Antibacteriano
Os inibidores antibacterianos são compostos que visam as células bacterianas, inibindo seu crescimento ou matando-as diretamente. Esses inibidores são essenciais no desenvolvimento de tratamentos para infecções bacterianas e são amplamente utilizados na pesquisa para estudar a fisiologia bacteriana, os mecanismos de resistência e a eficácia de novos agentes antibacterianos. Na CymitQuimica, oferecemos uma variedade de inibidores antibacterianos para apoiar sua pesquisa em microbiologia, doenças infecciosas e desenvolvimento de medicamentos.
Foram encontrados 2949 produtos de "Antibacteriano"
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PptT-IN-3
<p>PptT-IN-3 (5p), an inhibitor of PptT in Mycobacterium tuberculosis, IC50=3.5μM, is key for TB research.</p>Fórmula:C16H27N5O3SCor e Forma:SolidPeso molecular:369.48RhlR antagonist 1
<p>RhlR antagonist 1: IC50 of 26 μM, selective for RhlR, inhibits P. aeruginosa biofilm and virulence factors.</p>Fórmula:C12H10F2OCor e Forma:SolidPeso molecular:208.2HKI12134085
CAS:<p>HKI12134085 (compound 3), an orally administered nitrobenzothiazinone (BTZ) derivative, demonstrates antibacterial efficacy against Mycobacterium tuberculosis. This compound exhibits significant in vivo inhibitory potency within a BALB/c mouse model of Mycobacterium tuberculosis infection [1].</p>Fórmula:C18H18F3N3O5SCor e Forma:SolidPeso molecular:445.41trans-Clopenthixol
CAS:<p>Trans-Clopenthixol ((E)-Clopenthixol) is an antibiotic without any sedative properties. It can be used in vitro to inhibit Pseudomonas aeruginosa and Plasmodium falciparum.</p>Fórmula:C22H25ClN2OSCor e Forma:SolidPeso molecular:400.965Antibacterial agent 266
CAS:<p>Antibacterialagent 266 (Compound C5) is an inhibitor of plant pathogenic bacteria that disrupts the integrity of bacterial cell membranes. It exhibits an EC50 of 24.1 μg/mL against Xanthomonasoryzaepvoryzae (Xoo) and 39.0 μg/mL against X. axonopodispvcitri (Xac). Antibacterialagent 266 is valuable for research in plant pathology and the development of agricultural antibacterial agents.</p>Fórmula:C13H11N3OCor e Forma:SolidPeso molecular:225.246MA220607
CAS:<p>MA220607 is an antibacterial agent characterized by low hemolytic toxicity and a dual-target mechanism of action (MOA). It promotes FtsZ protein polymerization, increases bacterial membrane permeability, and inhibits biofilm formation. The resistance rate of MA220607 is low, with MICs against Gram-positive bacteria and Gram-negative bacteria ranging from 0.062-2 μg/mL and 0.5-4 μg/mL, respectively [1].</p>Fórmula:C34H38INCor e Forma:SolidPeso molecular:587.58KPC-2-IN-2
<p>KPC-2-IN-2 (6c) inhibits KPC-2 enzyme in Klebsiella pneumoniae (Ki 0.038 μM) and boosts cefotaxime in E. coli KPC-2.</p>Fórmula:C12H10BN3O2SCor e Forma:SolidPeso molecular:271.1Aurantiogliocladin
CAS:<p>Aurantiogliocladin is a mild antibiotic effective against Staphylococcus epidermidis, but it shows no efficacy against Staphylococcus aureus. It is also capable of inhibiting biofilm formation.</p>Fórmula:C10H12O4Cor e Forma:SolidPeso molecular:196.2LolCDE-IN-2
CAS:<p>LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1].</p>Fórmula:C22H17N5OPureza:98%Cor e Forma:SolidPeso molecular:367.40Penethamate hydriodide
CAS:<p>Penethamate hydriodide is a diethylaminoethyl ester prodrug of penicillin, utilized via intramuscular injection to treat mastitis in cattle.</p>Fórmula:C22H32IN3O4SCor e Forma:SolidPeso molecular:561.477BM635 mesylate
<p>BM635 mesylate inhibits MmpL3; kills Divergent bacterium with 0.6 µM MIC50; boosts bioavailability.</p>Fórmula:C26H33FN2O4SCor e Forma:SolidPeso molecular:488.61Antitubercular agent-11
<p>Antitubercular agent-11 (Compound 1e) is an antitubercular agent with a bulkier electron-donating group (Bu-t) that shows the best MIC value of 0.060 μg/mL [1].</p>Fórmula:C16H15N3O4Cor e Forma:SolidPeso molecular:313.31Anti-MRSA agent 27
CAS:<p>Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.</p>Fórmula:C15H10F3N3OSCor e Forma:SolidPeso molecular:337.32LasR antagonist 1
CAS:<p>LasR antagonist 1 (Compound 7), with an IC50 of 0.4 μM, is an effective antagonist of LasR that modulates quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa [1].</p>Fórmula:C20H15F3N2O3Cor e Forma:SolidPeso molecular:388.34MtTMPK-IN-2
CAS:<p>MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).</p>Fórmula:C23H24ClN3O3Cor e Forma:SolidPeso molecular:425.919-tert-Butyldoxycycline
CAS:<p>9-tert-Butyldoxycycline exhibits immunomodulatory activity by altering the polarization state of polymorphonuclear neutrophils and ameliorating inflammatory responses in ischemia-reperfusion injury models. Additionally, 9-tert-Butyldoxycycline serves as a ligand for the "Tet-On" inducible gene expression system.</p>Fórmula:C26H32N2O8Cor e Forma:SolidPeso molecular:500.541β-Glucuronidase-IN-2
<p>β-Glucuronidase-IN-2 is a potent inhibitor of E.</p>Fórmula:C21H17Cl3O7Cor e Forma:SolidPeso molecular:487.71Pisiferic acid
CAS:<p>Pisiferic acid is a novel PP2C activator and an an antimicrobial diterpenoid</p>Fórmula:C20H28O3Cor e Forma:SolidPeso molecular:316.43Pneumolysin-IN-1
CAS:<p>Pneumolysin-IN-1 (compound PB-3), characterized as a targeted small molecule inhibitor of Pneumolysin (PLY) with an IC50 value of 3.1 µM, acts as a pore-blocking agent and an anti-virulence factor. This compound is useful for researching infections caused by Streptococcus pneumoniae [1].</p>Fórmula:C23H16Cl2N2O4Cor e Forma:SolidPeso molecular:455.29Antibacterial agent 66
<p>Compound 6q, a trifluoromethylpyridine oxadiazole, targets Xanthomonas oryzae with EC50 of 7.2 μg/mL.</p>Fórmula:C17H10ClF6N3O2SCor e Forma:SolidPeso molecular:469.79MsbA-IN-3
<p>MsbA-IN-3 is a potent and highly selective MsbA inhibitor (IC50: 2 nM). MsbA-IN-3 inhibits Escherichia coli activity (MIC: 35 μM).</p>Fórmula:C24H22Cl2N2O4SCor e Forma:SolidPeso molecular:505.41LasR-IN-1
<p>LasR-IN-1 (9g) strongly inhibits LasR, potent vs E. coli, with a 28.13 μM MIC against P. aeruginosa.</p>Fórmula:C23H21N3O2Cor e Forma:SolidPeso molecular:371.43NFC nitro probe 1
CAS:<p>NFC nitro probe 1 (compound 18) is a chemical probe designed for the detection of Mtb, exhibiting high potency against both R-Mtb and NR-Mtb.</p>Fórmula:C19H19NO6Cor e Forma:SolidPeso molecular:357.357N6-Benzoyl-2'-deoxyadenosine monohydrate
CAS:<p>N6-Benzoyl-2'-deoxyadenosine monohydrate is a nucleoside analogue that helps diagnose bacterial infections by binding to double-stranded DNA and altering its structure, which can subsequently be detected using electrophoresis.</p>Fórmula:C17H19N5O5Cor e Forma:SolidPeso molecular:373.363L-threo-β-Hydroxyaspartic acid
CAS:<p>L-threo-β-Hydroxyaspartic acid is an amino acid antibiotic with activity against Bacillus subtilis, Xanthomonas oryzae, Mycobacterium phlei, and Botrytis cinerea.</p>Fórmula:C4H7NO5Cor e Forma:SolidPeso molecular:149.102Probenecid sodium
CAS:<p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>Fórmula:C13H18NNaO4SCor e Forma:SolidPeso molecular:307.341Antibacterial agent 262
CAS:<p>Antibacterialagent 262 (compound A23) is a potent antibacterial agent that inhibits the activity of Xanthomonas oryzae pv oryzae. It also disrupts the integrity of bacterial cell membranes by preventing the formation of biofilms of Xanthomonas oryzae pv oryzae.</p>Fórmula:C17H18F2N6O4S3Cor e Forma:SolidPeso molecular:504.554Antibacterial agent 204
CAS:<p>Antibacterial agent 204 (Compd P2-56-3) enhances the activity of Rifampin (RIF) against Acinetobacter baumannii and Klebsiella pneumoniae by disrupting the outer membrane of A. baumannii. T [1].</p>Fórmula:C14H18N2Cor e Forma:SolidPeso molecular:214.31Cephalosporin C
CAS:<p>Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.</p>Fórmula:C16H21N3O8SCor e Forma:SolidPeso molecular:415.418K13787
CAS:<p>K13787 is an acetohydroxy acid synthase (AHAS) inhibitor with antibacterial properties. It exhibits antimicrobial activity against various non-tuberculous mycobacteria (NTM) as well as clarithromycin (CLR) resistant strains.</p>Fórmula:C14H11F2N5O4SCor e Forma:SolidPeso molecular:383.33Colistin adjuvant-2
<p>Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].</p>Fórmula:C14H7Cl2F3N2OCor e Forma:SolidPeso molecular:347.12NDM-1 inhibitor-5
CAS:<p>NDM-1 Inhibitor-5 (compound 57) exhibits strong inhibition of NDM-1, characterized by a K i of 2.5 μM. Additionally, it demonstrates synergistic antibacterial effects when combined with meropenem [1].</p>Fórmula:C24H23NO4Cor e Forma:SolidPeso molecular:389.44MurA-IN-6
CAS:<p>MurA-IN-6 (Compound L16) is a selective MurA inhibitor with an IC50 of 26.63 μM. It exhibits antibacterial activity by inhibiting the function of MurA, a key protein essential for bacterial cell wall synthesis.</p>Fórmula:C22H17N3O3SCor e Forma:SolidPeso molecular:403.454LasR-IN-2
<p>LasR-IN-2 blocks LasR via H-bond with TRY-56, useful in bacterial infection and CF research.</p>Fórmula:C21H16ClN3O2Cor e Forma:SolidPeso molecular:377.82MtMetAP1-IN-1
<p>MtMetAP1-IN-1 is an inhibitor of methionine aminopeptidase 1 ( MetAP1 ). MtMetAP1-IN-1 shows antimycobacterial activity.</p>Fórmula:C15H10BrN5O2SCor e Forma:SolidPeso molecular:404.24Antitubercular agent-23
<p>Antitubercular agent-23 combats Candida albicans (MIC: 1.1 μg/ml) and M. tuberculosis (MIC: 1 μg/ml).</p>Fórmula:C20H22FN5O8SCor e Forma:SolidPeso molecular:511.48BDM91288
CAS:<p>BDM91288, an orally active AcrB efflux pump inhibitor of pyridinium piperazine, enhances the in vivo efficacy of levofloxacin in treating Klebsiella pneumoniae pulmonary infection in mouse models [1].</p>Fórmula:C17H22ClN5Cor e Forma:SolidPeso molecular:331.84TBAJ-5307
CAS:<p>TBAJ-5307 is a broad-spectrum anti-non-tuberculous mycobacteria inhibitor that targets the FO-domain of the engine, preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo [1].</p>Fórmula:C30H35BrN4O6Cor e Forma:SolidPeso molecular:627.53BWC0977
CAS:<p>BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.</p>Fórmula:C22H21FN6O5Cor e Forma:SolidPeso molecular:468.44Ibafloxacine
CAS:<p>Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect against</p>Fórmula:C15H14FNO3Pureza:97.67%Cor e Forma:SolidPeso molecular:275.274-Bromo A23187
CAS:<p>4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.</p>Fórmula:C29H36BrN3O6Pureza:98%Cor e Forma:SolidPeso molecular:602.52NBTIs-IN-5
CAS:<p>NBTIs-IN-5 inhibits Mycobacterium abscessus DNA with IC50 1.5μM, halts growth at MIC90 0.4μM.</p>Fórmula:C24H25F3N4O2Cor e Forma:SolidPeso molecular:458.48FPI-1465
CAS:<p>FPI-1465: Dual serine-β-lactamase & PBP inhibitor; IC50 PBP2=1.0 μg/mL; Kd CTX-M-15=0.011μM, OXA-48=5.3μM.</p>Fórmula:C11H18N4O7SCor e Forma:SolidPeso molecular:350.352'-Amino-2'-deoxyadenosine
CAS:<p>2'-Amino-2'-deoxyadenosine (9-(2-Amino-2-deoxypentofuranosyl)-9H-purin-6-amine) is a nucleoside antibiotic that effectively inhibits various Mycoplasma strains.</p>Fórmula:C10H14N6O3Peso molecular:266.26Diclosulam
CAS:<p>Diclosulam (XDE 564) is an herbicide with a Ki value of less than 32 nM. It exhibits a MIC of 6.25 and 12.5 μM, and a MIC50 of 1.40 and 3.01 μM against the CBS10913 and CBS12373 strains, respectively.</p>Fórmula:C13H10Cl2FN5O3SCor e Forma:SolidPeso molecular:406.22MtTMPK-IN-3
CAS:<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Fórmula:C23H23Cl2N3O3Cor e Forma:SolidPeso molecular:460.35Xeruborbactam
CAS:<p>QPX7728 is an of ultra-broad-spectrum boronic acid beta-lactamase.</p>Fórmula:C10H8BFO4Pureza:98%Cor e Forma:SolidPeso molecular:221.98MBX-1162
CAS:<p>MBX-1162, a bis-indole compound, has demonstrated unique substrate specificity related to MepA and MepR in studies investigating its resistance mechanisms in Staphylococcus aureus. It has not shown cross-resistance with related compounds.</p>Fórmula:C30H28N6Cor e Forma:SolidPeso molecular:472.58Meclocycline
CAS:<p>Meclocycline: a tetracycline antibiotic, inhibits LDH, reduces cell toxicity from mutant huntingtin, doesn't change protein levels in PC12 cells.</p>Fórmula:C22H21ClN2O8Cor e Forma:SolidPeso molecular:476.86Quorum sensing-IN-9
CAS:<p>Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding to the PqsR protein. It suppresses the expression of quorum sensing system-related genes lasB, rhlA, and pqsA, thereby preventing the production of virulence factors elastase, pyocyanin, and rhamnolipid. Quorum sensing-IN-9 disrupts the motility of P. aeruginosa, inhibits biofilm formation, and reduces the bacterium's virulence and pathogenicity. Additionally, it exhibits anti-infective activity in the Galleria mellonella larval model.</p>Fórmula:C9H10OS2Cor e Forma:SolidPeso molecular:198.305
