Antibacteriano

Carfecillin Sodium, a phenyl ester of Carbenicillin, becomes an active antibacterial in intestines, treating urinary infections.

Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.

Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.

Antibacterial agent 55 (example 21) is a antibacterial agent.

Tylosin lactate: a vet macrolide antibiotic; broad vs. Gram-positive, limited on Gram-negative; from Streptomyces fradiae.

Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].

Clindamycin palmitate hydrochloride (Clindamycin palmitate HCl) is the hydrochloride salt of clindamycin and palmitate, a lincosamide antibiotic.

Tet-20, a synthetic cathelicidin-derived peptide with biological activity, has been evaluated for its efficacy as an infection-resistant coating on medical

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.

Antibacterialagent 260 (Compound 4r) exhibits broad-spectrum antibacterial activity, effectively inhibiting P. aeruginosa and S. aureus with a minimum inhibitory concentration (MIC) of 0.0076 μM. Additionally, Antibacterialagent 260 serves as a herbicide, hindering the growth of radish (Raphanus sativus L.) seed roots and stems.

Esculentin 1A, a potent antimicrobial peptide (AMP) derived from frog skin, demonstrates significant in vitro activity against Pseudomonas [1].

Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.

Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

FtsZ-IN-5: Potent inhibitor blocking bacterial division, low resistance and toxicity, enhances FtsZ polymerization.

Enopeptin A: depsipeptide antibiotic with unique amino acids, combats Gram-positive/negative bacteria, not antifungal.

Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.

Cefoperazone dihydrate, a semi-synthetic cephalosporin, exhibits a wide range of antibacterial properties.

Nybomycin, a fungal metabolite from Streptomyces sp. A717, has antibacterial properties; effective against various bacteria including M. tuberculosis.