Bioquímicos e reagentes

<p>Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine is used to prepare ppGpp analogs as inhibitors of RelA from Gram-negative/-positive bacteria. It is also used to synthesize guanosine 5'-conjugates as initiator molecules for transcription priming.<br>References Wexselblatt, E., et al.: Bioorg. Med. Chem., 18, 4485 (2010); Wolf, J., et al.:Org. Biomol. Chem., 6, 899 (2008)<br></p>

<p>Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.<br>References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),<br></p>

<p>Stability Very Hygroscopic<br>Applications Fluorescent label for glycoproteins and saccharides.Dyes and metabolites.<br>References Wang, D., et al.: Langmuir, 17, 1262 (2001), Cappuccio, F., et al.: J. Fluoresc., 14, 521 (2004), Cordes, D., et al.: Org. Biomol. Chem., 3, 1708 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications gamma-Polyglutamic acid - sodium salt (cas# 25513-46-6) is a useful research chemical.<br></p>

<p>Applications Anthrose (cas# 769959-88-8) is a compound useful in organic synthesis.<br>References Saksena, R., et al.: Carbohydrate Research, 340, 1591 (2005)<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Applications Nisin Z Hydrochloride is a peptide antibiotic synthesized by Lactococcus lactis. Nisin Z interacts with lipid II, a lipid component of cell wall, to form pores in the plasma membrane.<br>References Kuipers, O. P., et al.: J. Biol. Chem. 270, 27299 (1995); Breukink, E., et al.: Science 286, 2361 (1999); Breukink, E., et al.: Biochemistry 36, 6968 (1997)<br></p>

<p>Applications D-Idose is a monosaccharide that is an important component of dermatan sulfate and heparan sulfate.<br>References Olsen, S.G., et al.: J. Biol. Chem., 264, 15982 (1989);<br></p>

<p>Applications Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness.<br>References Shimshick, E., et al.: Biochemistry, 1973, 12, 2351 (1973), Kolesnick, R., et al.: J. Cell Physiol., 184, 285 (2000), Goni, F., et al.: Biochim. Biophys. Acta., 1758, 1902 (2006),<br></p>

<p>Applications 4,6-Di(methyl-d3)benzen-2,3,5-d3-amine is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.<br>References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications 2-Pentylidenecyclohexanone, is the fragrance chemical. It can also be used in the synthesis of dialkylphenols in the presence of zirconium catalyst.<br>References Tetsuo, B. et al.: Kenkyu Hokoku - Asahi Garasu Zaidan, 58, 201 (1991); Hostynek, J. J., et al.: Toxicology in Vitro, 11, 377 (1997);<br></p>

<p>Applications 1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine is a long chain fatty acid, acting as a luminescence marker. Is used in enhancing radiotherapy for cancer treatment<br>References Dotsikas, Y. et al.: Anal. Sci., 28, 753 (2012); Choi, J. et al.: J. Nanomet., 8, 863704, (2012);<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 2000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications Eosine-5-isothiocyanate is a fluorescence probe.<br></p>

<p>Applications Hydantoin (cas# 461-72-3) is a compound useful in organic synthesis.<br></p>