Bioquímicos e reagentes

<p>Stability Moisture Sensitive<br>Applications Succinic Anhydride is a useful compound in the paper manufacturing process.<br>References Ikeda, S., et al.: Jpn. Tokkyo Koho (2021), JP 6822596 B1<br></p>

<p>Applications Pigment Red 170 (cas# 2786-76-7) is a useful research chemical.<br></p>

<p>Applications A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.<br>References Sznaidman, M.L., et al.: Bioorganic and Medicinal Chemistry Letters, 13, 1517 (2003)<br></p>

<p>Applications 4-Vinylphenol, 10 wt.% In propylene glycol (cas# 2628-17-3) is a useful research chemical.<br></p>

<p>Applications Chocolate Brown HT (CAS# 4553-89-3) is a synthetic organic food colourant, and a long-term carcinogen.<br>References Amchova, P.; et al.: Regul. Toxicol. Pharm., 73, 914 (2015); Aguilar, F.; et al.: EFSA Journal, 8, 1536 (2010).<br></p>

<p>Applications S-Methyl-L-cysteine is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). It has been studied as a theurapeutic for neurodegenerative diseases including Parkinson′s.<br>References Wassef, R., et al.: J. Neurosci., 21, 12808 (2007)<br></p>

<p>Applications (25R)-26-Hydroxycholesterol is a desmosterol metabolite that is found in the brain. 26-Hydroxycholesterol has been used as a biomarker for carbon cycling in the northwestern Mediterranean Sea.<br>References Meljon, A., et. al.: J. Lipid Res., 53, 2469 (2012); Christodoulou, S., et. al.: Marine Chem., 113, 25 (2009)<br></p>

<p>Applications A Cholesterol (C432501) metabolite. Lathosterol (indicating cholesterol synthesis) and Sitosterol (indicating cholesterol absorption) also decreased with deteriorating health. Low Lathosterol, Sitosterol (S497050), and Cholesterol (C432501) predicted mortality additively and independently of each other.<br>References Chyou, P., et al.: Age Ageing, 29, 69 (2000), Schatz, I., et al.: Lancet, 358, 351 (2001), Bjorkman, M., et al.: Eur. J. Endocrinol., 158, 749 (2008),<br></p>

<p>Applications Methyl 2-Acetamido-4-O-(2-acetamido-2-deoxy-β-D-gluco- pyranosyl)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 97242-84-7) is a compound useful in organic synthesis.<br>References Carb. Res., 103, 15 (1982)<br></p>

<p>Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays &gt;800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.<br>References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Calcifediol is a metabolite of Vitamin D. The principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Morii, et al.: Arch. Biochem. Biophys., 120, 513 (1967); Blunt, et al.: Biochemistry, 7, 3317 (1968), Liu, et al.: Science, 311, 1770 (2006);<br></p>

<p>Applications Novel acridinium esters are disclosed that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays.<br>References Bolt, H., et al.: Toxicol. Lett., 151, 251 (2004), Malhotra, S., et al.: Bioorg. Med. Chem. Lett., 20, 581 (2010), Natrajan, A., et al.: Anal. Biochem., 406, 204 (2010),<br></p>

<p>Applications N-Carbamyl-L-glutamic Acid has been shown to have protective effects against ammonia intoxication and is used in the treatment of acute hyperammonemia.<br>References Paik, W.K. et al.: Life Sci., 15, 1189 (1974); O'Connor, J.E. et al.: Eur. J. Pediat., 148, 540 (1989); Lee, J.H. et al.: Biochem. Biophys. Res. Chem., 248, 391 (1998);<br></p>

<p>Stability Light Sensitive<br>Applications δ-Tocotrienol is a natural substance with vitamin E activity. It can work as an antioxidant. It inhibits the growth of human breast cancer cells.<br>References Sen, C., et al.: Life Sci., 78, 2088 (2006); Yoshida, Y., et al.: Chem. Phys. Lipids, 123, 63 (2005)<br></p>

<p>Stability Light Sensitive<br>Applications 1,2-Dilinoleoyl-3-palmitoyl-rac-glycerol is a triacylglycerol found in sesame oil.<br>References Lee, D., et al.: Analytica Chimica Acta, 429, 321 (2001); Jahaniaval, F., et al.: J. AM. Oil Chem. Soc., 77,847 (2000)<br></p>

<p>Applications Used for fragrance compositions and perfumes with long-lasting fragrance.<br>References Ternes, T., et al.: Sci. Total Environ., 225, 81 (1999), Simonich, S., et al.: Environ. Sci. Technol., 36, 2839 (2002) Metcalfe, C., et al.: Environ. Toxicol. Chem., 22, 2872 (2003),<br></p>

<p>Applications Ethyl β-D-Thiogalactopyranoside (cas# 56245-60-4) is a compound useful in organic synthesis.<br></p>