Bioquímicos e reagentes

<p>Please enquire for more information about (Pyr³)-Amyloid B-protein (3-42) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CA 125 antibody (biotin) was raised in mouse using affinity pure human CA 125 antigen as the immunogen.</p>

<p>Guaiacin is a guaianolide that is an inhibitor of the protein phosphatase 1 (PP1). It has been shown to bind to PP1 and inhibit its activity, leading to increased levels of the cellular messenger cAMP. Guaiacin has also been shown to activate PP2A, which may contribute to its anti-inflammatory effects. Guaiacin has been used as a research tool in cell biology and pharmacology studies. It is available in high purity and can be used as an antibody reagent for immunocytochemistry.</p>

<p>1-Palmitoyl-rac-glycero-3-phosphocholine is a biological lipid that has been shown to be a potent growth factor for cells in culture. It binds to DNA and modulates transcriptional regulation. 1-Palmitoyl-rac-glycero-3-phosphocholine also inhibits the production of lysophosphatidylcholine, which is an inflammatory mediator that promotes the release of histamine from mast cells. This compound may be useful as an antimicrobial agent, as it has been shown to inhibit the growth of bacteria and fungi.</p>

<p>Please enquire for more information about H-Gly-Leu-Gly-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TFA salt</p>

<p>Please enquire for more information about 3-Bromo-L-thyroxine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cagrilintide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The hCG protein is a growth factor that plays a crucial role in various biological processes. It is involved in the regulation of cell growth, differentiation, and development. This protein has been extensively studied in the field of Life Sciences and has shown promising results in various applications. One of the key characteristics of the hCG protein is its ability to interact with arginase, an enzyme involved in the metabolism of arginine. Through molecular docking studies, it has been shown that hCG can bind to arginase and modulate its activity, leading to potential therapeutic applications. Monoclonal antibodies targeting the hCG protein have been developed for research purposes. These antibodies are highly specific and can be used in immunoassays to detect and quantify hCG levels in human serum samples. They have also been used for the immobilization of hCG on electrodes, enabling the development of biosensors for diagnostic purposes. Furthermore, studies have demonstrated that the hCG protein plays a role in the regulation of mes</p>

<p>The Methotrexate antibody is a monoclonal antibody that specifically targets and binds to Methotrexate, a commonly used cytotoxic drug in the field of Life Sciences. This antibody has been extensively tested and validated for its high affinity and specificity towards Methotrexate. It can be used in various applications such as ELISA, Western blotting, immunohistochemistry, and flow cytometry. The Methotrexate antibody works by binding to Methotrexate molecules and preventing their interaction with their target enzymes involved in DNA synthesis. This inhibits the growth of cancer cells and autoimmune responses mediated by activated T-cells. Additionally, this antibody can also be utilized as a tool for studying the intracellular localization and trafficking of Methotrexate within cells. The unique features of this Methotrexate antibody include its ability to recognize both free Methotrexate molecules as well as Methotrexate conjugated to proteins or other biomolecules. It exhibits minimal cross-reactivity with</p>

<p>TES, also known as N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, is a buffering agent that is used in protein assays and forms complexes with DNA and copper ions. The optimal pH range of this zwitterionic buffer is 6.8-8.2 and its pKa is 7.4.</p>

<p>LY 117018 is a dopamine analog that binds to the toll-like receptor and blocks the production of proinflammatory cytokines. LY 117018 also inhibits epidermal growth factor (EGF) in liver cells and cyclin D2, which is involved in cell cycle regulation. This drug has been shown to be effective in a model system using fetal bovine serum with angiogenic factors, such as vascular endothelial growth factor (VEGF). The effect on blood vessels was dose-dependent for LY 117018. This drug potentiates the actions of 17β-estradiol on mcf-7 cells and serum prolactin levels are significantly decreased in vivo by this compound.</p>

<p>Please enquire for more information about H-Leu-Leu-Gly-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Endogenous heptapetide which causes vasodilation and has anti-hypertensive properties.</p>

<p>Imidazole-15N2 is an analog of the calcium channel blocker nifedipine that has been shown to have anticancer properties. It induces apoptosis in cancer cells by inhibiting protein kinases, which are involved in tumor growth and survival. Imidazole-15N2 has been studied in both Chinese hamster ovary cells and human cancer cell lines, where it has demonstrated potent inhibition of kinase activity. This drug is a promising candidate for the development of novel cancer therapies due to its ability to selectively target cancer cells while sparing normal cells. Imidazole-15N2 can be detected in urine and may serve as a biomarker for the presence of protein kinase inhibitors in the body.</p>

<p>FAPI-46 trifluoroacetate is a fibroblast activation protein (FAP) inhibitor, which is synthesized as part of targeted cancer research efforts. It is derived from chemical engineering processes focusing on the modification of small molecules to selectively interact with FAP, an enzyme overexpressed in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. FAPI-46 binds to and inhibits FAP, reducing its enzymatic activity. By blocking FAP, FAPI-46 trifluoroacetate disrupts the tumor-promoting interactions between CAFs and tumor cells, potentially impeding tumor growth and progression.</p>

<p>Please enquire for more information about Ethyl N,N,N',N'-Tetraisopropylphosphorodiamidite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Opiorphin trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzoylecgonine antibody was raised in mouse using benzoyl ecgonine-BSA as the immunogen.</p>

<p>Diynes are a group of unsaturated fatty acids that have two carbon-carbon double bonds. 16:0-23:2 Diyne pe is a growth factor that has been shown to increase the proliferation of prostate cancer cells in vitro. It has also been shown to stimulate angiogenesis, or the formation of new blood vessels from pre-existing ones. It has been found to be an important prognostic factor for cervical cancer and may be used as a predictive marker for prognosis and treatment. This compound is present in human serum at low levels and is increased by liver damage, inflammation, or other diseases such as hepatitis. 16:0-23:2 Diyne pe may also play a role in preeclampsia and cell culture, where it stimulates cell proliferation. In addition, this compound may act as a receptor for fatty acid metabolism.</p>

<p>UK 383367 is a chemical compound classified as a synthetic small molecule, which is derived from a meticulously controlled chemical synthesis process. Its mode of action involves modulating specific biochemical pathways by binding to target receptors, thereby influencing cellular processes at a molecular level. This compound is utilized extensively in pharmaceutical research for its potential therapeutic effects, particularly in the context of investigating receptor activity and signaling pathways. Additionally, UK 383367 finds applications in various industrial processes, serving as an intermediate in the synthesis of more complex compounds. Due to its precision in targeting and influencing biological systems, UK 383367 is a valuable tool for scientists seeking to elucidate the mechanistic pathways underlying disease and for the development of novel therapeutic strategies.</p>

<p>Mucin antibody was raised in mouse using Mucin isolated from ovarian mucinous cysts and colonic mucosa as the immunogen.</p>

<p>Please enquire for more information about H-Ala-Ala-Ala-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Acetylpiperazine-N-(4-phenol) ketoconazole is an analog inhibitor that has been shown to inhibit the activity of several kinases. This compound has been tested against a variety of cancer cells and has demonstrated potent anticancer activity, inducing apoptosis in Chinese hamster ovary cells. N-Acetylpiperazine-N-(4-phenol) ketoconazole also inhibits the activity of dapoxetine, a drug used to treat premature ejaculation. In addition to its anticancer properties, this compound has shown promise as an anti-inflammatory agent due to its ability to inhibit the production of prostaglandins. This inhibitor can be detected in urine and may have potential therapeutic applications in the treatment of various cancers.</p>

<p>ALX-1393 is a synthetic compound that acts as an inhibitor, specifically targeting the glycine transporter 1 (GlyT1). As a small molecule inhibitor derived from chemical synthesis, it modulates neurotransmitter systems by blocking the reuptake of glycine, an important co-agonist of the NMDA receptor, in the central nervous system. The mode of action of ALX-1393 involves binding to the GlyT1 transporter, thereby increasing the synaptic concentration of glycine. This elevation in glycine levels enhances NMDA receptor function, which is crucial for synaptic plasticity, learning, and memory.</p>

<p>Please enquire for more information about H-Val-Val-Val-OH trifluroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzoic acid 5-amino-1-(4-methoxy-benzenesulfonyl)-1H-pyrazol-3-yl ester is a synthetic chemical compound used primarily in advanced organic synthesis. It is derived from benzoic acid and functionalized with a pyrazole moiety, enhancing its reactivity and versatility in chemical transformations. This compound acts as an intermediate in the synthesis of more complex molecules, playing a crucial role as a precursor or reagent due to its unique structure, which facilitates targeted chemical modifications.</p>

<p>Lactimidomycin is a peptide antibiotic that blocks the activity of ion channels, which are proteins that control the flow of ions across cell membranes. Lactimidomycin binds to specific ligands on the surface of cells and inhibits membrane depolarization. It has been shown to inhibit the activity of calcium-gated potassium channels, hyperpolarize nerve cells, and inhibit neuronal excitability. Lactimidomycin has also been shown to be an inhibitor of protein interactions with antibodies and other cellular factors. This drug can be used as a research tool for studying protein interactions in living cells. Lactimidomycin is available in high purity and at CAS No. 134869-15-1.</p>

<p>1,2-Dipalmitoyl-3-dimethylammonium-propane is a cationic lipid, which is a type of synthetic lipid commonly used in biochemical and biophysical research. It is sourced from chemical synthesis, involving the formulation of lipid molecules with specific chemical modifications to confer particular properties. The mode of action of this compound involves its ability to integrate into lipid bilayers and form liposomes. These liposomes can encapsulate nucleic acids, facilitating their delivery into cells by merging with cell membranes, which is crucial for gene delivery applications.</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPK{pT}PPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Foslevodopa is a prodrug that is converted to levodopa in the body. This drug has been shown to be safe and effective for the treatment of Parkinson's disease with minimal side effects, although it does not affect the progression of the disease. Foslevodopa is a synthetic compound that has been synthesized using chemical methods. It can be manufactured in large quantities, making it a scalable pharmaceutical formulation.</p>

<p>Diethoxy disulfide is a cyclin-dependent kinase inhibitor that induces apoptosis in cancer cells. It is an analog of the medicinal plant compound, alliin, and has been found to have potent anticancer activity. Diethoxy disulfide inhibits the activity of Chinese hamster ovary cell cycle kinases and human tumor-associated kinases, leading to cell cycle arrest and inhibition of cancer cell growth. This compound has been shown to be effective against a variety of cancer types, including breast, lung, and prostate cancer. Additionally, it has been found to sensitize cancer cells to other anticancer drugs by enhancing their cytotoxic effects. Overall, diethoxy disulfide is a promising candidate for the development of novel anticancer therapies.</p>

<p>A naturally isolated steroid</p>

<p>S 25585 is a psychostimulant that has been shown to modulate the function of animals. It can be used in the treatment of cancer and autoimmune diseases, as well as to induce overfeeding in animals. S 25585 is an endogenous molecule with a cyclic structure. The affinity for binding of S 25585 to its receptor may depend on whether it is bound or unbound at the time of binding. This drug also has anti-cancer effects, which are due to its ability to inhibit uptake and stabilize cells that are not undergoing cell division. 6-Fluoro-3-indoxyl-beta-D-galactopyranoside (Rifapentine) is an antituberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing</p>

<p>H-Met-Gln-OH TFA salt is a recombinant human metalloproteinase that has been shown to activate polymorphonuclear and mononuclear cells. H-Met-Gln-OH TFA salt enhances the production of reactive oxygen species and induces the release of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1, and interleukin 6. This protein also cleaves sulfoxide bonds in proteins, which may be due to its ability to catalyze the oxidation of sulfhydryl groups in proteins. H-Met-Gln-OH TFA salt has been shown to be effective in enhancing red blood cell production, which may be due to its ability to cleave hemoglobin S bonds in erythrocytes.</p>

<p>Secologanate is a peptide that has been used as a research tool to study the interactions between proteins and ligands. Secologanate is an inhibitor of ion channels, which are membrane-spanning proteins that control the flow of ions in and out of cells. It also inhibits protein interactions by blocking the binding site on one molecule for a second molecule. Secologanate has been shown to inhibit the ion channel TRPV1, which is involved in pain sensation. Secologanate has also been shown to be a ligand for the human angiotensin II receptor type 1 (AT1R).</p>

<p>The Tetracycline antibody is a highly specific monoclonal antibody that binds to tetracycline, a broad-spectrum antibiotic. This antibody has a high receptor binding affinity and can be used in various applications, such as polymerase chain reactions (PCR), immunohistochemistry, and Western blotting. It specifically targets tetracycline residues in biological samples, allowing for the detection and quantification of this antibiotic. In addition to its use in research, the Tetracycline antibody has potential applications in the field of medicine. It can be used to study the cellular localization of tetracycline within cells or tissues, providing valuable insights into its mechanism of action. Furthermore, this antibody can be utilized to investigate protein-protein interactions involving tetracycline or its derivatives. The Tetracycline antibody is produced using advanced techniques in monoclonal antibody production. It exhibits high specificity and sensitivity, ensuring reliable and accurate results. This antibody is compatible with various sample types, including</p>

<p>Cys-Gly-3M3SH is a cationic antimicrobial peptide that has been shown to be effective against Staphylococcus aureus. Cys-Gly-3M3SH binds to the bacterial enzyme urease, which is responsible for converting urea into ammonia and carbon dioxide. The binding of this peptide prevents the hydrolysis of urea, leading to cell death by disruption of the proton motive force. Cys-Gly-3M3SH is also biotransformed by bacteria in humans and can be used as a probe for transport studies in vitro. It can also be used as a molecular probe for structural biology research, such as protein crystallization and electron microscopy studies.</p>

<p>N-[(1S)-1-(3-Fluorophenyl)-3-[(1R,5S)-3-[2-methyl-5-(2-methylpropanoyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-1-yl]-8-azabicyclo[3.2. 1]octan-8-yl]propyl]acetamide is a research tool for use in cell biology and pharmacology studies. It is an activator that binds to the receptor or ligand and stimulates the activity of the protein. It has been shown to bind to ion channels, which are proteins that regulate the flow of ions across a biological membrane. This drug also interacts with antibodies and peptides (small chains of amino acids), which are important in life sciences as they are involved in many cellular functions including enzyme regulation and energy production.</p>

<p>CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.</p>

<p>Please enquire for more information about Cyclo(L-alanyl-L-tryptophyl) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response</p>

<p>D-Hyoscyamine is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It works by inhibiting kinases, which are enzymes that play a key role in the regulation of cell growth and division. D-Hyoscyamine has been tested on both human and Chinese hamster ovary cells, and has demonstrated significant anticancer activity. It is an analog of several kinase inhibitors, including cyclin-dependent kinase (CDK) inhibitors, which are commonly used in cancer therapy. In addition to its anticancer properties, D-Hyoscyamine has also been found to have potential therapeutic applications for other diseases such as Alzheimer's disease and Parkinson's disease. It is derived from urine and acts as a potent inhibitor of protein kinases.</p>

<p>Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is a fluorescent marker that can be used in immunohistochemical staining. It binds to endogenous vasoactive intestinal peptide, calcitonin and other proteins in tissues and can be detected using immunostaining. Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is optimised for use as a substrate for neutral endopeptidase and metalloendopeptidase enzymes, which are responsible for the degradation of vasoactive intestinal peptide.</p>

<p>Aryl hydrocarbon receptor (AhR) agonist</p>

<p>Please enquire for more information about 1,8-Dinitropyrene-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Pheromone Cymit Quimicaesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Demethylcolchicine is a research tool for the study of ligand-receptor interactions and cell biology. It has also been used to study ion channels in the central nervous system, as well as antibody production. 1-Demethylcolchicine is a potent inhibitor of protein synthesis and is used to study peptides and proteins. 1-Demethylcolchicine binds to the receptor site on cells, which inhibits the activity of the ion channels that are responsible for generating an action potential. This inhibition leads to decreased nerve impulses in neurons, which may contribute to its sedative effects.</p>

<p>VS1 is a novel synthetic peptide, which is engineered to function as an antimicrobial agent. This peptide originates from recombinant DNA technology, providing a customizable approach to target specific microbial strains. Its mode of action involves the selective disruption of microbial cell membranes, leading to the lysis and consequent death of the target cell. The specificity of VS1 for microbial cells over mammalian cells minimizes off-target effects, making it a highly effective agent for infection control.</p>

<p>DTR-I is an analog of ghrelin, a protein hormone that regulates appetite and energy balance. It is a potent inhibitor of kinases, which are enzymes that play a crucial role in cancer cell growth and survival. DTR-I has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells. This anticancer effect is thought to be due to its ability to inhibit the activity of protein kinases that are overexpressed in human tumors. In addition, DTR-I has been found in urine samples from Chinese cancer patients, indicating its potential as a diagnostic marker for certain types of cancer. The development of DTR-I as a novel anticancer agent holds promise for the treatment of various types of cancer in the future.</p>

<p>L-leucine with a lipid chain.</p>

<p>Please enquire for more information about 4-[3-[5-Amino-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl]propyl]phenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Faradiol 3-laurate is an analog that has been shown to induce apoptosis in cancer cells. It is a promising compound for the treatment of tumors due to its ability to inhibit proteins that are involved in cancer cell growth and survival. Faradiol 3-laurate has been found in medicinal plants and human urine, and has been used as a Chinese traditional medicine for centuries. This compound is also a potent inhibitor of kinases, which are enzymes that play a critical role in the regulation of cellular processes such as cell growth and differentiation. Its anticancer properties make it an attractive candidate for further research in the development of novel cancer therapies.</p>

<p>1-Oleoyl-2-docosahexaenoyl phosphatidylcholine is a fatty acid derived from the biogenesis of phosphatidylcholine, which is an important component of all cell membranes.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TPCN1 antibody, catalog no. 70R-5158</p>

<p>Sheep polyclonal Mescaline antibody</p>

<p>Osmanthuside H is a natural compound, specifically a phenylethanoid glycoside, which is predominantly sourced from the plant Osmanthus fragrans, as well as other related species. This compound is characterized by a specific glycosidic linkage that contributes to its stability and bioactivity. The mode of action of Osmanthuside H primarily involves its significant antioxidant properties, attributed to the presence of its phenolic structure and glycosidic moiety. This facilitates its role in scavenging free radicals and reducing oxidative stress within biological systems.</p>

<p>The CYFRA21-1 antibody is a powerful tool in the field of Life Sciences. This antibody specifically targets fibronectin, a protein involved in cell adhesion and migration. It has cytotoxic properties, making it useful for studying cellular processes and identifying potential therapeutic targets. Additionally, the CYFRA21-1 antibody can be used to detect inhibitory factors or antiphospholipid antibodies in biological samples. It is also effective in detecting insulin antibodies, autoantibodies, and antibodies involved in glycosylation processes. With its high specificity and sensitivity, this monoclonal antibody is an invaluable tool for researchers looking to uncover new insights into various biological pathways and disease mechanisms.</p>

<p>Please enquire for more information about Coibamide A including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Bantag-1 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>S-Lenalidomide is a drug that is used to treat cancer and autoimmune diseases. It is an immunomodulatory agent that induces cytokine release and inhibits the production of interleukin-2 (IL-2) by T cells. This drug also has a concentration-dependent effect on the activity of oxidative enzymes, such as benzalkonium chloride and light emission. S-Lenalidomide has been shown to be clinically relevant in infectious diseases, with concentrations producing significant effects on disease activity. The water vapor stability of this drug makes it suitable for use in humid environments such as those found in developing countries. S-Lenalidomide has been shown to induce antitumor responses without causing immunosuppression or toxicity in rats.</p>

<p>The POLR3A protein (His &amp; Thioredoxin tag) is a highly versatile and essential component in Life Sciences research. This medicament is a Conjugated Protein that offers numerous applications in various fields. It can be used as a valuable tool for studying protein-protein interactions, carbon quantum dynamics, chemokine signaling pathways, and influenza hemagglutinin structure and function. Additionally, the POLR3A protein (His &amp; Thioredoxin tag) has been employed in the development of novel therapeutic strategies. Its unique properties make it an ideal candidate for the production of Proteins and Antigens, collagen-based scaffolds for tissue engineering, peptide agents for drug delivery systems, and as a carrier for endogenous erythropoietin. Furthermore, this product can be utilized as a reliable reagent in monoclonal antibody production and neutralizing assays against TGF-beta. Its exceptional binding affinity ensures accurate results in these experiments. The POLR3A protein (</p>

<p>Please enquire for more information about Bromantane-d5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors</p>

<p>N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.</p>

<p>Mycosubtilin is a potent antifungal lipopeptide, which is a secondary metabolite produced by the bacterium Bacillus subtilis. It is characterized by its ability to disrupt fungal cell membranes, leading to cell lysis and eventual death of the fungus. This mode of action is attributed to its amphiphilic structure, which allows it to integrate into the lipid bilayers of fungal cells, compromising the integrity of the membrane and altering its permeability.Mycosubtilin finds applications in various scientific and agricultural fields due to its efficacy against a broad spectrum of fungal pathogens. It is particularly useful in plant disease management, where it plays a role in biocontrol strategies against phytopathogenic fungi. Additionally, its antifungal properties make it a subject of interest in pharmaceutical research, where it is investigated for potential therapeutic applications in combating fungal infections. Researchers also explore Mycosubtilin as a model compound to understand lipopeptide interactions with membranes, contributing to the broader knowledge of antimicrobial agents.</p>

<p>Crt0066101 hydrochloride is a peptide that has been shown to inhibit the activity of receptors for the neurotransmitter acetylcholine. It binds to the receptor and blocks access by acetylcholine, which prevents activation of the receptor. Crt0066101 hydrochloride is a ligand that inhibits ion channels in cells, including potassium channels, calcium channels, and sodium channels. This drug can be used as a research tool to study protein interactions in cell biology and pharmacology as well as to identify new drugs with potential therapeutic benefits. Crt0066101 hydrochloride is an inhibitor of G-protein coupled receptors (GPCRs) that has been shown to block the activation of muscarinic receptors on heart tissue. It also inhibits calcium-activated potassium channels on smooth muscle cells, leading to reduced blood pressure in animal models.</p>

<p>3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is a potent and selective inhibitor of the ion channel TRPM8. It reduces pain and inflammation by inhibiting the action of TRPV1 and TRPA1. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is an inhibitor of the TRPM8 ion channel with IC50 value of 0.06 μM. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone inhibits TRPA1 with IC50 value of</p>

<p>Fentanyl p Conjugate for use in immunoassays</p>

<p>L-MobileTrex is an advanced analytical technology platform, which is a product of cutting-edge research in data science and computational modeling. This platform operates by integrating multi-dimensional datasets through sophisticated algorithms, providing enhanced data visualization and interpretability.</p>

<p>A negative allosteric modulator of Flt-3 receptor tyrosine kinase</p>

<p>Purified native Human CEA protein (Preservative-free)</p>

<p>Please enquire for more information about MS67N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Desethyl N-methyl rivastigmine is an analog of rivastigmine and a potent inhibitor of kinases. It has been shown to induce apoptosis in cancer cells, making it a promising candidate for the treatment of various types of tumors. This medicinal compound is excreted through urine and has been found to have anticancer properties by inhibiting protein kinases. In Chinese hamster ovary cells, N-Desethyl N-methyl rivastigmine was found to inhibit the activity of several kinases involved in cell proliferation and survival. This inhibitor has potential therapeutic applications for cancer treatment due to its ability to target specific kinases that are essential for tumor growth and progression.</p>

<p>Please enquire for more information about Fmoc-D-Asp(OtBu)-(Dmb)β-Ala-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Alvameline is a muscarinic receptor agonist, which is a small molecule drug derived from synthetic chemistry processes. Its primary source is the intricate design of pharmacologically active compounds targeting the central nervous system. Alvameline exerts its effects through selective agonism of muscarinic acetylcholine receptors, playing a pivotal role in modulating neurotransmission. Specifically, by activating these receptors, it enhances cholinergic signaling, which is crucial for cognitive functions such as memory and attention.</p>

<p>Cortisol antibody was raised in mouse using cortisol-3 BSA as the immunogen.</p>

<p>Pseudoisoeugenyl 2-methylbutyrate is an analog of astaxanthin that has shown promising results in inhibiting tumor growth and inducing apoptosis in cancer cells. It acts as a kinase inhibitor, preventing the replication of cancer cells and promoting anticancer effects. Pseudoisoeugenyl 2-methylbutyrate has been tested on human and Chinese hamster ovary cell lines, demonstrating its potential as a potent anticancer agent. This compound has also been found in urine samples, suggesting that it may have natural sources in the body. Its ability to inhibit kinases makes it a promising candidate for further research into cancer treatment.</p>

<p>Please enquire for more information about 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranose including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Indicaxanthin is a natural pigment that has been found to possess potent anticancer properties. It is an analog of oseltamivir, a drug used to treat influenza by inhibiting the neuraminidase enzyme. Indicaxanthin has been shown to inhibit the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and proliferation. This inhibition leads to apoptosis (programmed cell death) in cancer cells. Studies have demonstrated that indicaxanthin has anticancer effects against various types of cancer, including breast, colon, and prostate cancer. Additionally, it has been detected in human urine following ingestion of foods containing this pigment, suggesting that it may have potential as a dietary supplement for cancer prevention and treatment.</p>

<p>Pigment Red 48 (C.I. 15865) is a red organic pigment that is soluble in water and most organic solvents. It has a melting point of 200°C and is used in paints, plastics, textiles, paper, and other products. Pigment Red 48 (C.I. 15865) can be synthesized by the diazonium salt coupling reaction between an aromatic amine and an acid chloride. The pigment also has a hydroxyl group that enables it to form covalent bonds with other molecules such as polymers or proteins. Pigment Red 48 (C.I. 15865) is used in many products because of its high stability, excellent heat resistance, low toxicity, non-irritating properties, high transparency, and good color fastness to light and washing.BR&gt; Pigment Red 48 (C.I. 15865) is not considered hazardous according to the Globally Harmonized System of Classification and Lab</p>

<p>PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.</p>

<p>Extracellular signal-regulated kinase 1/2 (ERK1/2) is a mitogen-activated protein kinase (MAPK) family protein and part of the Ras-Raf-MEK-ERK signalling pathway which plays a key role in controlling cell proliferation, differentiation and cell survival. ERK1/2 acts downstream of activated growth factor receptors, RAF protein kinases and mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1 and MEK2 activate ERK1/2 by phosphorylation and once activated ERK1/2 enters the nucleus and phosphorylates transcription factors to induce changes in gene expression. In addition to this active ERK1/2 also translocates to other organelles including the endoplasmic reticulum, endosomes, golgi and mitochondria where it influences cell physiology. Overall ERK1/2 phosphorylates more than 200 different substrates including other protein kinases, transcription factors, RNA-binding proteins, regulators of mRNA translation and regulators of cell death. ERK1/2 pathway is strongly implicated in cancer where its hyperactivation underpins the growth and maintenance of many tumour types. Data: Western blot analysis of whole cell extract of Mouse embryonic Fibroblasts (MEFs).</p>

<p>Primate-specific Mas-related G protein-coupled receptor-X1 (MRGPR-X1) is highly enriched in dorsal root ganglia (DRG) neurones as well as in connective tissue mast cells (CTMC) and the leukaemia-derived human mast cell line (LAD)-2. MRGPR-X1 activation induces acute pain and therefore represents a promising target for future pain therapy. MRGPR-X1 is activated by bovine adrenal medulla peptide-8-22 (BAM 8-22) which is cleaved from pro-enkephalin by pro-hormone convertases. Unlike most if not all Gq-coupled receptors MRGPR-X1 does not undergo agonist-promoted endocytosis. Data: Western blot analysis of rat brain preparation. Lane 1: Rat brain preparation (20µg). Secondary: Goat anti-rabbit IgG conjugated to HRP 1:5000.</p>

<p>Sotirimod is a monocytic degradable drug that has been shown to be effective in the treatment of skin cancer. It is also used as a diagnostic agent for prostate, colorectal, and breast cancer. Sotirimod binds to fatty acid molecules on the surface of cells. The drug then enters the cell where it forms crosslinks with DNA or RNA, which prevents cell division and replication. This causes cell death by apoptosis. Sotirimod can also be conjugated with affinity ligands such as antibodies or peptides to target specific types of cells.</p>

<p>BCR-ABL-IN-2 is a small molecule inhibitor, which is synthetically derived for precision-targeted therapeutic applications. It functions as a selective inhibitor of the BCR-ABL fusion protein, a tyrosine kinase that is constitutively active in certain leukemias, particularly chronic myeloid leukemia (CML). The product is engineered via chemical synthesis to ensure high specificity and selectivity in binding to the ATP-binding site of the BCR-ABL protein, effectively inhibiting its kinase activity.</p>

<p>Cytochrome P450 2C19 (CYP2C19) is an enzyme that metabolizes retinoic acid, which is an important signaling molecule in the development and homeostasis of various tissues. CYP2C19 also metabolizes a variety of other compounds including xenobiotics such as drugs, carcinogens and environmental pollutants. CYP2C19 has been found to have a polymorphism at position 331 (I331V), which has been shown to be associated with an increase in metabolism of retinoic acid. This variant leads to increased activity for the enzyme and can result in vitamin A deficiency, hypervitaminosis A or teratogenicity.</p>

<p>CB-1158 is an arginase inhibitor, which is a small molecule derived from a synthetic source designed to modulate immune functions. Its mode of action involves the inhibition of the arginase enzyme, a key player in the urea cycle responsible for the hydrolysis of arginine into ornithine and urea. By blocking arginase, CB-1158 effectively prevents the depletion of extracellular arginine, a vital amino acid required for the activation and proliferation of T cells within the immune system. This inhibition leads to enhanced immune responses against tumors.</p>

<p>L 162389 is a synthetic, non-steroidal, anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase. It inhibits the production of prostaglandins, which are known to cause pain and inflammation in the body. L 162389 is used for the treatment of inflammatory conditions such as rheumatoid arthritis and osteoarthritis.</p>

<p>MCOPPB is a new type of drug that is used to treat chronic neuropathic pain and other syndromes. MCOPPB has shown an analgesic effect in vivo, which may be due to its ability to stimulate the release of endogenous opioids. MCOPPB also reduces the pain threshold and increases tolerance to pain by stimulating the release of endorphins. This drug has been shown to have no effects on locomotor activity in knockout mice and has been tested for efficacy in clinical studies with humans.</p>

<p>Debio-0827 is a peptide that activates the human G protein coupled receptor (GPCR) of the serotonin type 2A (5HT2A) receptor. It has been used as a research tool for studying the activation of 5HT2A receptors and their effects on ion channels and protein interactions. Debio-0827 is a potent inhibitor to the binding of ligands to 5HT2A receptors, which may be used in pharmacological studies.</p>

<p>Anti-Trop2</p>

<p>Panulisib is a Toll-like receptor (TLR) modulator that inhibits the TLR signaling pathway. It has been shown to inhibit the replication of certain viruses and to induce significant cytotoxicity in cancer cells. Panulisib binds to the toll-like receptor 7 (TLR7) and prevents it from activating downstream signaling pathways, which may be due to its ability to inhibit endothelial cell proliferation. The drug also shows some activity against hepatitis B virus-induced hepatitis in preclinical studies. In addition, panulisib inhibits growth factor signaling pathways and suppresses tumorigenesis by inhibiting the downstream effects of angiogenesis.</p>

<p>2A peptide-linked polycistronic vectors can be used to express multiple proteins from a single open reading frame (ORF). The small 2A peptide sequences, when cloned between genes, allows for efficient, stoichiometric production of discrete protein products within a single vector through a novel "cleavage" event within the 2A peptide sequence. 2A was discovered in the foot-and-mouth disease virus (FMDV, a picornavirus). The 2A peptide acts through ribosomal skipping to allow for the encoding of polyproteins which can dissociate into individual proteins upon translation. Anti-T2A antibody recognises 2A tagged recombinant proteins and is an excellent tool for researchers using 2A peptide based expression systems.<br>0.2mg/ml TEA (Rb L02T), 0.5mg/ml Glycine (Rb L02G). Used for ELISA (1:1000). Reacts with T2A tag.</p>

<p>Muscarine chloride hydrate is a receptor agonist. Muscarine binds to the acetylcholine receptors on the surface of muscle cells and nerve cells, causing an influx of calcium ions into the cell. Muscarine is used as a research tool for studying ion channels, proteins interactions, and peptides. It has been shown to be an activator of phospholipase C and phosphatidylinositol-specific phospholipase C in pancreatic acinar cells.</p>

<p>FR-190809 is a peptide that acts as an inhibitor of protein interactions. It binds to the receptor and blocks the activation of phospholipase C. FR-190809 also stimulates the production of cyclic AMP, which in turn activates protein kinase A, thereby inhibiting the production of cAMP. FR-190809 has been shown to have a high purity and is used as a research tool for studying protein interactions.</p>

<p>1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphatidylethanolamine is a broad spectrum antimicrobial that has been shown to have binding properties to peptides. This compound can be used as a potential antimicrobial for the treatment of bacterial infections and gramicidin, an antibiotic that is active against bacteria. It has also been shown to permeabilize cell membranes, which may lead to its function as an antimicrobial agent. 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphatidylethanolamine is water soluble and has been shown to have conformational properties. These conformational properties are responsible for its binding activity with peptides. 1POGPE is stable in both calorimetric assays and bilayers, which allows it to maintain its structure when interacting with other compounds. 1POGPE also has a high affinity for</p>

<p>O 1812 is a cannabinoid receptor antagonist. It blocks the binding of cannabinoids to their receptors, thereby inhibiting the effects of cannabinoids. O 1812 has been shown to have therapeutic potential in treating kidney disease, bone growth, and cardiovascular disorders. This drug can also be used in cancer therapy and Alzheimer's disease treatment due to its ability to modulate the activity of certain receptors. O 1812 is a programmable compound that can be configured for specific purposes by adding or removing functional groups from the molecule. The addition of an alkoxy radical group at one end of the molecule allows it to be used as an endpoint marker for DNA sequencing reactions because it fluoresces when excited with ultraviolet light.</p>