Bioquímicos e reagentes

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Suc-Leu-Leu-Val-Tyr-pNA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.</p>

<p>Please enquire for more information about 5-TAMRA-Amyloid beta-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5,6-Dehydro finasteride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Fluorescein-6-carbonyl-Leu-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lcz696 is an ester prodrug of the active compound crizotinib, which is a selective inhibitor of the enzyme tyrosine kinase. Lcz696 has been shown to be effective in combination therapy for the treatment of patients with metastatic non-small cell lung cancer and those who are resistant to first-line chemotherapy. This drug has also been shown to have beneficial effects on cardiac function and blood pressure. Lcz696 inhibits MMP-9 activity and reduces levels of natriuretic peptides, which may be due to its inhibition of Toll-like receptor 4 (TLR4).</p>

<p>Methyl (2S)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acetate, also know as Clopidogrel, is a potent inhibitor of the platelet aggregation. It reduces blood clotting by inhibiting the ADP receptor on the surface of platelets, thereby inhibiting the aggregation and adhesion of platelets. Clopidogrel has been shown to be effective in preventing thrombosis, myocardial infarction (heart attack), and stroke. Clopidogrel inhibits the activity of cytochrome P450 3A4 (CYP3A4) and p2Y 12 receptors. Clopidogrel has been shown to have synergic effects with nonsteroidal anti-inflammatory drugs (NSAIDs). The polymorphic nature of Clopidogrel can be monitored using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification in biological samples such as human serum and plasma.</p>

<p>SR8278 is a synthetic, chemical compound that functions as a highly selective inverse agonist of the Rev-Erb nuclear receptors, which is derived from extensive biochemical research. It operates by binding to these orphan nuclear receptors, Rev-Erbα and Rev-Erbβ, inhibiting their activity. This antagonistic action disrupts the regulation of circadian rhythms, metabolism, and inflammatory responses that these receptors typically control. This modulation occurs at the transcriptional level, where SR8278 interferes with gene expression governed by Rev-Erb receptors.</p>

<p>Myelin oligodendrocyte glycoprotein (MOG) is a myelin protein found in the central nervous system. MOG is a ligand for CD200, which is an inhibitory receptor expressed by astrocytes. It has been shown that MOG can induce the proliferation and differentiation of primary cultures of rat astrocytes in vitro. MOG induces the production of reactive oxygen species in mitochondria and increases the expression of acid-binding protein, which are both important factors in the demyelination process. MOG has also been implicated as a potential factor in the development of multiple sclerosis. Further research into this protein may lead to new treatments or cures for disorders such as encephalomyelitis, nervous system diseases, or even cancer.</p>

<p>Please enquire for more information about (Gly21)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Semaglutide impurity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Fmoc-D-Asp(OMpe)-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Dreadd agonist 21 dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about YM-53601 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Seglitide is a cyclic peptide that is a model system for the receptor activity of somatostatin. Somatostatin inhibits cells by binding to its receptors, which are found on the surface of endocrine cells and in the hypothalamus. Seglitide has been shown to inhibit cell growth in tissue culture and is a potent inhibitor of epidermal growth factor (EGF) production. Seglitide also activates locomotor activity in mice, suggesting that it may have some clinical relevance. Structural analysis has revealed that seglitide's amino acid sequence is similar to somatostatin's, making them closely related compounds. It also binds to DNA-dependent RNA polymerase, preventing transcription and replication.</p>

<p>Please enquire for more information about H-Ala-Ala-Ala-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Indoprofen-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Indicaxanthin is a natural pigment that has been found to possess potent anticancer properties. It is an analog of oseltamivir, a drug used to treat influenza by inhibiting the neuraminidase enzyme. Indicaxanthin has been shown to inhibit the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and proliferation. This inhibition leads to apoptosis (programmed cell death) in cancer cells. Studies have demonstrated that indicaxanthin has anticancer effects against various types of cancer, including breast, colon, and prostate cancer. Additionally, it has been detected in human urine following ingestion of foods containing this pigment, suggesting that it may have potential as a dietary supplement for cancer prevention and treatment.</p>

<p>PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.</p>