Compostos Deuterados

<p>Applications Thymine-alpha,alpha,alpha,6-d4 Glycol (mixture of diastereomers) (CAS# 132523-94-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Butyl-1,1,2,2,3,3-d6 Alcohol (CAS# 1219794-84-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Quinaldic-d6 Acid (CAS# 1219802-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-4,4-d2 Acid (CAS# 30719-28-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N2-Acetyl Acyclovir Benzoate-d5 is the isotope labelled analog of N2-Acetyl Acyclovir Benzoate (A167975); a derivative of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Ashton, D.S., et al.: J. Chromatogr. A, 707, 367 (1995)<br></p>

<p>Applications 2-Chloro-N,N-diethylethylamine-d10 Hydrochloride is the isotope labelled analog of 2-Chloro-N,N-diethylethylamine Hydrochloride. 2-Chloro-N,N-diethylethylamine Hydrochloride used in the preparation of nonsteroidal antiestrogens. As well, it is used in the synthesis of novel cyanopyridine derivatives used in the design of antibacterial drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, C. et al.: J. Med. Chem., 27, 1057 (1984); Bogdanowicz, A. et al.: J. Hetero. Chem., 50, 544 (2013);<br></p>

<p>Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase.<br>References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);<br></p>

<p>Applications 1-Bromotridecane-d27 (CAS# 349553-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propane-d6-diamine, Dihydrochloride is used in the study of trimethylsilylated di and polyamine and their isotopically labelled analogs.<br>References Smith, R. G., et al.: J. Org. Chem., 43, 2178 (1978)<br></p>

<p>Applications n-Propyl-d7-benzene (CAS# 65087-58-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity.<br>References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);<br></p>

<p>Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propane-1,1,3,3-d4-diamine (CAS# 347840-13-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate for the preparation of isotope Labelled Haloperidol.<br></p>

<p>Applications Methyl Alcohol-d4 is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dawson, D.M. et al.: Phys. Chem. Chem. Phys., 15, 919 (2013);<br></p>

<p>Applications N-2-Hydroxyethyl-N-(methyl-d3)-p-toluenesulfonamide (cas# 854634-39-2) is a compound useful in organic synthesis.<br>References du Vigneaud, V., et al.: J. Biol. Chem., 164, 603 (1946),<br></p>

<p>Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.<br>References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);<br></p>

<p>Applications Anteisoheneicosanoic acid-d3 is labelled Anteisoheneicosanoic acid which is used in cosmetics as it allows hair fiber to lie flat and parallel with respect to each other while its removal formed coarse tangled bundles, aligned in disorderly manner.<br>References Tanamachi, H., et al.: J. Cosmetic Sci., 61, 147 (2010); Breakspear, S., et al.: PMSE Preprints, 90, 276 (2004)<br></p>

<p>Applications 2-Naphthylhydrazine-D3 is an intermediate used in the synthesis of Indocyanine Green-d12 (I697002), which is an isotopic analog of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).<br>References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003)<br></p>

<p>Applications Di(methyl-d3)dimyristylammonium Chloride is labelled Dimethyldimyristylammonium Chloride (D472560) which is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications Butoxy-d9-acetic Acid (CAS# 669720-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Benzoate-d8 (CAS# 91929-46-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis.<br>References De Smet, E. et al.: Nephrol. Dial. Transplant., 24, 2938 (2009); Kivele, R. et al.: Carb. Pol., 85, 645 (2011);<br></p>

<p>Applications 2-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 25319-49-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Intermediate in the biosynthesis of carotenoids<br>References Davidovich-Rikanati, R. et al.: Plant J., 56, 228 (2008); Puri, A. et al.: Weed Sci. 57, 482 (2009); Serino, S. et al.: J. Agric. Food Chem., 57, 8753 (2009);<br></p>

<p>Applications N-Methyl-d3-epsilon-caprolactam (CAS# 203645-60-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Xylene-alpha,alpha,alpha-d3 (CAS# 26204-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications β-(p-Nitrophenyl)ethyl Bromide-d4 (cas# 1794971-35-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled (R)-tert-Butyl 2-(tert-Butoxycarbonylamino)-5-oxo-5-phenylpentanoate is used in inhibition studies relating to elucidating the mechanism for carbapenam synthetase. Also used in the synthesis of sphingosine 1-phosphate receptor antagonists in the treatment of multiple sclerosis<br>References Gerratana, B. et al.: Biochem., 42, 7836 (2003); Ibrahim, M. et al.: J. Med. Chem., 55, 1368 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications L-3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine (CAS# 586954-09-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Hexanoate-6,6,6-d3 (CAS# 1219794-91-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hydrocinnamic-d5 Acid (phenyl-d5) (CAS# 35845-62-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Deuterium labelled analog of (±)-α-Bisabolol, which is found in a variety of beauty and skin care products, including compositions for skin lightening cosmetic creams, color change cosmetic compositions for makeup fused with antioxidant function and oil-to-gel makeup removing compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, P. et al.: Faming Zhuanli Shenqing 11pp. Patent 2017 CODEN:CNXXEV; Son, T.; et al.: Repub. Korean Kongkae Taeho Kongbo 14pp.; Chemical Indexing Equivalent to 167:543596 (WO) Patent 2017 CODEN:KRXXA7; Lin, X.; et al.; Faming Zhuanli Shenqing 8pp. Patent 2017 CODEN:CNXXEV<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Hexadecanoate-16,16,16-d3 (CAS# 347841-37-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Octene-2-d1 (CAS# 56975-78-1) is a useful isotopically labeled research compound that can be used as a catalyst and in various photochemistry experiments.<br>References Gao, F. et.al., J. Org. Chem.,26, 9361-9367, (2002); Martin, C., et.al., J. Mol. Catal., 37, 201-212,(1986);<br></p>

<p>Applications Ethyl-d5-benzene (CAS# 38729-11-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tetradecyl-d29-trimethylammonium Bromide (CAS# 95523-73-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pyrrolidine-2,2,5,5-d4 (CAS# 42403-25-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3-Dihydro-5-benzofuranethanol-d4 (cas# 1185079-36-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Phenyl-d5-alanine-3,3-d2 (CAS# 74228-83-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Desmethyl Sorafenib-d4 is the isotope labelled analog of N-Desmethyl Sorafenib (D293290); a metabolite of Sorafenib (S676850) that has anti-proliferative activity in human breast cancer cells.<br>References Cui, P.H., et al.: Biochem. Pharmacol., 86, 419 (2013); Ghassabian, S., et al.: Biochem. Pharmacol., 84, 215 (2012)<br></p>

<p>Applications N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide -d4 is labelled N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (C988880) which was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.<br>References Russell, J.L., et al.: ACS. Chem. Biol., 7, 1077 (2012); Schneider, J.W., et al.: ACS. Chem. Neurosci., 3, 557 (2012);<br></p>

<p>Applications Lys-SMCC-DM1-D9 is deuterium labelled Lys-SMCC-DM1 (L488780). Lys-SMCC-DM1 (L488780) is designed to eradicate cancer cells that express the target antigen on their cell surface.<br>References Erickson, H., et al.: Bioconjugate Chem., 21, 84 (2010)<br></p>

<p>Applications 1-Bromotetradecane-14,14,14-d3 (CAS# 347840-09-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347 (1982),<br></p>

<p>Applications Bis(2-hydroxyethyl)-1,1,2,2-d4-amine (CAS# 352431-07-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloroacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications 4-n-Pentyl-d11-phenol (CAS# 1219805-30-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Nitrobenzyl-d6 Alcohol (CAS# 1219795-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Choline-d13 Bromide (cas# 203645-64-1) is a useful research chemical.<br></p>

<p>Applications 4-Acetamidobenzene-d4-sulfonyl Chloride is the deuterium labelled form of 4-(Acetylamino)benzenesulfonyl Chloride (A170950), which is a sulfanilamide derivative of Chitosan with antifungal properties.<br>References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008); Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009);<br></p>

<p>Applications Carboxymethoxyamine-d2 Hemihydrochloride (cas# 1246817-66-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope Labelled Adipodinitrile is used in the preparation of alkyl/arylthiazolines in the efficient synthesis of bacillamide A. Also used in the preparation of arylketones via insertion of nitriles.<br>References Fache, F. et al.: Synth. Comm., 42, 2098 (2012); Hsieh, J. et al.: Org. Lett., 14, 1282 (2012);<br></p>

<p>Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>

<p>Stability Hygroscopic<br>Applications Catechol-13C6 (cas# 115881-16-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications n-Hexyl-d13 Alcohol (CAS# 204244-84-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Eicosanyl-d41 Alcohol (CAS# 349553-89-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.<br>References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)<br></p>

<p>Applications 3-Pentanone-d6 is labelled 3-Pentanone (P273600) which is a simple, symmetrical dialkyl ketone. It is mainly used as a solvent in paint and a precursor to vitamin E. It is a useful synthetic intermediate. It can be used as a reagent to synthesize Ethyl 2-Cyano-3,3-diethylacrylate (E907600) by Knoevenagel condensation. It also shows anticonvulsant effect in several types of mouse seizure models.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hasebe, N., et al.: Eur. J. Pharma., 642, 66 (2010); Siegel, H., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2002)<br></p>

<p>Applications 2,3-Butane-1,1,1,4,4,4-d6-diol (CAS# 344750-80-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetyl-2,6-dichlorodiphenylamine-d5 is labelled N-Acetyl-2,6-dichlorodiphenylamine (A173570) which is an impurity of diclofenac (D436450, Na salt), a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>