proteínas maduras e funcionais, bloqueando assim a produção de novos virions infecciosos. Os inibidores da protease do HIV são um pilar da terapia antirretroviral altamente ativa (HAART) utilizada para o tratamento do HIV/AIDS. Na CymitQuimica, oferecemos uma variedade de inibidores da protease do HIV para apoiar sua pesquisa em tratamento do HIV, resistência a medicamentos e virologia.
Foram encontrados 447 produtos de "HIV Protease"
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Lopinavir
CAS:<p>Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation.</p>Fórmula:C37H48N4O5Pureza:98% - 99.62%Cor e Forma:White Crystalline SolidPeso molecular:628.8Didanosine
CAS:<p>Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).</p>Fórmula:C10H12N4O3Pureza:99.64%Cor e Forma:White Crystalline PowderPeso molecular:236.23Rilpivirine
CAS:<p>Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment</p>Fórmula:C22H18N6Pureza:97.22% - 98.83%Cor e Forma:SolidPeso molecular:366.42Obefazimod
CAS:<p>Obefazimod (ABX-464) is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs).</p>Fórmula:C16H10ClF3N2OPureza:99.86%Cor e Forma:SolidPeso molecular:338.712,4-Dihydroxypyridine
CAS:<p>2,4-Dihydroxypyridine: a pyridine derivative, chelates metals, assesses ion levels, measures enzymatic reactions, and quantifies biomolecules.</p>Fórmula:C5H5NO2Pureza:97.79%Cor e Forma:White To Yellow-Beige Crystals OrPeso molecular:111.1Dimercaprol
CAS:<p>Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-</p>Fórmula:C3H8OS2Pureza:98.91% - 99.64%Cor e Forma:Viscous Oily LiquidPeso molecular:124.22Raltegravir potassium
CAS:<p>Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.</p>Fórmula:C20H20FN6O5·KPureza:98% - 99.55%Cor e Forma:Off-White SolidPeso molecular:482.51NBD-557
CAS:<p>NBD-557 is a potentially HIV-1 inhibitor.</p>Fórmula:C17H24BrN3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:382.3Raltegravir
CAS:<p>Raltegravir (MK-0518) is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV</p>Fórmula:C20H21FN6O5Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:444.42IMB-301
CAS:<p>IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.</p>Fórmula:C19H17Cl2FN2OPureza:99.72%Cor e Forma:SolidPeso molecular:379.26Lamivudine 13C,15N2
CAS:<p>Lamivudine 13C,15N2, a BCH-189 impurity, blocks HIV/HBV reverse transcriptase as an NRTI.</p>Fórmula:C8H9N3O4SPureza:98%Cor e Forma:SolidPeso molecular:246.22Nelfinavir
CAS:<p>Nelfinavir (AG1341), with Ki=2 nM, is an HIV treatment and broad-spectrum anticancer drug.</p>Fórmula:C32H45N3O4SPureza:98.16% - 99.5%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:567.78Elipovimab
CAS:<p>Elipovimab, a potent and broadly neutralizing antibody against HIV-1, targets and eliminates HIV-infected cells [1].</p>Cor e Forma:LiquidSemzuvolimab
CAS:<p>Semzuvolimab, a murine IgG1κ antibody, targets the p55 T-cell surface antigen T4/Leu-3 (CD4).</p>Cor e Forma:LiquidSuvizumab
CAS:<p>Suvizumab (KD-247) is a neutralizing anti-HIV-1 antibody with IC50 values of 0.1-1.0 µg/mL; it lowers viral load and prevents infection.</p>Cor e Forma:LiquidAntiviral agent 55
CAS:<p>Antiviralagent 55 (Compound 95) is an inhibitor of human immunodeficiency viruses 1 and 2 (HIV1 and HIV2), demonstrating antiviral activity.</p>Fórmula:C21H20N2O4Cor e Forma:SolidPeso molecular:364.39Benzalphthalide
CAS:<p>Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.</p>Fórmula:C15H10O2Pureza:99.94%Cor e Forma:Pale Yellow To Yellow Crystalline PowderPeso molecular:222.24Zinlirvimab
CAS:<p>Zinlirvimab is a humanized IgG1-λ2 monoclonal antibody that neutralizes HIV by targeting the HIV-1 gp120 envelope glycoprotein, specifically the IIIB gp120 V3</p>Cor e Forma:LiquidNipamovir
CAS:<p>Nipamovir is a nitroimidazole prodrug that exhibits antiviral activity comparable to SAMT-247 and NS-1040 in cellular assays and a human ex vivo model of HIV infection, with low toxicity. Nipamovir has EC50 values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively [1].</p>Fórmula:C14H15N5O4SCor e Forma:SolidPeso molecular:349.37Antiviral agent 9
<p>Antiviral agent 9: EC50 0.006 nM vs HIV-1, 300x more selective than TAF.</p>Fórmula:C38H50N7O8PCor e Forma:SolidPeso molecular:763.82APOBEC3G-IN-1
CAS:<p>APOBEC3G-IN-1 (MN136.0185) is a targeted APOBEC3G inhibitor with anti-HIV activity for the study of infectious diseases and cancer.</p>Fórmula:C15H11NO3Pureza:96.54%Cor e Forma:SolidPeso molecular:253.25HIV-IN-6
CAS:<p>HIV-IN-6, an anti-HIV agent, blocks replication by targeting SFKs like Hck involved with Nef protein.</p>Fórmula:C20H16N4O3SPureza:97.12%Cor e Forma:SolidPeso molecular:392.43HIV-1 inhibitor-49
<p>HIV-1 inhibitor-49, an oral HEPT analog, has strong pharmacokinetics, potent reverse transcriptase inhibition (IC50=30nM), and is safe in mice.</p>Fórmula:C21H18F2N2O3SCor e Forma:SolidPeso molecular:416.44MK-2048
CAS:<p>MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.</p>Fórmula:C21H21ClFN5O4Pureza:98%Cor e Forma:SolidPeso molecular:461.87HIV-1 inhibitor-22
CAS:<p>HIV-1 inhibitor-22 effectively blocks HIV-1 RT (IC50=3.63 μM) with low cytotoxicity (CC50 > 227 μM).</p>Fórmula:C30H26N6O3SCor e Forma:SolidPeso molecular:550.63HIV-1 integrase inhibitor 4
CAS:<p>HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM).</p>Fórmula:C24H20F2N4O5SPureza:98%Cor e Forma:SolidPeso molecular:514.5HIV-1 inhibitor-29
CAS:<p>HIV-1 inhibitor-29: Blocks HIV-1 IIIB (EC50: 2.18μM), resists F227L/V106A (EC50: 0.974μM), low toxicity (CC50: 211μM), for AIDS research.</p>Fórmula:C30H36N6O5Cor e Forma:SolidPeso molecular:560.64D77
CAS:<p>D77 is anti-HIV-1 inhibitor. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).</p>Fórmula:C28H22BrNO7SPureza:98%Cor e Forma:SolidPeso molecular:596.45HIV-1 inhibitor-34
CAS:<p>HIV-1 inhibitor-34 (5q): potent, selective; EC50: 6.4 nM; MT-4 CC50: 16 μM; useful in AIDS research.</p>Fórmula:C26H27N7OCor e Forma:SolidPeso molecular:453.54HIV-IN-4
CAS:<p>HIV-IN-4 (Compound 12) is a potent HIV inhibitor that exhibits promising anti-HIV activities [1].</p>Fórmula:C14H18N2O3Cor e Forma:SolidPeso molecular:262.3HIV-1 inhibitor-16
CAS:<p>HIV-1 inhibitor-16: potent with EC50 1.3 nM for wild-type; inhibits K103N, E138K, Y181C, L100I strains; good solubility; stable; low CYP impact; non-toxic.</p>Fórmula:C23H16F2N6Cor e Forma:SolidPeso molecular:414.41HIV-1 inhibitor-57
CAS:<p>HIV-1 Inhibitor-57 (Compound 12g) is an antiviral agent that potently inhibits both wild-type and five common NNRTI-resistant strains of HIV-1, exhibiting EC50</p>Fórmula:C25H24FN5O3SCor e Forma:SolidPeso molecular:493.55SARS-CoV-IN-3
CAS:<p>SARS-CoV-IN-3 is an effective SARS-CoV replication inhibitor.</p>Fórmula:C25H28ClFeN3OPureza:98%Cor e Forma:SolidPeso molecular:477.81Mesoxalic acid
CAS:<p>Mesoxalic acid is a dicarboxylic acid and a ketonic acid which blocks RT translocation.</p>Fórmula:C3H2O5Pureza:98%Cor e Forma:SolidPeso molecular:118.04SAMT-247
CAS:<p>SAMT-247 is an HIV inhibitor that acts by modifying the nucleocapsid NCp7 region of Gag in infected cells and blocking Gag processing and reducing infectivity.</p>Fórmula:C12H14N2O3SCor e Forma:SolidPeso molecular:266.32TMC310911
CAS:<p>TMC310911 is an oral HIV-1 protease inhibitor with an EC50 of 2.2-14.2 nM, effective against various HIV-1 strains.</p>Fórmula:C38H53N5O7S2Pureza:98%Cor e Forma:SolidPeso molecular:755.99Reverse transcriptase-IN-3
<p>Reverse transcriptase-IN-3, a pyrimidine carboxamide, inhibits HIV-1 including mutant strains.</p>Fórmula:C28H31N7O4SCor e Forma:SolidPeso molecular:561.66DQBS
CAS:<p>DQBS is an HIV-1 Nef function antagonist.</p>Fórmula:C22H17ClN4O4SPureza:98%Cor e Forma:SolidPeso molecular:468.91HIV-1 integrase inhibitor 7
CAS:<p>HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM).</p>Fórmula:C30H26O16Pureza:98%Cor e Forma:SolidPeso molecular:642.52β-L-D4A
CAS:<p>beta-L-D4A inhibits HIV-1 reverse transcriptase, stopping DNA synthesis.</p>Fórmula:C10H11N5O2Pureza:99.45%Cor e Forma:SolidPeso molecular:233.23MK-4965
CAS:<p>MK-4965 is a new type of non-nucleoside reverse transcriptase inhibitor with antiviral activity.</p>Fórmula:C20H13Cl2N5O2Cor e Forma:SolidPeso molecular:426.26gp120-IN-1
CAS:<p>gp120-IN-1 (4e) is a potent HIV-1 inhibitor, IC50 2.2 μM, CC50 100.90 μM, and blocks HIV entry.</p>Fórmula:C15H18N2O4SCor e Forma:SolidPeso molecular:322.38HIV-1 inhibitor-25
CAS:<p>Compound R-12a is a potent HIV-1 reverse transcriptase inhibitor (IC50: 0.1061 nM), with low cytotoxicity and effective against multiple mutants.</p>Fórmula:C26H19N5O2Cor e Forma:SolidPeso molecular:433.46LEDGIN6
CAS:<p>HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.</p>Fórmula:C21H20ClNO2Cor e Forma:SolidPeso molecular:353.84NIT
CAS:<p>NIT is an HIV-1 protease inhibitor.</p>Fórmula:C15H7N3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:357.36HIV-1 inhibitor-36
CAS:<p>HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1 inhibitor with significant potential as a novel latency reversing agent [1].</p>Fórmula:C14H14Cl2N2O2SCor e Forma:SolidPeso molecular:345.24HIV-1 inhibitor-24
CAS:<p>HIV-1 inhibitor-24 (S-12a) blocks HIV reverse transcription effectively (IC50: 9.5 nM), low toxicity, well-tolerated in mice, good heart safety.</p>Fórmula:C26H19N5O2Cor e Forma:SolidPeso molecular:433.46DPC-681
CAS:<p>DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).</p>Fórmula:C35H48FN5O5SCor e Forma:SolidPeso molecular:669.85HIV-1 inhibitor-19
CAS:<p>HIV-1 inhibitor-19 is a potent NNRTI targeting L100I, K103N, V106A/F227L mutants; EC50s: 7.3, 9.2, 21.0 nM respectively.</p>Fórmula:C24H22BClN2O5SCor e Forma:SolidPeso molecular:496.77HIV-1 inhibitor-15
CAS:<p>HIV-1 inhibitor-15 (compound 9d): Potent, broad-spectrum, EC50=1.7-9 nM for various strains, good solubility/safety, oral use.</p>Fórmula:C24H20N6Cor e Forma:SolidPeso molecular:392.46
