Compostos Policiclícos

<p>Applications Tricyclohexylchlorotin is used as in the synthesis of organotin derivatives of 2-thiophene carboxylic acid as enzyme inhibitors and antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abbas, S. et al.: J. Organometal. Chem., 724, 255 (2003); Zia-ur-Rehman et al.: J. Coord. Chem., 65, 3238 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Applications 5-(2-Bromo-1-oxobutyl)-8-hydroxy-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.<br>References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);<br></p>

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Applications 1-benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas# 155413-72-2) is a useful research chemical.<br></p>

<p>Applications 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 5488-36-8) is a useful research chemical.<br></p>

<p>Applications 2-[(Dimethylamino)methyl]indole (cas# 3978-16-3) is a compound useful in organic synthesis.<br>References Inion, H., et al.: Eur. J. Med. Chem., 10, 276 (1975),<br></p>

<p>Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.<br></p>

<p>Applications 2-chloro-1-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethan-1-one (cas# 1087784-16-4) is a useful research chemical.<br></p>

<p>Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.<br>References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);<br></p>

<p>Applications 4,7-Dichloro-2-phenyl-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity.<br>References Marriott, G. J., et al.: J. Chem. Soc., 134 (1939); Katayama, H., et al.: Tetrahedron., 63, 6642 (2007);<br></p>

<p>Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation<br>References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)<br></p>

<p>Applications 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline<br></p>

<p>Applications 4,4-difluoro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 1443981-83-6) is a useful research chemical.<br></p>

<p>Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.<br></p>

<p>Applications 7-Aminoindole<br></p>

<p>Applications 2,3-dihydrobenzo[g]quinolin-4(1H)-one (cas# 21516-07-4) is a useful research chemical.<br></p>

<p>Applications 5-Fluoro-8-nitroquinoline (cas# 152167-85-6) is a useful research chemical.<br></p>

<p>Applications 9,10-Phenanthrenequinone is used in the formation of spirophosphoranes containing acyclic 5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl substituent.<br>References Mironov, V. F., et al.: Russ. J. Electrochem., 88, 430-438 (2018)<br></p>

<p>Applications 7-Chloro-4-nitroquinoline is used in the synthesis of aminonitropyridine.<br></p>

<p>Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>

<p>Applications (3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)<br></p>

<p>Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.<br></p>

<p>Applications 6-hydroxyquinoline-2-carboxylic acid (cas# 75434-18-3) is a useful research chemical.<br></p>

<p>Applications 8-Chloro-5-isoquinolinesulfonic Acid (cas# 1246816-17-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 2-Aminoindole-3-carboxylate (cas# 6433-72-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Benzyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (cas# 54329-48-5) is a useful research chemical.<br></p>

<p>Applications 7-Phenyl-7H-purine (cas# 18346-05-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-AMINO-1,2,3,4-TETRAHYDROISOQUINOLINE-1,3-DIONE (cas# 22177-46-4) is a useful research chemical.<br></p>

<p>Applications 6-Fluoroquinolin-2(1H)-one<br></p>

<p>Applications Methyl-2-aminoquinoline-6-carboxylate is an organic building block of ester and amine category.<br>References Li, L., et al.: PCT Int. Appl. (2018), WO 2018196823 A1 20181101<br></p>

<p>Applications A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent.<br>References Weyer, R., et al.: Arzneim.-Forsch., 24, 269 (1974),<br></p>

<p>Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.<br>References WO Patent 2014089324 (2014); CN 104016979 (2014);<br></p>

<p>Applications N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide is used in synthesis of an antitumor agent, neratinib (N390090).<br>References Zhang, P., et al.: Zhongguo Yaowu Huaxue Zazhi, 18, 355 (2008);<br></p>

<p>Applications 4-Hydroxy-quinoline-6-carboxylic acid<br></p>

<p>Applications 4-Bromo-2,8-Bis(Trifluoromethyl)Quinoline (cas# 35853-45-3) is a useful research chemical.<br></p>

<p>Applications tert-butyl 7-hydroxy-3,4-dihydroisoquinoline-2(1h)-carboxylate (cas# 188576-49-0) is a useful research chemical.<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxamide<br></p>

<p>Applications 3-Aminoquinoline-2-carboxylic acid (cas# 887245-74-1) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications Alpha-Pyridoin (cas# 1141-06-6) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Chloroacetyl)isoindoline was used in the reaction with potassium thiocyanate to synthesize N-​(α-​Thiocyanatoacetyl)​indolines, which is useful as agricultural fungicides.<br>References Richter, S.: U.S. (1975), US 3929830 A 19751230.<br></p>

<p>Applications 2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.<br>References Katamreddy, S. R., et al.: PCT Int. Appl. (2020), WO 2020140055 A1<br></p>

<p>Applications 7-Deazapurine (cas# 18549-65-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(prop-2-en-1-yl)-1h-indole (cas# 16886-09-2) is a useful research chemical.<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications 4-Chloro-1-hydroxy-7-isoquinolinesulfonyl Chloride (cas# 223671-81-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Quinoline-3-sulfonyl Chloride (cas# 159182-40-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Triclocarban Related Compound A (cas# 1219-99-4) is a useful research chemical.<br></p>

<p>Applications 4-Acetoxyindole is a useful intermediate for organic synthesis of Psilocine and Psilocine analogs.<br>References Julia, M., et al.: Chimica Therapeutica, 5, 279 (1970); Repke, D. B., et al.: J. Heterocycl. Chem., 14, 71 (1977)<br></p>