Bioquímicos e reagentes

<p>CTX-712 is an innovative small-molecule inhibitor, which is synthesized through state-of-the-art organic chemical processes. This compound functions by selectively targeting and inhibiting specific intracellular pathways critical for tumor cell proliferation and survival. Through its precise mechanism of disrupting key signaling cascades, CTX-712 effectively impairs the growth of cancer cells while minimizing the impact on normal, healthy tissues.</p>

<p>Please enquire for more information about HPV18 E7 antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Quetiapine is a psychotropic drug that is used for the treatment of schizophrenia and bipolar disorder. It is an inhibitor of D2-type dopaminergic, serotoninergic, adrenergic, histaminergic, and muscarinic receptors. Quetiapine binds to specific receptors on the cell surface and prevents the binding of other drugs or endogenous substances such as dopamine. This results in the activation or inhibition of various cellular processes like ion channels. Quetiapine has been shown to be an antibody cross-reactive ligand for two different subtypes of dopamine receptors: D2L and D3R.</p>

<p>TPPB is a small molecule inhibitor, which is synthetically derived for targeted biochemical studies. It functions by selectively modulating G-protein-coupled receptor (GPCR) signaling pathways through the inhibition of specific protein-protein interactions. This mode of action makes TPPB an insightful tool for dissecting the complex mechanisms by which G-proteins relay extracellular signals to intracellular responses.</p>

<p>Etanercept is a recombinant protein that binds to both the soluble and transmembrane forms of TNF-α. It is used to treat rheumatoid arthritis, psoriasis, Crohn's disease, ankylosing spondylitis, and other inflammatory diseases. Etanercept has been shown to be effective in reducing symptoms of rheumatoid arthritis and decreasing levels of c-reactive protein (CRP). Etanercept binds to TNF-α and prevents it from activating cells. It also reduces production of other pro-inflammatory cytokines such as IL-1 receptor antagonist and necrosis factor.</p>

<p>Please enquire for more information about Gastrointestinal Cancer Antigen (CA 19-9) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Hemoglobin, Freeze Dried including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Our CPP Click Kit (alkyne) facilitates efficient exploration of intracellular delivery. It includes four commonly used cell-penetrating peptides (CPPs) with alkyne functionalization, enabling easy conjugation with azide-modified cargo via Click chemistry. This kit streamlines the process of attaching cargo to a variety of CPPs, allowing researchers to optimize delivery for specific cargo and cell types.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PLCB1 antibody, catalog no. 70R-5669</p>

<p>Oxytocin is an endogenous hormone.</p>

<p>CD24 antibody (PE) was raised in rat using murine heat stable antigen as the immunogen.</p>

<p>CD49e antibody (FITC) was raised in rat using C57BL/6 x A/J F1 murine mast cell line MC/9 as the immunogen.</p>

<p>CD23 antibody (Allophycocyanin) was raised in rat using CD23 low affinity IgE Fc receptor as the immunogen.</p>

<p>CD44 antibody (FITC) was raised in mouse using human CD44 as the immunogen</p>

<p>The VEGF antibody is a highly effective inhibitor of vascular endothelial growth factor (VEGF), a key growth factor involved in angiogenesis and the formation of new blood vessels. This antibody specifically targets the VEGF receptor, blocking its activation and preventing the growth and proliferation of endothelial cells.</p>

<p>CD3e antibody (FITC) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>CD45R antibody (FITC) was raised in rat using abelson murine leukemia virus-induced pre-B tumor cells as the immunogen.</p>

<p>CD40 antibody (biotin) was raised in rat using CD40 as the immunogen</p>

<p>CD19 antibody (PE-CY5.5) was raised in rat using murine CD19-expressing K562 human erythroleukemia cells as the immunogen.</p>

<p>CD107a antibody (Allophycocyanin) was raised in rat using murine CD107a (LAMP-1) as the immunogen.</p>

<p>CD11b antibody (PE) was raised in rat using peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of C22orf28 antibody, catalog no. 70R-4339</p>

<p>CD45R antibody (Spectral Red) was raised in rat using abelson murine leukemia virus-induced pre-B tumor cells as the immunogen.</p>

<p>CD40 antibody (PE) was raised in rat using CD40 as the immunogen</p>

<p>CD102 antibody (biotin) was raised in rat using COS cells transfected with mouse ICAM-2 cDNA as the immunogen.</p>

<p>CD45.2 antibody (CY5) was raised in mouse using CD45.2 as the immunogen.</p>

<p>Purified native Human Luteinizing Hormone (Intact) (&gt; 98% pure)</p>

<p>CD24 antibody (Spectral Red) was raised in rat using murine heat stable antigen as the immunogen.</p>

<p>CD3e antibody (FITC) was raised in hamster using T cell receptor complexes derived from C6VL-BS thymoma cells as the immunogen.</p>

<p>CD44 antibody (FITC) was raised in mouse using chicken CD44 as the immunogen.</p>

<p>CD103 antibody (PE) was raised in hamster using murine CD103 as the immunogen.</p>

<p>CD38 antibody (Spectral Red) was raised in rat using CD38 as the immunogen.</p>

<p>CD3 antibody (Allophycocyanin) was raised in mouse using the epsilon chain of CD3/T-cell antigen receptor complex as the immunogen.</p>

<p>CD19 antibody (Spectral Red) was raised in rat using murine CD19-expressing K562 human erythroleukemia cells as the immunogen.</p>

<p>CD44 antibody (Spectral Red) was raised in mouse using chicken CD44 as the immunogen.</p>

<p>CD3e antibody (Spectral Red) was raised in rat using CD3e as the immunogen.</p>

<p>CD40 antibody (Allophycocyanin) was raised in rat using CD40 as the immunogen</p>

<p>CD11c antibody (FITC) was raised in Mouse using human rheumatoid synovial fluid cells/monocytes as the immunogen.</p>

<p>CD19 antibody (PE-CY5.5) was raised in mouse using human CD19 as the immunogen.</p>

<p>CD20 antibody (Spectral Red) was raised in mouse using human CD20 as the immunogen.</p>

<p>CD31 antibody (biotin) was raised in rat using murine leukocyte cell line 32D as the immunogen.</p>

<p>CD166 antibody (biotin) was raised in mouse using human thymic epithelial cells as the immunogen.</p>

<p>CD11b antibody (biotin) was raised in rat using peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice as the immunogen.</p>

<p>Mirvetuximab is an antibody-drug conjugate (ADC), which is a targeted cancer therapy designed to deliver cytotoxic agents specifically to cancer cells. This ADC is derived from a monoclonal antibody that specifically binds to the folate receptor alpha (FRα), a protein overexpressed in certain types of cancer cells, including ovarian cancer. The mode of action involves the binding of Mirvetuximab to FRα on the cancer cell surface, followed by internalization of the complex. Once inside the cell, the cytotoxic drug is released, leading to cell death.Mirvetuximab is primarily utilized in the treatment of FRα-positive ovarian cancer, particularly in patients with platinum-resistant disease. By exploiting the differential expression of FRα, Mirvetuximab can deliver lethal doses of chemotherapy directly to the cancer cells, thereby minimizing systemic toxicity. This targeted approach enhances the therapeutic index of the treatment, improving efficacy while reducing adverse effects typically associated with conventional chemotherapy. Ongoing clinical trials are exploring its potential in other FRα-expressing malignancies, making it a pivotal component in the advancement of personalized cancer therapy.</p>

<p>CD90.2 antibody (Azide free) was raised in rat using CD90.2/`Thy-1.2 alloantigen as the immunogen.</p>

<p>Antibody-drug conjugate (ADC) of anti-CD138 chimerized MAb (nBT062) linked to the maytansinoid DM4</p>

<p>Streptococcus group B antibody (biotin) was raised in rabbit using group B Streptococci as the immunogen.</p>

<p>CD122 antibody (Azide free) was raised in rat using rat myeloma YB2/0 transfected with truncated murine IL-2RB cDNA as the immunogen.</p>

<p>CD11b antibody (Spectral Red) was raised in rat using C57BL/10 murine splenic T-cells and concanavalin A-activted C57BL/10 splenocytes as the immunogen.</p>

<p>CD147 antibody (PE) was raised in mouse using human T cell line Molt 13 as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of Gm527 antibody, catalog no. 70R-9128</p>

<p>CD31 antibody (PE) was raised in rat using murine leukocyte cell line 32D as the immunogen.</p>

<p>CD16 antibody (PE-CY5.5) was raised in rat using murine CD16/32 (CD16/Fc gamma II and CD32/Fc gamma III receptors)</p>

<p>CD3e antibody (biotin) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>CD45 antibody (Allophycocyanin) was raised in Rat using CD45/LCA as the immunogen.</p>

<p>CD19 antibody (PE) was raised in mouse using human CD19 as the immunogen.</p>

<p>CD11b antibody (Allophycocyanin) was raised in rat using C57BL/10 murine splenic T cells and concanavalin A-activated C57BL/10 splenocytes as the immunogen.</p>

<p>CD38 antibody (biotin) was raised in rat using CD38 as the immunogen.</p>

<p>A humanised IgG1 anti-BCMA (TNFRSF17) monoclonal antibody.</p>

<p>CD18 antibody (biotin) was raised in rat using cell membrane lysates derived from murine T cell lymphoma BW5147 as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of AKT1S1 antibody, catalog no. 70R-3068</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF41 antibody, catalog no. 70R-8765</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PNLIP antibody, catalog no. 70R-1591</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of P2RX2 antibody, catalog no. 70R-1518</p>

<p>H-RFARKGALRQKNVHEVKN-OH peptide, corresponding to 19-36 amino acids of Protein Kinase C.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ATP4B antibody, catalog no. 70R-6951</p>

<p>Z-Gly-Pro-Leu is a bacterial enzyme that belongs to the group of carboxypeptidases. It has an optimal pH of neutral ph, and can be found in ascidian tissue. Z-Gly-Pro-Leu is a synthetic substrate, and its sequences have been determined. Functional groups of this enzyme are carboxylic acid, hydroxyl, amine and thiol. This enzyme is used in the production of synthetic peptides and it has been shown to have a high level of activity on homogenates. It has also been shown to have an effector function in pancreatic tissue when injected subcutaneously.</p>

<p>Please enquire for more information about Cancer Hydrolase KIAA1363 Inhibitor, JW480 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>As a member of the tachykinin neuropeptide family, Neurokinin B is involved in the dilation of blood vessels, the contraction of smooth muscles and the excitation of neurons. This product can be applied as a NK3 receptors selective agonist.</p>

<p>Human pleiotrophin is a peptide that belongs to the family of neuropeptides. It has been shown to bind to ion channels in the cell membrane and is believed to regulate their function. This protein also binds with high affinity to the receptor tyrosine kinase, which are important for many cellular functions including signal transduction and cell growth. Pleiotrophin has been used as a research tool for studying protein interactions and for understanding how ion channels work. It can be used to study the mechanisms of various diseases such as hypertension, asthma, and diabetes mellitus.</p>

<p>Amyloid Beta-Protein (Human, 1-40) Antiserum is an antibody, which is a protein that recognizes and binds to a specific antigen. The Amyloid Beta-Protein (Human, 1-40) Antiserum can bind to amyloid beta protein in the brain and trigger immune system cells to clear it from the body. This antibody can also be used as a research tool for studying the structure of amyloid beta protein and how it affects human cells.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ABCF3 antibody, catalog no. 70R-6278</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PRKAB1 antibody, catalog no. 70R-3695</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of LAMC1 antibody, catalog no. 70R-6061</p>

<p>ARFIP1 antibody was raised in Rabbit using Human ARFIP1 as the immunogen</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of LPIN2 antibody, catalog no. 70R-10338</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of C14orf21 antibody, catalog no. 70R-4983</p>

<p>Please enquire for more information about S-[(1R,2E,4E,6Z,9Z,12Z)-15-Carboxy-1-[(1S,3Z)-1-hydroxy-3-hexen-1-yl]-2,4,6,9,12-pentadecapentaen-1-yl]-L-cysteinyl-glycine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Glycopyrrolate is a drug that is used to treat drooling, chronic cough, and bowel disease. It is an anticholinergic drug that blocks the action of acetylcholine in the body by blocking receptors for this neurotransmitter. Glycopyrrolate has been shown to have a low risk of drug interactions with other drugs due to its low plasma protein binding. Glycopyrrolate also has a stable dose-response relationship and does not need to be titrated for efficacy. The effects of glycopyrrolate are primarily on the gastrointestinal tract, where it inhibits gastric motility and reduces acid secretion. This medication also decreases the tone of smooth muscle in the bronchi, which helps relieve chronic coughs. In addition, glycopyrrolate may decrease the release of histamine from mast cells by inhibiting calcium release from intracellular stores in these cells. Glycopyrrolate also decreases muscle contractions in the uterus, which can help reduce</p>

<p>5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid (5S,12R-HPETE) is a potent activator of the TRPA1 ion channel. It binds to the receptor in a cooperative manner with other molecules and activates it. 5S,12R-HPETE also inhibits the activity of protein kinase C and phospholipase A2. It has been used as a research tool to study the molecular mechanisms of inflammation and pain sensation. 5S,12R-HPETE is also a ligand for the prostaglandin receptor EP4 and has been shown to have anti-inflammatory effects in vitro.</p>

<p>Resolvin D2 is a potent inhibitor of kinases that has been shown to have anticancer properties. This Chinese medicinal analog has been found to induce apoptosis in cancer cells by inhibiting protein kinases involved in tumor growth and survival. Resolvin D2 has also been shown to be effective in reducing the size of tumors in human studies. Additionally, this compound exhibits anti-inflammatory properties and has been found in human urine, suggesting its potential as a biomarker for cancer diagnosis and treatment. With its promising anticancer effects, Resolvin D2 is an exciting area of research for the development of novel cancer inhibitors.</p>

<p>Mouse monoclonal CD81 / TAPA-1 antibody</p>

<p>Please enquire for more information about Neurokinin B trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mouse monoclonal CD9 antibody</p>

<p>β-Amyron is a natural product that has been isolated from the leaves of Boswellia sacra. It has inhibitory activities against protocatechuic acid, hexane, preparative HPLC and acetate extract. β-Amyron also showed inhibitory activities against α-amyrin acetate and caffeine. Furthermore, β-Amyron inhibited the growth of bacteria that were isolated from human skin (bel-7402) and ethanol extracts. β-Amyron belongs to the genus of boswellic acids and its nmr spectra are consistent with those of boswellic acids.</p>

<p>β-Cortolone is a synthetic drug that is used to treat high blood pressure. It has been shown to reduce the risk of death from cancer in women, and may be a potential biomarker for bladder cancer. β-Cortolone binds with high affinity to corticosteroid receptors, which are expressed in many different tissues. This binding can lead to the release of inflammatory mediators and has been linked to increased risk of cardiovascular disease, osteoporosis, and diabetes. β-Cortolone may also have metabolic effects on the kidneys, liver, or brain cells.</p>

<p>Crotamine is a bioactive compound that is isolated from Croton tiglium, which is a plant indigenous to Southeast Asia. It is the most active component of the extract, and has been shown to have anti-inflammatory properties in various animal models. Crotamine has been used as an analytical standard for HPLC and can be used as a reference material for screening purposes. CAS No. 58740-15-1</p>

<p>Mouse sequence expressed in NS0 Cells; purity &gt;90% by SDS-PAGE and analyzed by silver stain; Fc Fusion Protein.</p>

HRP Conjugated Goat anti-Rat IgE antibody:Zhou C. et al. Allergenicity of recombinant human lactoferrin to an animal model Brown Norway ratsFood and agricultural immunology; ISSN : 1465-3443 Raju A et al.Evaluation of anti asthmatic activity of hydro alcoholic extract of Citrullus colocynths and Cucumis trigonus fruits.J App Pharm Sci. 2015; 5(8): 126-130 doi: 10.7324/JAPS.2015.50819

<p>Please enquire for more information about Affinity Purified anti-Human IgE Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mouse sequence expressed in sf Insect Cells; purity &gt;97% by SDS-PAGE and analyzed by silver stain.</p>

<p>Affinity Purified Goat anti-Human Lambda b+f Antibody</p>

<p>Mouse sequence expressed in NS0 Cells; purity &gt;90% by SDS-PAGE and analyzed by silver stain; Fc Fusion Protein.</p>

<p>This Monoclonal anti-Human PSA antibody is suitable for ELISA and LFD applications.</p>

<p>Chicken IgY enriched fraction that is suitable for use as a blocking agent. Please inquire for discounted bulk pricing. &gt;80% Purity.</p>

Human sequence expressed in sf Insect Cells; purity >95% by SDS-PAGE and analyzed by silver stain.

<p>Affinity Purified Donkey anti-Sheep IgG h+l Antibody</p>

<p>Mouse sequence expressed in NS0 Cells; purity &gt;97% by SDS-PAGE and analyzed by silver stain; Fc Fusion Protein.</p>

<p>The 6xHis tag is a commonly used protein purification tag in molecular biology and biochemistry. It consists of a short amino acid sequence containing six consecutive histidine residues (His). This tag is often genetically fused to the target protein of interest, allowing for purification of the fusion protein using affinity chromatography. The purification process typically involves the use of a metal ion affinity resin, such as nickel-nitrilotriacetic acid (Ni-NTA) agarose, which has a high affinity for the His-tagged protein. The His-tag binds specifically to metal ions immobilized on the resin, allowing for selective purification of the fusion protein from a complex mixture of proteins.After purification, the His-tag can sometimes be removed from the target protein through enzymatic cleavage or chemical methods, leaving behind the native protein. The 6xHis tag is widely used due to its small size, high affinity for purification resins, and minimal interference with the structure and function of the target protein. This antibody detects the 6 x His tag on proteins and can determine if it has been cleaved by loss of signal.</p>

<p>Mouse sequence expressed in E. coli Cells; purity &gt;97% by SDS-PAGE and analyzed by silver stain.</p>