Antibacteriano

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>

<p>Flambamycin is an antibiotic isolated from Streptomyces hygroscopicus.</p>

<p>Arugomycin is an anthracycline natural product that functions as an antibiotic effective against Gram-positive bacteria. It has the ability to intercalate into DNA, giving it potential as an antitumor agent.</p>

<p>Mycophenolate Mofetil: Non-competitive, selective inhibitor of IMP dehydrogenase I/II, IC50: 39/27 nM.</p>

<p>Rubrosulphin is a toxic metabolite found in a number of fungi.</p>

<p>Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

<p>Enopeptin A: depsipeptide antibiotic with unique amino acids, combats Gram-positive/negative bacteria, not antifungal.</p>

<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Lysozyme chloride: enzyme that kills gram-positive bacteria; used in HIV, emphysema research.</p>

<p>ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.</p>

<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>

<p>"Antibacterial Synergist 2 inhibits biofilms of S. enterica, S. aureus, P. aeruginosa, and C. albicans."</p>

<p>Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.</p>

<p>Setomimycin is an antibiotic against Gram positive bacteria, including mycobacteria.</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.</p>

<p>Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.</p>

<p>Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.</p>

<p>Chitinase, found in bacteria, fungi, animals, plants, is a glycosyl hydrolase that hydrolyzes chito-oligosaccharides.</p>

<p>BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.</p>

<p>Tomopenem is a penem antibiotic.</p>

<p>Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis.</p>

<p>Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba &amp;amp; Aplysina aerophoba.</p>

<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>

<p>Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .</p>

<p>Loloatin B 10 is a bioactive chemical.</p>

<p>Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25</p>

<p>Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.</p>

<p>Cefaloglycin: oral nephrotoxic β-lactam antibiotic, active against Gram-positive cocci, impairs mitochondrial function.</p>

<p>Parasin I (TFA), a peptide derived from the 19 amino acids of histone H2A and isolated from catfish skin, exhibits antimicrobial activity [1].</p>

<p>Zaloganan exhibits broad-spectrum antibacterial activity by disrupting bacterial cell membranes.</p>

<p>Hp1404 is a novel cationic antimicrobial peptide with specific inhibitory activity against Gram-positive bacteria, including Laburnetin-resistant Staphylococcus aureus (MRSA). Its antibacterial properties, low toxicity, and low likelihood of inducing resistance make it a useful candidate for antimicrobial agent research.</p>

<p>IN-2-LF, an inhibitor of lethal factor, also demonstrates inhibitory activity against furin, possessing an IC50 of 2 μM. Moreover, when used alongside D6R [1], IN-2-LF significantly enhances protection from anthrax lethal toxin.</p>

<p>Kapurimycin A3 is an antitumor antibiotics.</p>

<p>Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].</p>

<p>(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (</p>

<p>PhoPS is a photoactivatable β-lactamase inhibitor. Upon exposure to light, PhoPS releases the active β-lactamase inhibitor Sulbactam. This compound is capable of inhibiting the synthesis of bacterial cell walls and the formation of biofilms in Escherichia coli, thereby exhibiting antibacterial activity.</p>

<p>DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE</p>

<p>Anthracen-1-amine exhibits inhibitory activity against Escherichia coli.</p>

<p>Impurity B in Cefpodoxime Proxetil, a broad-spectrum oral antibiotic, is a third-generation cephalosporin.</p>

<p>Isodihydroauroglaucin is a useful organic compound for research related to life sciences. The catalog number is T124274 and the CAS number is 74886-31-0.</p>

<p>Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].</p>

<p>LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces.</p>

<p>Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.</p>

<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>

<p>Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Human Immunoglobulin G (HumanIgG) is an immunoglobulin that plays a protective role in humoral immunity by generating antibody responses against specific pathogens, such as Bacteroides forsythus and Prevotella intermedia. It serves as an antibody standard for quantification in enzyme-linked immunosorbent assays (ELISA). Additionally, Human Immunoglobulin G antibody levels are utilized in research on rheumatoid arthritis (RA) and periodontal disease.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Ibezapolstat hydrochloride is an antibacterial agent.</p>

<p>(-)-Cleistenolide, an α,β-unsaturated δ-lactone derived from Cleistochlamys kirkii Oliver, exhibits antibacterial and antitumor activity [1].</p>

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.</p>

<p>Desferriferribactin is a biogenetic precursor of pyoverdin.</p>

<p>DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.</p>

<p>Antibacterial agent 127 (Compound 23) is a potent antibacterial agent [1] .</p>

<p>Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.</p>

<p>Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.</p>

<p>Thiocoraline: depsipeptide, DNA intercalator, antibacterial, anticancer, targets Gram-positive, inhibits polymerases, cytotoxic to cancer cells.</p>

<p>(R)-Mucronulatol is a natural product that can be used as a reference standard. The CAS number of (R)-Mucronulatol is 57128-11-7.</p>

<p>Maximin 77 is an antimicrobial peptide with antibacterial activity against S.</p>

<p>Compound 15015-57-3, with CAS No. 15015-57-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 15015-57-3 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.</p>

<p>Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Calpinactam, from M. alpina, fights M. smegmatis (MIC 0.78 μg/ml), boosts silkworm survival, but ineffective against 13 other species.</p>

<p>BacPROTAC-1, a potent mSA BacPROTAC degrader, exhibits high affinity for both mSA and the N-terminal domain (NTD) of ClpC, with dissociation constants (K D) of</p>

<p>Bipolamine G is an antibacterial polyketide alkaloid [1] .</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Compound 16 is an antimicrobial with 4-8 μg/mL MIC, effective on gram-positive/negative bacteria and has anti-inflammatory properties.</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>

<p>Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.</p>

<p>Ceftaroline fosamil (TAK-599) is a cephalosporin-derived MRSA antibiotic prodrug.</p>

<p>FtsZ-IN-5: Potent inhibitor blocking bacterial division, low resistance and toxicity, enhances FtsZ polymerization.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>Mupirocin calcium, an antibiotic from Pseudomonas fluorescens, halts bacterial protein and RNA synthesis.</p>