Antibacteriano

<p>Antimicrobial OV-1 peptide, derived from SMAP29, inhibits antibiotic-resistant Pseudomonas aeruginosa strains.</p>

<p>Lipid X is a monosaccharide precursor of E coli lipid A.</p>

<p>Cephalonium (Cefalonium) is a first-generation cephalosporin antibiotic.</p>

<p>LL D05139(beta) is an novel antitumor antibiotic agent.</p>

<p>Aszonapyrone A: a fungally-derived meroditerpene that inhibits various cancer cells (GI50=10.2-13.6 μM) and combats multidrug-resistant bacteria and malaria.</p>

<p>Gramicidin C, a naturally occurring polypeptide antibiotic, is isolated from B. brevis var. G.B.</p>

<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>

<p>Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).</p>

<p>EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>Secnidazole hemihydrate is an oral azole antibiotic for treating amoebiasis, giardiasis, and bacterial vaginitis. It inhibits P. aeruginosa and S. marcescens.</p>

<p>Antibacterial agent 40 is an antibacterial agent.</p>

<p>Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Mirosamicin is a macrolide antibiotic, it has antimicrobial effect against gram-positive bacteria, some gram-negative bacteria and mycoplasma.</p>

<p>Polyunsaturated anacardic acid diene from cashew shells fights MRSA, S. mutans, and S. mansoni; inhibits soybean lipoxygenase-1.</p>

<p>Maximin H4, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory activity against a</p>

<p>Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Wychimicin C, a spirotetronate polyketide, combats MRSA and Enterococcus (IC50: 0.125-0.5 µg/mL), from Actinocrispum MI503-AF4.</p>

<p>Piscidin-1 (22-42) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).</p>

<p>Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.</p>

<p>Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.</p>

<p>SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.</p>

<p>Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.</p>

<p>Antibacterial agent 55 (example 21) is a antibacterial agent.</p>

<p>PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.</p>

<p>Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.</p>

<p>Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.</p>

<p>Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.</p>

<p>Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.</p>

<p>Sperabillin A (free base) is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>Gramicidin B is a nonribosomal peptide with antibiotic properties [1].</p>

<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>

<p>Showdomycin is an antibiotic with antineoplastic activity.</p>

<p>Lauryl-LF 11 displays antimicrobial activity.</p>

<p>XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>P-113 is a peptide with antimicrobial activity.</p>

<p>Bagougeramine B is an orally active nucleoside antibiotic with antibacterial properties, discovered in Bacillus circulans. It inhibits the growth of both Gram-positive and Gram-negative bacteria, as well as some fungi.</p>

<p>Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase, acts as an antibiotic against malaria, Plasmodium spp.</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>

<p>Antibacterialagent 273 (Compound 15e) is an antimicrobial agent targeting bacterial cell membranes, effectively disrupting them with a MIC value of 4 μg/mL against Staphylococcus aureus. It causes the leakage of intracellular nucleic acids and proteins, inhibits bacterial metabolic activity, and induces the accumulation of reactive oxygen species (ROS) within bacteria. Antibacterialagent 273 is applicable in research on infections caused by Staphylococcus aureus.</p>

<p>Compound A11 is a potent antibacterial, with MIC 0.00191 μg/mL against MRSA, outperforming tiamulin and retapamulin by 162x and 32x.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.</p>

<p>Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.</p>

<p>Kasugamycin is an antibiotic that acts by binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis.</p>

<p>Rose Bengal is a photosensitizer effective against microbial cells. In the presence of light and oxygen, it inhibits the growth of yeast cells and other microorganisms, sometimes leading to their death. Rose Bengal can also limit bacterial growth, restrict the colony size of filamentous fungi, and suppress the growth of "spreading fungi" such as Rhizopus and Trichoderma.</p>

<p>LpxC-IN-5: potent non-hydroxamate LpxC enzyme inhibitor, IC50=20 nM, antibacterial, with MICs for E. coli, P. aeruginosa, K. pneumoniae at 16, 4, 64, 4 μg/mL.</p>

<p>Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.</p>

<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>

<p>Griseoluteic acid is a breakdown product of griseolutein A and B. Griseoluteic acid is a phenazine antibiotic and is originally isolated from S. griseoluteus.</p>

<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>

<p>Pectin, a plant cell wall derived heteropolysaccharide, forms nanoparticles for delivery and acts as an antimicrobial adsorbent.</p>

<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>

<p>3α-Akebonoic acid is a natural product isolated from Holboellia coriacea Diels with antitumor activity.</p>

<p>SPR206 acetate, a polymyxin analog, fights Gram-negative and MDR bacteria, with MICs of 0.125 mg/L against P. aeruginosa and A. baumannii.</p>

<p>Gallichrome: an active peptide that interacts with siderophore hydroxamate; used in iron uptake research in gram-positive/negative bacteria.</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

<p>Bombinin H2, an antimicrobial peptide sourced from Bombina variegata skin, exhibits potential for combating microbial infections [1].</p>

<p>Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia.</p>

<p>Rabelomycin is an angucycline group antibiotic.</p>

<p>Chevalone B, a meroterpenoid from E. chevalieri fungus, is cytotoxic with IC50s: KB cells 2.9 μg/ml, NCI-H187 9.8 μg/ml.</p>

<p>Himastatin, an antitumor antibiotic from S. hygroscopicus, is a dimeric cyclohexadepsipeptide with piperazic acid and a unique aromatic core.</p>

<p>Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.</p>

<p>Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.</p>

<p>Pyrocoll, from Streptomyces, stops various bacteria and cancer cells; active against P. falciparum, T. rhodesiense.</p>

<p>Cefluprenam is a a cephalosporin type antibacterial agent.</p>

<p>Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.</p>

<p>α-Lipomycin is an acyclic polyene antibiotic isolated from the Gram-positive bacterium Streptomyces aureofaciens Tü117.</p>

<p>Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].</p>

<p>Chloramine-T (Chloralone) is a N-chlorinated, and N-deprotonated sulfonamide, used as a biocide and a mild disinfectant.</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Compound 14, also known as Tuberculosis Inhibitor 11, enhances the antimycobacterial efficacy of antitubercular agent [1].</p>

<p>10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures.</p>

<p>Compound 6 (Antibacterial agent 161, trifluoromethanesulfonate) exhibits antibacterial properties and demonstrates significant antiproliferative effects against</p>

<p>Reltecimod TFA (AB-103 TFA) is a CD28 antagonist and mimetic, inhibiting the stimulation of t-cells thereby attenuating acute inflammation NSTI.</p>

<p>Bactobolin is a biochemical.</p>

<p>Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.</p>

<p>Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.</p>

<p>N-Hydroxypipecolic acid potassium is a metabolite of plant and a systemic acquired resistance (SAR) regulator.</p>

<p>Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.</p>

<p>Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.</p>

<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>

<p>Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.</p>

<p>Angolamycin is a macrolide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Lytixar (LTX-109): Synthetic peptide effective against various resistant S. aureus strains, MIC 2-4 μg/ml, fast-acting regardless of prior resistance.</p>