Antibacteriano

<p>TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks</p>

<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>

<p>Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.</p>

<p>Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with</p>

<p>Amoxycillin arginine salt is a bioactive chemical.</p>

<p>JM 1397 is a bioactive chemical.</p>

<p>Compound 1b, also known as Antibacterial agent 145, targets the bacterial iron uptake pathway to exert its effects.</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

<p>Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).</p>

<p>Omadacycline: an aminomethylcycline antibiotic, cidal against four Streptococcus pneumoniae strains.</p>

<p>Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>

<p>Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with</p>

<p>Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.</p>

<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>

<p>SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.</p>

<p>Antibacterial agent 49 (example 12) is a antibacterial agent.</p>

<p>Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of</p>

<p>Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.</p>

<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>

<p>N-3-oxo-hexadecanoyl-L-homoserine lactone, a C16 AHL, aids bacterial quorum sensing and primes plant systemic resistance.</p>

<p>Arylomycin A5 is a lipohexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.</p>

<p>Aerocyanidin is an antibiotic (antibiotic) that contains an isonitrile group and is primarily effective against Gram-positive bacteria.</p>

<p>Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.</p>

<p>Aurein 2.2, a principal constituent of L.aurea skin secretions, exhibits broad-spectrum antibacterial properties, particularly effective against Gram-positive</p>

<p>3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.</p>

<p>Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.</p>

<p>CjGlmU, a sugar nucleotidyltransferase, uses UTP and GlcNAc-1-P to make UDP-GlcNAc, and has antimicrobial research potential.</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>LeuRS-IN-1 is a leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity that inhibits M.tb LeuRS.</p>

<p>Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.</p>

<p>2-Phenoxyphenol has antibacterial against Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Burkholderia pseudomallei, etc.</p>

<p>Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.</p>

<p>Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>Natural stilbene Longistyline A from Cajanus cajan leaves; antimicrobial against MRSA, MIC 1.56 μg/mL; neuroprotective.</p>

<p>Funalenone, from A. niger, inhibits HIV-1 integrase, HIV replication, and MMP-1, also curbing S. aureus growth. Less toxic to human cells.</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>Lysolipin I is a bioactive chemical.</p>

<p>Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and</p>

<p>Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.</p>

<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>

<p>Albofungin is a xanthone isolated from A. tumemacerans.</p>

<p>6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.</p>

<p>Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.</p>

<p>Teixobactin is a recently described antibiotic .</p>

<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>

<p>Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting</p>

<p>Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.</p>

<p>CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) shows antibacterial and antiparasitic activities against Chlamydia pneumoniae and</p>

<p>Quorum sensing involves bacteria using AHLs to coordinate gene expression for biofilm formation and virulence, via LuxR regulators.</p>

<p>Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>UCM53 has a wide range of applications in life science related research.</p>

<p>Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].</p>

<p>Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.</p>

<p>DS86760016 inhibits LeuRS; potent against MDR Gram-negative bacteria; IC50: E. coli 0.38μM, P. aeruginosa 0.62μM, A. baumannii 0.16μM.</p>

<p>Terephthalonitrile exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and can be used in related research in the field of life sciences.</p>

<p>LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.</p>

<p>"Antibacterial Synergist 2 inhibits biofilms of S. enterica, S. aureus, P. aeruginosa, and C. albicans."</p>

<p>Monogalactosyl diglyceride is a key lipid in photosynthesis and myelin, also boosting PKCα in oligodendrocytes.</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>Trans-β-terpineol, a monoterpenoid compound extracted from Schinus terebinthifolius leaves, exhibits antioxidant and antibacterial properties.</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Pentalysine is a peptide.</p>

<p>Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).</p>

<p>Neoaureothin, a Streptomyces metabolite, is an AR antagonist with anti-androgen and cytotoxic effects, also active against B. xylophilus.</p>

<p>MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].</p>

<p>FR-295389 is a cephalosporin. FR-295389 shows effective antibacterial activity against metallo-beta-lactamase (MBL)-producers in vitro.</p>

<p>Samandarone is a major alkaloid from the European fire salamander (Salamandra salamandra terrestris).</p>

<p>Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.</p>

<p>Ceftaroline fosamil (TAK-599) is a cephalosporin-derived MRSA antibiotic prodrug.</p>

<p>Spirolaxine from Sporotrichum laxum shows anti-Helicobacter pylori activity.</p>

<p>Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.</p>

<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>

<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>

<p>Desotamide: an antibiotic cyclic hexapeptide targeting S. aureus, S. pneumoniae, and MRSE with MICs 16, 12.5, 32 μg/ml.</p>

<p>Thiotropocin is an antibiotic.</p>

<p>Defensin HNP-3 human, a cytotoxic antibiotic peptide referred to as "defensin," exhibits inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa,</p>

<p>Reveromycin B: a spiroketal from Streptomyces, blocks EGF in Balb/MK (IC50=6 μg/ml), antifungal vs. C. albicans, pH-sensitive, not active on KB, K562 cells.</p>

<p>Racemomycin B is a beta-lysine-rich streptothricin antibiotic.</p>

<p>SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.</p>

<p>NR-NO2 is a prospective therapeutic agent with targeted delivery and image-guided capability for use in antitumor studies, also demonstrating antibacterial</p>

<p>Paldimycin B is a semi-synthetic antibiotic.</p>

<p>Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and</p>

<p>Rifasutenizol (TNP-2198) is a powerful, oral dual-target antibacterial effective against microaerophilic and anaerobic bacteria.</p>

<p>Urechistachykinin II (Uru-TK II) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms.</p>

<p>Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.</p>

<p>Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>pBD-1 TFA: an innate AMP from pigs, prevalent in mucosa, with systemic defensive properties.</p>

<p>Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.</p>

<p>LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.</p>

<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>

<p>Colistin: polypeptide antibiotic for Gram-negative bacteria, including drug-resistant strains, but may cause nephrotoxicity.</p>

<p>T3SS-IN-1 (compound B9) is a potent type III secretion system (T3SS) inhibitor that also suppresses hpa1 promoter activity and harpin protein expression,</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly</p>

<p>Antimicrobial OV-1 peptide, derived from SMAP29, inhibits antibiotic-resistant Pseudomonas aeruginosa strains.</p>

<p>Lipid X is a monosaccharide precursor of E coli lipid A.</p>

<p>Cephalonium (Cefalonium) is a first-generation cephalosporin antibiotic.</p>

<p>LL D05139(beta) is an novel antitumor antibiotic agent.</p>

<p>Aszonapyrone A: a fungally-derived meroditerpene that inhibits various cancer cells (GI50=10.2-13.6 μM) and combats multidrug-resistant bacteria and malaria.</p>

<p>Gramicidin C, a naturally occurring polypeptide antibiotic, is isolated from B. brevis var. G.B.</p>