Antibacteriano

Amoxycillin arginine salt is a bioactive chemical.

Maximin 2, an antimicrobial peptide sourced from the skin secretions of Bombina maxima, exhibits cytotoxicity in tumor cells and possesses spermicidal

Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.

Methicillin sodium hydrate, a narrow-spectrum antibiotic, combats methicillin-resistant Staphylococcus strains and treats various infections.

Corynecin III, a chloramphenicol-like antibiotic, combats Gram-positive/negative bacteria, MICs 2.6-83 μg/ml.

Pseudin-2, an AMP from Pseudis paradoxa, inhibits Gram-negative bacterial growth.

YJ182 is an NDM-1 inhibitor with an IC50 of 0.23 μM, and additionally inhibits IMP-1, VIM-2, GIM-1, and MMP-2 with respective IC50 values of 0.25, 0.61, 0.49,

Furaltadone L-tartrate, a nitrofuran, may help study Salmonella enteritidis in chickens; it's an antibacterial agent against staphylococci.

Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).

3-(1-Carboxyvinyloxy)benzoic acid is a useful organic compound for research related to life sciences.

Omadacycline: an aminomethylcycline antibiotic, cidal against four Streptococcus pneumoniae strains.

Ellagic acid 4-O-β-D-xylopyranoside, an ellagitannin found naturally, exhibits antimicrobial properties and acts as an inhibitor of xanthine oxidase, displaying

Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

IspE kinase-IN-1 (compound 4) is a potent inhibitor of IspE kinase, exhibiting IC50 values of 6.2 µM against EclspE and 5.2 µM against KplspE.

Antibacterial agent 53 (example 19) is a antibacterial agent.

Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with

Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.

Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.

SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.

Antibacterial agent 50 targets E. coli strains with MICs: 32 mcg/mL for NCTC 13351, 64 for M 50, and 128 for 7 MP.

Lankacidinol A is a metabolite of macrolide antibiotic.

Antibacterial agent 49 (example 12) is a antibacterial agent.

Malacidin B, a macrocyclic lipopeptide antibiotic, demonstrates calcium-dependent antibacterial activity [1] [2].

Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of

Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.

A 269A is an antibiotic isolated from broth of Streptomyces sp., strain.

C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.

FtsZ-IN-7: strong FtsZ inhibitor, blocks bacterial cell division, low resistance risk, minimal toxicity to mammals.

6-Deoxy-8-O-methylrabelomycin is a useful organic compound for research related to life sciences.

A32390A, an antibiotic inhibitor, shows antimicrobial activity against gram-positive bacteria and fungi.

Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.

Arylomycin A5 is a lipohexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.

Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.

Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of

Compound 16 is an antimicrobial with 4-8 μg/mL MIC, effective on gram-positive/negative bacteria and has anti-inflammatory properties.

Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.

FtsZ-IN-5: Potent inhibitor blocking bacterial division, low resistance and toxicity, enhances FtsZ polymerization.

Mupirocin calcium, an antibiotic from Pseudomonas fluorescens, halts bacterial protein and RNA synthesis.

BacPROTAC-1, a potent mSA BacPROTAC degrader, exhibits high affinity for both mSA and the N-terminal domain (NTD) of ClpC, with dissociation constants (K D) of

Bipolamine G is an antibacterial polyketide alkaloid [1] .

3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.

Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].

(-)-Cleistenolide, an α,β-unsaturated δ-lactone derived from Cleistochlamys kirkii Oliver, exhibits antibacterial and antitumor activity [1].

Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.

Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].

β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (

Burnettramic acid A: Fungus-derived, fights B. subtilis, S. aureus, C. albicans, S. cerevisiae. Toxic to NS-1 cells, not to fibroblasts.

Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.

Kyotorphin is a Morphine-like dipeptide.

Niddamycin is a new macrolide antibiotic.

A51493A is a novel antibiotic in the class of anthracyclinone, it is produced by a strain of Streptomyces humifer.

3-O-Demethylfortimicin A is an antibiotic.

Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.

Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Ilicicolin B is a useful organic compound for research related to life sciences. The catalog number is T125288 and the CAS number is 22581-07-3.

Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.

PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.

CN-CC-861 is a broad-spectrum antibiotic that exhibits antimicrobial activity against both sensitive and multidrug-resistant bacteria. It demonstrates potent bactericidal activity in vivo.

2-Butyldecanoic acid has potential antibacterial and antiviral activity, with high activity against mosquito larvae.

Sulfamerazine sodium salt is a sulfonamide antibacterial.

Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.

Im5, an antimicrobial peptide, exhibits antibacterial activity, with minimum inhibitory concentrations (MIC) of 10 μM for E.

Compound 5a: MICs of 25, 25, 50, 50 μg/mL vs. B. subtilis, S. aureus, P. aeruginosa, E. coli.

Maximin 49, an antimicrobial peptide, exhibits antibacterial activity against S.

HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin.

"Antibacterial Synergist 2 inhibits biofilms of S. enterica, S. aureus, P. aeruginosa, and C. albicans."

LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.

Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.

Flambalactone is a degradation product formed by methanolysis of the antibiotic flambamycin.

Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.

Flambamycin is an antibiotic isolated from Streptomyces hygroscopicus.

Albofungin is a xanthone isolated from A. tumemacerans.

Tosufloxacin tosilate is a fluoroquinolone antibiotic.

Aldecalmycin is a new antimicrobial antibiotic isolated from Streptomyces.

BE-24566B, a polyketide from S. violaceusniger, inhibits various bacteria and blocks ET receptors (ETA IC50=11 μM, ETB=3.9 μM).

Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.

Chitinase, found in bacteria, fungi, animals, plants, is a glycosyl hydrolase that hydrolyzes chito-oligosaccharides.

Cefaloglycin: oral nephrotoxic β-lactam antibiotic, active against Gram-positive cocci, impairs mitochondrial function.

Asperglaucin B, from Aspergillus chevalieri, fights Pseudomonas syringae and Bacillus cereus with 6.25 μM MIC.

Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.

Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.

Antimicrobial agent-37 (compound 6a) is a potent broad-spectrum antibacterial agent that disrupts bacterial biofilms by targeting and lysing the bacterial membrane.

Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

Antibiotic LB 10517 is a catechol-substituted cephalosporin with a broad spectrum of antibacterial.

Tetrahydromethotrexate is a folic acid derivative.

LasR-IN-5 (compound 3C) acts as an antagonist of LasR with an IC50 of 1.37 μM, exhibiting a 77% inhibition in the formation of Pseudomonas biofilms. Moreover, LasR-IN-5 also demonstrates inhibitory activity against quorum sensing (QS) and is applicable in infection research.

Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.

UCM53 has a wide range of applications in life science related research.

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .

Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.

Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.

1-Methyl-2-tridecenylquinolinone fights H. pylori (MIC50: 22 µM, MIC90: 50 µM); may research ulcers.

Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.

Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.

EBL-3183 is a reversible, competitive indole-2-carboxylate NDM-1 inhibitor with a pIC50 of 7.7, targeting metallo-β-lactamases.

Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.