Antibacteriano

Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.

Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).

Antibacterial agent 136, an oxadiazolone antibiotic, highly potent against MRSA with MIC 50 at 0.8 μM.

'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).

Dodec-1-ene is toxic to MIAPaCa2 cells, Pseudokirchneriella subcapitata, and Daphnia magna,antibacterial. It can also be used in the synthesis of surfactants.

Bombinin H2, an antimicrobial peptide sourced from Bombina variegata skin, exhibits potential for combating microbial infections [1].

Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Mirosamicin is a macrolide antibiotic, it has antimicrobial effect against gram-positive bacteria, some gram-negative bacteria and mycoplasma.

Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].

Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.

Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.

Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.

Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.

Piscidin-1 (22-42) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).

Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.

Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.

Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).

PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.

Antimicrobial agent-40 exhibits antibacterial activity against fungi, Gram-negative, and Gram-positive bacteria. It also shows anticancer properties, displaying significant cytotoxicity towards MCF-7 cells with an IC50 of 33.52 μM.

Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.

Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.

Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.

Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.

Showdomycin is an antibiotic with antineoplastic activity.

Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.

Sperabillin A (free base) is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.

LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.

Gramicidin B is a nonribosomal peptide with antibiotic properties [1].

Lacto-N-fucopentaose I is a milk oligosaccharide.

2,4-Dihydroxyphenylacetyl-L-asparagine is a natural product for research related to life sciences.

Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].

XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.

P-113 is a peptide with antimicrobial activity.

Bagougeramine B is an orally active nucleoside antibiotic with antibacterial properties, discovered in Bacillus circulans. It inhibits the growth of both Gram-positive and Gram-negative bacteria, as well as some fungi.

Ibericin, an anthraquinone from Prismatomeris filamentosa roots, exhibits antibacterial effects on Gram-positive and Gram-negative bacteria.

Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase, acts as an antibiotic against malaria, Plasmodium spp.

Antibacterialagent 273 (Compound 15e) is an antimicrobial agent targeting bacterial cell membranes, effectively disrupting them with a MIC value of 4 μg/mL against Staphylococcus aureus. It causes the leakage of intracellular nucleic acids and proteins, inhibits bacterial metabolic activity, and induces the accumulation of reactive oxygen species (ROS) within bacteria. Antibacterialagent 273 is applicable in research on infections caused by Staphylococcus aureus.

Compound A11 is a potent antibacterial, with MIC 0.00191 μg/mL against MRSA, outperforming tiamulin and retapamulin by 162x and 32x.

C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.

Antiangiogenic agent 8 (Compound 3m) functions as both an antibacterial agent and an antiangiogenic compound. It shows minimum inhibitory concentrations (MIC) of 16, 8, 4, 16, and 8 μg/mL against E. coli, P. aeruginosa, B. subtilis, S. aureus, and C. glabrata, respectively, with minimum bactericidal concentrations (MBC) ranging from 32 to 64 μg/mL. This compound holds potential for applications in infection control and cardiovascular disease research.

Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against

Naphthalene is the simplest polycyclic aromatic hydrocarbon (PAH) and a major component of coal tar, serving as an insect repellent in camphor balls

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.

Kasugamycin is an antibiotic that acts by binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis.

Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.