Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1381 produtos de "Sinalização Citoesquelética"
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Myoseverin B
CAS:<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582Cemdomespib
CAS:<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Fórmula:C24H30FNO6Cor e Forma:SolidPeso molecular:447.5Ack1 inhibitor 1
CAS:<p>Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].</p>Fórmula:C39H40F3N7O4Cor e Forma:SolidPeso molecular:727.77Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Fórmula:C27H28N2O6Cor e Forma:SolidPeso molecular:476.52Dioleyl phosphatidylserine
CAS:<p>Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.</p>Fórmula:C42H78NO10PCor e Forma:SolidPeso molecular:788.04SPA0355
CAS:<p>SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.</p>Fórmula:C22H21N3O2SCor e Forma:SolidPeso molecular:391.486TTBK1/2-IN-1
CAS:<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Fórmula:C17H16N4OCor e Forma:SolidPeso molecular:292.335Hsp90-IN-34
CAS:<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Fórmula:C22H14F2N6OCor e Forma:SolidPeso molecular:416.38Ethaboxam
CAS:<p>Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.</p>Fórmula:C14H16N4OS2Pureza:99.37%Cor e Forma:SolidPeso molecular:320.43GR 83895
CAS:<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Fórmula:C29H39N9O8SPureza:98%Cor e Forma:SolidPeso molecular:673.74Quinagolide hydrochloride
CAS:Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.Fórmula:C20H34ClN3O3SPureza:98%Cor e Forma:SolidPeso molecular:432.02Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Fórmula:C29H30N2O7Cor e Forma:SolidPeso molecular:518.56APN/AKT-IN-1
<p>APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.</p>Fórmula:C18H27N7O3Cor e Forma:SolidPeso molecular:389.45TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Fórmula:C20H22FN5O2Cor e Forma:SolidPeso molecular:383.419Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Fórmula:C27H35NO7SPeso molecular:517.63JC168
CAS:<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Fórmula:C26H40O7Cor e Forma:SolidPeso molecular:464.592KY-02327 acetate
<p>KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.</p>Fórmula:C22H31N3O6Cor e Forma:SolidPeso molecular:433.5AKT Kinase Inhibitor
CAS:<p>AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.</p>Fórmula:C16H19N7O3Pureza:97.83% - 99.13%Cor e Forma:SolidPeso molecular:357.37NRX-103094
CAS:<p>NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.</p>Fórmula:C20H11Cl2F3N2O4SPureza:99.13%Cor e Forma:SolidPeso molecular:503.28NRX-252114
CAS:<p>NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).</p>Fórmula:C22H12Cl2F3N3O2SPureza:99.70%Cor e Forma:SolidPeso molecular:510.32Ombrabulin
CAS:<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Fórmula:C21H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:402.44Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Fórmula:C16H11F4N5O2Cor e Forma:SolidPeso molecular:381.28ZW4864
CAS:<p>ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.</p>Fórmula:C33H43ClN6O3Cor e Forma:SolidPeso molecular:607.220-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Fórmula:C20H32O3Pureza:99.79%Cor e Forma:SolidPeso molecular:320.4724-Methylenecycloartanyl ferulate
CAS:<p>24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.</p>Fórmula:C41H60O4Cor e Forma:SolidPeso molecular:616.927Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Fórmula:C29H26O10Pureza:98%Cor e Forma:SolidPeso molecular:534.51Tau tracer 2
CAS:<p>Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].</p>Fórmula:C15H9FN4Cor e Forma:SolidPeso molecular:264.263PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Fórmula:C23H25F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:474.48CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Fórmula:C16H26N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:406.52Cevipabulin fumarate
CAS:<p>Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).</p>Fórmula:C22H22ClF5N6O5Pureza:98%Cor e Forma:SolidPeso molecular:580.89BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Fórmula:C30H33N7O5Pureza:98%Cor e Forma:SolidPeso molecular:571.63
