Bioquímicos e reagentes

<p>Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion - in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide.GIP is derived from a 153-amino acid pro-protein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on β-cells in the pancreas. These β-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM)- studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.</p>

<p>N-terminal biotin adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.</p>

<p>CMV pp65 (415-429) (HLA-B7) is a CEF (cytomegalovirus, Epstein-Barr virus, and influenza virus) control peptide that is derived from the Cytomegalovirus (CMV). CMV is capable of infecting a wide range of human cell types, where the body's primary immune response to CMV is innate, and relies on inflammatory cytokines and costimulatory molecules in order to control the spread of the virus. CMV pp65 (415-429) (HLA-B7) is defined as a CEF control peptide due to its antigenic properties. Clinically, these peptides are suitable epitopes for CD8+ T cells and can be used to stimulate the release of IFNg. HLA-B7 refers to the cell HLA type that this peptide acts on.</p>

<p>Peptide H-LDVHYAPTIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>[Cy3B]-LifeAct (Abp140 1-17) contains the 17amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. On application, lifeact can be used in the study of plant development and pathogen defence as filamentous actin within the plant actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements.The addition of the Cy-Dye fluorophore, Cy3B allows the location of the LifeAct (Abp140 1-17) to be detected. Cy3B is described as being conformationally locked meaning it is less likely to undergo photo-isomerization and one of its main applications is within DNA related studies.</p>

<p>SGS-acid is a tripeptide consisting of a serine residue followed by a glycine and another serine residue. SGS-acid was synthesised from the dipeptide glycyl-L-serine (GS-acid)- the dipeptide GS-acid is also available in our catalogue. SGS-acid has a net charge of 0, it can act as a Bronsted base by accepting a hydron from a donor thus giving it diverse biological and chemical uses.</p>

<p>Avi tag is a short 15 amino acid peptide that is capable of biotin modification to the lysine residue without effecting the protein function. The avi tag with biotin is highly specific and stable which makes it an ideal choice for protein interaction studies via purification or detection. Avi tag is more effective than a His tag at protein purification, with these advantages the stabilised version with an N-terminal acetylation is a vital tool in many research fields including drug delivery and DNA-protein interactions.</p>

<p>Peptide Ac-LGRI-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>PLP(178-191) corresponds to amino acids 178 to 191 of the mouse ProteoLipid Protein (PLP).</p>

<p>This sequence corresponds to the peptide bond between mammalian Lys63- (K63) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K63-linked chains are the second most abundant linkage types found in cells and are modified with Met1-linked chains in mixed or branched architectures. K63-linked chains have a variety of non-degradative roles including- roles in intracellular trafficking, kinase signalling, DNA damage response, inflammatory signalling and NF-KB activation, however they may also be involved in some proteosome dependent pathwaysThe N-terminal arginine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>Cytomegalovirus (CMV) is a prevalent human pathogen of concern in the immunocompromised such as during organ transplant or in AIDs patients- it can potentially be fatal. Due to the commonness of CMV, one strategy being developed is prevention of viral reactivation in immunosuppressed groups. Current antivirals have significant toxicity thus pushing the search for a specific CMV therapy.Murine CMV has been well established as a model for human CMV, including its susceptibility to T cell mediated clearance. The immediate-early protein 1 (IE1) was fragmented and used to find the best IE1 epitope as a vaccine. YPHFMPTNL, provided here, recognized by H-2 Ld-restricted CD8+ T cells was the best epitope of IE1 for T cell recognition. The fragment has been used to successfully generate CD8+ T cell clones specific for the IE1 epitope of murine CMV. This peptide has the potential to further the development of antiviral immunotherapy for CMV and better understand its ability to evade the host immunity.</p>

<p>Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cell. Tet-20 antimicrobial peptide is often sued as a control peptide and has antifouling.</p>

<p>Overlaping peptide library of ovalbumin, 15 amino acids per peptide with offset 11. Purity crude. All peptides are pooled in a single tube.</p>

<p>Influenza virus budding from infected cells requires membrane remodelling, is a multistep process with many proteins involved. Therefore there are numerous stages and proteins that could be antiviral targets if the mechanism can be better understood.The matrix 2 (M2) protein has recently been shown to be essential for completion of membrane scission at the end of buddinng. Initially, proteins aid membrane curvature, including matrix 2 (M2) protein, a bud forms, and finally membrane scission occurs to release the bud at the neck from the membrane occurs- M2 amphipathic helix domain in the cytoplasmic tail is essential for completion of scission to release the virus bud. The residues 44-62, provided here, have been identified as the motif responsible for allowing the scission mechanism to occur. Work is ongoing to understand the exact molecular mechanism by comparison to other scission proteins such as Arf1, Epsin1. Use of this M2 peptide motif may provide functional knowledge of virus budding and lead to novel antiviral drugs.</p>

<p>Peptide Ac-AGGKAGKDSGKAKAKAVSR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-RPPGF^SPF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Serum levels of thyroglobulin (Tg) is considered a valuable measurement for quantitively evaluating thyroid cancer treatment efficacy. Immunoassays are commonly used for Tg level evaluation but return many false negatives. This is due to a large proportion of patients expressing anti-Tg antibodies (TgAb), which outcompete the reagent antibodies for Tg.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is potentially better at quantification of Tg as TgAb should less influence it. Tg digestion with trypsin yields the specific peptide Tg-FSP peptide (FSPDDSAGASALL) that is a reliable target for LC-MS/MS and unique to Tg.The Tg-FSP heavy arginine residue at position 14 is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide. This will allow absolute quantification applications such as quantitative proteomics, the quantification of complex protein mixtures at very low concentrations, or NMR studies.</p>

<p>Endogenous peptide GPR83 agonist derived from processing of precursor protein, proSAAS. It is widely expressed in a number of species where it is involved in feeding, stress modulation and addiction and reward circuits.</p>

<p>Anti-microbial peptide (AMP) designed using only residues G, L, and K (GLK-19). Active against-Escherichia coli-with higher activity relative to human AMP LL-37 and also weakly active against methicillin-resistant Staphylococcus aureus (MRSA), but not-active against HIV-1. Activity against E. coli with a minimal inhibitory concentration (MIC) at 10 mM.</p>

<p>Peptide H-YEASILTHDSSIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Unsubstituted Resins for Solid Phase Synthesis; 0.3-0.65 meq/g</p>

<p>Alpha-melanocyte stimulating hormone (alpha-MSH) is a melanocortin family neuropeptide which plays important roles in metabolic and immune homeostasis. It is formed from the cleavage of adrenocorticotropic hormone, the cleavage product of proopiomelanocortin hormone. alpha-MSH is expressed ubiquitously to varying degrees in a wide variety of cells including the hypothalamus, monocytes and retinal pigment epithelial cells. alpha-MSH is a non-selective agonist of melanocortin receptors.alpha-MSH is a suppresser of inflammation from both innate and adaptive immune pathways, it is involved in hair and skin pigmentation (through MC1 receptor activation), has reproductive functions, cardio protective functions and regulates food intake and energy metabolism. The N-terminal of the peptide is protected by an acetyl group.</p>

<p>Peptide H-YNQLLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Kemptide is a synthetic substrate of the PKA catalytically active subunit (PKAc), and can bind along with ATP to PKAc. It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>H-NYMNLGATL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-NYMNLGATL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-NYMNLGATL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-NYMNLGATL-OH at the technical inquiry form on this page</p>

<p>The Insulysin FRET substrate [Mca]/[Dnp] is a synthetic insulysin peptide substrate that contains an N-terminal fluorescent 7-methoxycoumarin (Mca) group and a C-terminal 2, 4-dinitrophenyl (Dnp) quencher. This FRET peptide exhibits internal fluorescence quenching when intact, however hydrolysis of the peptide between the donor/acceptor pair generates fluorescence, enabling the quantitative measure of enzymatic activity.Insulysin, also known as insulin-degrading enzyme (IDE), is a highly conserved zinc metallopeptidase that contains an inverted zincin motif (HXXEH), characteristic of the inverzincin family of proteases. Insulysin functions as a dimer and exhibits allosteric kinetics, whereby small substrate peptides and polyphosphates such as ATP can act as enzyme activators. The endopeptidase cleaves a wide variety of substrates that are diverse in length, structure and sequence and exhibits a preference for basic or bulky hydrophobic residues.Insulysin is ubiquitously expressed and is responsible for insulin catabolism and the degradation of many bioactive peptide substrates including glucagon, TGF-alpha, β-endorphin, dynorphins and atrial natriuretic peptide. Insulysin also selectively degrades amylin and β-amyloid amyloidogenic peptides at multiple sites.Fluorescence Resonance Energy Transfer (FRET) peptides are convenient tools for the study of peptidase specificity and enzymatic activity.</p>

<p>Galantide is a reversible and non-specific galanin receptor antagonist.  In vitro it dose dependently antagonizes galanin mediated inhibition of the glucose induced insulin secretion from mouse pancreatic islets.  In vivo intracerebroventricular injection of galanin inhibits sexual behavior in male rats without producing any other locomotor or behavioral deficit.  Galantide has been found to improve social memory in animal models.</p>

<p>Sal-like4 (SALL4) derived peptide able to antagonise the SALL4-NuRD complex in hepatocellular carcinoma, turning SALL4 from a dual transcription repressor-activator to a singular transcription activator. Displays antitumour effects in xenograft mouse models.</p>

<p>B8R (20-27) is derived from the B8R protein, a virulence factor of the poxvirus. Due to B8R being a homolog of the extracellular domain of the IFN- γ receptor, B8R can bind to and prevent IFN- γ from binding to its receptor. IFN- γ has antiviral activity against encephalomyocarditis virus and the vesicular stomatitis virus is inhibited when B8R is expressed.</p>

<p>Protein kinase B (also known as RAC-alpha serine/threonine-protein kinase: Atk) is a serum and glucocorticoid-regulated protein kinase with three highly homologous isoforms (Akt1, 2 and 3). Akt1 and Akt3 are the predominant isoforms expressed in the brain, whereas Akt2 is mainly expressed in skeletal muscle and embryonic brown fat. These proteins play major regulatory roles in a range of physiological processes including: growth, proliferation, cell survival, angiogenesis, metabolism and Akt is also considered a proto-oncogene.This peptide (AKTide) is a selective substrate for these kinases and enables quick, easy and sensitive assays of Akt activity.</p>

<p>Peptide Ac-ETFG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Vasculotide</p>

<p>Wilms tumor protein is a protein that is encoded by the WT1 gene on chromosome 11p in humans. WT1 is a tumour suppressor gene associated with the development of Wilms' Tumour, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently identified in acute myeloid leukemia and associated with poorer prognosis and chemotherapy resistance.The WT1 peptide is a transcription factor that contains four zinc finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system.WT1 has been ranked by the National Cancer Institute (NCI) as the Number 1 target for cancer immunotherapy.The valine is isotopically labelled with carbon-13(5) and nitrogen-15(1).</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Alpha-synuclein (1-13) is derived from the alpha-synuclein intrinsically disordered protein which is found in neurons and presynaptic terminals. Encoded by the SNCA1/PARK1 gene alpha-synclein is structurally composed of 140 amino acids, making up the three domains: N-terminal membrane binding domain, a hydrophobic non-amyloid-β component domain and a hydrophilic C-terminal domain. Usually alpha-synuclein plays a role in protecting neurons from apoptotic stimuli and is involved in synaptic vesical trafficking.Accumulation of alpha-synuclein aggregates can lead to neurodegenerative diseases such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy. It is further involved in the fibrilisation of amyloid β and tau which play a major role in Alzheimer disease. Amyloid fibrils are formed from alpha synuclein monomers within the cytosol and when bound to membranes these monomers can undergo conformational changes to form protofibrils and then ring like oligomers. This can result in the formation of transmembrane pores which disrupts the membrane, calcium homeostasis and signalling.In familial Parkinson disease the SNCA1 gene, can be subjected to point mutations such as A30P, E46K and A53T, or over expression. These can result in the increased aggregation of alpha-synuclein.</p>

<p>Adrenomedullin (ADM), is a free circulating peptide of the amylin/calcitonin gene-related peptide (CGRP) super-family. It is widely expressed in virtually all human tissues and is involved in regulation of endothelial barrier function- vascular tone- immunoregulation- cellular proliferation and apoptosis. ADM is implicated in the pathophysiology of several diseased states including: sepsis- heart failure- inflammatory bowel disease- diabetes- eye pathologies and many cancers. ADM levels are often increased during these diseased states often correlating with disease severity and mortality. ADM is therefore of interest as a target for these diseases. ADM also displays potent antimicrobial action against Gram-positive and Gram-negative bacteria.The 52 amino acid ADM is produced by multiple cleavage steps from the original 85 amino acid long preprohormone (prepro-ADM). ADM exerts its effects by ligation of receptor complexes consisting of the calcitonin receptor-like receptor (CRLR) combined with a specific receptor activity-modifying protein (RAMP). Interaction of ADM with its receptor occurs through its C-terminal moiety.</p>

<p>Temporin L is a highly potent anti-microbial peptide (AMP) active against both Gram-positive and Gram-negative bacteria. Temporins are a large family of short, linear, AMPs produced in the skin of frogs belonging to Rana species, but are also found in wasp venom. Temporin L was originally isolated from the frog Rana temporaria and has the highest anti-microbial potency among tested temporins, especially against Gram-negative bacteria.Temporin L increases bacterial inner membrane permeability in a dose-dependent manner without destroying cell integrity. At low peptide concentrations, the inner membrane becomes permeable to small molecules but this does not kill the bacteria. At high concentrations, larger molecules, but not DNA, leak out, resulting in cell death. Temporin L has a different mode of action to many AMPs as it does not lyse the cells but instead forms ghost-like bacteria shells.</p>

<p>SCO-spondin is a large multi-domain glycoprotein of the extracellular matrix, widely distributed in the central nervous system (CNS). SCO-spondin is expressed and secreted in early development by the subcommissural organ (SCO), an ependymal differentiation of the brain. SCO-spondin is part of the Reissner's fiber (RF), a thread-like structure in the spinal cord and is involved in axonal pathfinding, development of brain commissural fibres and spinal cord regeneration in vertebrates. SCO-spondin also interferes with several developmental processes including: neuronal development- axonal pathfinding- neuronal survival- neurite extension- neuronal aggregation, and fasciculation.SCO-spondin has several conserved domains, including 26 thrombospondin type 1 repeats (TSR), nine low-density lipoprotein receptor (LDLr) type A domains, two epidermal growth factor (EGF)-like domains, and N- and C-terminal von Willebrand factor (vWF) cysteine-rich domains. The TSR motifs are highly important in many of SCO-spondins neuronal responses.NX210 corresponds to part of the SCO-spondin TSR sequence, it can increase adhesivity and neuritic outgrowth and is involved in cell-cell and cell-matrix interactions. NX210 can increase cell survival and induce neurite outgrowth.</p>

<p>Proprotein convertase subtilisin/kexin type 9 (PCSK9) is negative regulator of hepatic low-density lipoprotein (LDL) receptors by promoting their degradation. This leads to an increase in plasma levels of cholesterol-LDL (LDL-c). PCSK9 binds to the LDL receptor at the epidermal growth factor precursor homology domain A (EGF-A) which leads the receptor to be targeted for degradation. Natural loss of function mutations in PCSK9 have been linked to improved coronary health and lower cholesterol levels with reduced risk of coronary heart disease. This has led to further study to find inhibitors of PCSK9 with the hope that they may be clinically relevant in the future.As discussed, PCSK9 binds to EGF-A on the LDL receptor. A peptide named pep 2-8 is a mimic of EGF-A and binds PCSK9 in the same manner observed with the LDL receptor. Pep 2-8 is a potent selective competitive inhibitor of PCSK9. Pep 2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells. This is still an active area of research to optimise inhibition of PCSK9 for cholesterol regulation.Pep 2-8 has also been utilised as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.Peptide Ac-TVFTSWEEYLDWV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Abltide represents the optimal substrate peptide of Abl (or c-Abl), a non-receptor tyrosine kinase (NRTK) and the oncogenic Bcr-Abl tyrosine kinase (TK) (formed via a fusion between the Abelson (Abl) TK gene and the break point cluster region protein Brc). Abl was discovered as the gene from which the Abelson leukaemia virus derived its Gag-v-Abl oncogene.TKs are critical enzymes involved in multiple signalling pathways. However, Tks can promote cancer progression when deregulated, for example deregulated TK, Bcr-Abl gives rise to chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphocytic leukaemia (Ph+ ALL).Abl is activated by various signals including: growth factors, cytokines, cell adhesion, DNA damage and oxidative stress and results in the stimulation of both pro- and anti-apoptotic roles, cell proliferation or differentiation, retraction, or migration. Abl phosphorylates a large number of functionally diverse substrates, in part due to its ability to shuttle between the cytosol and the nucleus and bind both DNA and actin&amp;mdash-two biopolymers with fundamental roles in almost all biological processes.</p>

<p>H-AMLLSKFGSL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AMLLSKFGSL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AMLLSKFGSL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AMLLSKFGSL-OH at the technical inquiry form on this page</p>

<p>Sakamototide is phosphorylated by members of the 5'-adenosine monophosphate-activated protein kinase (AMPK) family of kinases as is therefore ideal for use in kinase assays to test the activity of AMPK family members. The AMPK family includes- salt inducible kinases (SIKs), NUAK's, sucrose non-fermenting (Snf1)-related kinase (SNRK), microtubule affinity regulating kinases (MARKs) and brain specific kinase/BR serine/threonine kinase (BRSK). The kinase activity of AMPK and AMPK-related kinases, is dependent on its phosphorylation at Thr175 by the upstream kinase LKB1 (also known as STK11).</p>

<p>Farnesylated a-factor is a post-translationally modified mating pheromone derived from Saccharomyces cerevisiae. The addition of a farnesyl group to the C-terminus is crucial for the biological activity of the a-factor.During the mating of Saccharomyces cerevisiae, the haploid state of yeast can be either α-type or a-type. Mating pheromones produced by these haploid cells can induce two different cell types to mate. The α-factor is released from α-type cells and bind to the G-protein coupled receptor (GPCR) Ste2p on a-cells, whereas the a-factor is released from a-type cells and binds to the GPCR Ste3p on α-cells.</p>

<p>Fibrinogen is a large plasma glycoprotein with a complex structure, and one of the most abundant proteins in blood. Fibrinogen is important in fibrin clot formation, haemostasis, and inflammatory responses. Increased plasma fibrinogen indicates a proinflammatory state and is a risk factor for vascular inflammatory diseases including hypertension and atherosclerosis. Fibrinogen cleavage products act as inflammatory activators in the pathophysiology of allergic asthma.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to fibrinogen and catalyses cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB). Fibrinopeptide B is protected from modifications such as carbamylation by pyroglutamination of the N-terminal amino acid.</p>

<p>Peptide H-WRQAAFVDSY-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Spexin is a neuropeptide that is conserved amongst humans and rodents. Spexin activates galanin2/3 receptors, inducing a different active conformation of GalR2 to galanin. The broad distribution of spexin suggests multiple physiological roles including as a regulating factor in obesity and energy metabolism. Spexin is ubiquitously expressed in human tissue, however, a correlation has been found with obesity and age. Obese patients had significantly lower levels of circulating spexin than those with a healthy weight range. The significance of this suggests spexin regulates appetite, feeding behaviour, and energy expenditure. Spexin also specifically inhibits the uptake of long-chain fatty acids by adipocytes.Spexin is a central modulator of cardiovascular and renal function and can elicit central nervous system behavioural responses. As spexin levels decrease with age there is research to understand if it plays a role in age-related pathophysiology of cardiometabolic conditions. Spexin is also being considered an early biomarker for cardiovascular disease due to the magnitude with which it decreases as the pathophysiology progresses.</p>

<p>FLAG tag with a GGC linker (Cy3B)</p>

<p>Substrate peptide for histone deacetylase (HDAC) enzymes for use in assaying HDAC activity. Histone deacetylases (HDACs) are a family of enzymes which are highly evolutionary conserved across all eukaryotes. HDACs modify histones by removing acetyl groups from the tail regions. Histone deacetylation is generally associated with reduced gene expression due to a more compact chromatin state less accessibility for transcription factors (TFs). HDACs are essential for many physiological processes including development and cellular homeostasis. They also play an important role in disease states, including neurodegenerative disorders, genetic diseases and cancers.This peptide is the fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Fluorescence can be detected upon fluorophore release.</p>

<p>Setd8 is a member of the SET domain containing family of proteins and is the sole methyltransferase that catalyses monomethylation of lysine 20 on histone H4 (H4K20me1). This histone modification is involved in regulating DNA replication, chromosome condensation and gene expression.Setd8 is widely expressed and in addition to modifying histone H4, it can modify non-histone proteins, including p53. Setd8 has been shown to play a role in maintaining skin differentiation and is dysregulated in multiple cancer types.</p>

<p>Peptide H-TLADLTLLDSPIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>