Sinalização Citoesquelética

(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.

YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).

TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an …

Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for …

Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through …

Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia …

Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor …

Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, …

PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.

3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM …

Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as …

GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. …

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of …

Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt …

Epothilone D (KOS 862) is an effective microtubule stabilizer.

Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and …

Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 …

2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.

LXH254 is a potent C-Raf and B-Raf inhibitor.

Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding …

Nilotinib (AMN107) is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It …

DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is …

Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).

Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and …

Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent …

Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the …

Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of …

CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin …

Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. …

Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino …

Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of …

Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.

Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.

Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and …

RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 …

ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.

Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.

LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin …

FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for …

Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple …

KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 …

4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.

Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus …

Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and …

Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).

Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of …

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 …

Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.

CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which …

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently …

CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).

Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and …

Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound …