Compostos Policiclícos

Lactone

Applications A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),

Applications 1,2,3,4-tetrahydro-1,2-dimethyl-4,8-isoquinolinediol, is a Tetrahydroisoquinoline derivative, that can be used for the synthesis of pharmaceutical drugs, containing tetrahydroisoquinoline skeleton.

Applications 5,7-Diazaspiro[3.4]Octane-6,8-Dione (cas# 89691-88-3) is a useful research chemical.

Applications 2,2':6',2''-Terpyridine (cas# 1148-79-4) is a useful research chemical.

Applications 6-Chloroisatin (cas# 6341-92-0) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Isoquinoline-5-sulfonic Acid (cas# 27655-40-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-(gamma,gamma-Dimethylallylamino)purine riboside hemihydrate

Applications 1-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.
References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)

Applications 6-Chloropurine-9-(2,3-isopropylidene-β-D-ribofuranoside) (cas# 39824-26-5) is a compound useful in organic synthesis.

Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.
References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);

Applications Isoquinoline is used in the synthesis of nitrated indenoisoquinolines as a potent topoisomerase I inhibitor.This compound is a contaminant of emerging concern (CECs).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Morrell, A., et. al.: J. Med. Chem., 49, 7740 (2006)

Applications 8-Azaxanthine Monohydrate (cas# 59840-67-4) is a compound useful in organic synthesis.
References Balnk, U.H., et al.: JOC, 35, 4, 1131 (1970)

Applications 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas# 5807-14-7) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Impurity Famciclovir USP Related Compound F
Applications Famciclovir USP Related Compound F

Applications A chelating agent, forming complexes with most metal ions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References El-Didamony, A., et al.: Drug Test. Anal., 2, 122 (2010), Chan, A., et al.: J. Med. Chem., 53, 3086 (2010), Ehrman, T., et al.: Bioorg. Med. Chem., 18, 2204 (2010),

Applications 6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.
References Nandanan et al.: J. Med. Chem., 43, 829 (2000); Kim, H. S. et al.: J. Med. chem., 46, 4974 (2003); Chem. and Eng. News p.6 Apr. 4 (2016)

Applications trans-Indole-3-acrylic Acid is a regent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize polyphenols.
References Madrigal-Carballo, S., et al.: Int Food Res J, 20, 2023-2034 (2013)

Applications N-(2,6-Dichlorophenyl)isatin can be obtained from 2,6-Dichloroiodobenzene (D434690) which is a reactant in the synthesis of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors. Also an impurity of Diclofenac (D436465).
References Van Orden, L.J., et. al.: Bioorg. Med. Chem. Lett., 23, 1456 (2013)

Applications 6-Dimethylaminopurine-9-riboside (cas# 2620-62-4) is a compound useful in organic synthesis.
References Elion, G.B., et al.: JACS, 74, 411-414 (1952), Kelley, J.L., et al.: J. Med. Chem., 32, 1020-1024 (1989)

Applications Indazole-3-carboxylic Acid is an indole derivatives useful in treatment of pain and inflammation.
References Khanna P., et al.: Biochemistry, 40, 1441 (2001);

Stability Light Sensitive
Applications 5,6-Dibromo-1,10,11,12,13,13-hexachloro-11-tricyclo[8.2.1.02,9]tridecene is a flame retardant and a standard for environmental testing and research.
References EPA. Method 1668, (EPA 821-R-00-002) (1999); Dodson, R. E., et al.: Environ. Sci. Technol. 51, 4860 (2017)

Applications 3(6R,7R)--Hydroxy-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Diphenylmethyl Ester is a useful synthetic intermediate. It was used to prepare cephalosporin-derived inhibitors. It can also be used to synthesize Ceftaroline Fosamil which is a cephalosporin antibiotic.
References Buynak, J., et al.: Bioorg. Med. Chem. Lett., 12, 1663 (2002); Kanafani, Z., et al.: Future Microbiology, 4, 25 (2009); Parish, D,, et al.: Curr. Opinion Invest. Drugs, 9, 201 (2000)

Applications Tricyclohexylchlorotin is used as in the synthesis of organotin derivatives of 2-thiophene carboxylic acid as enzyme inhibitors and antibacterial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Abbas, S. et al.: J. Organometal. Chem., 724, 255 (2003); Zia-ur-Rehman et al.: J. Coord. Chem., 65, 3238 (2012);

Stability Volatile
Applications 1,​1'-​Bicyclopentyl along with butanal mixtures are used to produce high density aviation fuel.
References Yang, J., et al.: Ind. Eng. Chem. Res., 54, 11825-11837 (2015)

Applications 1,​2-​Dihydro-​2-​oxo-4-​quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.
References Chen, P., et al.: Zhongyaocai, 34, 1728 (2011); Kuryatnikov, A.B., et al.: Russ., RU 2581882 C1 20160420 (2016)

Applications Methyl Oxindole-6-carboxylate is an intermediate used to prepare BIBF 1120, an indolinone as triple angiokinase inhibitors.
References Roth, G., et al.: J. Med. Chem., 52, 4466 (2009)

Stability Hygroscopic
Applications 3-Amino-3-azabicyclo[3,3,0]octane is used as a reactant in the synthesis of Gliclazide (G409875), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.
References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)

Applications 1-Ethyl-1,2-dihydro-2,2,4-trimethyl-7-quinolinol is a reagent used in the preparation of fluorescent dyes and can be applied toward labeling of biological macromolecules.
References Liu, W., et.al., Faming Zhuanli Shenqing, 21, (2020);

Applications Tricyclene, is one of the main constituent of many essential oils having antioxidant activities.
References Tamta, A., et al.: Cogent Chemistry, Vol.2, issue1 (2016);

Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.

Applications Indoline metabolite
References Lacroix, I., et al.: Nat. Prod. Lett., 7, 15 (1995), Yamada, Y., et al.: Chem. Pharm. Bull., 54, 788 (2006), Whitehead, T., et al.: App. Environ. Microbiol., 74, 1950 (2008),

Applications Halquinol is an antimicrobial compound belonging to the group of hydroxyl-quinolines indicated for use in poultry and swine. It depresses the activity of the gastro-intestinal tract, causing longer transit time of feed through the intestine, thereby enhancing digestion and absorption of nutrients. It increases weight gain and improve feed conversionprevent and control nonspecific diarrhea or wet dropping in farming animals.
References Costa, M. et al.: PLoS One, Vol. 12, (2017);

Applications Used in synthesis of 3-amino-5H-pyrido[4,3-b]indoles, carcinogenic .gamma.-carbolines.
References Akimoto, H., et al.: Bull. Chem. Soc. Jpn., 58, 123 (1985),

Applications Indole analogue; shows pharmacological activity.
References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),

Applications This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution.
References Wolfbeis, O.S. & K. Schaffner: Photochem. Photobiol., 32, 143(1980), Bickoff et al.: J.Am. Chem Soc. 80, 3969 (1958)

Applications 1-Ethyl-2,3,3-trimethylindolenium-5-sulfonate (cas# 146368-07-2) is a compound useful in organic synthesis.

Applications 6,7-Dimethoxyisoquinoline is used as an organocatalyst in the chemoselective O-tert-butoxycarbonylation of phenols.
References Saito, Yukako, et al.: Tetrahedron Let., 51(52), 6915-6917 (2010)

Applications tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (cas# 203661-69-2) is a useful research chemical.

Applications A metabolite of 6-Mercaptopurine (M225450).
References Zimm, S., et al.: Biochem. Pharmacol., 33, 4089 (1984), Lennard, L., et al.: Clin. Pharmacol. Ther., 46, 149 (1989), Knoester, P., et al.: Anticancer Res., 13, 1795 (1993), McLeod, H., et al.: Leukemia, 14, 567 (2000),

Applications Intermediate in the preparation of P2X7 antagonists
References Donnelly-Roberts, D., et al.: Neuropharmacol., 56, 223 (2009), Perez-Medrano, A., et al.: J. Med. Chem., 52, 3366 (2009),

Applications 6-Benzylamino-7-deazapurine (cas# 60972-04-5) is a compound useful in organic synthesis.
References Tedder, M., et al.: Bioorg. Med. Chem. Lett., 14, 3165 (2004),

Applications A useful intermediate for drug discovery research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Caldwell, J., et al.: Tet. Lett., 48, 1527 (2007)

Applications Indole-3-acetamide is a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.
References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010)

Applications 3-Phenanthrenecarboxylic Acid is a useful building block.

Applications 6-Benzylaminopurine can be used as reagent/reactant in pharmacological activity and synthesis preparation for modification of the length and structure of the linker of N6-benzyladenosine modulates its selective antiviral activity against enterovirus 71.
References Drenichev, M., S.: Eur. J. Med. Chem., 111, 84-94 (2016);

Applications Pyridoxamine Dihydrochloride (cas# 524-36-7) is a compound useful in organic synthesis.