ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos de "ATM/ATR"
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Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Fórmula:C21H26N6O3Pureza:99.6% - 99.93%Cor e Forma:SolidPeso molecular:410.47AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Fórmula:C24H28N4O3Pureza:98.01%Cor e Forma:SolidPeso molecular:420.5Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Fórmula:C23H21FN6O3Pureza:99.9%Cor e Forma:SolidPeso molecular:448.45ATR-IN-17
CAS:<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Fórmula:C22H28N6O2SCor e Forma:SolidPeso molecular:440.56ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Fórmula:C26H29FN6O3Cor e Forma:SolidPeso molecular:492.55ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Cor e Forma:SolidPeso molecular:489.57ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Cor e Forma:SolidPeso molecular:480.53Decarbamoylmitomycin C
CAS:<p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>Fórmula:C14H17N3O4Cor e Forma:SolidPeso molecular:291.302WSD0628
CAS:<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Fórmula:C23H23F2N5O2Cor e Forma:SolidPeso molecular:439.46ATM Inhibitor-1
CAS:<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Fórmula:C27H36N6O3Pureza:98%Cor e Forma:SolidPeso molecular:492.61ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OCor e Forma:SolidPeso molecular:393.42KU 59403
CAS:<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Fórmula:C29H32N4O4S2Pureza:99.10%Cor e Forma:SolidPeso molecular:564.72ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Cor e Forma:SolidPeso molecular:513.54ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Cor e Forma:SolidPeso molecular:492.59ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Cor e Forma:SolidPeso molecular:511.53ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Fórmula:C22H27N5O3SCor e Forma:SolidPeso molecular:441.55ATR-IN-19
CAS:<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Fórmula:C18H19N7OSCor e Forma:SolidPeso molecular:381.45(S)-WSD0628
CAS:<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Fórmula:C23H23F2N5O2Cor e Forma:SolidPeso molecular:439.458ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Cor e Forma:SolidPeso molecular:446.54KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Fórmula:C30H33N3O5SPureza:98.05% - 98.50%Cor e Forma:SolidPeso molecular:547.67ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Fórmula:C23H26N6O2Pureza:98%Cor e Forma:SolidPeso molecular:418.49Ref: TM-T79058
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