Oligossacarídeos

α-1,4-glucododecasaccharide derived from starch by hydrolysis and chromatography

<p>GalNAca1-3(Fuca1-2)Gal-HSA (6 atom spacer)</p>

<p>Heparin derived dp20 saccharide ammonium salt is a synthetic, high purity, complex carbohydrate that has been modified with fluorination and methylation. It is a polysaccharide composed of repeating units of D-glucosamine and D-mannose, which are linked by alternating alpha 1-6 and alpha 1-4 glycosidic bonds. This product can be used as a monosaccharide or sugar in the synthesis of oligosaccharides or polysaccharides.</p>

<p>Man-9-Glc N-Glycan is a synthetic carbohydrate that is a modification of the natural sugar, Man-9-GlcNAc. It can be used as an ingredient in pharmaceutical products, such as vaccines and other therapeutic agents. This product is a custom synthesis that can be produced to order.</p>

<p>Gangliotriose is the core trisaccharide structure in gangliosides, such as, GD2 (GalNAcβ1,4Galβ1,4Glc) (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that posess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

<p>The glycoconjugate is a glycosylation of an oligosaccharide with a monosaccharide. It is synthesized by the reaction of an activated saccharide with an alcohol or amine, and is modified by methylation, click modification, fluorination or acetylation. The glycoconjugate has been shown to be used as a potential treatment for cancer.</p>

<p>Man-6 N-Glycan is a custom synthesis of an oligosaccharide. It is also classified as a polysaccharide and carbohydrate. The glycosylation of this product involves the addition of a sugar to the glycan, which is then modified by methylation or fluorination. This product has been shown to be stable in a buffer solution at pH 7 and can be used for click chemistry. The purity is high with no detectable impurities.</p>

<p>Verbascotetraose is a disaccharide that is found in plants. Its chemical structure is composed of one glucose molecule and one fructose molecule. Verbascotetraose is produced by the plant tissue through a biosynthetic process, which involves the transfer reactions of phosphorylated hexoses. The resulting product is then converted to stachyose and oligosaccharides by dephosphorylation, glycan synthesis, and chromatographic method.<br>The production of verbascotetraose has been demonstrated in soybean products incubated with cellotriose and glycoside derivatives.</p>

1,4-b-D-Cellotriitol is a methylated cellobiose with a 1,4 glycosidic linkage. It is an oligosaccharide that can be used for the synthesis of complex carbohydrates. This product has a high purity and is custom synthesis.

<p>2,3,1',3',4',6'-Hexa-O-acetyl-sucrose is a custom synthesis carbohydrate with a complex structure. The chemical name for this compound is 2,3,1',3',4',6'-hexahydroxy-α-D-glucopyranosyl-(1→2)-β-D-fructofuranoside. It has the CAS number 52706-47-5 and the molecular weight of 593.54 g/mol. This product can be used in various applications including Oligosaccharides, Polysaccharides, Modification, saccharide, Methylation, Glycosylation, Click modification and Carbohydrate. 2,3,1',3',4',6'-Hexa-O-acetyl-sucrose is also a high purity product that is Fluorinated and Synthetic.</p>

<p>Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 1000 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.</p>

<p>NeuAc-a2,3-Gal-b-1,4-Glc-GlycineNH2 is a carbohydrate that belongs to the group of saccharides. It is an oligosaccharide that has been synthesized via a custom synthesis. This product is high purity and has been modified with methylation, glycosylation, and click modification.</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agarodecaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.</p>

<p>A2 N-glycan is a complex carbohydrate that is found in invertebrates and mammals. The A2 N-glycan was found to be the most abundant of all glycoproteins in invertebrates, with a relative abundance of over 50%. It has been shown that the A2 N-glycan can be modified by covalent linking to proteins, differentiating it from other glycans. These modifications may have an effect on the structural stability of the molecule and its susceptibility to environmental degradation. The A2 N-glycan also plays an important role in immunity, as it is immunogenic and can stimulate antibody production. This carbohydrate is uniquely found in humans, which suggests that it may have some importance in human physiology.</p>

<p>Fluorogenic substrate is used for detection of hyaluronidase activity. Urinary hyaluronidase activity is elevated in patients with intermediate and high grade bladder cancer; the expression of hyaluronidase and hyaluronan synthase-1 mRNA in malignant tissue can predict bladder cancer metastasis and disease recurrence (Kramer, 2011). These findings underscore the potential utility of the hyaluronidases to serve as biomarkers for bladder cancer. A novel fluorescent substrate labelled with two dyes: fluorescein as a green donor fluorophore, and rhodamine B as a red acceptor fluorophore, was therefore developed to measure hyaluronidase enzyme kinetics (Zhang, 2008). It was then demonstrated that simultaneous measurements of green and red emission of HA–FRET could be used to measure hyaluronidase presence and activity (Fudala, 2011).</p>

Gala1-3(Fuca1-2)Galb1-3GlcNAcb1-3Gal (B antigen pentasaccharide Type I)

<p>N-Glycolyl GM1 ganglioside has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with N-glycolyl sialic acid linked α2,3 to the central galactose residu,e and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). SV40, Py, and the human BK viruses are unusual among viruses in that they use glycolipids as their major cell surface receptors. SV40 uses the N-glycolylneuraminic acid (NeuGc) analog of the ganglioside GM1 [GM1(Gc)] as the cell surface receptor and it gave markedly stronger binding signals than the NeuAc analog [GM1(Ac)] (Campanero-Rhodes, 2007).</p>

<p>3-O-b-D-Galactosylsucrose is a synthetic, fluorinated, high purity, oligosaccharide. It is a complex carbohydrate that contains an O-linked glycosylated monosaccharide. This product has been modified with a click modification. The CAS number for this product is 686717-73-7 and it can be synthesized to order.</p>

<p>N-Acetylneuraminic acid pentamer penta sodium is a modification of the N-acetylneuraminic acid monomer. It is a carbohydrate that is made up of five saccharide units linked by glycosidic bonds. The first four saccharides are N-acetylneuraminic acid and the fifth unit is D-mannose. This molecule has been synthesized for use as a vaccine adjuvant to increase the body's immune response to vaccines.</p>

<p>GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).</p>