Bioquímicos e reagentes

<p>Myoglobin antibody was raised in mouse using human heart myoglobin as the immunogen.</p>

<p>Please enquire for more information about Plasmodium Falciparum HRP-2 (Malaria) Mouse Monoclonal Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Plasmodium LDH (Malaria) Mouse Monoclonal Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-DFFVWLHYYSVRDTL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DFFVWLHYYSVRDTL-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DFFVWLHYYSVRDTL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DFFVWLHYYSVRDTL-OH at the technical inquiry form on this page</p>

<p>H-Asp(Ala-OH)-OH is an amino acid that has been found to be selectively active in the cerebral cortex. It has a high affinity for the cerebral cortex, with a Kd of 1.5 nM and a brain tissue concentration of 3.3 µg/g. H-Asp(Ala-OH)-OH has been shown to have neuroprotective effects against hypoxia, glutamate toxicity, and oxygen deprivation. This compound reverses the effects of oxidative stress in cultured cells and can also stimulate protein synthesis in cultured cells. The mechanism by which it works is not yet known but may involve inhibition of cysteine uptake into the cell or stimulation of protein synthesis by increasing intracellular levels of cAMP.</p>

<p>Ac-His-D-Phe(p-Iodo)-Arg-Trp-NH2 is a peptide that binds to the melanocortin receptor. It is a potent antagonist of MSH and related peptides and has been shown to be effective in the treatment of cancer, including melanoma.</p>

<p>Human Serum Albumin</p>

<p>Gly-Pro is a cyclic peptide that binds to DPP-IV and inhibits proteolytic activity. It has been shown to have inhibitory properties against infectious diseases and cancer tissues, as well as a fluorescence probe for the detection of DPP-IV. Gly-Pro is also a potential inhibitor of neuronal death and has been shown to have structural analysis in the form of molecular docking analysis.</p>

<p>Cystatin C protein is a neutralizing protein that plays a crucial role in various biological processes. It is involved in the regulation of ornithine metabolism, glucose-6-phosphate production, and the activation of p53 protein. This protein is essential for the growth and development of cells, as it interacts with growth factors such as epidermal growth factor and histidine. Cystatin C also has binding properties with sclerostin, alpha-fetoprotein, and collagen, contributing to their stability and functionality. With its diverse functions and interactions, Cystatin C protein proves to be an integral component in Life Sciences research and applications.</p>

<p>H-CMFSLPLESDSMDPFR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CMFSLPLESDSMDPFR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CMFSLPLESDSMDPFR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CMFSLPLESDSMDPFR-OH at the technical inquiry form on this page</p>

<p>Tachyplesin is a type of cationic β-hairpin antimicrobial peptide (AMP) discovered from horseshoe crab hemocytes. This product has disulfide bonds between Cys3-Cys16, Cys7-Cys12 and is available as a trifluoroacetate salt.<br>One letter code: H-KWCFRVCYRGICYRKCR-NH2</p>

<p>Pdgfrb active human is an antibody that blocks the receptor tyrosine kinase of the platelet-derived growth factor family. It can be used for research in cell biology, pharmacology, and life science. The Pdgfrb active human antibody has been shown to inhibit PDGFRB phosphorylation and activation by a number of ligands, including PDGF-BB, PDGF-AB, and platelet-derived growth factor (PDGF). This antibody also inhibits the binding of PDGF to its receptor and can be used as a research tool to study protein interactions.</p>

<p>The Plasmodium vivax antibody is a highly specialized product that consists of polymers designed to target and neutralize the antigen produced by the Plasmodium vivax parasite. This monoclonal antibody is specifically developed to bind to the surface proteins of the parasite, preventing its ability to invade human red blood cells and causing malaria.</p>

<p>Teriflunomide isomer E is an antimicrobial agent which has been shown to inhibit the growth of bacteria by binding to basic proteins. This antibiotic has been used in vivo on humans and in vitro on human cells, and it has been shown to inhibit autophagy. Teriflunomide isomer E binds to uridine and inhibits the polymerase chain reaction (PCR) of DNA, preventing replication. It also inhibits the production of cyclin D2, an anti-inflammatory cytokine that limits inflammatory responses. In addition, teriflunomide isomer E binds to nonsteroidal anti-inflammatory drugs (NSAIDs), inhibiting their activity.</p>

<p>SARS-CoV-2/Flu A/Flu B/RSV Negative Human Nasal Swab (UTM) is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about SARS-CoV-2/Flu A/Flu B/RSV Negative Human Nasal Swab (UTM) including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Natriuretic; vasodilatory;diuretic; treats decompensated congestive hear failure</p>

<p>Proinsulin antibody was raised in mouse using human proinsulin as the immunogen.</p>

<p>Ac-CRVTHPHLPRALMRS-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CRVTHPHLPRALMRS-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CRVTHPHLPRALMRS-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CRVTHPHLPRALMRS-NH2 at the technical inquiry form on this page</p>

<p>Ac-TEAAGAM-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-TEAAGAM-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-TEAAGAM-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-TEAAGAM-NH2 at the technical inquiry form on this page</p>

<p>H-EGVTVLINEDK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EGVTVLINEDK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EGVTVLINEDK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EGVTVLINEDK-OH at the technical inquiry form on this page</p>

<p>Gly-Leu-Gly is a peptide that has a conformation in which the side chain of the amino acid glycine is attached to the alpha-carbon atom of the amino acid leucine. It is a labile molecule, meaning that it can react with other molecules or break down spontaneously. Gly-Leu-Gly is also called glycylleucine. This peptide has been found to have protonation properties that depend on temperature and kinetic energy. The carbonyl group of this peptide interacts with other molecules by donating or accepting electrons. In addition, this compound can be analyzed using spectrometers and gas chromatographs.</p>

<p>Dipeptidyl peptidase 4 (DPP4) inhibitor</p>

<p>Hepatitis A virus antibody was raised in mouse using purified hepatitis A as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SLC38A1 antibody, catalog no. 70R-1754</p>

<p>Analeptic</p>

<p>This is a monoclonal antibody that binds to the alpha-integrin receptor. The alpha-integrin receptor is an integrin that is involved in cell adhesion and migration, as well as the activation of several signaling pathways. This antibody has been shown to inhibit the binding of alpha-integrins to phospholipid membranes, which may be due to inhibition of protein kinase C (PKC). This antibody also inhibits thrombin receptor activation and dextran sulfate-induced cytosolic calcium mobilization.</p>

<p>Dengue Virus lgG/lgM Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Dengue Virus lgG/lgM Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide H-SAVTALWGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide LCBiot-PSKPSKRSFIEDLLFNKV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-YLPNPALQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LSARLAF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Darifenacin is a muscarinic antagonist that is used for the treatment of urinary incontinence. It specifically blocks the M3 muscarinic acetylcholine receptor which in return reduces the urgency to urinate.</p>

<p>Purified native Human hCG alpha protein</p>

<p>Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression. Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types._x000D_<br>_x000D_<br>This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.</p>

<p>CDK16 peptide substrate is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified native Human Urokinase protein (Low MW)</p>

<p>Activator of RET signalling cascade and a derivative of a GFL mimetic compound BT 13. Molecular docking calculations and molecular dynamics simulations were performed in GDNF−GFRα1−RetA complex and showed that BT 18 binds to the allosteric site in GFRα1 as well as RetA surface interfacing GFRα1.</p>

<p>Gluten Exorphin A5 is a δ opioid that has been synthetically produced. It binds to the μ-opioid receptor, which is found on cells in the gastrointestinal tract, and can be used to treat inflammatory diseases and autoimmune diseases. Gluten Exorphin A5 also has anti-cancer properties, as it inhibits cell proliferation and induces apoptosis in colon cancer cells by binding to their surface. Gluten Exorphin A5 is orally active and can be used for the treatment of infectious diseases. This drug also binds to bacterial surfaces and blocks the pain response induced by naloxone. The molecular weight of Gluten Exorphin A5 has been determined using a spectrometer after purification.</p>

<p>Peptide derived from vitronectin, the mammalian glycoprotein which plays a key role in tissue repair and remodelling. Its properties as an adhesive protein allow mammalian cells in serum to interact with culture vessels.</p>

<p>A human truncated analog of Obestatin, a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.</p>

<p>Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is an RNA-binding protein (RBP) which recognises two related GGC-core elements (GGCA and CGGC) and is of particular interest in tumorigenesis and tumour progression.RBPs play a major role in regulating the RNA life cycle via directing nuclear export, translation and degradation rates, and in the intracellular localisation of RNA transcripts. IGF2BP3 has been implicated in various aspects of human tumour progression including cell growth, migration, and the response to drugs, depending on cellular context. IGF2BP3 is able to bind and segregate oncogene transcripts into granules (locasomes). Once in these granules they are protected from let-7-dependent silencing and other miRNAs and therefore offer a safe house from degradation. However in other contexts IGF2BP3 can also promote the association between mRNAs and RISC, to favour mRNA degradation.IGF2BP3 is expressed in mouse embryos in neural cells, intestine, thymus, pancreas, and kidney epithelial germ layers where it plays a general role in neural development and organogenesis. IGF2BP3 is also detected in the placenta, lymph nodes, tonsils, and testes in adult humans. The lysine residue at position 1 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.</p>

<p>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB is a resin that has been synthesized by the Fmoc group. The resin is used to attach peptides, proteins and other organic molecules to a solid support for use in research. The resin is also an activator of ligands and can be used as a receptor for the binding of antibodies. The resin has high purity and is made from methacrylate polymer. It contains no detectable levels of hydroquinone and 4-Vinylpyridine.<br>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB can be used as a research tool in cell biology, immunology, pharmacology, protein interactions, receptor binding, ion channel activation and more. CAS No.: 58897-27-6</p>

<p>H-YLLPAIVHI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YLLPAIVHI-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YLLPAIVHI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YLLPAIVHI-OH at the technical inquiry form on this page</p>

<p>HIV-1 replication is rapid and error prone which is beneficial to the virus as it allows mutations to arise that aid evasion of the host immune system and resistance to drug treatment. RT is the key target for most anti-HIV drugs and therefore conserved sequences are useful to aid further research into new less toxic antiviral treatments.  HIV-1 reverse transcriptase (RT) converts the RNA genome into DNA during retroviral replication. HIV-1 RT is a heterodimer composed of 2 subunits, p66 and p51. HIV-1 RT heterodimer has 2 enzymatic functions, DNA polymerase and Rnase H resulting in nucleic acid translation to a linear DNA duplex. Complete inhibition of viral replication is the only known method of preventing HIV-1 drug resistance and disease progression.HIV RT epitopes have become a useful research tool as an in vitro antigenic challenge to study cytotoxic T lymphocyte (CTL) responses to retroviruses. The HIV-1 RT A2-YI9 sequence has been shown to be an effective epitope for CTL recognition leading to lysis of HIV-infected T cells. The A2-YI9 is also considered a potential for vaccine development due to it being a well conserved sequence. Synthesised HIV-1 RT A2-YI9 is provided here with N-terminal acetylation to mimic the charge of the native peptide more closely. The epitope is also available without acetylation from our catalogue.</p>

<p>H-Arg-Glu(Edans)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dabcyl)-Arg-OH is a peptide that is a substrate for the enzyme beta secretase. It has been observed to inhibit γ secretase activity in cell culture. This product can be used as an enzyme substrate or biochemicals, such as memapsin.</p>

<p>CBL-B (22-37) is derived from the CBL-B E3 ubiquitin ligase which targets receptor tyrosine kinases to lysosome degradation. CBL-B and its family member CBL are expressed in hematopoietic cells and as E3 ubiquitin ligases they contain a tyrosine kinase domain and an RF domain joined by a linker domain. The function of the RF domain is to transfer ubiquitin from E2 ubiquitin-conjugating enzymes onto the target protein which is often phosphorylated. Consequently the ubiquitinated substrate, the receptor tyrosine kinases, are ultimately targeted to the lysosome for degradation.EGFR is an example of a receptor tyrosine kinase whose activation is prevented by CBL and CBL-B when they bind and recruit GRb2, the adapter protein to EGFR. Consequently the ubiquitinylation of EGFR occurs and targets it for recognition by the endosomal protein complex and then lysosome degradation.It has also been found that the CBL family can negatively regulate through ubiquitinylation, PI 3-kinases, Rap G-protein guanine nucleotide exchange factor (GEF), C3G and Rho GTPase GEF Vav which are all non-receptors.If CBL or CBL-B becomes non-functional it can be associated with malignancies such as acute mye-loid leukemia and myelodysplastic syndrome.The lysine residue at position 16 is isotopically labelled with carbon-13 (6) and nitrogen-15 (2).</p>

<p>M3541 is a potent inhibitor of tyrosine kinases that blocks the activity of the enzyme epidermal growth factor receptor by binding to its ATP-binding site. It is also an inhibitor of protein kinase C. M3541 has been shown to induce apoptosis in many types of cancer cells, including leukemia, breast and lung cancer cells.</p>

<p>H-LPPYIFT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LPPYIFT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LPPYIFT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LPPYIFT-OH at the technical inquiry form on this page</p>

<p>H-SGQQQGLPRAAGGSVPC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SGQQQGLPRAAGGSVPC-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SGQQQGLPRAAGGSVPC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SGQQQGLPRAAGGSVPC-OH at the technical inquiry form on this page</p>

<p>Peptide Ac-RKST-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>