Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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AS-605240 potassium
<p>AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 µM and 0.550 µM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.</p>Fórmula:C12H6KN3O2SCor e Forma:SolidPeso molecular:294.98178AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.32Echistatin
CAS:<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Fórmula:C217H341N71O74S9Pureza:98%Cor e Forma:SolidPeso molecular:5417.1LY 379196
<p>LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.</p>Fórmula:C30H34N4O5SCor e Forma:SolidPeso molecular:562.68Tubulin polymerization-IN-50
<p>Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cell</p>Fórmula:C24H20FN3O3Cor e Forma:SolidPeso molecular:417.43αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.01SNIPER(ABL)-020
<p>SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.</p>Fórmula:C44H59ClN10O8SPureza:98%Cor e Forma:SolidPeso molecular:923.52gp96-II
<p>Gp96-II is a gp96-blocking peptide that antagonizes cytokine production induced by gp96-mediated LPS. This compound is useful for research into inflammatory diseases.</p>Fórmula:C200H353N59O53SCor e Forma:SolidPeso molecular:4464.37INY-03-041 trihydrochloride
<p>INY-03-041 trihydrochloride: potent, selective PROTAC AKT degrader; combines Ipatasertib and Lenalidomide; IC50s: AKT1 (2.0 nM), AKT2 (6.8 nM), AKT3 (3.5 nM).</p>Fórmula:C44H59Cl4N7O5Cor e Forma:SolidPeso molecular:907.8STX-100
<p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:Odour Liquid6-Epi-ophiobolin G
<p>6-Epi-ophiobolin G (MHO7) is a marine-derived fungal metabolite that serves as an orally active Akt inhibitor capable of crossing the blood-brain barrier. It effectively inhibits the proliferation of glioblastoma (GBM) cells and promotes apoptosis. 6-Epi-ophiobolin G (MHO7) is suitable for research in glioblastoma studies.</p>Fórmula:C24H32O2Cor e Forma:SolidPeso molecular:352.24023Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:Odour LiquidZolbetuximab MMAE
<p>Zolbetuximab MMAE (IMAB362 MMAE) is a compound targeting Claudin 18.2 (CLDN18.2) with anti-cancer activity, used in the study of gastric and pancreatic cancers.</p>Pureza:95% - 95%Cor e Forma:LiquidPeso molecular:150 kDaFGFRs-IN-1
<p>FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.</p>Fórmula:C28H26Cl2N4O3Cor e Forma:SolidPeso molecular:537.44huATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Cor e Forma:Odour LiquidSudocetaxel
CAS:<p>Sudocetaxel is a compound that serves as a microtubule depolymerization inhibitor, specifically designed for the pH-sensitive delivery of docetaxel.</p>Fórmula:C48H59NO16Cor e Forma:SolidPeso molecular:905.9819-O-Acetylchaetoglobosin A
CAS:<p>19-O-Acetylchaetoglobosin A, from C. globosum, inhibits actin polymerization and is cytotoxic to HeLa cells at 3.2-32 μg/ml.</p>Fórmula:C34H38N2O6Cor e Forma:SolidPeso molecular:570.686SNIPER(ABL)-058
CAS:<p>SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein</p>Fórmula:C62H75N11O9SPureza:98%Cor e Forma:SolidPeso molecular:1150.39PDS-0330
CAS:<p>PDS-0330, a claudin-1 inhibitor, hinders CRC growth and metastasis with micromolar affinity and promising pharmacokinetics.</p>Fórmula:C25H17N3O2SPureza:99.93%Cor e Forma:SoildPeso molecular:423.49SNIPER(ABL)-033
CAS:<p>SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein</p>Fórmula:C61H73F3N10O9S2Pureza:98%Cor e Forma:SolidPeso molecular:1211.42SMART1
<p>SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.</p>Fórmula:C40H35N9O7Cor e Forma:SolidPeso molecular:753.76Sangivamycin
CAS:<p>Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.</p>Fórmula:C12H15N5O5Pureza:99.85%Cor e Forma:SolidPeso molecular:309.28SNIPER(ABL)-019
<p>SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a</p>Fórmula:C60H77ClN12O9SPureza:98%Cor e Forma:SolidPeso molecular:1177.85KT D606
CAS:<p>KT D606 is a PAK kinase family inhibitor with an IC50 of 4 μM. It selectively inhibits the proliferation of cancer cells transformed by oncogenic RAS mutants, making it useful for studying RAS/PAK1-induced cancers.</p>Fórmula:C59H50N6O10Cor e Forma:SolidPeso molecular:1003.06Gamitrinib TPP hexafluorophosphate
CAS:<p>Gamitrinib TPP hexafluorophosphate is a mitochondrial-targeted HSP90 inhibitor with anticancer activity that can be used to study cancer and viral infection.</p>Fórmula:C52H65F6N3O8P2Pureza:98.52% - 98.52%Cor e Forma:SolidPeso molecular:1036.03Gantofiban
CAS:<p>Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.</p>Fórmula:C21H29N5O6Pureza:99.57%Cor e Forma:SolidPeso molecular:447.48Alvespimycin TFA
<p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>Fórmula:C34H49F3N4O10Cor e Forma:SolidPeso molecular:730.340082-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Fórmula:C12H24ClNO4Cor e Forma:SolidPeso molecular:281.78Gamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Fórmula:C52H65N3O8PPureza:98%Cor e Forma:SolidPeso molecular:891.078ML-B01
<p>ML-B01 is an orally active inhibitor targeting Akt and PKA, with IC50 values of 2 nM and 136 nM, respectively. It demonstrates good blood-brain barrier (BBB) permeability in mice.</p>Fórmula:C24H31Cl2N5OCor e Forma:SolidPeso molecular:476.44Kanosamine hydrochloride
CAS:<p>Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species.</p>Fórmula:C6H14ClNO5Pureza:98%Cor e Forma:SolidPeso molecular:215.63Microtubule-associated protein tau (26-44)
<p>Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.</p>Fórmula:C83H127N25O34SPureza:98%Cor e Forma:SolidPeso molecular:2051.11α2β1 Integrin Ligand Peptide
CAS:<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Fórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.35Pep2m, myristoylated
CAS:<p>Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.</p>Fórmula:C63H118N18O14SPureza:98%Cor e Forma:SolidPeso molecular:1383.8TAT-Gap19
CAS:<p>Cx43 blocker, IC50 ~7μM; doesn't affect gap junctions/Panx1. TAT motif enhances effect; works in vivo, brain-penetrant.</p>Fórmula:C119H212N46O26Pureza:98%Cor e Forma:SolidPeso molecular:2703.28Cyclo(RGDfC) TFA
<p>Zelminemab (AMG-301) is a humanized monoclonal antibody targeting ADCYAP1R1 for use in neurological disorders.</p>Fórmula:C26H35F3N8O9SPureza:98.59%Cor e Forma:SolidPeso molecular:692.67DynaMin inhibitory peptide, myristoylated
CAS:<p>Cell-permeable dynamin inhibitor; blocks its binding to amphiphysin, hindering endocytosis; curbs NMDA receptor internalization.</p>Fórmula:C61H107N19O14Pureza:98%Cor e Forma:SolidPeso molecular:1330.64PROTAC HSP90 degrader BP3
CAS:<p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>Fórmula:C32H29ClN8O5Cor e Forma:SolidPeso molecular:641.08Fibronectin CS1 Peptide
CAS:<p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>Fórmula:C38H64N8O15Pureza:98%Cor e Forma:SolidPeso molecular:872.96RA-PR058
<p>RA-PR058 is an orally active Ramalin derivative capable of penetrating the blood-brain barrier, with multi-target regulatory functions. By reducing BACE1 expression, decreasing excessive tau protein phosphorylation, and mitigating anxiety-like behaviors, along with displaying favorable pharmacokinetic properties, RA-PR058 shows promise as a multi-target modulator for Alzheimer's disease.</p>Fórmula:C11H15ClF3N3OCor e Forma:SolidPeso molecular:297.7SQLE-IN-1
CAS:<p>SQLE-IN-1 is a SQLE inhibitor with antitumor activity that inhibits the proliferation of Huh7 and the protein expression of PI3K and AKT.</p>Fórmula:C24H21F2N5O2SPureza:99.89%Cor e Forma:SoildPeso molecular:481.52Vinflunine Tartrate
CAS:<p>Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.</p>Fórmula:C45H54F2N4O8·xC4H6O6Pureza:98%Cor e Forma:SolidPeso molecular:967.02Adhesamine diTFA
CAS:<p>Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.</p>Fórmula:C28H32Cl2F6N8O6S2Cor e Forma:SolidPeso molecular:825.63Jatrophone
CAS:<p>Jatrophone is a novel inhibitor of the macrocyclic diterpenoid tumor.</p>Fórmula:C20H24O3Cor e Forma:SolidPeso molecular:312.4TNIK-IN-7
CAS:<p>TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cells</p>Fórmula:C23H22N4O2Pureza:99.87%Cor e Forma:SoildPeso molecular:386.45SNIPER(ABL)-050
<p>SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.</p>Fórmula:C68H84N12O9Pureza:98%Cor e Forma:SolidPeso molecular:1213.47DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Cor e Forma:Odour SolidNMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Fórmula:C22H22N4O7Pureza:99.84%Cor e Forma:SolidPeso molecular:454.43Chromeceptin
CAS:<p>Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.</p>Fórmula:C19H16F3N3OPureza:99.85%Cor e Forma:SoildPeso molecular:359.35Box5 TFA
<p>Box5 TFA, a potent Wnt5a antagonist, impedes Wnt5a signaling, restricts Wnt5a-initiated Ca2+ release, and hampers cell migration, showing promise for melanoma</p>Fórmula:C32H51F3N6O15S2Cor e Forma:SolidPeso molecular:880.9
