Bioquímicos e reagentes

<p>Thymosin β-4 (TB4) is an actin binding proteins (ABP), encoded by the TMSB4X gene and is regarded as the principal actin-sequestering protein in many cell types. TB4 is involved in maintaining sufficient amounts of intracellular monomeric actin that is readily available for use if needed. TB4 works by binding monomeric G-actin rendering it resistant to polymerisation into F-actin. TB4 is present in all cells except red blood cells and is located both in the cytoplasm and nucleus of the cell.TB4 is also involved in cell proliferation, migration, differentiation and tissue regeneration and may contribute to repair of human heart muscle damaged by heart disease and heart attack. TB4 reduces levels of inflammatory mediators, lowers reactive oxygen species, and up-regulates anti-oxidative enzymes, anti-inflammatory genes, and anti-apoptotic enzymes.The proline residue at position 4 of this peptide and the lysine residue at position 13 of this peptide are isotopically labelled with carbon-13 and nitrogen-15, giving this peptide a mass increase of 14 compared to the unlabelled peptide.</p>

<p>Peptide H-IGDFGLATK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GFYYSLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Fmoc-Asp(OtBu)-OH is a chemical compound that belongs to the group of modified amino acids. The synthesis of Fmoc-Asp(OtBu)-OH starts with the reaction of nicotinic acetylcholine, sodium carbonate, and chloride in trifluoroacetic acid. The product is then reacted with a disulfide bond and modified with polymerase chain and saponified. The final modification is achieved by reacting Fmoc-Asp(OtBu)-OH with messenger RNA (mRNA), which produces the desired product. Fmoc-Asp(OtBu)-OH has been shown to have minimal activity, as it does not elute from an ion exchange column under normal conditions. It also has no effect on acetylcholine release in rat hippocampal slices or on morphology when incubated in vitro for 24 hours at 37 degrees Celsius.

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

<p>Ara h 3 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins. The Ara h 3 allergen is recognised by serum IgE from approximately 45% of peanut allergy patients. Ara h 3 belongs to the glycinin family of legume storage proteins (S11 plant storage proteins) and is extensively proteolytically processed.This peptide represents a tryptic peptide of Ara h 3. The leucine residue at position 6 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.</p>

<p>H-Ala-Tyr-Pro-Gly-Lys-Phe-OH is a peptide that activates toll-like receptor 4 (TLR4). It is a potent inhibitor of the enzyme phospholipase A2 and has been shown to inhibit the production of proinflammatory cytokines, such as IL1β, IL6, IL8, and TNFα. This peptide also has anti-inflammatory effects on autoimmune diseases, such as rheumatoid arthritis. H-Ala-Tyr-Pro-Gly-Lys-Phe-OH has been shown to inhibit prostate cancer cell growth in vitro and in vivo. It appears to exert its action by interfering with the transcriptional process at the level of RNA polymerase II. The mechanism may involve inhibition of the activation of basic fibroblast cells or suppression of epidermal growth factor signaling. H-Ala-Tyr - Pro - Gly - Lys - Phe -</p>

JAK3tide is a synthetic peptide, which is a highly specific substrate. Derived from comprehensive biochemical studies, it targets the catalytic activity of the Janus kinase 3 (JAK3) enzyme. JAK3tide's mode of action involves being phosphorylated by JAK3, an essential kinase involved in the signaling pathways of certain cytokines, making it a vital tool for assaying JAK3 activity.When used in in vitro kinase assays, it enables precise quantification of JAK3's enzymatic activity, which is pivotal for understanding pathway dynamics involved in immune responses. Its application extends to research areas focused on elucidating the mechanisms of immune signaling pathways and for the development of inhibitors as potential therapeutic agents in immunological disorders. JAK3tide provides a robust framework for scientists aiming to dissect the nuanced interactions within the JAK-STAT pathway and identify novel therapeutic targets, particularly in conditions where JAK3 is dysregulated.

<p>Peptide H-NIDALSGMEGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-DSSTSPGDYVL^SVSENSR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Eosinophil major basic protein antibody was raised in mouse using human eosinophil major basic protein as the immunogen.</p>

<p>TAPI-2 is an inhibitor of ADAM-17 (also called TACE) and matrix metalloproteinases (MMPs). It acts as a broad-spectrum inhibitor of these enzymes. TAPI-2 prevents the shedding of tumor necrosis factor-alpha (TNF-α) from cell membranes and can sensitize cancer stem cells to the effects of chemotherapy such as 5-fluorouracil (5-FU) in vitro. It also blocks the phorbol ester-induced shedding of other cell surface proteins like TGF-α and β-amyloid precursor protein.</p>

<p>Fmoc-Trp(Boc)-OH is a building block for the synthesis of peptides and other bioactive molecules. It is used in the synthesis of daptomycin, an antibiotic that is used to treat bacterial infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Fmoc-Trp(Boc)-OH is also used as a synthon in the production of natural products such as kynurenine, which has been shown to have anti-cancer properties.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-ENFAGEATLQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ENFAGEATLQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ENFAGEATLQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ENFAGEATLQR-OH at the technical inquiry form on this page</p>

<p>Inhibitor of ornithine decarboxylase</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Antipain (supplied as the HCl salt) is a cytosolic and bound form of antipain. It binds to ATP-binding cassette transporter proteins, which are involved in the transport of substances across cell membranes, and inhibits their enzymatic activity. Antipain 2HCI also has inhibitory properties on enzymes such as DNA polymerase II and pyruvate kinase. It has been shown to have an effect on biochemical properties such as protein synthesis, enzyme activities, and polymerase chain reactions. This drug has been shown to be effective in preventing myocardial infarcts and cellular apoptosis by inhibiting the release of cytochrome c from mitochondria. Antipain 2HCI may also have some anti-inflammatory effects due to its inhibition of prostaglandin synthesis.</p>

<p>C-type natriuretic peptide (CNP) is a novel urinary biomarker which is part of the natriuretic peptide family. CNP is produced in the kidney and the endothelium and has been localised to renal tubules. CNP expression has also been detected in cardiomyocytes, vascular endothelium, and bone.CNP is synthesized as the precursor 103 amino acid (AA) protein, proCNP (AA 1-103), which is then cleaved into NT-proCNP (AA 1-50) and CNP53 (AA 51-103) by the intracellular endoprotease furin. CNP53 is then cleaved to give the biologically active mature form CNP22 (AA 82-103) and inactive form NT-CNP53 (51-81). CNP primarily acts as an autocrine or paracrine factor and has anti-proliferative and anti-fibrotic properties, including suppression of fibroblast proliferation and collagen production, inhibition of vascular smooth muscle cell proliferation and accelerated regeneration of endothelial cells. CNP is a vasodilator and potent venodilator and slightly elevated levels have been detected in heart failure and renal disease states. CNP has renoprotective properties and is activated during renal injury, where it helps preserve glomerular function and suppress pro-fibrotic processes. Hypoxia, cytokines and fibrotic growth factors, are stimuli for CNP production and release.CNP selectively activates the cell surface particulate guanylyl cyclase receptor B (GC-B), catalysing the conversion of GTP to the downstream second messenger, cyclic guanosine monophosphate (cGMP).</p>

Protease free Bovine Serum Albumin

<p>H-QNQYVHISSSPQNTGRTASP-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QNQYVHISSSPQNTGRTASP-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QNQYVHISSSPQNTGRTASP-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QNQYVHISSSPQNTGRTASP-OH at the technical inquiry form on this page</p>

<p>Ac-CSAQPKLLQMEKRPSL-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CSAQPKLLQMEKRPSL-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CSAQPKLLQMEKRPSL-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CSAQPKLLQMEKRPSL-NH2 at the technical inquiry form on this page</p>

<p>Melittin is a major component of bee venom that has been shown to have antibacterial efficacy against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. It also demonstrates anti-viral activity, for example it inhibits human immunodeficiency virus and herpes simplex virus. Furthermore it can be used in the treatment of inflammatory-related illnesses due to it inhibiting the phospholipase A2 enzyme. In addition to this Melittin's abaility to inhibit inflammatory mediators such as nitric oxide and cyclooxygenase-2 aids in the treatment of inflammatory diseases. As a result of Melittin having the capabilities of attacking lipid membranes and it surpressing COX-2 mRNA expression it can also be used in the treatment of tumours. The bound form of melittin is not toxic to mammalian cells, but it is toxic when it is released into the cell cytoplasm. Melittin has been shown to inhibit transcriptional regulation and locomotor activity in mice. This may be due to its ability to bind DNA, preventing transcription and translation of certain genes. Lastly It has strong hemolytic activity and been seen to increase insulin secretion via depolarization of pancreatic beta-cells. Melittin is a diverse peptide which can be used ina whole spectrum of research and therapeutic areas.</p>

<p>Peptide Ac-TATKSGSTTKNR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>This peptide is phosphorylated by Janus kinase 1 (JAK1) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This JAK1 substrate peptide contains an N-terminal glycine-residue.</p>

<p>AMG 176 is a potent and selective inhibitor of the Src kinase. It has been shown to inhibit the proliferation of cancer cells in vitro and induce apoptosis in vivo. AMG 176 may be used as a potential therapeutic for cancer treatment.</p>

<p>H-Gly-Arg-Gly-Asp-Asn-Pro-OH is a peptide that is used in the detection of damaged tissue. This peptide has been shown to have significant cytotoxicity, with an EC50 at around 100 nM. H-Gly-Arg-Gly-Asp-Asn-Pro-OH has also been shown to be reactive with integrin receptors, which are found on the surface of pluripotent cells and are involved in cell adhesion. The fluorescence intensity of this peptide increases when it binds to the integrin receptor, indicating that it may be useful for measuring changes in cellular calcium levels.</p>

<p>The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life &lt;-2 minutes) due to proteolytic degradation by the serine protease- dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical use.In this peptide the phenylalanine residue at position 6 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1), the leucine residue at position 14 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1), and the leucine residue at position 26 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1). Additionally, the peptide contains an uncharged C-terminal amide.</p>

<p>Soluble amyloid-β (Aβ) oligomers are key to Alzheimer's disease (AD) pathology. Aβ oligomers constitute a significant component of senile plaques, and the presence of plaques is used to define AD.  Soluble Aβ is the most neurotoxic species- its presence correlates with AD onset and early progression. There is no current treatment to prevent the formation of neurotoxic Aβ oligomers. A proposed strategy to treat AD is the inhibition of Aβ oligomer interacting with the NMDA receptor. Disruption of NMDA receptor function and signalling molecules affect neuronal plasticity and development.Pep63 was identified via peptide array to block the interaction between Aβ oligomers and EphB2. Mouse AD model stereotactic administration of Pep63 into the dorsal hippocampus blocked the interaction between Aβ and EphB2, as shown by co-immunoprecipitation and Western blotting. Reduced Aβ presence was detected following Pep63 treatment seen by ELIZA. Pep63 effectively reverses impaired memory deficits determined by the Morris water maze (MWM) on the AD mouse model.</p>

<p>Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells to the cytoplasm and to the nucleus in a receptor-independent mechanism. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK), named penetratin, and used in several studies to aid entry of fusion proteins into cells.The full 60 amino acid homeodomain was fused to a T cell epitope of the influenza nucleoprotein and successfully internalised into T cells for presentation. The fragment known as penetratin was fused to a ligand for Grb-2 resulting in inhibition of downstream Grb-2 signalling events.- Penetratin has also been used in vivo to prime cytotoxic T lymphocytes by conjugating short antigenic peptides to the CPP. This penetratin has been synthesised with an N-terminal 6-azidohexanoic acid (Azhx) which can be used for various applications as a linker.</p>

<p>Antimicrobial and cytolytic peptide isolated from the venom of the spider wasp Anoplius samariensis. Anoplin has potent and board-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, antifungal properties against some plant pathogenic fungi, and no haemolytic activity against human erythrocytes. At 10 amino acids long, anoplin is the smallest naturally occurring antimicrobial and cytolytic peptide, its small size may have advantages for chemical manipulation and medical application.</p>

<p>Please enquire for more information about C.I.Direct Yellow 147 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Regaloside D is a natural product derived from plant sources, specifically isolated from certain species known for their bioactive properties. It functions as a glycoside, a compound in which a sugar is bound to a non-carbohydrate moiety, potentially influencing a variety of cellular processes through its interaction with specific molecular targets.</p>

<p>Dpp-iv is a serine protease enzyme that is important for the production of vasoactive peptides and inflammatory mediators. It is involved in the regulation of heart function, blood pressure, and vascular tone. Inhibitors of Dpp-iv have been shown to be useful in the treatment of a variety of diseases including hypertension, coronary artery disease, myocardial infarction, and stroke. Diprotin A is a synthetic inhibitor that has been shown to prevent adenoviral vector-mediated heart damage in neonatal animals. This drug also inhibits the production of vasoactive peptides and inflammatory mediators by blocking Dpp-iv activity, preventing cardiac dysfunction following an infarction.</p>

<p>Humanin is an endogenous peptide which is encoded for by mitochondrial DNA. It has been described as a rescue factor due to it demonstrating the capabilities of abolishing neuronal cell death, therefore is can be used to as a potential treatment of Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.<br>Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.<br>Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance.<br>This Humanin product has had the serine at position 14 on the amino acid chain replaced with a Glycine. This modification has been known to enhance the cytoprotective activity of Humanin by 1000 fold and proves to be highly anti-apoptotic. Therefore this product is of scientific interest for research laboratories. It is available as a 0.5mg vial.</p>

Complement Component 3C (C3c), Highly Purified (Lyophilised) is a life science tool for use in IVD applications. Please enquire for more information about Complement Component 3C (C3c), Highly Purified (Lyophilised) including the price, delivery time and more detailed product information at the technical inquiry form on this page.

<p>ß-Endorphin, also known as Equine ß-Endorphin, is a polypeptide hormone that is a member of the endorphin family. It is a peptide consisting of nine amino acids. ß-Endorphin has been found in the pituitary gland and in other tissues in concentrations much higher than those of other endorphins. Beta-endorphin is thought to be involved in pain relief and stress relief.</p>

<p>RSV Antibody is a medicament that contains Monoclonal Antibodies, which are highly specific antibodies produced in a laboratory setting. These antibodies are designed to target and neutralize the Respiratory Syncytial Virus (RSV), a common viral infection that affects the respiratory system. RSV Antibody is used in the field of Life Sciences as an antiviral treatment option.</p>

<p>The progress of cardiovascular disease (CVD) comes from the damage and necrosis of cardiomyocytes. Although treatment has improved, once these cells are damaged, they cannot be recovered. Therefore, further research into cardiomyocytes is vital. Cardiomyocytes need to be in an exceedingly pure culture for research work. However, this requires identification of these cells from the ESCs present. With the use of a phage biopanning library, this sequence has been shown to have a high affinity to a receptor on the membrane surface of mouse ESC-derived cardiomyocytes. The functionality of this sequence allows it to be used a conjugate for drug or gene delivery to target cardiomyocytes or to purify cardiomyocytes in a research setting.</p>

<p>Fmoc-Cys(Trt)-Wang Resin (100-200 mesh) 1% DVB is a research tool that is used as an activator, ligand or receptor for cell biology, antibody production or ion channels. It has been used in the study of protein interactions and pharmacology. Fmoc-Cys(Trt)-Wang Resin (100-200 mesh) 1% DVB is a high purity resin that can be used to synthesize peptides and compounds for life science purposes. It is also an inhibitor that can be used to block enzymatic reactions.</p>

The Yersinia pestis antibody is a highly specialized antibody used in the field of Life Sciences. It is known for its neutralizing properties, which means it can effectively block the harmful effects of Yersinia pestis, a bacterium responsible for causing the plague. The antibody works by binding to specific antigens on the surface of Yersinia pestis, triggering an antigen-antibody reaction that prevents the bacterium from infecting host cells.

<p>The CRP calibrator is a high-quality Biological Reagent used in various laboratory applications. It contains specific inhibitors and nucleotide molecules that are essential for accurate calibration of CRP (C-reactive protein) assays. This calibrator is designed to provide precise and reliable results, ensuring the highest standard of performance.</p>

<p>Please enquire for more information about rec IL-4 (murine) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Acetly-Claudin-9 is derived from the tight junction protein Claudin-9 which is encoded by the CLDN6 gene and can be found within epithelial cell to cell contacts. Structurally, the Claudin family, of which Claudin-9 is a member, are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.Reduction in the number of Claudins has been associated with tumour formation. This may be due to Claudin role in maintaining cell detachment and migration.Claudin-9 has been shown to be overexpressed in hepatocellular carcinoma (HCC) and has the ability to increase the metastasis of hepatocytes. It further influences the activation of the Stat3 signalling pathway through tyrosine kinase 2. Overall CLDN9 demonstrates itself to be a HCC proto-oncogene.</p>

<p>CEF (cytomegalovirus, Epstein-Barr virus, and influenza virus) control peptide pool for immune cell activation. CEF32 peptide pool is a positive control for CD8 cell activation.</p>

<p>H-VVSTHNLWLLSFLR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VVSTHNLWLLSFLR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VVSTHNLWLLSFLR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VVSTHNLWLLSFLR-OH at the technical inquiry form on this page</p>

<p>For-Met-Leu-pNA is a synthetic peptide that can be used as a research tool for studying protein interactions. It has been shown to inhibit ion channels and may be useful in the treatment of epilepsy, especially in cases of drug resistant seizures. For-Met-Leu-pNA is also an inhibitor and can be used as an anticonvulsant.</p>

<p>This sequence corresponds to the peptide bond between mammalian Lys33- (K33) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.Lys33-linked polyUb chains are assembled by the HECT E3 ligase AREL1. K33-linked polyUb chains have been linked to DNA damage response and in the regulation of innate immunity. Ubiquitination with K33-linked chains also regulates T-cell receptor function and contributes to the stabilization of actin for post-Golgi transport.The proline residues at position 9, and the N-terminal arginine residue of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (5), giving this peptide a mass increase of 16 compared to the unlabelled peptide</p>

<p>The Fibronectin antibody is a monoclonal antibody that specifically targets fibronectin, a glycoprotein involved in cell adhesion and migration. This antibody has been shown to inhibit the activation of fibronectin and its interaction with other proteins, such as alpha-synuclein. It can also block the activity of growth factors and interferons, which are important for immune responses and tissue repair. The Fibronectin antibody is widely used in Life Sciences research to study cell signaling pathways, protein-protein interactions, and the role of fibronectin in various diseases. With its high specificity and affinity, this antibody is a valuable tool for researchers studying fibronectin-related processes.</p>

<p>H-CQSTPLSPPPLTPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CQSTPLSPPPLTPK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CQSTPLSPPPLTPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CQSTPLSPPPLTPK-OH at the technical inquiry form on this page</p>