Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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Certepetide
CAS:<p>Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.</p>Fórmula:C37H60N14O14S2Cor e Forma:SolidPeso molecular:989.09MS98
CAS:<p>MS98, a specific PROTAC AKT degrader, depletes T-AKT with DC50 of 78 nM; binds AKT1, AKT2, AKT3 with Kds of 4, 140, 8.1 nM.</p>Fórmula:C58H81ClN10O7SCor e Forma:SolidPeso molecular:1097.86Gantofiban
CAS:<p>Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.</p>Fórmula:C21H29N5O6Pureza:99.57%Cor e Forma:SolidPeso molecular:447.48BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Fórmula:C21H16N2O6Cor e Forma:SolidPeso molecular:392.36SMS 121
CAS:<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Fórmula:C20H21NO5Pureza:98.29%Cor e Forma:SoildPeso molecular:355.38MAL3-101
CAS:<p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>Fórmula:C54H66N4O10Cor e Forma:SolidPeso molecular:931.12Fuzapladib
CAS:<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Fórmula:C15H20F3N3O3SPureza:99.87%Cor e Forma:SoildPeso molecular:379.4Arimoclomol citrate
CAS:<p>Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.</p>Fórmula:C20H28ClN3O10Cor e Forma:SolidPeso molecular:505.91SIAIS100
<p>SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy.</p>Fórmula:C44H50ClF2N9O5SCor e Forma:SolidPeso molecular:890.44Peptide5
CAS:<p>Connexin43 peptide: lessens swelling, astrogliosis, inflammation, neuron death post-spinal injury; analgesic for neuropathic pain.</p>Fórmula:C60H98N16O20SCor e Forma:SolidPeso molecular:1395.6K34c hydrochloride
CAS:<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Cor e Forma:SoildPeso molecular:483.99PM050489
CAS:<p>PM050489, a polyketone inhibitor from Lithoplocamia lithistoides, halts mitosis at 26.4 nM IC50 and aids cancer research.</p>Fórmula:C31H44ClN3O7Cor e Forma:SolidPeso molecular:606.15SRI 37892
CAS:<p>SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.</p>Fórmula:C26H19N5O2SPureza:99.93%Cor e Forma:SolidPeso molecular:465.53Wortmannin-Rapamycin Conjugate
CAS:<p>Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer.</p>Fórmula:C88H131N3O23Cor e Forma:SolidPeso molecular:1599.014c(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Fórmula:C29H42F3N9O9Cor e Forma:SolidPeso molecular:717.69Solidagonic acid
CAS:<p>Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.</p>Fórmula:C22H34O4Cor e Forma:SolidPeso molecular:362.5YS-49 monohydrate
<p>YS-49, a PI3K/Akt activator, curbs RhoA/PTEN; inhibits VSMC growth by inducing HO-1; an isoquinoline alkaloid that stimulates cardiac β-adrenoceptors.</p>Fórmula:C20H22BrNO3Cor e Forma:SolidPeso molecular:404.3Akt/SKG Substrate Peptide
CAS:<p>substrate for Akt/PKB</p>Fórmula:C36H59N13O9Pureza:98%Cor e Forma:SolidPeso molecular:817.94MS170
CAS:<p>MS170, specific PROTAC AKT degrader, potent with DC 50 of 32 nM, binds AKT1/2/3 with Kd 1.3, 77, 6.5 nM respectively.</p>Fórmula:C45H56ClN9O7Cor e Forma:SolidPeso molecular:870.45Chaetominine
CAS:<p>Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.</p>Fórmula:C22H18N4O4Cor e Forma:SolidPeso molecular:402.40MS21
CAS:<p>MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.</p>Fórmula:C58H79ClN12O6SCor e Forma:SolidPeso molecular:1107.86Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Fórmula:C17H13ClN6OSCor e Forma:SolidPeso molecular:384.84Tubulin inhibitor 21
<p>Compound 6f, a chalcone-melatonin hybrid, is a potent tubulin inhibitor with IC50=0.26μM in SW480 cells, less toxic to non-cancer cells.</p>Fórmula:C28H25N3O4SCor e Forma:SolidPeso molecular:499.58Orbofiban acetate
CAS:<p>Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administered</p>Fórmula:C19H27N5O6Cor e Forma:SolidPeso molecular:421.45Lys-Gln-Ala-Gly-Asp-Val
CAS:<p>KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.</p>Fórmula:C25H44N8O10Cor e Forma:SolidPeso molecular:616.66Vinzolidine
CAS:<p>Vinzolidine is a semi-synthetic vinca alkaloid. It exerts cytotoxic effects on tumor cells by inhibiting cell division through disruption of tubulin polymerization. Vinzolidine can be utilized in research to investigate synergy with other chemotherapy or biotherapy drugs, as well as cancer cell tolerance or resistance, and to explore strategies to overcome these challenges.</p>Fórmula:C48H58ClN5O9Cor e Forma:SolidPeso molecular:884.46Dihydrocephalomannine
CAS:<p>Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.</p>Fórmula:C45H55NO14Pureza:98%Cor e Forma:SolidPeso molecular:833.928SQLE-IN-1
CAS:<p>SQLE-IN-1 is a SQLE inhibitor with antitumor activity that inhibits the proliferation of Huh7 and the protein expression of PI3K and AKT.</p>Fórmula:C24H21F2N5O2SPureza:99.89%Cor e Forma:SoildPeso molecular:481.52Fibronectin CS1 Peptide
CAS:<p>Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.</p>Fórmula:C38H64N8O15Pureza:98%Cor e Forma:SolidPeso molecular:872.96RA-PR058
<p>RA-PR058 is an orally active Ramalin derivative capable of penetrating the blood-brain barrier, with multi-target regulatory functions. By reducing BACE1 expression, decreasing excessive tau protein phosphorylation, and mitigating anxiety-like behaviors, along with displaying favorable pharmacokinetic properties, RA-PR058 shows promise as a multi-target modulator for Alzheimer's disease.</p>Fórmula:C11H15ClF3N3OCor e Forma:SolidPeso molecular:297.7Alvespimycin TFA
<p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>Fórmula:C34H49F3N4O10Cor e Forma:SolidPeso molecular:730.34008Eudebeiolide B
CAS:<p>Eudebeiolide B, isolated from Salvia plebeia R.</p>Fórmula:C15H18O4Pureza:98%Cor e Forma:SolidPeso molecular:262.3DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Cor e Forma:Odour SolidSNIPER(ABL)-047
<p>SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels,</p>Fórmula:C67H82F3N11O9SPureza:98%Cor e Forma:SolidPeso molecular:1274.5MPH-220
CAS:<p>MPH-220: Oral myosin-2 inhibitor, induces muscle relaxation, useful for spasticity research.</p>Fórmula:C20H21N3O3SCor e Forma:SolidPeso molecular:383.46Anti-inflammatory agent 60
<p>Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin</p>Pureza:98%Cor e Forma:Odour SolidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Cor e Forma:Odour SolidTubulin inhibitor 24
CAS:<p>Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.</p>Fórmula:C22H21N3O3Pureza:99.99%Cor e Forma:SolidPeso molecular:375.42TNIK-IN-7
CAS:<p>TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cells</p>Fórmula:C23H22N4O2Pureza:99.87%Cor e Forma:SoildPeso molecular:386.45Jatrophone
CAS:<p>Jatrophone is a novel inhibitor of the macrocyclic diterpenoid tumor.</p>Fórmula:C20H24O3Cor e Forma:SolidPeso molecular:312.4Zolbetuximab
CAS:<p>Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2 for certain gastrointestinal and pancreatic cancers.</p>Pureza:95.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97%+Cor e Forma:LiquidPeso molecular:147.09 kDaMyelin Basic Protein
CAS:<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Fórmula:C60H103N21O17Pureza:98%Cor e Forma:SolidPeso molecular:1390.59Bisindolylmaleimide III
CAS:<p>Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6</p>Fórmula:C23H20N4O2Pureza:98.6%Cor e Forma:SolidPeso molecular:384.43β-catenin-IN-7
<p>β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, and</p>Fórmula:C17H13BrN2O2SCor e Forma:SolidPeso molecular:389.27Gamitrinib TPP hexafluorophosphate
CAS:<p>Gamitrinib TPP hexafluorophosphate is a mitochondrial-targeted HSP90 inhibitor with anticancer activity that can be used to study cancer and viral infection.</p>Fórmula:C52H65F6N3O8P2Pureza:98.52% - 98.52%Cor e Forma:SolidPeso molecular:1036.03LXY3
CAS:<p>LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.</p>Fórmula:C32H43N11O15S2Cor e Forma:SolidPeso molecular:885.88SNIPER(ABL)-039
CAS:<p>SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of</p>Fórmula:C54H68ClN11O9S2Pureza:98%Cor e Forma:SolidPeso molecular:1114.77FAK-IN-7
CAS:<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>Fórmula:C16H13N3OSPureza:98.18%Cor e Forma:SolidPeso molecular:295.36Pep2m, myristoylated
CAS:<p>Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.</p>Fórmula:C63H118N18O14SPureza:98%Cor e Forma:SolidPeso molecular:1383.8DynaMin inhibitory peptide, myristoylated
CAS:<p>Cell-permeable dynamin inhibitor; blocks its binding to amphiphysin, hindering endocytosis; curbs NMDA receptor internalization.</p>Fórmula:C61H107N19O14Pureza:98%Cor e Forma:SolidPeso molecular:1330.64
