HBV
Os inibidores do HBV são compostos projetados para atingir e inibir várias etapas do ciclo de vida do vírus da hepatite B (HBV). Esses inibidores podem interferir na replicação, montagem ou liberação viral, reduzindo assim a carga viral e ajudando a gerenciar infecções crônicas por HBV. A pesquisa sobre inibidores do HBV é crucial para o desenvolvimento de terapias antivirais eficazes para prevenir doenças hepáticas e câncer associados ao HBV. Na CymitQuimica, oferecemos uma variedade de inibidores do HBV para apoiar sua pesquisa em virologia, desenvolvimento de medicamentos antivirais e controle de doenças infecciosas.
Foram encontrados 185 produtos de "HBV"
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HBV-IN-30
CAS:HBV-IN-30, a flavone derivative, inhibits cccDNA in HBV research.Fórmula:C22H18BrClO6Cor e Forma:SolidPeso molecular:493.73Besifovir Dipivoxil maleate
CAS:Besifovir Dipivoxil maleate, an oral HBV prodrug (LB80380), suppresses HBV DNA in naive and lamivudine-resistant CHB cases.Fórmula:C22H34N5O8PPureza:98%Cor e Forma:SolidPeso molecular:527.51IR415
CAS:IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBxFórmula:C13H14F2N4SPureza:99.85%Cor e Forma:SolidPeso molecular:296.34Ref: TM-T11669
5mg43,00€10mg71,00€25mg128,00€50mg215,00€100mg318,00€200mg444,00€1mL*10mM (DMSO)47,00€SHR5133
CAS:SHR5133 is a potent, orally active regulator of HBV capsid assembly that reduces HBV DNA (EC50: 26.6 nM).Fórmula:C19H18F4N6O2Cor e Forma:SolidPeso molecular:438.38HEC72702
CAS:HEC72702: New HBV capsid inhibitor, from GLS4. No CYP1A2, CYP3A4, CYP2B6 induction at 10μM.Fórmula:C24H26BrFN4O5SCor e Forma:SolidPeso molecular:581.45HBV-IN-17
CAS:HBV-IN-17 (compound 8) is a potent regulator of HBV capsid assembly (EC50: 511 nM).Fórmula:C17H15F6N5O2Cor e Forma:SolidPeso molecular:435.32Oxynitidine
CAS:Oxynitidine, an HBV inhibitor (ID50 = 30.8 µg/mL), effectively suppresses HBV DNA replication and may be utilized in viral infection research [1].Fórmula:C21H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:363.36HBV-IN-13
CAS:HBV-IN-12 is a potent inhibitor of hepatitis B surface antigen (HBsAg).Fórmula:C22H25NO7Cor e Forma:SolidPeso molecular:415.44ent-Entecavir
CAS:Ent-Entecavir, an enantiomeric impurity of Entecavir (an oral HBV drug), inhibits HBV replication as a reverse transcriptase inhibitor.Fórmula:C12H15N5O3Cor e Forma:SolidPeso molecular:277.28HBV-IN-8
CAS:HBV-IN-6 is a potent inhibitor of HBV (EC50: 287.9 nM).Fórmula:C21H25ClFN5O5S2Cor e Forma:SolidPeso molecular:546.04Lagociclovir valactate
CAS:Lagociclovir valactate is a prodrug of Lagociclovir . Lagociclovir valactate is an orally active anti- HBV agent [1] .Fórmula:C18H25FN6O6Cor e Forma:SolidPeso molecular:440.43Valtorcitabine dihydrochloride
CAS:Valtorcitabine dihydrochloride, a DNA polymerase inhibitor, is used potentially for the treatment of HBV infection.Fórmula:C14H24Cl2N4O5Cor e Forma:SolidPeso molecular:399.27HBF-0259
CAS:HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells.Fórmula:C16H12Cl2FN5Pureza:98.07% - 99.42%Cor e Forma:SolidPeso molecular:364.2Ref: TM-T27527
2mg35,00€5mg52,00€10mg74,00€25mg120,00€50mg175,00€100mg263,00€200mg369,00€1mL*10mM (DMSO)52,00€AB-836
CAS:AB-836, an orally active hepatitis B virus (HBV) capsid inhibitor, hampers viral replication by engaging with the HBV core protein.Fórmula:C20H15F3N4O2Cor e Forma:SolidPeso molecular:400.35Tenofovir amibufenamide
CAS:Tenofovir amibufenamide (HS-10234) 是一种 Tenofovir 前药，是一种具有口服活性的抗病毒化合物。Tenofovir amibufenamide 对乙型肝炎病毒 (HBV)具有抑制作用，可用于慢性乙型肝炎 (CHB) 研究。Fórmula:C22H31N6O5PPureza:99.19% - 99.87%Cor e Forma:SolidPeso molecular:490.49Linvencorvir
CAS:Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.
Fórmula:C29H35FN6O5SPureza:99.9% - 99.9%Cor e Forma:SolidPeso molecular:598.69ALG-000184
CAS:ALG-000184, a prodrug of the potent HBV capsid assembly modulator ALG-001075, shows potential for use in HBV infection research.
Fórmula:C23H20FN4Na2O8PCor e Forma:SolidPeso molecular:576.379SAG-524
CAS:SAG-524 is a powerful oral small molecule that inhibits HBV viral replication. In HepG2.2.15 cells, SAG-524 reduced HBV-DNA and HbsAg levels in the supernatant with IC₅₀ values of 0.92 nM and 1.4 nM, respectively [1].Fórmula:C30H32ClN5O4SCor e Forma:SolidPeso molecular:594.12HBV/HDV-IN-2
CAS:HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.
Fórmula:C38H44ClN7O5Cor e Forma:SolidPeso molecular:714.25HBV-IN-18
HBV-IN-18 (Compound 3) is an HBV capsid assembly modulator (CpAM) (EC50: 2790 nM).Fórmula:C17H15F6N5O2Cor e Forma:SolidPeso molecular:435.32HBV-IN-20
HBV-IN-20 is a potent, orally active HBV inhibitor (EC50: 0.46 μM). HBV-IN-20 is a classical type II CpAM (core protein assembly regulator).Cor e Forma:SolidHBV-IN-31
CAS:HBV-IN-31: strong cccDNA inhibitor, anti-HBV, IC50=0.13 µM HBsAg, hampers cell growth.Fórmula:C23H18ClNO6Cor e Forma:SolidPeso molecular:439.85HBV-IN-11
CAS:HBV-IN-11 is a potent inhibitor of HBsAg secretion (EC50: 0.46 μM).Fórmula:C21H24ClNO6Cor e Forma:SolidPeso molecular:421.87HBV-IN-19 TFA
CAS:HBV-IN19 TFA suppresses HBsAg, hampers HBV infection, and aids in HBV research.Fórmula:C26H31F3N2O8Cor e Forma:SolidPeso molecular:556.53HBV-IN-12
CAS:HBV-IN-12: strong HBsAg & HBV DNA inhibitor; EC50 0.001-0.05 μM & 0.001-0.02 μM respectively. (WO2021204252A1)Fórmula:C23H27NO8Cor e Forma:SolidPeso molecular:445.46TLR8 agonist 4
TLR8 agonist 4 inhibits wild-type and lamivudine/entecavir-resistant HBV; IC50: 0.15 μM and 0.10 μM.Fórmula:C28H27N5O5SCor e Forma:SolidPeso molecular:545.61FNC-TP trisodium
FNC-TP trisodium, active intracellular FNC form, inhibits NRTI, fights HIV, HBV, and HCV.Fórmula:C9H11FN6Na3O13P3Cor e Forma:SolidPeso molecular:592.11HBV/HDV-IN-3
CAS:HBV/HDV-IN-3 (Compd 1) acts as a dual inhibitor for HBV and HDV, demonstrating an efficacy (EC 50) below 50 nM against HBV .
Fórmula:C28H27BrF3N5O3Cor e Forma:SolidPeso molecular:618.44HBV-IN-48
CAS:HBV-IN-48, an HBV inhibitor, exhibits potent antiviral activity against HBV in HepDE19 cells, demonstrated by its EC 50 value of 0.005 μM. Additionally, it effectively reduces serum HBV DNA levels in mouse models of HBV infection.Fórmula:C22H15F4N3O3Cor e Forma:SolidPeso molecular:445.37HBV-IN-24
HBV-IN-24 inhibits HBV DNA, HBsAg, HBeAg (EC50: 0.6, 0.6, 4.6 nM), and has antiviral properties with neurotoxicity mitigation.Fórmula:C23H27NO6Cor e Forma:SolidPeso molecular:413.46TLR7/8 agonist 13
CAS:TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 μM) and TLR8 (LEC [hTLR8] of 1.6 μM). It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 μM). In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNα, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.Fórmula:C12H22N4O2Cor e Forma:SolidPeso molecular:254.33CCC-0975
CAS:CCC-0975 is an inhibitor of hepatitis B virus (HBV) with an EC50 of 10 μM. It interferes with the conversion of relaxed circular DNA (rcDNA) to covalently closed circular DNA (cccDNA) and reduces cccDNA and its precursor deproteinized rcDNA (DP-rcDNA), without promoting their degradation inside cells. CCC-0975 holds potential for chronic hepatitis B research.Fórmula:C21H17ClF3N3O3SCor e Forma:SolidPeso molecular:483.89HBV-IN-34
CAS:HBV-IN-34 (compound 17i) is a potent inhibitor of HBsAg production, demonstrating remarkable in vitro anti-HBV efficacy with EC50 values of 0.018 μM for HBV DNA
Fórmula:C21H19F2N7Pureza:98%Cor e Forma:SolidPeso molecular:407.42Ref: TM-T79469
Produto descontinuadoYhhu6669
CAS:Yhhu6669 is an anti-HBV agent that suppresses viral DNA and replication by promoting DNA-free capsid assembly, effectively reducing HBV DNA and HBcAg levels in
Fórmula:C29H28ClFN6O3Pureza:98%Cor e Forma:SolidPeso molecular:563.02Ref: TM-T78756
Produto descontinuadoHBV-IN-38
CAS:HBV-IN-38 (Example 193), an HBV DNA inhibitor with an EC50 value of ≤100 nM, serves as a research tool for investigating viral infections [1].
Fórmula:C18H16F3N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:487.48
