Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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Mps-BAY2b
CAS:<p>Mps-BAY2b is a novel MPS1 inhibitor.</p>Fórmula:C20H23N5OCor e Forma:SolidPeso molecular:349.43Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Fórmula:C26H31F3N6O2Cor e Forma:SolidPeso molecular:516.56AP 24149
CAS:<p>AP 24149, a potent dual inhibitor targeting Src and Abl, exhibits IC50 values of 9.1 nM for Src and 3.6 nM for Abl, respectively.</p>Fórmula:C23H24N5OPCor e Forma:SolidPeso molecular:417.44SB26019
CAS:<p>SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.</p>Fórmula:C24H20O4Cor e Forma:SolidPeso molecular:372.41YW1159
CAS:<p>YW1159 is an inhibitor of Wnt signaling.</p>Fórmula:C19H14FN5OCor e Forma:SolidPeso molecular:347.35AMXI-5001
CAS:<p>AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.</p>Fórmula:C25H20FN5O3Cor e Forma:SolidPeso molecular:457.46Tubulin polymerization-IN-21
CAS:<p>Tubulin polymerization-IN-21 disrupts microtubules, affects glucose metabolism, and has anticancer properties.</p>Fórmula:C30H29NO7Cor e Forma:SolidPeso molecular:515.55AM-9635
CAS:<p>AM-9635: Potent PI3Kδ inhibitor, cellular IC50 4.2 nM, reduces IgG/IgM, well-tolerated, affects cell growth/division.</p>Fórmula:C19H14F2N8Cor e Forma:SolidPeso molecular:392.36Clathrin-IN-2
CAS:<p>Clathrin-IN-2: CME inhibitor, IC50 - 2.3μM; also blocks dyn I GTPase, IC50 - 7.7μM.</p>Fórmula:C17H18Br2N2OCor e Forma:SolidPeso molecular:426.15Tubulin inhibitor 20
CAS:<p>Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].</p>Fórmula:C19H18O4Cor e Forma:SolidPeso molecular:310.34BIIB028
CAS:<p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>Fórmula:C19H21ClN5O5PCor e Forma:SolidPeso molecular:465.83Tubulin inhibitor 26
CAS:<p>Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.</p>Fórmula:C17H19N3O3Cor e Forma:SolidPeso molecular:313.35O-GlcNAcase-IN-4
CAS:<p>O-GlcNAcase-IN-4, an inhibitor from patent WO2018140299A1, may aid in neurodegenerative disease research.</p>Fórmula:C16H22FN5O3SCor e Forma:SolidPeso molecular:383.44BMS-587101
CAS:<p>BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.</p>Fórmula:C26H20Cl2N4O4SCor e Forma:SolidPeso molecular:555.43Tubulin polymerization-IN-37
CAS:<p>Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.</p>Fórmula:C19H20N2O4Cor e Forma:SolidPeso molecular:340.37BOP sodium
CAS:<p>BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.</p>Fórmula:C25H29N3NaO7SCor e Forma:SolidPeso molecular:538.57THK-5117
CAS:<p>THK-5117, a tau PET probe, has a high tau fibril affinity (Ki 10.5 nM) and binds well to AD brain aggregates.</p>Fórmula:C19H19FN2O2Cor e Forma:SolidPeso molecular:326.36Integrin modulator 1
CAS:<p>Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.</p>Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26XVA143
CAS:<p>XVA143, an α/β I-like allosteric antagonist, blocks LFA-1 adhesion and combats P. gingivalis in mice, preventing bone loss.</p>Fórmula:C25H21Cl2N3O8Cor e Forma:SolidPeso molecular:562.36Debio 0617B
CAS:<p>Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.</p>Fórmula:C28H23ClF3N7O2Cor e Forma:SolidPeso molecular:581.98Antitumor agent-68
CAS:<p>Potent Antitumor-68 inhibits tubulin, IC50: 3.6μM HeLa, 3.8μM MCF-7; also scavenges ROS/DPPH dose-dependently.</p>Fórmula:C17H11NO2Cor e Forma:SolidPeso molecular:261.27Antitumor agent-71
CAS:<p>Antitumor Agent-71 inhibits tubulin aggregation; IC50 of 3.98-15.70 μM against cancer cells.</p>Fórmula:C26H31N5O4SCor e Forma:SolidPeso molecular:509.62BMS-358233
CAS:<p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>Fórmula:C25H25ClN6O2SCor e Forma:SolidPeso molecular:509.02PU24FCl
CAS:<p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>Fórmula:C20H21ClFN5O3Cor e Forma:SolidPeso molecular:433.86KIF18A-IN-4
CAS:<p>KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.</p>Fórmula:C22H27N3O3SCor e Forma:SolidPeso molecular:413.53Sabeluzole
CAS:<p>Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.</p>Fórmula:C22H26FN3O2SPureza:98.51%Cor e Forma:SolidPeso molecular:415.52Valategrast hydrochloride
CAS:<p>Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.</p>Fórmula:C30H33Cl4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:641.41αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
<p>αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).</p>Fórmula:C28H35F3N6O8SPureza:98%Cor e Forma:SolidPeso molecular:672.67K-80003
CAS:<p>K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.</p>Fórmula:C22H21FO2Pureza:99.76%Cor e Forma:SolidPeso molecular:336.4PS315
CAS:<p>PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.</p>Fórmula:C23H19ClO2Pureza:98%Cor e Forma:SolidPeso molecular:362.85AKT-IN-2
CAS:<p>AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).</p>Fórmula:C25H34F3N7OPureza:98%Cor e Forma:SolidPeso molecular:505.58Balamapimod
CAS:<p>Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.</p>Fórmula:C30H32ClN7OSPureza:98%Cor e Forma:SolidPeso molecular:574.14GB1874
CAS:<p>GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.</p>Fórmula:C24H27N3O2SCor e Forma:SolidPeso molecular:421.56AMP-PCP
CAS:<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Fórmula:C11H18N5O12P3Pureza:98%Cor e Forma:SolidPeso molecular:505.21SR31527
CAS:<p>SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.</p>Fórmula:C15H14ClN3OSPureza:98%Cor e Forma:SolidPeso molecular:319.81Eg5 Inhibitor V, trans-24
CAS:<p>Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.</p>Fórmula:C26H21N3O3Pureza:99.75%Cor e Forma:SolidPeso molecular:423.46BBO-10203
CAS:<p>BBO-10203 is an oral small molecule that disrupts PI3Kα-Ras interaction, inhibits Akt signaling selectively, and targets KRAS-mutant tumors.</p>Fórmula:C34H30F2N6O3SPureza:98.62%Cor e Forma:SolidPeso molecular:640.7ZINC194100678
CAS:<p>ZINC194100678 is an effective PAK1 inhibitor with IC50 of 8.37μM.</p>Fórmula:C10H13N5OPureza:98.3%Cor e Forma:SolidPeso molecular:219.24TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Fórmula:C17H20N6OPureza:98%Cor e Forma:SolidPeso molecular:324.38KP-23172
CAS:<p>KP-23172 is a inhibitor of PI3-K/Akt pathway.</p>Fórmula:C10H4N6OPureza:98%Cor e Forma:SolidPeso molecular:224.18Tau-aggregation and neuroinflammation-IN-1
CAS:<p>Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.</p>Fórmula:C25H20N2O7Pureza:99.85%Cor e Forma:SolidPeso molecular:460.44BCR-ABL-IN-7
CAS:<p>BCR-ABL-IN-7 is an inhibitor of ABL kinase activity in WT and T315I mutants.BCR-ABL-IN-7 can be used in chronic myeloid leukemia (CML) research.</p>Fórmula:C19H16FN3O3SPureza:98.28%Cor e Forma:SolidPeso molecular:385.41CpCDPK1/TgCDPK1-IN-1
CAS:<p>CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.</p>Fórmula:C18H17N5Pureza:99.61%Cor e Forma:SolidPeso molecular:303.36AM-5308
CAS:<p>AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.</p>Fórmula:C26H35N5O5SPureza:98.06% - 99.58%Cor e Forma:SolidPeso molecular:529.65CGP60474
CAS:<p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>Fórmula:C18H18ClN5OPureza:98.81%Cor e Forma:SolidPeso molecular:355.82Pentachloropseudilin
CAS:<p>Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.</p>Fórmula:C10H4Cl5NOPureza:98.14%Cor e Forma:SolidPeso molecular:331.41Tyrphostin AG 568
CAS:<p>Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.</p>Fórmula:C13H9N5O2Pureza:98%Cor e Forma:SolidPeso molecular:267.24DHNQ
CAS:<p>DHNQ is a novel inhibitor of the PI3K enzyme activity and transcriptional as well as translational expression levels in colorectal cancer (CRC).</p>Fórmula:C18H14N2OCor e Forma:SolidPeso molecular:274.32NSC305787
CAS:<p>NSC305787 is an ezrin inhibitor with antitumor activity, inhibits ezrin phosphorylation caused by PKCΙ, and can be used in the study of pancreatic cancer.</p>Fórmula:C25H30Cl2N2OPureza:99.40%Cor e Forma:SolidPeso molecular:445.42Clathrin-IN-25
CAS:<p>Clathrin-IN-25 is the most effective clathrin terminal domain-amphiphysin inhibitor reported to date.</p>Fórmula:C19H13KNO5SCor e Forma:SolidPeso molecular:406.47
