Bioquímicos e reagentes

<p>LY2812223 is a drug that is currently in clinical development. It is a low-potency antagonist of the N-methyl-D-aspartate (NMDA) receptor and it has been shown to be effective in animal models of neurodevelopmental, psychotic, and other disorders. LY2812223 binds reversibly to the NMDA receptor and prevents the ion channel from opening. This drug has not been tested in humans, but it has been shown to have good absorption across the blood brain barrier and does not produce any neurotoxic effects. LY2812223 is being developed for the treatment of schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders, and Alzheimer’s disease.<br>END&gt;&gt;</p>

<p>Ro 08-2750 is a potent anti-tumor agent that inhibits the growth of cancer cells. It is structurally similar to a natural compound, largazole, which has been shown to inhibit prostate cancer cell proliferation. Ro 08-2750 may be useful for the treatment of prostate cancer and other cancers with glucocorticoid receptors. The drug also inhibits the production of proinflammatory prostaglandins and shows potent antitumor activity in both cell culture and animal models. Ro 08-2750 binds to the enzyme p-nitrophenyl phosphate (PNPP) and inhibits its activity, inhibiting DNA synthesis by blocking polymerase chain reaction (PCR). The binding affinity between Ro 08-2750 and PNPP is increased by cofactors such as ATP, making it more effective at inhibiting DNA synthesis.</p>

<p>Noggin is a protein that is involved in the regulation of neuronal growth and development. It acts as a morphogen, binding to a receptor on the surface of cells and initiating signaling cascades that lead to changes in gene expression. Noggin binds to Retinoid-X-receptor (RXR) and the Ligand-binding domain of Notch1. These interactions may be important for the regulation of CNS cells, such as neurons and glial cells. The protein has been shown to have a role in synaptic plasticity, axonal guidance, and synaptogenesis. Noggin has also been shown to be an inhibitor of cell proliferation and an activator of cell differentiation.</p>

<p>5-Chloro-2-fluoro-4-[[(tetrahydro-1H-pyrrolizin-7a(5H)-yl)methyl]amino]-N-2-thiazolylbenzenesulfonamide is a potent inhibitor of voltage gated sodium channels. It has been shown to inhibit the activation of these channels, which are involved in the transmission of nerve impulses. This leads to an increase in neuronal excitability and also has an effect on cardiac function. 5CFB is a high purity compound, with &gt;95% purity by HPLC and NMR measurements.</p>

<p>AP39 is a potent small molecule that acts as a mitochondrially-targeted hydrogen sulfide (H2S) donor exhibiting promising anticancer properties. Beyond its antitumor activity, AP39 demonstrates remarkable protective effects in renal oxidative injury and cardiomyopathy. The mechanism of action of AP39 appears to improve mitochondrial function, attenuate inflammation, and regulate mitophagy via the AMPK-ULK1-FUNDC1 pathway. Notably, AP39 prevents gastric mucosal damage and enhances cardiac function in doxorubicin-induced cardiotoxicity models. These pleiotropic effects makes AP39 to be a potential therapeutic candidate with broad applicability,  and it could bring further studies for preclinical and clinical research.</p>

<p>2-(1-Bromonaphthalen-2-yloxy)-N-(pyridin-3-yl)acetamide (CGP55845) is an antiarrhythmic drug that blocks the delayed rectifier potassium current (IKr). It has been shown to have a high potency and good selectivity in inhibiting IKr. CGP55845 is being studied for use in the treatment of cardiac arrhythmias. The compound also has potential as an antiarrhythmic agent because it inhibits contractility, prevents ventricular fibrillation and tachycardia, and has a low incidence of proarrhythmia.</p>

<p>Anti IL-1alpha (Rat) Serum is a serum that provides an inhibitor for IL-1alpha. The serum is used in the study of peptides and cell biology. This serum is made from high purity, life science grade material and has been shown to be effective in inhibiting the activation of ion channels.</p>

<p>Human-monoFITC (PheB1) is a peptide with the amino acid sequence Phe-B1. It is a fluorescent ligand that is used as a research tool for receptor binding studies. The antibody conjugated to human-monoFITC (PheB1) can be used to detect and quantify the protein in Western blots.</p>

<p>Hydroxy bosentan-d6 is an analog of the medicinal compound bosentan that has potent anticancer properties. It works by inhibiting protein kinases, which are enzymes that play a crucial role in cell division and growth. Hydroxy bosentan-d6 has been shown to induce apoptosis, or programmed cell death, in cancer cells. This compound can be used as a urinary biomarker for tumor progression and is being studied as a potential treatment for various types of cancer. In Chinese medicine, Hydroxy bosentan-d6 has been used as an inhibitor of kinase activity and has been found to have promising results against certain types of tumors. With its potent anti-cancer properties, Hydroxy bosentan-d6 is a valuable tool in the fight against cancer.</p>

<p>Integrin modulator 1 is a peptide that binds to integrins and inhibits their interaction with extracellular matrix proteins. Integrin modulator 1 has been shown to inhibit the activation of ion channels, which may be due to its ability to bind to different peptides on the cell surface.</p>

<p>Besulpamide is a peptide that has been shown to act as an activator of the ion channel TRPV1. It binds to the receptor, which leads to conformational changes and activation of the channel. Besulpamide also has an inhibitory effect on protein interactions, such as antibody-antigen binding or receptor-ligand binding. Besulpamide may be used in research as a tool for studying ion channels and their role in cell biology. This peptide has been shown to have high purity and is available at CAS No. 90992-25-9 in order to conduct research on Protein interactions, Receptor ligands, or Pharmacology.</p>

<p>A glucose analog; can enter mammalian cells and be used as a glucose tracer</p>

<p>Agonist of ?7 nicotinic acetylcholine receptor</p>

<p>Retinoic acid receptor (RAR) agonist</p>

<p>Fak ligand-linker conjugate 1 is a recombinant protein that contains the extracellular domain of the human Fak receptor. This antibody is useful for studying protein interactions, ion channels, and other cell biology and pharmacology research. It has a purity of &gt;95% and a CAS number of 2307461-45-4. This antibody can be used as a research tool in life science.</p>

<p>The Total GLP-1-HS ELISA (1ea) is a sandwich enzyme-linked immunosorbent assay that measures the concentration of active GLP-1 in human serum. The assay employs a monoclonal antibody specific to human GLP-1 and an enzyme conjugate, which is a radiolabeled anti-human GLP-1 antibody. The Total GLP-1-HS ELISA (1ea) has been validated for use with samples from both healthy subjects and subjects with type 2 diabetes mellitus.</p>

<p>FGF 9 is a protein that belongs to the FGF family. It is a ligand of FGFR3 and FGFR4, which are receptor tyrosine kinases. FGF 9 has been shown to have many biological activities, including the ability to activate other ligands such as EGF and PDGF. FGF 9 also has been shown to be able to stimulate the proliferation of cells, promote cell migration, and regulate ion channels. This protein may also be involved in angiogenesis by stimulating endothelial cell proliferation and migration.</p>

<p>Insulin is a hormone that regulates the metabolism of carbohydrates and fats. It is produced by beta cells in the pancreas and prevents hyperglycemia. Insulin binds to insulin-specific receptors on the cell membrane, resulting in increased glucose uptake by muscle and fat cells. Monoclonal Mouse Anti-Human Insulin is an antibody that binds to human insulin and blocks its action, thereby lowering blood sugar levels. This antibody was immunised with human insulin and purified from mouse spleen cells. The antibody has been shown to block glycogen synthesis and fatty acid synthesis in vitro. Monoclonal Mouse Anti-Human Insulin also has a high binding affinity for erythrocytes and penetrates these cells easily. When injected into humans, this antibody binds to the erythrocytes in the blood stream and prevents their passage through capillary walls into tissues such as muscle or fat cells, thereby preventing glycolysis (the conversion of glucose into energy) in those tissues</p>

<p>Z-Gly-Pro-Leu-Gly is a synthetic peptide with a kinetic and biochemical profile that is similar to that of the bacterial enzyme monoiodotyrosine hydroxylase. Z-Gly-Pro-Leu-Gly has been shown to react with the substrate, monoiodotyrosine, by forming hydrogen bonds. The enzyme activities of Z-Gly-Pro-Leu-Gly are inhibited by neutral pH and increased at acidic pH. The optimum pH for this reaction is 4.5. When injected subcutaneously, Z-Gly-Pro-Leu-Gly can penetrate the skin and hydrolyze monoiodotyrosine in ascidians.</p>

<p>Glomeratose A is a saponin that has inhibitory effects on the enzyme dehydrogenase. It has been shown to have an inhibitory effect on pro-inflammatory cytokines in animal experiments, which may be due to its ester linkage and inhibitory activities. Glomeratose A has been identified as a possible candidate for clinical use due to its efficient method of extraction and high purity.</p>

<p>GSK962040 hydrochloride is a selective sodium channel blocker, which is derived from synthetic chemical processes involving precise organic synthesis methods. This compound operates by selectively inhibiting specific sodium channel subtypes, thereby altering the electrophysiological properties of neuronal and muscle tissues. The mode of action involves blocking the influx of sodium ions through voltage-gated sodium channels, which diminishes excitatory signaling and stabilizes nerve membranes.</p>

<p>Inhibitor of class 1 histone deacetylase (HDAC)</p>

<p>Tc ask 10 is a chemokine that belongs to the C-C chemokine family. This chemokine is activated by TNF-α and induces hyperproliferation and muscle, as well as other types of cell death. The receptor for this chemokine is found on the surface of cells in the type I category, which includes monocytes, macrophages, and neutrophils. Tc ask 10 has been found to inhibit the production of TNF-α in mice with metabolic disorders such as diabetes mellitus.</p>

<p>Portion of EBV RTA</p>

<p>D-Erythro-α-phenyl-2-piperidineacetamide is a peptide that belongs to the class of ligands. It binds to and activates ion channels, which are protein complexes that form pores in the cell membranes. D-Erythro-α-phenyl-2-piperidineacetamide may be used as a research tool for pharmacology, proteomics, and cell biology. The peptide is an inhibitor of the antibody response in vitro.</p>

<p>Please enquire for more information about S55746 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fk1052 hydrochloride is a drug that has been shown to be mediated by the 5-HT4 receptor. It has been shown to have an inhibitory effect on cancer cells in vivo. Fk1052 hydrochloride binds to the 5HT4 receptor, which is expressed in regions of the brain that are involved with mood and anxiety. This binding leads to an increase in serotonin release and inhibition of cancer cell growth. Fk1052 hydrochloride also inhibits cisplatin-induced nausea and vomiting, which occurs through its ability to inhibit serotonin release from the gut.</p>

<p>Kras g12C inhibitor 13 is a peptide that has been shown to be an activator of Kras. It has also been shown to have the ability to inhibit the activity of k-Ras. This inhibitor binds to the ATP binding site on K-Ras, which blocks the interaction with other proteins and prevents activation. This peptide was purified from E. coli and has a purity of &gt;98%.</p>

<p>N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide is a modulator of metabotropic glutamate receptors. It has been shown to be orally bioavailable and to have an effect on the spinal cord. This drug is effective in doses ranging from 1 mg/kg to 10 mg/kg. N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide is still in preclinical stages and has not been tested on humans yet.</p>

<p>Glt-Ala-Ala-Pro-Leu-pNA hydrate is a peptide substrate that is used in the study of elastase activity. This compound has been shown to be hydrolyzed by human pancreatic elastase and human recombinant elastase. Glt-Ala-Ala-Pro-Leu-pNA hydrate also has a high affinity for proteases, such as chymotrypsin, trypsin, and pepsin.</p>

<p>Monobiotin is a pharmacological substance that has been used as an activator of protein kinase C (PKC) and for the inhibition of ion channels. It is also responsible for the phosphorylation of proteins such as glycogen synthase kinase-3β, which are involved in cell proliferation and differentiation. Monobiotin can be used as a research tool to study PKC activation and ion channel inhibition.</p>

<p>Peptide T is a synthetic peptide that has been shown to inhibit the activity of protein kinase C. This inhibition may be due to its ability to bind with high affinity and specificity to a site on the receptor protein. Peptide T is a research tool used in studies of cell biology, pharmacology, and physiology. It has been used as an inhibitor for studies of ion channels and has also been used as an activator for studies of receptor-ligand interactions. Peptide T is also known by its CAS number, which is P25657-1-2.</p>

<p>BMS 193885 is a blood pressure lowering agent that is an analog of candesartan. It binds to angiotensin II type 1 receptors in the body, which are located on the surface of blood vessels and heart muscle cells. These receptors are responsible for regulating the contraction of these muscles, thereby controlling blood pressure. BMS 193885 has been shown to be effective against cancer cells in knockout mice and has potential use as a cancer drug. The effect of BMS 193885 on cancer cells has been shown to be due to its ability to modulate cellular pathways involved in tumor growth and survival, such as cell cycle progression and protein synthesis. <br>BMS 193885 is not active against Caco-2 cells at high concentrations (10 μM or greater), but does have activity against other types of cancer cells. There is also no evidence that this drug inhibits any specific proteins or enzymes at concentrations up to 10 μM.</p>

2-Chloro-N-[2-[[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]amino]pyrimidin-5-yl]-5-(3-trifluoromethylbenzoylamino)benzamide is a high purity, research tool that has been shown to be an activator of ion channels. It is also an inhibitor of protein interactions and receptor binding. This product has not been evaluated in any clinical trials.

<p>Ro 25-6981 is a potent, selective, and reversible inhibitor of the extracellular glutamate transporter. It has been shown to have antidepressant properties in animal studies. Ro 25-6981 also blocks MK-801 binding to the NMDA receptor and inhibits MK-801-induced convulsions in animals. This agent has a profile of excitatory effects on neuronal growth factors and is an uptake inhibitor for 2-aminoethoxydiphenyl borate (2APB). Ro 25-6981 also inhibits carrageenan-induced paw edema in animals, as well as stepwise pain behavior induced by perirhinal cortex stimulation.</p>

<p>SCR7 pyrazine is a synthetic, catalytic subunit that belongs to the group of protein complexes. It has been shown to have a homologous structure with human DNA polymerase beta, which is involved in transcriptional regulation and DNA replication. SCR7 pyrazine is not efficient in its function, but it has shown an increase in fibroblast proliferation and a shift in the cell cycle from G2/M to S phase. This can be seen by the increased levels of RNA synthesis and DNA replication. SCR7 pyrazine also inhibits the expression of genes involved in apoptosis and cell death. This drug may be used as a potential cancer treatment due to its ability to inhibit proteins involved in apoptosis.</p>

<p>Epidermal Growth Factor, Human sequence. Produced recombinantly in E.Coli. 53 amino acids (6 kDa) including 3 intramolecular disulfide-bonds.</p>

<p>Sourced from the Spider, Agelena opulenta, this product is a presynaptic Ca2+ channel antagonist with disulfide bonds between Cys3-Cys19, Cys10-Cys24 and Cys18-Cys34. It is available as a 0.1mg vial.</p>

<p>Sr-3306 is a nonsteroidal anti-inflammatory drug (NSAID) that is the active form of the prodrug sulfasalazine. It inhibits prostaglandin synthesis by blocking cyclooxygenase (COX) activity and preventing the conversion of arachidonic acid to prostaglandins, which are important mediators of inflammation. Sr-3306 also inhibits COX-2 expression through a variety of mechanisms, including inhibition of NF-κB signaling pathways and activation of peroxisome proliferator-activated receptor gamma (PPARγ). It has been shown to inhibit cell growth in cancer cells and has neuroprotective effects against dopamine toxicity in animal models. In addition, it has been shown to inhibit epidermal growth factor (EGF), which causes inflammation and tumorigenesis, as well as inhibitory effects on the development of acute ischemic stroke.</p>

<p>SIB-1893 is a GABA analogue that binds to the gamma-aminobutyric acid receptor and inhibits neuronal death. It has been shown to be neuroprotective in cell culture. SIB-1893 also has potent antagonist effects on glutamate receptors, which may be related to its potential clinical use as an anti-epileptic drug. SIB-1893 does not show any significant binding affinity for other glutamate receptor subtypes, such as AMPA or kainate receptors. The uptake of this drug by cells is dependent on the presence of functional uptake transporters (e.g., GLT1) and the expression levels of these transporters are variable between different cell types. These uptake transporters play an important role in determining the therapeutic efficacy of this drug, since it can only enter cells if they express a functional transporter. Furthermore, SIB-1893 induces necrotic cell death when applied to cultured cells, but apoptotic cell death when injected</p>

<p>2-((2-Chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d ]imidazole-5-carboxamide is a potent and selective inhibitor of the ion channel TRPV1. TRPV1 is responsible for sensing heat and inflammation in the body. This compound has been shown to inhibit the activity of TRPV1 by blocking the channel pore.</p>

<p>2,6-Difluoro-N-(1-(2-phenoxybenzyl)-1H-pyrazol-3-yl)benzamide is a peptide that is used as a research tool. It has been shown to activate the antibody and cytotoxic T cells in mice, which may be due to its ability to inhibit the interaction of certain proteins. This peptide also has been shown to have an effect on ion channels, such as Kv1.7 and Kv1.5, which are important for proper nerve function. 2,6-Difluoro-N-(1-(2-phenoxybenzyl)-1H-pyrazol-3-yl)benzamide binds to receptors on the surface of cells and can act as a ligand or antagonist. It has been shown to inhibit protein interactions with other proteins, such as Fyn tyrosine kinase and Lck tyrosine kinase in vitro</p>

<p>GroEL is a protein that is found in bacteria. It is an ATPase and a chaperone, which helps other proteins maintain their correct shape. GroEL can be purified from E. coli or from the bacterium Bacillus stearothermophilus. The recombinant form of GroEL consists of the protein and its co-factor, dithiothreitol (DTT). This protein has been shown to have ion channel activity, which may play a role in cell excitability as well as receptor-ligand interactions. It also binds to peptides and has been used as a research tool for pharmacology, protein interactions, and cell biology studies. GroEL has been shown to activate certain enzymes such as proteases, kinases, phosphatases, and ribonucleotide reductase. It also inhibits other enzymes such as lipases and esterases.</p>

<p>PKI 402 is a potent enzyme inhibitor, which is derived synthetically to target specific kinase activities. The product's source involves sophisticated chemical synthesis techniques designed to enhance selectivity and potency. PKI 402 functions primarily by modulating protein kinase activities, inhibiting phosphorylation processes crucial in cell signaling pathways.</p>

<p>1-Deoxyfructosyl-Val-His (1DFVH) is a research tool that belongs to the group of activators. It has been shown to activate receptors and ion channels, as well as inhibit antibody production. 1DFVH also has an effect on cell biology, which may be due to its ability to interact with proteins in a variety of ways. 1DFVH binds to the receptor by competitive inhibition and activates the receptor by mimicking the natural ligand. This compound has been shown to activate ion channels in cells through the opening of potassium channels, leading to depolarization and increased calcium influx into cells.</p>

<p>2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-D)pyrimidin-4-one (PDMP) is a peptide that has been shown to act as an inhibitor of the enzyme phosphodiesterase 4 (PDE4). It binds reversibly to the catalytic site of this enzyme and blocks the conversion of cyclic adenosine monophosphate (cAMP) to its noncyclic form. PDMP has also been shown to activate protein kinase A. In addition, PDMP acts as a ligand for the receptor for thrombin and proteases such as trypsin.</p>

<p>Quinabactin is a peptide that is an activator of a specific G protein-coupled receptor called the metabotropic glutamate receptor 3 (mGluR3). It has been shown to be effective in the prevention and treatment of pain, specifically neuropathic pain. It also functions as an inhibitor of ion channels and has been shown to have beneficial effects on cells. Quinabactin is a research tool for studying protein interactions and receptor ligand pharmacology.</p>

Cystatin C Heavy Tryptic Peptide Standard for use in protein identification and quantitation studies. Cystatin C is a non-glycosylated, basic protein which can be used as a biomarker to determine kidney function.

<p>Please enquire for more information about Triphenyl[2-(pyrrolidin-1-yl)ethyl]phosphanium bromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2amino -8bromo-5H-purin-6one is a peptide that can be used as a research tool for studying protein interactions and ligand binding. 9-[(4aR,6R,7R,7aS)-7hydroxy 2oxido 2sulfanylidene 4a 6 7 7atetrahydro 4h fur 3 2 d 1 3 2 dioxaphosphinin 6yl] 2amino 8bromo 5h purin 6one has a high purity and is an inhibitor of ion channels.</p>