Antibacteriano

<p>P-113 is a peptide with antimicrobial activity.</p>

<p>Antibacterialagent 273 (Compound 15e) is an antimicrobial agent targeting bacterial cell membranes, effectively disrupting them with a MIC value of 4 μg/mL against Staphylococcus aureus. It causes the leakage of intracellular nucleic acids and proteins, inhibits bacterial metabolic activity, and induces the accumulation of reactive oxygen species (ROS) within bacteria. Antibacterialagent 273 is applicable in research on infections caused by Staphylococcus aureus.</p>

<p>Compound A11 is a potent antibacterial, with MIC 0.00191 μg/mL against MRSA, outperforming tiamulin and retapamulin by 162x and 32x.</p>

<p>C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.</p>

<p>Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against</p>

<p>BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.</p>

<p>Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity.</p>

<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>

<p>Griseoluteic acid is a breakdown product of griseolutein A and B. Griseoluteic acid is a phenazine antibiotic and is originally isolated from S. griseoluteus.</p>

<p>Nemonoxacin (TG-873870), a potent oral antibiotic, treats various bacterial infections and pneumonia.</p>

<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>

<p>Talaromycesone A, from Talaromyces, fights S. epidermidis &amp; MRSA (IC50: 3.7 &amp; 5.48 μM), inhibits AChE (IC50: 7.49 μM).</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

<p>Bombinin H2, an antimicrobial peptide sourced from Bombina variegata skin, exhibits potential for combating microbial infections [1].</p>

<p>Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia.</p>

<p>Chevalone B, a meroterpenoid from E. chevalieri fungus, is cytotoxic with IC50s: KB cells 2.9 μg/ml, NCI-H187 9.8 μg/ml.</p>

<p>Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.</p>

<p>2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.</p>

<p>Cefluprenam is a a cephalosporin type antibacterial agent.</p>

<p>Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.</p>

<p>Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].</p>

<p>Methyl 3-hydroxybenzoate is a benzoic acid ester derivative commonly used as a preservative in cosmetics to inhibit microbial growth,</p>

<p>Reltecimod TFA (AB-103 TFA) is a CD28 antagonist and mimetic, inhibiting the stimulation of t-cells thereby attenuating acute inflammation NSTI.</p>

<p>Bactobolin is a biochemical.</p>

<p>Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.</p>

<p>Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.</p>

<p>Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.</p>

<p>Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.</p>

<p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>

<p>(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>WAY-329764 is an antibacterial agent.</p>

<p>Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.</p>

<p>Olaquindox can be used in relevant research in the life sciences. Its product number is T2779 and CAS number is 23696-28-8.</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Antibacterial agent 52 (example 18) is a antibacterial agent.</p>

<p>LmNADK1-IN-1 (MC1) inhibits L. monocytogenes NADK1, K_i 54 nM, useful in bacterial infection research.</p>

<p>Wychimicin A, from Actinocrispum wychmicini MI503-AF4, is a potent antibacterial against MRSA and Enterococcus. (IC50=0.125-0.5μg/mL).</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>Spirolaxine from Sporotrichum laxum shows anti-Helicobacter pylori activity.</p>

<p>LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.</p>

<p>Linearmycin A, a polyene antibiotic from Streptomyces, fights S. aureus, E. coli, S. cerevisiae, C. albicans, and A. niger with low MICs.</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

<p>Aureothricin: DTP antibiotic from Streptomyces, broad-spectrum, inhibits HUVEC adhesion to vitronectin.</p>

<p>Arbekacin is an aminoglycoside antibiotic.</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.</p>

<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>

<p>A unique collection of 904 antibacterial bioactive compounds, a powerful tool for antibacterial drug development;</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>Arylomycin A1 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>

<p>1-Phenylhexane exhibits antibacterial and antioxidant activity, inhibiting S. aureus, Pseudomonas aeruginosa, Proteus mirabilis, E. coli, and Bacillus cereus</p>

<p>(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.</p>

<p>A unique collection of xnum species of natural products with anti-infective activity for high throughput screening (HTS) and high content screening (HCS);</p>

<p>Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)</p>

<p>2,4-Diacetylphloroglucinol is a useful organic compound for research related to life sciences. The catalog number is T21619 and the CAS number is 2161-86-6.</p>

<p>Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Compound IA-8, an aryl isoxazoline derivative, exhibits insecticidal efficacy against M. separate [1].</p>

<p>BABX inhibits FAS-II, affecting fatty acid production in S. aureus/E. coli, and blocks LXRα agonist binding. IC50: 11.4/35.3 μg/ml. MIC: 0.2-0.4 μg/ml.</p>

<p>Etzadroxil, a volatile ester, treats drug-resistant urinary infections.</p>

<p>Deshydroxyethoxy ticagrelor (AR-C124910) is a metabolite of Ticagrelor that exhibits antibacterial activity against MRSA and possesses antiplatelet effects.</p>

<p>Cefditoren sodium: cephalosporin antibiotic for bacterial infections; alters Mrp2, Bcrp, Oat2, P-gp, Oct1 mRNA levels.</p>

<p>Etoposide Phosphate is a selective and orally active topoisomerase II inhibitor and anticancer chemotherapy drug that apoptosise, the p53, and G2/M</p>

<p>Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.</p>

<p>Cefixime trihydrate, a third-gen cephalosporin antibiotic, treats bacterial infections.</p>

<p>Antibiotic-5d is a synthetic antimicrobial compound.</p>

<p>Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.</p>

<p>Acyclovir-d4 is a deuterated compound of Acyclovir. Acyclovir has a CAS number of 59277-89-3. Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.</p>

<p>OES2-0017 exhibits strong synergistic effects and growth inhibition in collaboration with polyamines within a low micromolar range. At low concentrations, OES2-0017 inhibits spermidine/spermine N1-acetyltransferase (SpeG) (IC50: 34.82 μM) and other polyamine detoxifying enzymes, while at higher concentrations, it disrupts bacterial membranes.</p>

<p>Acyclovir (Aciclovir) hydrochloride is an effective oral antiviral agent with potent anti-herpetic activity. It exhibits IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2, indicating strong inhibitory effects against these strains. Additionally, Acyclovir hydrochloride induces cell cycle disturbances and apoptosis. This compound also prevents bacterial infections during induction therapy for acute leukemia.</p>

<p>Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15.</p>

<p>3-oxo-C14-HSL is a quorum sensing signal that regulates genes and metabolism in bacteria, affecting biofilm and putisolvin production.</p>

<p>IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux, used in atherosclerosis research.</p>

<p>Deuterium-labeled Sulfamethazine, an antimicrobial for treating animal diseases.</p>

<p>Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.</p>

<p>Acridine-9-carboxaldehyde is an acridine derivative that functions as a pH indicator for fluorescence lifetime measurements.</p>

<p>Balofloxacin is a fluoroquinolone antibiotic with oral activity.</p>

<p>Sulfadiazine D4 is a deuterium labeled Sulfadiazine. Sulfadiazine used for the treatment of toxoplasmosis.</p>

<p>Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and</p>

<p>Cefodizime: a new, well-tolerated cephalosporin antibiotic with immunomodulatory properties for serious respiratory and urinary infections.</p>

<p>Ternidazole hydrochloride (Ternidazole HCl) is a 5-nitroimidazole antibiotic with antimicrobial antioxidant and antiprotozoal activity.</p>

<p>Metronidazole acetic acid, a mutagenic metabolite of an antibiotic, targets protozoa and anaerobic bacteria.</p>

<p>Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi.</p>

<p>Cefepime dihydrochloride: fourth-gen cephalosporin, inhibits bacterial PBPs.</p>

<p>Rosuvastatin Sodium: HMGCR inhibitor, blocks hERG (IC50: 11 nM, 195 nM), reduces hERG expression, hinders Hsp70-hERG interaction.</p>

<p>Kanamycin (Kanamycin A) is an aminoglycoside antibiotic with antibacterial activity, used in research on tuberculosis and pneumonia.</p>

<p>Spectinomycin sulfate hydrate is a broad-spectrum antibiotic capable of inhibiting the growth of various Gram-positive and Gram-negative bacteria. It targets bacterial ribosomes specifically, thereby disrupting protein synthesis. Additionally, spectinomycin sulfate hydrate acts as a non-competitive inhibitor of td intron RNA, with a Ki of 7.2 mM.</p>

<p>Chloramphenicol-d5 is a deuterated compound of Chloramphenicol. Chloramphenicol has a CAS number of 56-75-7. Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.</p>