Antibacteriano

(±)-Heraclenol, a coumarin derivative isolated from the fruits of Angelica lucida, exhibits antibacterial properties [1].

Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).

Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity, commonly used in agriculture.

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

Valclavam is a biochemical.

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Mirosamicin is a macrolide antibiotic, it has antimicrobial effect against gram-positive bacteria, some gram-negative bacteria and mycoplasma.

Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity [1] .

Lauryl-LF 11 displays antimicrobial activity.

Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.

Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.

Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.

Piscidin-1 (22-42) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).

Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.

Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.

Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.

Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

Antimicrobial agent-40 exhibits antibacterial activity against fungi, Gram-negative, and Gram-positive bacteria. It also shows anticancer properties, displaying significant cytotoxicity towards MCF-7 cells with an IC50 of 33.52 μM.

Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.

Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.

Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.

Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.

Showdomycin is an antibiotic with antineoplastic activity.

Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.

Sperabillin A (free base) is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.

Improved compound potency against E. coli, A. baumannii, and B. cenocepacia; up to >128-fold increase in effectiveness.

Gramicidin B is a nonribosomal peptide with antibiotic properties [1].

Lacto-N-fucopentaose I is a milk oligosaccharide.

Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.

Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.

XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.

P-113 is a peptide with antimicrobial activity.

Bagougeramine B is an orally active nucleoside antibiotic with antibacterial properties, discovered in Bacillus circulans. It inhibits the growth of both Gram-positive and Gram-negative bacteria, as well as some fungi.

Ibericin, an anthraquinone from Prismatomeris filamentosa roots, exhibits antibacterial effects on Gram-positive and Gram-negative bacteria.

Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase, acts as an antibiotic against malaria, Plasmodium spp.

Antibacterialagent 273 (Compound 15e) is an antimicrobial agent targeting bacterial cell membranes, effectively disrupting them with a MIC value of 4 μg/mL against Staphylococcus aureus. It causes the leakage of intracellular nucleic acids and proteins, inhibits bacterial metabolic activity, and induces the accumulation of reactive oxygen species (ROS) within bacteria. Antibacterialagent 273 is applicable in research on infections caused by Staphylococcus aureus.

Compound A11 is a potent antibacterial, with MIC 0.00191 μg/mL against MRSA, outperforming tiamulin and retapamulin by 162x and 32x.

C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.

Antiangiogenic agent 8 (Compound 3m) functions as both an antibacterial agent and an antiangiogenic compound. It shows minimum inhibitory concentrations (MIC) of 16, 8, 4, 16, and 8 μg/mL against E. coli, P. aeruginosa, B. subtilis, S. aureus, and C. glabrata, respectively, with minimum bactericidal concentrations (MBC) ranging from 32 to 64 μg/mL. This compound holds potential for applications in infection control and cardiovascular disease research.

Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against

Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.

Kasugamycin is an antibiotic that acts by binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis.

DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.

2,4-Dihydroxyphenylacetyl-L-asparagine is a natural product for research related to life sciences.

HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive

Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.

Griseoluteic acid is a breakdown product of griseolutein A and B. Griseoluteic acid is a phenazine antibiotic and is originally isolated from S. griseoluteus.

Pectin, a plant cell wall derived heteropolysaccharide, forms nanoparticles for delivery and acts as an antimicrobial adsorbent.

Maximin 63, an antimicrobial peptide sourced from toad brain, exhibits potent efficacy against Staphylococcus aureus with a minimum inhibitory concentration (

Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.

Talaromycesone A, from Talaromyces, fights S. epidermidis & MRSA (IC50: 3.7 & 5.48 μM), inhibits AChE (IC50: 7.49 μM).

Naphthalene is the simplest polycyclic aromatic hydrocarbon (PAH) and a major component of coal tar, serving as an insect repellent in camphor balls

Enopeptin A: depsipeptide antibiotic with unique amino acids, combats Gram-positive/negative bacteria, not antifungal.

Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.

AA35 boosts Ceftazidime's efficacy by lowering its MIC.

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

Bombinin H2, an antimicrobial peptide sourced from Bombina variegata skin, exhibits potential for combating microbial infections [1].

Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia.

Rabelomycin is an angucycline group antibiotic.

Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.

Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.

α-Lipomycin is an acyclic polyene antibiotic isolated from the Gram-positive bacterium Streptomyces aureofaciens Tü117.

2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.

17-Hydroxyneomatrine, a compound derived from Sophora flavescens, exhibits multifaceted biological activities, including the inhibition of human cervical

Cefluprenam is a a cephalosporin type antibacterial agent.

Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].

Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.

K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.

Compound 14, also known as Tuberculosis Inhibitor 11, enhances the antimycobacterial efficacy of antitubercular agent [1].

Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent.

Compound 6 (Antibacterial agent 161, trifluoromethanesulfonate) exhibits antibacterial properties and demonstrates significant antiproliferative effects against

Reltecimod TFA (AB-103 TFA) is a CD28 antagonist and mimetic, inhibiting the stimulation of t-cells thereby attenuating acute inflammation NSTI.

Bactobolin is a biochemical.

Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.

LAB 149202F is a bioactive chemical.

Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.

Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.

Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.

Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.

Angolamycin is a macrolide antibiotic (antibiotic) effective against Gram-positive bacteria.

(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].

FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs

Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.

Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.

KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.

Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.

FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory

AA45 boosts Ceftazidime's efficacy by lowering its MIC value, showcasing strong antibacterial properties.

RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.

Latamoxef is an oxacephem antibiotic and is a member of the cephalosporins.