Outros inibidores

<p>Mal-PEG8-Boc, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone is a useful organic compound for research related to life sciences. The catalog number is T66997 and the CAS number is 461432-22-4.</p>

<p>Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside, a flavonoid extracted from Glycyrrhiza roots, exhibits low cytotoxicity on a variety of tumor and normal cells.</p>

<p>7-Azaindole-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67135 and the CAS number is 156270-06-3.</p>

<p>4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine is a useful organic compound for research related to life sciences. The catalog number is T66646 and the CAS number is 69675-10-1.</p>

<p>tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate oxalate is a useful organic compound for research related to life sciences. The catalog number is T66624 and the CAS number is 1210348-34-7.</p>

<p>ANNINE-6plus, a water-soluble dye from Germany's Max Planck Institute, tracks cell voltage changes with 30% (1-photon) &amp; &gt;50% (2-photon) intensity shifts.</p>

<p>N-Methyl Desloratadine is a useful organic compound for research related to life sciences. The catalog number is T65952 and the CAS number is 38092-89-6.</p>

<p>Octyl-β-D-Selenoglucoside is a useful organic compound for research related to life sciences. The catalog number is TF0035 and the CAS number is 1423273-53-3.</p>

<p>4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66332 and the CAS number is 123654-26-2.</p>

<p>(2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane is a useful organic compound for research related to life sciences. The catalog number is T66654 and the CAS number is 119302-24-8.</p>

<p>Glycyl-l-serine is a useful organic compound for research related to life sciences. The catalog number is T66681 and the CAS number is 7361-43-5.</p>

<p>Tri-n-butylphosphineoxide is a useful organic compound for research related to life sciences. The catalog number is T65487 and the CAS number is 814-29-9.</p>

<p>Arsenazo I is a calcium-sensitive, metallochromic dye used as reagent.</p>

<p>Echinocystic acid 28-O-β-D-glucoside, a metabolite produced through microbial oxidation and glucosidation of Echinocystic acid, demonstrates inhibitory activity against the tissue factor pathway, with an IC50 value of 10.61 nM.</p>

<p>Compound G541-1338 is a useful organic compound for research related to life sciences.Cost-effective and quality-assured.</p>

<p>Boc-D-Phe(2-Me)-OH, an amino acid derivative, has diverse applications in life science research.</p>

<p>3-Methoxybenzene-1,2-diamine is a useful organic compound for research related to life sciences. The catalog number is T65535 and the CAS number is 37466-89-0.</p>

<p>N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T67192 and the CAS number is 923036-30-0.</p>

<p>(S)-2-((tert-Butoxycarbonyl)amino)-3-(2-methoxyphenyl)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T67248.</p>

<p>AZD8154 is a newly developed inhaled compound that selectively inhibits dual PI3Kγδ, aimed at treating airway inflammatory diseases.</p>

<p>7-Amino-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T64948.</p>

<p>5-Bromo-2-(2H-tetrazol-5-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T64895 and the CAS number is 380380-60-9.</p>

<p>(1R,3S)-(+)-Camphoric acid is a useful organic compound for research related to life sciences. The catalog number is T66682 and the CAS number is 124-83-4.</p>

<p>6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64405 and the CAS number is 1006-21-9.</p>

<p>2-Chloroethyl palmitate is a useful organic compound for research related to life sciences. The catalog number is T66561 and the CAS number is 929-16-8.</p>

<p>Ceramide (Egg, Chicken) plays a major role in the anabolic and catabolic pathways of sphingolipid. Ceramide (Egg, Chicken) stimulates many cell differentiation, growth inhibition, cell senescence and apoptosis.</p>

<p>N-(4-Cyano-3-(trifluoromethyl)phenyl)methacrylamide is a useful organic compound for research related to life sciences. The catalog number is T65344 and the CAS number is 90357-53-2.</p>

<p>2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T66963 and the CAS number is 1056039-83-8.</p>

<p>H-L-Photo-lysine HCl is a diazirine lysine for site-specific protein incorporation and in vivo cross-linking.</p>

<p>3-(4-Fluorophenyl)propionic acid is a useful organic compound for research related to life sciences. The catalog number is T65009 and the CAS number is 459-31-4.</p>

<p>2-Oleoylglycerol is a lipid found in palm kernels that acts as a GPR119 agonist with neuroprotective properties and can be used in steatohepatitis modeling.</p>

<p>(-)-Corey lactone benzoate, catalog number T66946 and CAS number 39746-00-4, is a valuable organic compound for life sciences research.</p>

<p>Ferulenol, a sesquiterpene prenylated coumarin derivative, demonstrates potent antimycobacterial activity and [haemorrhagic] action by selectively targeting succinate ubiquinone reductase within the ubiquinone cycle.</p>

<p>8-Aminoquinoline is a common nitrogen-containing heterocyclic skeleton. It has antibacterial, antiviral and antitumor activities.</p>

<p>Expression System: E. coli&lt;br&gt;Activity: Not Tested</p>

<p>H-3-D-Pal-OH.HCl, an amino acid derivative, has diverse applications in life science research.</p>

<p>4-Cyano-2-fluorobenzoic acid is a useful organic compound for research related to life sciences. The catalog number is T67106 and the CAS number is 164149-28-4.</p>

<p>(4-Pyrazol-1-yl-phenyl)methanol is a useful organic compound for research related to life sciences. The catalog number is T65752 and the CAS number is 143426-49-7.</p>

<p>A031: PROTAC AR degrader, IC50 &lt; 0.25 μM, inhibits prostate cancer growth in zebrafish.</p>

<p>Bromo-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.</p>

<p>Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr</p>

<p>4-Bromo-3-hydroxybenzaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66219 and the CAS number is 20035-32-9.</p>

<p>ER degrader 2: Potent estrogen receptor disruptor; key for cancer research.</p>

<p>Policresulen is a useful organic compound for research related to life sciences. The catalog number is T66902 and the CAS number is 101418-00-2.</p>

<p>Antibacterial agent 30 exhibits remarkable in vitro activity against Xoo, as evidenced by its EC50 value of 1.9 μg/mL.</p>

<p>Gad m 1 Protein, Gadus morhua, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.28 kDa.</p>

<p>Phototherapeutic agent-1: a light-activated, ROS-generating cancer cell killer with aggregation-induced emission.</p>

<p>Chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T64659.</p>

<p>1-(2-Chlorophenyl)piperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65963 and the CAS number is 41202-32-8.</p>

<p>m-PEG24-azide is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T67589 and the CAS number is 67914-60-7.</p>

<p>4-Perhydroazepinone hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66790 and the CAS number is 50492-22-3.</p>

<p>Methyl 4-acetamido-2-methoxybenzoate is a useful organic compound for research related to life sciences. The catalog number is T65961 and the CAS number is 4093-29-2.</p>

<p>Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, designed to stabilize membrane proteins [1].</p>

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

<p>Target 5 has a wide range of applications in life science related research.</p>

<p>(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66938 and the CAS number is 331763-66-7.</p>

<p>(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione is a useful organic compound for research related to life sciences and the catalog number is T64820.</p>

<p>Microcystin-LY, from Microcystis aeruginosa, is a heptapeptide toxin that triggers oxidative stress by activating the Nrf2 pathway, most effective at 3μM.</p>

<p>Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.</p>

<p>3'-O-Angeloylhamaudol is a useful organic compound for research related to life sciences and the catalog number is T124112.</p>

<p>m-PEG4-azide, also referred to as 13-Azido-2,5,8,11-tetraoxatridecane, functions as a PEG-based PROTAC linker suitable for PROTACs synthesis[1].</p>

<p>Tenilapine is an atypical antipsychotic drug.</p>

<p>Bis(4-aminophenyl)methanone is a useful organic compound for research related to life sciences. The catalog number is T66084 and the CAS number is 611-98-3.</p>

<p>4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T65647 and the CAS number is 61312-87-6.</p>

<p>Cytochrome P450 2C9 metabolizes acidic drugs, including NSAIDs, anticoagulants, and diuretics.</p>

<p>Ganoderic acid LM2 exhibits potent enhancement of ConA-induced mice splenocytes proliferation in vitro.</p>

<p>LY 280748 is a bio-active chemical.</p>

<p>H-L-Photo-lysine: photo-cross-linker, diazirine-lysine for protein interaction studies in vitro/cells.</p>

<p>Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.</p>

<p>m-PEG-NH2 (MW 20000) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.</p>

<p>2-Acetamidothiazole is a useful organic compound for research related to life sciences. The catalog number is T67350 and the CAS number is 2719-23-5.</p>

<p>Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine is a useful organic compound for research related to life sciences. The catalog number is T66183 and the CAS number is 1160861-53-9.</p>

<p>Guanylthiourea is a useful organic compound for research related to life sciences. The catalog number is T64909 and the CAS number is 2114-02-5.</p>

<p>Expression System: HEK293 Cells&lt;br&gt;Activity: Not Tested</p>

<p>SH379, a 2-methylpyrimidine diterpene derivative, boosts testosterone synthesis enzymes and autophagy via AMPK/mTOR.</p>

<p>DiAzK has a wide range of applications in life science related research.</p>

<p>Boc-D-His(trt)-OH is an amino acid derivative and has a wide range of applications in life science related research.</p>

<p>PMAL-C16 has a wide range of applications in life science related research.</p>

<p>4-Ethylcyclohexanecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67671 and the CAS number is 91328-77-7.</p>

<p>Azido-PEG24-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>(S)-2-Amino-3-(2-hydroxyphenyl)propanoic acid hydrochloride is a valuable organic compound for life sciences research [Catalog No. T66634, CAS No. 1810074-88-4].</p>

<p>(R)-1-[(R)-1-(Di-tert-butylphosphino)ethyl]-2-[(R)-phenylphosphinoyl]ferrocene is a useful organic compound for research related to life sciences and the catalog number is T67232.</p>

<p>1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.</p>

<p>5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.</p>

<p>Methyl 2-(4-bromophenyl)quinoline-4-carboxylate is a useful organic compound for research related to life sciences and the catalog number is T64719.</p>

<p>Fos-Mea-10 is a useful organic compound for research related to life sciences. The catalog number is TF0021 and the CAS number is 557788-85-9.</p>

<p>(S)-2-Acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is a valuable organic compound for life sciences research [Catalog: T65171, CAS: 1027-28-7].</p>

<p>PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 &gt; 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 &gt; 100μM).</p>

<p>N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66071 and the CAS number is 799842-07-2.</p>

<p>12-(1-Pyrenyl)dodecanoic acid, catalog number T67159, CAS number 69168-45-2, is a valuable organic compound for life sciences research.</p>

<p>Aeide-C1-NHS ester, an alkyl/ether-based PROTAC linker, finds utility in the synthesis of PROTACs[1].</p>

<p>N2S2-CBMBC, a bromo-benzyl ether, binds to 99mTc for PD-L1 tumor imaging, offering a real-time alternative to immunohistochemistry.</p>

<p>4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine maleate is a useful organic compound for research related to life sciences and the catalog number is T66094.</p>

<p>2-(2-(4-Fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-phenylpentanamide is a useful organic compound for research related to life sciences. The catalog number is T65728 and the CAS number is 125971-96-2.</p>

<p>5-(tert-Butyl)isobenzofuran-1,3-dione, with catalog number T65299 and CAS number 32703-79-0, is a valuable organic compound for life sciences research.</p>

<p>IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.</p>