Compostos Deuterados

Applications 1,1,1,2-Tetrachloroethane-d2 (CAS# 117164-18-8) is a useful isotopically labeled research compound.

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.
References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Applications Labelled analogue of 2-Bromopropane, a short chain alkyl halide used in organic synthesis primarily as an alkylating agent for introducing the isopropyl functional groups.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mayants, A.G. et al.: Zhur. Org. Khim., 25, 419 (1989); Miller, B. et al.: J. Org Chem., 30, 3895 (1965);

Applications N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazine-d8-dicarboxamide is the labeled analog of N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide (B522635), an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.
References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)

Applications Ammonium-d4 Thiocyanate is used in the instrumentation/analytical characterization studies for ammonium thiocyanate and labelled ammonium thiocyanate samples.
References Gruwel, M. L. H., et al.: J. Chem. Phys., 85, 6240 (1986), Durig, J. R., et al.: Spectrochim. Acta, A Mol. Biomol. Spectrosc., 28, 1031 (1972)

Applications Benzyl-2,3,4,5,6-d5 trans-Cinnamate (CAS# 347840-02-2) is a useful isotopically labeled research compound.

Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.
References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014

Applications Labelled Des[(5-Methyl-1,3,4-thiadiazol-2-yl)thio] Cefazolin-3-methanol is an impurity of Cefazolin (C242500). Cefazolin impurity X3.
References Kidwai, M., et al.: Chem. Lett., 6, 487 (1999), Kidwai, M., et al.: Bioorg. Med. Chem., 8, 69 (2000),

Applications Tri-iso-propyl-d21-phosphine Carbon Disulfide Complex (CAS# 1219798-41-0) is a useful isotopically labeled research compound.

Applications Tartaric-2,3-d2 Acid (mixture of diastereomers) (CAS# 91469-46-4) is a useful isotopically labeled research compound.

Applications rac-6-Methyl-4-phenyl-2-chromanol-d6 is labelled rac-6-Methyl-4-phenyl-2-chromanol (M327070) which is an impurity of Tolterodine (T535800), an antimuscarinic agent used to treat patients with overactive bladder.
References Kaplan, S., et al.: JAmA, 296, 2319 (2006); Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997); Van Kerrebroeck, P., et al.: Urology, 57, 414 (2001)

Applications 1-Bromoheptane-5,5,6,6,7,7,7-d7 (CAS# 1219802-55-7) is a useful isotopically labeled research compound.

Applications Ethyl (Z)-Geranate-d6 is an intermediate in synthesizing Geraniol-D5 (G367003), a deuterium labelled analog of Geraniol. It is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.
References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);