Compostos Deuterados

Applications Labelled 2-(1-Piperazinyl)pyrimidine, the major metabolite of Tandospirone (T006430).
References Goa, K., et al.: Drugs, 32, 114 (1986); Lamberg, T., et al.: Clin. Pharmacol. Ther., 63, 640 (1998); Niwa, T., et al.: Biol. Pharm. Bull 28, 1711 (2005); Natsui, K., et al.: Eur. J. Drug Metab. Pharmacokinet., 32, 233 (2007);

Applications One of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). It has a role in transporting protein Bsu1, contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.
References Williams, R., et al.: J. Biol. Chem., 87, 581 (1930), Rodionov, D., et al.: J. Biol. Chem., 277, 48949 (2002),Nosaka, K., et al.: Mol. Microbiol., 58, 467 (2005),

Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);

Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.
References Goodwin, M., et al.: Science, 203, 559 (1979),

Applications N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Applications Isotope labelled Squalane is used as an emollient and moisturizer in cosmetic applications.
References Allison, A.: Method, 19, 87 (1999)

Applications Labelled Fenhexamid (F247650). Hydroxyanilide fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yamashita, M., et al.: J. Phys. Chem., 88, 4451 (1984), Kende, A., et al.: Microchem. J., 84, 63 (2006),

Applications 4-Aminophenol-15N is an intermediate in the synthesis of Acetaminophen-13C2,15N (A161228), a labelled analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis.

Applications Labelled Glycidol. Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981), Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984),

Applications The labelled analogue of a versatile ethylenediamine derivative used as an intermediate in the organic synthesis of neurochemicals, antitumor agents and other pharmaceutical compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Squires, R.F. et al.: Neurochem. Res., 18, 787 (1993); Murdock, K.C. et al.: J. Med. Chem., 22, 1024 (1974);

Applications tert-Butyl Alcohol-d10 is an isotopic analog of Tert-butyl Alcohol (T117540), an organic solvent. It is also used in the synthesis of proteosome inhibitors that are quite potent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kawamura, S. et al.: J. Med. Chem., 56, 3689 (2013); Galy, N. et al.: Tetrahedron Lett., 54, 2703 (2013)

Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D. et al.: J. Appl. Bacteriol., 72, 258 (1992); Routledge, E. et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998); Miller, C. et al.: J. Biol. Chem., 272, 32824 (1997); Nakagawa, Y. et al.: Biochem. Pharmacol., 55, 1907 (1998);

Applications Deuterium labelled analog of (±)-α-Bisabolol, which is found in a variety of beauty and skin care products, including compositions for skin lightening cosmetic creams, color change cosmetic compositions for makeup fused with antioxidant function and oil-to-gel makeup removing compositions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ma, P. et al.: Faming Zhuanli Shenqing 11pp. Patent 2017 CODEN:CNXXEV; Son, T.; et al.: Repub. Korean Kongkae Taeho Kongbo 14pp.; Chemical Indexing Equivalent to 167:543596 (WO) Patent 2017 CODEN:KRXXA7; Lin, X.; et al.; Faming Zhuanli Shenqing 8pp. Patent 2017 CODEN:CNXXEV

Applications n-Butyl 4-Hydroxybenzoate-2,3,5,6-d4 is the labelled analogue of butyl 4-​hydroxybenzoate (B693600), which is an antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications A labelled metabolite of Theophylline.
References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),

Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);

Applications Fumaric Acid-d2 is the isotope labelled analog of Fumaric Acid. Fumaric acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.
References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);

Applications 4-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.
References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)

Applications A labelled metabolite produced by Myxobacteria. Used in the study of pathways and substrate specificity of DMSP catabolism in marine bacteria of Roseobacter clade.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, D. et al.: Afr. J. Microbiol. Res., 3, 755 (2009); Dickschat, J. et al.: ChemBioChem, 11, 417 (2010);