Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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Kolavenic acid analog
CAS:<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Fórmula:C25H38O4Cor e Forma:SolidPeso molecular:402.57Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Fórmula:C27H28N2O6Cor e Forma:SolidPeso molecular:476.52TPI-287
CAS:<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Fórmula:C46H63NO15Cor e Forma:SolidPeso molecular:869.99Nrf2/HO-1 activator 1
CAS:<p>Compound 24: Potent Nrf2/HO-1 activator with neuroprotective, antioxidant properties; useful in PD research.</p>Fórmula:C21H18O5Cor e Forma:SolidPeso molecular:350.36Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Fórmula:C31H35N3O5Cor e Forma:SolidPeso molecular:529.63Onalespib lactate
CAS:<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Fórmula:C27H37N3O6Cor e Forma:SolidPeso molecular:499.6Antitumor agent-200
CAS:<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Fórmula:C19H21FN2O3SeCor e Forma:SolidPeso molecular:423.34Tubulin inhibitor 49
CAS:<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Fórmula:C18H14F3N3OSCor e Forma:SolidPeso molecular:377.383Quinagolide hydrochloride
CAS:<p>Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.</p>Fórmula:C20H34ClN3O3SPureza:98%Cor e Forma:SolidPeso molecular:432.02XD23
CAS:<p>XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.</p>Fórmula:C22H26ClN7O3Cor e Forma:SolidPeso molecular:471.94HSP90-IN-9
<p>HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.</p>Cor e Forma:SolidAChE/GSK-3β-IN-1
CAS:<p>AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-</p>Fórmula:C31H35N7O3SCor e Forma:SolidPeso molecular:585.72SPA0355
CAS:<p>SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.</p>Fórmula:C22H21N3O2SCor e Forma:SolidPeso molecular:391.486SF0166
CAS:<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Fórmula:C23H27F2N5O4Cor e Forma:SolidPeso molecular:475.49HSN748
CAS:<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.521Ethaboxam
CAS:<p>Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.</p>Fórmula:C14H16N4OS2Pureza:99.37%Cor e Forma:SolidPeso molecular:320.43AKT-IN-26
CAS:<p>AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.</p>Fórmula:C21H17N5O4SCor e Forma:SolidPeso molecular:435.456Hsp90-IN-38
CAS:<p>Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.</p>Fórmula:C28H35N3O5Cor e Forma:SolidPeso molecular:493.595NAP1051
CAS:<p>NAP1051, a biomimetic analog of Lipoxin A4, serves an anti-tumor role by targeting the inflammatory tumor microenvironment. It inhibits the chemotaxis of neutrophils to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 is utilized in research on colorectal cancer.</p>Fórmula:C23H34O5Cor e Forma:SolidPeso molecular:390.51
