Toxicologia

Stability Hygroscopic
Applications Isotope labelled 1,6-Anhydro-β-D-glucopyranose (A648100), an compound that have been proven to be a valuable synthon for the preparation of various biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.
References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987);

Applications (5R)-Flucloxacillin N4-[N-[[3-(20chloro-6-fluoro-phenyl)-5-methyl-4-isoxazolyl]carbonyl]-glycinyl] Penilloic Acid is an impurity of Flucloxacillin (F419200), a new semisynthetic penicillin.
References Markovich, M., et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986), Rahman, M., et al.: Biochem. Pharmacol., 46, 1721 (1993), Silva, D., et al.: Med. Biol. Res., 37, 963 (2004),

Applications bis(Thiazol-5-ylmethyl) ((2R,5R)-1,6-Diphenylhexane-2,5-diyl)dicarbamate is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.
References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)

Stability Unstable in Solution
Applications Desphenyl Tenofovir Alafenamide-d7 Ammonium Salt is labeled form of Desphenyl Tenofovir Alafenamide (D297043), which belongs to a group of tenofovir diesters compounds, which can inhibit HIV-1 virus replication. Desphenyl Tenofovir Alafenamide can also be used to investigate the effect of oral absorption and lymphoid cell loading of GS-7340 (a prodrug of tenofovir)
References You, G., et al.: PCT Int. Appl. WO 2014026582 A1 2014022 (2014); Babusis, D., et al.: Mol. Pharm. 10, 459 (2013)

Applications (S)-8,14-Dihydroxy Efavirenz, is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),

Applications N-[3-Methyl-1-(phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.
References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)

Applications O-Ethyl Adefovir is an intermediate in the synthesis of Mono-POM Ethyl Adefovir (M567050), which is an analogue of the antiviral drug Adefovir (A247500) with a mono-POM ester protecting group.
References Starrett, J.E. et al.: J. Med. Chem., 37, 1857 (1994);

Applications 3,4-Dihydroquinoline-2-one 6-Oxoacetic Acid is a derivative of 3,4-Dihydro-2-quinolone (D450600), which is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthetisze substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
References Molteni, V., et al.: Bioorg. Med. Chem. lett., 14, 1477 (2004); Webber, R., et al.: J. Med. Chem., 41, 96 (1998)