Antibacteriano

Antibacterialagent 256 (Compound C09) is an inhibitor of Type I signal peptidase (SPase I). It targets Gram-positive bacteria, effectively inhibiting S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1, and S. suis P1/7, with MIC values ranging from 1-16 μg/mL. In cancer cells HEp-2 and Caco-2, Antibacterialagent 256 exhibits cytotoxicity with CC50 values of 14.65 μg/mL and 21.93 μg/mL, respectively. Additionally, it shows hemolytic activity on mouse red blood cells with an HC50 of 13.29 μg/mL and can improve MRSA skin infections in mouse models.

HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive

Maximin 63, an antimicrobial peptide sourced from toad brain, exhibits potent efficacy against Staphylococcus aureus with a minimum inhibitory concentration (

Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.

Cloflucarban can be used as a disinfectant agent.

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.

Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.

Saquayamycin D is a glycoside of aquayamycin.

K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.

A 26771B is an antibiotic in the class of macrolide lactone.

Retro-indolicidin, a synthetic analog of the cathelicidin-derived antimicrobial peptide-amide indolicidin, comprises a reversed 13-amino acid sequence isolated

Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+).

Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.

Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].

Cyclothialidine is an inhibitor of DNA gyrase.

Massarigenin C from M. flavorosea inhibits neuraminidase (IC50=4.15μM) and α-glucosidase (IC50=1.25mM), reduces blood glucose in mice.

Daunosamnyl-daunorubicin is used as an antibody conjugate.

KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.

Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.

Amicetin, a potent antibiotic, is effective against gram-positive bacteria by inhibiting protein synthesis [1] [2] [3].

nTZDpa is an antibiotic with antimicrobial activity.

Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(8'α,9'β-Dihydroxy)-3-farnesylindole exhibits significant inhibitory effectiveness (EC 50 9.8 μM) against B. subtilis.

Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.

4-Methoxycoumarine has antitumour effects.

Gepotidacin S enantiomer is an S enantionmer of gepotidacin.

Antibacterial Agent 156 (Compound 57), a bactericidal that selectively targets C.

4-Ethoxycoumarin has antimicrobial activity.

Chrysomycin B is an antibiotic isolated from Streptomyces sp.

Dactimicin, a new pseudodisaccharide aminoglycoside, exhibits antibacterial properties and resists aminoglycoside 3-acetyltransferase better than astromicin.

Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.

2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.

ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.

(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid.

JM 1397 is a bioactive chemical.

Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.

JSF-4898 is an orally bioactive inhibitor of Mycobacterium tuberculosis MenG enzyme. It exhibits a minimum inhibitory concentration (MIC) of 0.78 μM against Mycobacterium tuberculosis H37Rv. Additionally, JSF-4898 enhances the efficacy of rifampicin in a subacute infection model of Mycobacterium tuberculosis in mice.

Cervinomycin A2 is an antibiotic effective against anaerobic bacteria, isolated from the Streptomyces genus, specifically Cervinomycetes. It exhibits strong inhibitory effects on Clostridium perfringens, Peptostreptococcus, and Bacteroides fragilis.

MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.

Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase

EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.

DC 86M is an antitumor antibiotic isolated from the culture broth of Streptomyces luteogriseus DO-86.

Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.

A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.

Rubradirin: an antibiotic targeting methicillin-resistant staph, complex structure, inhibits peptide initiation.

DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM

Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).