Bioquímicos e reagentes

<p>EGFR tyrosine kinase inhibitor</p>

<p>Peptide H-EGVLYVGSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about H1v Native 6 Peptide Mixture including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide Abz-GIEPFSDPMPEQ-EDDnp is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Selective vasopressin receptor V2 agonist</p>

<p>H-GPSVFPLAPSSK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GPSVFPLAPSSK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GPSVFPLAPSSK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GPSVFPLAPSSK-OH at the technical inquiry form on this page</p>

<p>Trastuzumab is a humanised immunoglobulin G1 monoclonal antibody against human epidermal growth factor receptor 2 (HER2), used in breast cancer treatments. Some potential extracellular and intracellular antitumor mechanisms of trastuzumab have been proposed, including activation of antibody-dependent cellular cytotoxicity, inhibition of extracellular domain cleavage, abrogation of intracellular signalling, reduction of angiogenesis and decreased DNA repair that result in tumour cell stasis and/or death. Its drug conjugate, trastuzumab deruxtecan (T-DXd), is used in the clinical therapy for pretreated HER2-mutant non-small cell lung cancer (NSCLC).</p>

<p>Peptide H-I^GHPAPNFK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified protein Heterophilic Antigen for Mononucleosis</p>

<p>Peptide H-GVASLFAGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VAVVRTPPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Residues 1-14 of the plasma glycoprotein angiotensinogen (ANG). ANG is a macromolecular precursor of angiotensin I and subsequent angiotensin family members. Angiotensins regulate blood pressure and electrolyte balance. ANG is selectively cleaved by the aspartic protease, renin, to initiate the angiotensin-processing cascade.This region represents the renin cleavage site of ANG, also known as renin substrate.</p>

<p>Peptide H-SLLMWITQV^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Amphipathic alpha-helical cationic antimicrobial peptides (AMPs) are rapidly bactericidal and have broad spectrum activity. As AMPs have non-specific modes of action involving membrane disruption, bacteria are less likely to develop resistance to them (unlike traditional antibiotics). KLAL is a model compound to form amphipathic helices that are able to bind to membranes and increase the membrane permeability. KLAL model peptides may also form a β-structure under appropriate conditions. Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Flurocitabine is a cytotoxic drug that is used in the treatment of cancer. It inhibits the activity of DNA polymerase and topoisomerase II, which are enzymes that maintain the integrity of DNA. Flurocitabine has been shown to be effective against inflammatory diseases, such as inflammatory bowel disease, and infectious diseases, such as HIV. Flurocitabine has also been shown to stimulate estrogen receptor modulators and fatty acid synthesis in vitro. Clinical studies have shown that flurocitabine can be implanted into c57/bl6 mice for slow-release delivery.</p>

<p>SARS-CoV-2 Spike (976-984)</p>

<p>Ara h 6 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins. Ara h 6 is a member of the 2S albumins (conglutinins) belonging to the prolamin superfamily which also includes Ara h 2. 2S albumins contain major food allergens from seeds of many mono- and dicotyledon plants and share a common compact structure that renders the proteins highly resistant to proteolysis.Ara h 6 contains multiple disulphide-bridged cysteine residues, resulting in a tightly coiled, heat-stable, protease resistant core structure that may be important for allergenicity. In mouse models Ara h 2 and Ara h 6 are the main cause of effector responses such as mast cell degranulation and anaphylaxis.This peptide represents a tryptic peptide of Ara h 6. The phenylalanine residue at position 11 of this peptide is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>Peptide H-NIPTVNENLENYYLEVNQLEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Mycoplasma pneumoniae antibody was raised in rabbit using purified Mycoplasma pneumoniae as the immunogen.</p>

<p>Piracetam is a nootropic drug that is used for the treatment of sickle cell disease, alcohol dependence and as a cognitive enhancer. This drug is a cyclic derivative of GABA and has neuroprotective and anticonvulsant properties. Piracetam has been said to improve neuronal plasticity.</p>

<p>Peptide derived from the HIV transactivator of transcription protein. TAT is a cationic cell-penetrating peptide.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system (CNS) on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for auto-antibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has an uncharged C-terminal amide, an acid form is also available in our catalogue.</p>

<p>H-LFFWWFTK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LFFWWFTK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LFFWWFTK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LFFWWFTK-OH at the technical inquiry form on this page</p>

<p>Normal Council Serum is a high-quality serum that contains a range of antibodies, interferon, and glycoproteins. It is derived from liver microsomes and is rich in lysine, which plays a crucial role in protein synthesis. This serum has been extensively tested for its antiviral properties and has shown significant activity against a variety of viruses. Additionally, Normal Council Serum contains lectins that have been proven to enhance immune response and promote the production of chemokines. It is widely used in life sciences research and veterinary applications due to its potent immunological effects. This serum is carefully formulated with excipients to ensure stability and efficacy. With its broad range of applications, Normal Council Serum is an essential tool for any researcher or veterinarian seeking to understand and manipulate the immune system.</p>

<p>Peptide H-VASLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about Metapneumovirus Fusion Antigen, Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CREB327/active transcription factor CREB-A (113-126) Biotinyl, human.</p>

<p>Histone H3 (32-47) is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.</p>

<p>Angiotensin II (Ang-II) is a key signalling peptide of the renin angiotensin system (RAS). The RAS is involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity is widely studied in relation to lifestyle-related diseases.Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGTis cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE), which removes a histidine and a leucine, from the C-terminus of Ang-I to form Ang-II.Ang-II exerts its affect by binding to the G-protein-coupled receptors- Ang-II type 1 (AT1) and Ang-II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer's disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancer. The effects of Ang-II appear to be supressed by another branch of the RAS- the ACE2/Ang-(1-7)/Mas pathway.The valine residue at position 3 and the isoleucine residue at position 5 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide.</p>

<p>Mouse monoclonal Zika virus envelope antibody</p>

<p>GnRH super-agonist</p>

<p>Peptide Fluor-HNSSLSPLATPA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified native Human VWF protein (Factor VIII Free)</p>

<p>Influenza A antibody was raised in mouse using Influenza A as the immunogen.</p>

<p>Peptide H-DCL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about Treponema Pallidum TmpA, Recombinant (No Sodium Azide) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-VMAPRTFLL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VMAPRTFLL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VMAPRTFLL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VMAPRTFLL-OH at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cy2 DiC18 (5) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Human Plasma from Cadaver including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Influenza B antibody was raised in mouse using nucleoprotein of influenza virus type B as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Inhibitor of angiotensin-converting enzyme</p>

<p>Region of IL13 protein corresponding to amino acids MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F.</p>

<p>Purified Human IgE Kappa protein</p>

<p>Peptide H-LGADMEDVCGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-SIRPP^YPSY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells to the cytoplasm and to the nucleus in a receptor-independent mechanism. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK), named penetratin, and used in several studies to aid entry of fusion proteins into cells.The full 60 amino acid homeodomain was fused to a T cell epitope of the influenza nucleoprotein and successfully internalised into T cells for presentation. The fragment known as penetratin was fused to a ligand for Grb-2 resulting in inhibition of downstream Grb-2 signalling events. Penetratin has also been used in vivo to prime cytotoxic T lymphocytes by conjugating short antigenic peptides to the CPP. Penetratin is provided here as a C-terminal amide with a C-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag often preferred over FITC due to its high stability- absorbance 492 (nm), 518 emission (nm).</p>

<p>Please enquire for more information about Follicle Stimulating Hormone (FSH), Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>