Compostos Deuterados

<p>Applications Labelled Cyanazine (C953500). Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Crayford, J.V., et al.: Pestic. Biochem. Physiol., 2, 295 (1975),<br></p>

<p>Applications α,α-Diphenyl-1-azabicyclo[2.2.2]octane-4-methanol-d10 is an intermediate in the synthesis of Umeclidinium Bromide-d5, which is considered as a potentially long-acting antimuscarinic agent.<br>References Cazzola, M., et al.: Pharmacol., Rev., 64, 450 (2012); Laine, D., et al.: J. Med. Chem., 52, 2493 (2009)<br></p>

<p>Applications A labelled reactant used in the preparation of inhibitors for treatment of neurodegenerative diseases.<br></p>

<p>Applications Intermediate in the production of labelled Cyclophosphamide metabolites.<br>References Takamizawa, A., et al.: Chem. Pharm. Bull., 20, 1612 (1972),<br></p>

<p>Applications Protected, labelled Guanine.<br>References Hakimelahi, G., et al.: J. Med. Chem., 44, 3710 (2001),<br></p>

<p>Applications Tri-n-butylallylphosphonium Bromide-d5 is isotope labelled intermediate in the synthesis of quaternary phosphonium reversible inhibitors of cholinesterases.<br>References Basova, N. E., et al.: J. Evo. Biochem. Physiol., 47, 420 (2011);<br></p>

<p>Applications 2,3-Dichlorobenzoic Acid-13C (cas# 1184971-82-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Reagent used in the preparation of labelled cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Acetylamino)butanoic Acid-d5 is an intermediate of Isotope labelled L-2-Aminobutyric Acid (A602930) Receptor antagonist.<br>References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995),<br></p>

<p>Applications 25-Hydroxyvitamin D2 (6,19,19-D3,97%) 100 Ug/Ml In Ethanol (cas# 1217467-39-4) is a useful research chemical.<br></p>

<p>Applications Diethyl Cromoglycate-D5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>

<p>Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.<br>References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),<br></p>

<p>Applications 2,5-Dihydro-2-hydroxy-5-nitro-2-furanmethanediol-d3 Triacetate (cas# 1346604-22-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Loratadine-d4 Epoxide N-Oxide (cas# 1794754-14-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(4-Chlorophenyl)-1-isoindolinone-d4 is the isotope labelled analog of 3-(4-Chlorophenyl)-1-isoindolinone (C378535), which is an intermediate of Chlorthalidone (C427500), a diuretic and antihypertensive agent.<br>References Beisenherz, et al.: Arch. Int. Pharmacodyn. Ther., 161, 76 (1966), Zsoter, et al.: J. Pharmacol. Exp. Ther., 180, 723 (1972), Singer, J.M., et al.: Anal. Profiles Drug Subs., 14, 1 (1985),<br></p>

<p>Applications Labelled Dapsone intermediate.<br>References Tingle, M., et al.: Brit. J. Clin. Pharmacol., 30, 829 (1990), Vage, C., et al.: Toxicol. App. Pharmacol., 129, 309 (1994),<br></p>

<p>Applications Intermediate for the synthesis of labelled Lercanidipine HCl<br></p>

<p>Applications A labelled substituted piperidine as pesticide.<br></p>

<p>Applications A deuterated intermediate in the synthesis of the metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Potassium Azide-15N is a labelled intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1, which is the labeled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.<br>References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),<br></p>

<p>Applications 4-Chloro-N-[2-(4-hydroxyphenyl)ethyl]benzamide-d4 (cas# 1189464-84-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled Methanol (M276585), which is a common chemical reagent in organic synthesis participating in a variety of reactions. Used to prepare novel triazole-polyphenol hybrid compounds as FabG4 (Rv0242c) enzyme inhibitors for the treatment of Mycobacterium Tuberculosis (1). Also used in the synthesis of prodelphinidin B1/B2/B4 which display antitumor activities against prostate cancer cells.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Banerjee, D. et al.: Org. Biomol. Chem. 2014 Jan 7;12(1):73-85.<br></p>

<p>Applications An intermediate in the preparation of labelled thymidine monophosphate analogues<br>References Vanheusden, V., et al.: Bioorg. Med. Chem. Lett., 12, 2695 (2002),<br></p>

<p>Applications N-Phenethylbenzamide-d5 is an isotope labelled intermediate in the synthesis of deteurerium-labeled amides within microreactors.<br>References Hooper, J., Watts, P.: J. Labelled Compd. Rad., 50, 189 (2007)<br></p>

<p>Applications p-Vinylguaiacol-d3 is the isotope labelled analog of p-Vinylguaiacol (V424960); an aromatic substance, one of the compounds responsible for the natural aroma of buckwheat, and also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.<br>References Janes, Damjan., et al.: Food Chem., 112(1), 120-124 (2009); Zhou, Rong., et al.: Yancao Keji, (7), 34-36, 42 (2013)<br></p>

<p>Applications A labelled intermediate in the preparation of DOPA-decarboxylase inhibitors.<br></p>

<p>Applications A deuterated intermediate in the synthesis of Carisoprodol.<br></p>

<p>Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Hydroxy-6-methyl-4-[[(4-methylphenyl)imino]methyl]-3-pyridinemethanol-d5 is an intermediate in the synthesis of labelled Pyridoxal phosphate.<br>References Sharif, S., et al.: J. Am. Chem. Soc., 129, 4440 (2007);<br></p>

<p>Applications 4-[[6-Chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d8 is an intermediate from the synthesis of Etravirine-d8 (E937003). Etravirine-d8 is a novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008); Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008)<br></p>

<p>Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)amine (cas# 1189957-44-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Iodoethane-1-d1 (CAS# 3652-81-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenyl-d5-alanine (CAS# 284664-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Aminohexane-1,1,1,2,3,3-d6 (CAS# 1219802-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Hydroxyacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications Ethyl-d5-benzene (CAS# 38729-11-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Deuterium labelled analog of (±)-α-Bisabolol, which is found in a variety of beauty and skin care products, including compositions for skin lightening cosmetic creams, color change cosmetic compositions for makeup fused with antioxidant function and oil-to-gel makeup removing compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, P. et al.: Faming Zhuanli Shenqing 11pp. Patent 2017 CODEN:CNXXEV; Son, T.; et al.: Repub. Korean Kongkae Taeho Kongbo 14pp.; Chemical Indexing Equivalent to 167:543596 (WO) Patent 2017 CODEN:KRXXA7; Lin, X.; et al.; Faming Zhuanli Shenqing 8pp. Patent 2017 CODEN:CNXXEV<br></p>

<p>Applications n-Hexyl-5,5,6,6,6-d5 Alcohol (CAS# 64118-18-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopentane-1-d1 (CAS# 148404-92-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyanogen-15N Bromide is an intermediate in the synthesis of 5-Azacytidine-15N4 (A796002), which is a labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Applications Ethyl-d5 Methanesulfonate (CAS# 1219795-44-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications β-(p-Nitrophenyl)ethyl Bromide-d4 (cas# 1794971-35-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Abiraterone Isopropyl Ether-d7 is the labeled analog of Abiraterone Isoproply Ether (A108532), an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications Isotope labelled dulcitol (D720500), is the reduction product of Galactose (G155250). An increase in the level of Dulcitol is often a result of metabolism defect caused by a defect in galactose-1-phosphate uridylyltransferase (an autosomal recessive disorder).<br>References Ning, C. et al.: Pediat. Res., 48, 211 (2000); Cheng, H. et al.: Exp. Eye Res., 51, 345 (1990); Wells, W.W. et al.: Galactosemia, 227 (1969);<br></p>

<p>Applications Hydrazinecarboxamide-13C Monohydrochloride is an intermediate used in the synthesis of 1-Amino Hydantoin-13C3 (A611092), which is a metabolite of Nitrofuran. Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),<br></p>

<p>Applications n-Tetradecyltrimethylammonium-d38 Bromide (CAS# 95523-72-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,2-Bis(hydroxymethyl-d2)propionic-3,3,3-d3 Acid (CAS# 1219802-03-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.<br>References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);<br></p>

<p>Applications rac-N-(2,3-Dihydroxyphenyl)-m-synephrine-d3 is the isotope labelled analog of rac-N-(2,3-Dihydroxyphenyl)-m-synephrine (D454500); a derivative of rac-Synephrine (S920001, HCl salt) which is an α-adrenergic receptor agonist and vasoconstrictor.<br>References Louw, A., et al.: Biochem. Pharmacol., 53, 189 (1997)<br></p>

<p>Applications 1-Octadecane-d37-thiol (CAS# 668433-57-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications di(Dodecanedioic-d20 Acid 1-Methyl Ester) Barium is a labeled salt analogue of Dodecanedioic Acid 1-Methyl Ester (D494535), which is used in cosmetic compostions.<br>References Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 13, 1179 (2003); Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 14, 4253 (2004)<br></p>

<p>Applications 1-Iodopropane-2,2-d2 (CAS# 25493-15-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoheptane-6,6,7,7,7-d5 (CAS# 1219805-66-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-15N-1-oxyl (CAS# 90429-66-6) is a useful isotopically labeled research compound that is used in various spectroscopic analysis.<br>References Bales, B. et.al., Appl.Magn.Reson.,48,1399-1445,(2017);<br></p>

<p>Applications Methylcyclohexane-d11 (ring-d11) (CAS# 352431-19-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-4,4,5,5,6,6,6-d7 (CAS# 1276197-43-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,10-Decane-d20-diol (CAS# 347841-78-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-2-d1 Alcohol (CAS# 6181-08-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Octylbenzene-d22 (CAS# 1219799-28-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Alanine-N,N,O-d3 (CAS# 19470-97-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Ethoxyacrylic Acid Ethyl Ester-13C2 is an intermediate used in the synthesis of 2-Chloro-5-thiazolecarboxylic Acid-13C3,15N (C411468), which is an isotopically labeled analog of 2-Chloro-5-thiazolecarboxylic Acid (C411465), which was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.<br>References Ford, K., et al.: Chem. Res. Toxicol., 19, 1549 (2006);<br></p>

<p>Applications 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine-d4 is labelled 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine (D448690) which is a derivative of 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine. 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine is used to prepare benzanilide derivatives for use as anticancer agents.<br></p>

<p>Applications Phenmetetrazine-d5 Hydrochloride is the labelled form of Phenmetetrazine Hydrochloride (P296400). Phenmetetrazine is an analog of Phenmetrazine (P314500, HCl salt) which is an anorexic.<br>References Klosa, et al.: J. Prakt. Chem., 21, 12 (1963); Leibowitz, S.F., et al.: Eur. J. Pharmacol., 53, 69 (1978)<br></p>

<p>Applications (±)-1-Phenylethan-1-d1-ol (CAS# 3101-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications m-Cresol-d8 (CAS# 302911-90-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Leucine-d7 (iso-propyl-d7) (CAS# 259225-40-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile-d1 is the deuterated form of (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile (C363780), which is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>

<p>Applications N-Methylacetamide-2,2,2-d3 (CAS# 3669-69-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled benzyl bromide is a compound used in organic synthesis for the introduction of the benzyl protecting group for alcohols and carboxylic acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kudou, N., et al.: Euro. J. Med. Chem., 60, 76 (2013); Cahiez, G., et al.: Advan. Synthesis. Catalysis., 354, 1519 (2012);<br></p>

<p>Applications 1-Bromotridecane-d27 (CAS# 349553-91-9) is a useful isotopically labeled research compound.<br></p>