Compostos Policiclícos

2-Acetamido-6-chloropurine (2ACAP) is a nucleophilic agent that inhibits cancer cells by binding to the enzyme cholinesterase. It is used in the treatment of T-cell leukemia and herpes simplex virus. 2ACAP binds to the amine group of cholinesterase, which prevents it from breaking down acetylcholine. This inhibition leads to accumulation of acetylcholine, which has been shown to induce apoptosis in k562 cells. The molecular modeling study showed that 2ACAP binds to both chlorine atom and benzyl groups in the active site of cholinesterase. 2ACAP also has a potent inhibitory effect on cancer cell proliferation and can be used as an anti-cancer agent for many types of cancers including colon, breast, and prostate cancer.

4,4'-Dinonyl-2,2'-bipyridine is a high-yield transfer reagent that is used in organic synthesis. It can be used to transfer aryl or alkyl groups from ancillary to the functional group on the substrate. 4,4'-Dinonyl-2,2'-bipyridine is also used for the production of polymers and organic semiconductors. In addition, this compound has been shown to be useful in the production of silicon solar cells and as a catalyst for photovoltaic devices. 4,4'-Dinonyl-2,2'-bipyridine has been shown to be thermostable and can be used in temperatures up to 200°C. This compound is also a ligand with ruthenium complex properties and can be used as an electron acceptor in radiation therapy procedures.

N-Acetyl-3-hydroxyindole is a colorless liquid that inhibits the activity of enzymes such as butyric acid, active methylene, and acyl halides. It is also used to inhibit the enzyme eosinophil peroxidase in clinical tests. N-Acetyl-3-hydroxyindole has been shown to be an efficient method for high-throughput analysis of enzymatic reactions. This chemical can be immobilized on porous supports and used to measure enzyme activities. N-Acetyl-3-hydroxyindole has been shown to have therapeutic effects in clinical data with a potent inhibitor of eosinophil peroxidase.

Isatin dianilide is an organic compound with the chemical formula C8H6N2O. It is a white solid that is soluble in water, ethanol and acetone. Isatin dianilide can be synthesized by reacting phenylacetic acid with ammonia and formaldehyde. Isatin dianilide has been shown to have efficient oxidation reaction with Baeyer-Villiger oxidation, which makes it suitable for industrial use. Isatin dianilide also has biological activities such as inhibition of aminopeptidase N and aminopeptidase M, which are enzymes involved in protein synthesis. Yields of isatin dianilide are high because it can be produced from the commercially available compounds isatin and amidine.

4,5,6-Trimethoxyindole is a chemical compound that is found in the plant Chinensis. This compound has been shown to have potent anticancer properties and can be used as a treatment for inflammatory diseases. 4,5,6-Trimethoxyindole has been shown to modulate the activity of some bacteria and it has been hypothesized that this may be due to its interaction with formylation. The acidic nature of 4,5,6-Trimethoxyindole makes it soluble in ethanol. It can also be synthesised from butyric acid and other chemicals.

4-Aminoindole hydrochloride is a white crystalline solid that can be used as a versatile building block in organic synthesis. It is also used as an intermediate in the production of various pharmaceuticals and other chemical compounds. 4-Aminoindole hydrochloride is soluble in most polar solvents, but insoluble in ethers and oils. This compound is also a useful reagent for the conversion of nitrobenzenes to aminobenzoic acids. CAS Number 174854-93-4

Angelicin is a furanocoumarin compound, which is derived from various plant sources, particularly within the Apiaceae family. The source of angelicin is often linked to traditional medicinal plants, where it is extracted and subsequently isolated for scientific investigation. Angelicin's mode of action involves intercalating within DNA strands, thereby affecting transcription and replication processes. This action is understood to be primarily photoactivated, leading to the formation of covalent bonds with DNA upon exposure to ultraviolet light, which can result in cross-linking.

8-Geranyloxypsoralen is a natural furanocoumarin, which is a secondary metabolite typically derived from plants, particularly those in the Rutaceae family. Its source lies predominantly in certain fruits and herbs, where it functions as a natural defense compound.