Bioquímicos e reagentes

<p>IACS-8968 is a peptide that exhibits a high degree of specificity for the L-type voltage-gated calcium channels. It has been shown to inhibit these channels without affecting other ion channels, and it can also block the binding of an antibody to its antigen by competitive inhibition. IACS-8968 has a number of potential applications in life science research and cell biology. It may be used as a research tool to study protein interactions, receptor ligand binding, or pharmacology. The high purity of IACS-8968 makes it possible for researchers to work with milligram quantities.</p>

<p>NVP-BBD130 is an orally administered, small molecule inhibitor of the mammalian target of rapamycin (mTOR) kinase. It was designed to selectively inhibit mTORC1. NVP-BBD130 has been shown to be a potent inhibitor of melanoma tumor growth in mice and also inhibits the activation of phosphoinositide 3-kinase and Akt. This compound has been evaluated in a pharmacokinetic study as well as a mouse model for melanoma with promising results. In addition, NVP-BBD130 was shown to have an acceptable safety profile in healthy volunteers.</p>

<p>LGD-2226 is a designer drug that belongs to the class of selective androgen receptor modulators. It binds to the androgen receptor, which allows it to inhibit cell growth by blocking transcription. LGD-2226 has been shown to be effective in treating metabolic disorders such as obesity and type II diabetes. The drug also has potential for use in the treatment of cancer, possessing low toxicity as well as high efficacy for cancer cells. LGD-2226 induces an apoptotic pathway in human adrenocortical carcinoma cells by inhibiting protein synthesis through inhibition of cyclin D1 expression. This drug has been shown to have a tumour suppressor gene activity, with the ability to induce apoptosis in deficient mice with lung cancer.</p>

<p>TC-A2317 hydrochloride is a selective nicotinic acetylcholine receptor (nAChR) agonist, which is synthesized through chemical methods. It acts by specifically targeting nAChRs, which are ionotropic receptors predominantly found in the central nervous system and peripheral nervous system. These receptors are ligand-gated ion channels that, upon activation by agonists like TC-A2317 hydrochloride, result in increased neuronal excitability and neurotransmitter release.</p>

<p>B355252 is a small molecule that has cytosolic, signal pathways, and autophagy-inducing effects. It also has neuroprotective properties, as it prevents mitochondrial membrane potential collapse and oxidative injury in mouse hippocampal cells. B355252 binds to the mitochondria and regulates the growth factor of mitochondria, which is essential for cell survival. Moreover, B355252 inhibits glutamate excitotoxicity by regulating chloride channel activity.</p>

<p>GDC046 is a triazole compound with inhibitory properties that acts as a tyrosine kinase inhibitor. It binds to the active site of the enzyme and prevents ATP from binding, inhibiting the enzyme's activity. GDC046 has shown efficacy in vitro against several cancer cell lines and has been found to be safe in vivo. GDC046 has also been found to be selective for the target enzyme, which minimizes off-target effects.</p>

<p>Chidamide is an inhibitor of histone deacetylases (HDACs) that belongs to the drug therapy groups. It induces apoptosis by increasing the expression of Bcl-2 protein and decreasing the expression of Bax protein in squamous cell carcinoma cells. Chidamide also has a significant cytotoxicity, which is caused by its ability to inhibit HDACs and induce apoptosis. Combination therapy with nonsteroidal anti-inflammatory drugs and other drugs may have a synergistic effect on cancer treatment.</p>

<p>ICI-118551 Hydrochloride is a drug that binds to the β-adrenergic receptor, which may be an important therapeutic target for the treatment of depression. ICI-118551 Hydrochloride has been shown to have positive effects in vivo in animal studies, and also stabilizes cancer cells. ICI-118551 Hydrochloride is a potent agonist at β-adrenergic receptors with a high affinity for these receptors. It has been found to be efficacious in assays measuring receptor binding and activity, and it also binds selectively to β-adrenergic receptors.<br>ICI-118551 Hydrochloride is not active against primary tumours, but it does show anti-cancer effects. This drug stabilizes cancer cells by inhibiting the activation of G proteins downstream of the β adrenoceptor.</p>

<p>PD 176252 is a cytosolic calcium ionophore that has been shown to enhance the cytotoxicity of cisplatin in cancer cells. It binds to cyclic adenosine monophosphate (cAMP) and increases intracellular calcium concentrations by opening the channels of R-type voltage dependent calcium channels. PD 176252 also inhibits epidermal growth factor receptor tyrosine kinase activity, which may contribute its anti-cancer effects. The molecular modeling study showed that PD 176252 binds to the peptide binding site on metalloproteases by hydrogen bonding with the backbone amide group of Asp residues, which are often found in this region. This drug does not inhibit proteolysis, but blocks the catalytic domain of metalloproteases from binding to substrates.</p>

<p>NSC-57969 is a peptide that has been shown to inhibit the binding of a number of different ligands to their receptors. NSC-57969 is an activator for ion channels, including the nicotinic acetylcholine receptor (nAChR) and 5-HT3 receptor. It has also been shown to be a potent inhibitor of the aminergic G protein coupled receptor (GPCR) subfamily, including dopamine D2 and serotonin 5HT2A receptors.</p>

<p>Diproqualone is a quinazolinone compound that is used in the treatment of cancer. It has potent inhibition effects against human leukemias and, as an active substance, can be found in pharmaceutical preparations. The prognosis for treatment with this drug is determined by the binding constants of diproqualone to specific sites on DNA and protein molecules. Turbidimetric methods have been used for diagnosis in humans.</p>

<p>4-Hydroxychrysene is a hydrocarbon that is found in coal tar and petroleum products. It has been shown to be a carcinogen in animals, causing lung cancer when inhaled. 4-Hydroxychrysene also causes DNA damage, chromosomal aberrations, as well as mutations. The aromatic ring of the molecule is susceptible to hydroxylation, leading to the formation of other compounds such as 2-hydroxychrysene and 3-hydroxychrysene. These compounds are also known to be carcinogenic. 4-Hydroxychrysene can also cause tumors in rats by forming adducts with DNA and proteins. 4-Hydroxychrysene emissions have been shown to cause DNA damage in cells from rat liver microsomes and mammalian cells.</p>

<p>γ6 Tm1A Trifluoroacetate is a potent inhibitor of the acetylcholinesterase enzyme, which degrades the neurotransmitter acetylcholine. It has been shown to have high purity and is suitable for research purposes. γ6 Tm1A Trifluoroacetate binds to the active site of acetylcholinesterase, blocking the access of acetylcholine and preventing its degradation, leading to an accumulation of acetylcholine at synapses in the brain. This leads to increased transmission across synapses and higher levels of excitation in neurons.</p>

<p>NVP-BEP800 is a small molecule inhibitor, which is a synthetic compound designed to target specific proteins. This product is developed by Novartis and falls under the category of Hsp90 inhibitors. Hsp90, or Heat Shock Protein 90, is a molecular chaperone involved in the proper folding, stability, and function of many client proteins, many of which are implicated in cancer progression. NVP-BEP800 binds to the ATP-binding site of Hsp90, thereby inhibiting its chaperone activity.</p>

<p>Nipradolol is a selective β-adrenergic receptor antagonist. It is used to treat bowel diseases, including constipation and diarrhea. Nipradolol has been shown to inhibit the release of cytosolic Ca2+ in intestinal cells by inhibiting the activity of sodium-dependent glucose co-transporter 1 (SGLT1). Nipradolol has also been shown to have antimicrobial activity against bacteria such as Escherichia coli, Salmonella enterica, and Staphylococcus aureus. This drug may be used for the treatment of inflammatory bowel disease (IBD) or other intestinal disorders induced by ischemia reperfusion. Nipradolol can also be used for cardiac prophylaxis in high-risk patients undergoing noncardiac surgery. The drug inhibits cardiac ion channels and blocks the action of catecholamines on these channels. This agent has also been found to be useful for fetal bov</p>

<p>Geissoschizine methyl ether is a chemical compound that belongs to the group of 5-HT2C receptor antagonists. It is also known as geissoschizine methyl ether and uncaria. Geissoschizine methyl ether binds to the serotonin 5-HT2C receptor, which leads to an increase in intracellular calcium levels and subsequently neuronal death. In addition, this agent has been shown to inhibit voltage-dependent calcium channels, leading to a decrease in neurotransmitter release. The compound has also been shown to inhibit polymerase chain reaction (PCR) of DNA and RNA in vitro. This inhibition may be due to its ability to bind with basic proteins such as histones. Geissoschizine methyl ether also inhibits protein synthesis by binding with the ribosome at the peptidyl transferase site on the ribosome.</p>

<p>VER 49009 is a chaperone that binds to the amide group of proteins, inhibiting their function. VER 49009 has been shown to inhibit cancer cells in vitro and in vivo by preventing protein synthesis. This compound also inhibits the production of heat-shock proteins. It can be used for the treatment of cancer, as well as other diseases associated with high levels of heat-shock proteins, such as pediatric cancer.</p>

<p>Inhibitor of methionine aminopeptidase METAP2</p>

11-(2-Chlorophenyl)-2,3,4,5,10,11-hexahydro-10-(1-oxopentyl)-1H-dibenzo[b,e][1,4]diazepin-1-one is a synthetic ligand for the GABA A receptor. It has been shown to be an activator of the GABA A receptor and has been used as a research tool in cell biology and neuroscience. 11-(2-Chlorophenyl)-2,3,4,5,10,11-hexahydro-10-(1-oxopentyl)-1H-dibenzo[b,e][1,4]diazepin-1-one binds to the receptor with high affinity and selectivity. It has also been shown to inhibit ion channels such as potassium channels.

<p>HIF-2α-IN-3 is a peptide that is a potent and selective activator of HIF-2α. It binds to the C-terminal domain of HIF-2α and activates the transcriptional activity of this protein. This peptide can be used as a research tool for studying the pharmacology, protein interactions, receptor, ligand, antibody and ion channels.</p>

<p>Draflazine is a fluorescent derivative of the fatty acid arachidonic acid that binds to the phospholipase A2 receptor. This binding inhibits the release of arachidonic acid from membrane phospholipids and blocks the synthesis of prostaglandins. Draflazine has been shown to increase cardiac function after myocardial infarction, which may be due to its inhibition of reactive oxygen species production and activation of adenosine receptors. The drug also has antinociceptive properties, which have been shown in animal models using nociceptive tests such as tail-flick, hot-plate, and writhing tests. These effects are mediated by G protein-coupled adenosine receptors (A1, A2A).</p>

<p>CGP 48369 is a calcium antagonist that has been shown to lower blood pressure in patients with cirrhosis and congestive heart failure. It also exhibits an anti-angiotensin effect, which may contribute to its ability to increase the release of nitric oxide. CGP 48369 inhibits the enzyme that converts angiotensin I into angiotensin II, thereby blocking the effects of this hormone on the kidneys, blood vessels, and heart. CGP 48369 is not metabolized by cytochrome P450 enzymes and is excreted unchanged in urine. The drug binds to vitamin B12 and retinoic acid, which may contribute to its negative effects on red blood cells.</p>

<p>CZC 54252 hydrochloride is a cancer drug that inhibits the growth of cancer cells by inhibiting the production of DNA and RNA. It binds to topoisomerase II, which is an enzyme that maintains the integrity of DNA. CZC 54252 hydrochloride also inhibits protein synthesis, leading to cell death. This drug has been shown to be effective against a variety of cancers, such as colon and lung cancer.</p>

<p>Palonidipine is an experimental pharmaceutical compound classified as a calcium channel blocker, which is derived from synthetic chemical processes. This product functions by inhibiting the influx of calcium ions through L-type calcium channels located on the vascular smooth muscle cells and cardiac myocytes. By blocking these channels, Palonidipine causes vasodilation, reducing systemic vascular resistance, and thereby lowering blood pressure.</p>

<p>BM 131246 is a carnitine palmitoyltransferase inhibitor that has been shown to reduce plasma concentrations of long-chain fatty acids, as well as to improve the symptoms of congestive heart failure. BM 131246 also improves the symptoms of cirrhosis and metabolic disorders such as insulin resistance. This drug may have potential use in the treatment of macrovascular complications of diabetes, including coronary artery disease and peripheral vascular disease. BM 131246 has been shown to produce dose-dependent effects in animals with congestive heart failure, suggesting that it may be used for cardiovascular disorders related to diabetes.</p>

<p>BC-LI-0186 is a microbial inoculant, which is a blend of beneficial microbes derived from natural soil environments with symbiotic relationships with plants. The mode of action involves colonization of the rhizosphere and the enhancement of nutrient uptake by solubilizing phosphates and fixing atmospheric nitrogen. Additionally, it facilitates the production of growth-promoting substances such as auxins and cytokinins.</p>

<p>CPI-637 is a potential drug for the treatment of prostate cancer. It is a small molecule that binds to the bromodomain, which is an important cellular protein that regulates transcriptional regulation. Bromodomains are found in many proteins and are known to be involved in many cellular processes and cancers. CPI-637 has been shown to inhibit the expression of genes associated with prostate cancer, HIV infection, and carcinogenesis. This agent does not bind to DNA but binds to histone h3 at a specific site called the response element-binding protein (RBP), which inhibits gene expression by binding to the RBP.</p>

<p>Lamiide is a sodium salt of the iridoid, lamiidine. It has been found to have anti-cancer effects against cervical cancer and other human pathogens, including amorphous substances. Lamiide is an amorphous substance that can be obtained from the genus Verbenaceae, which includes plants such as clove, lavender, sage, and thyme. Lamiide has been shown to inhibit tumor growth in animal models of carcinogenesis by inhibiting proliferation and inducing apoptosis. This compound also inhibits the growth of bacteria by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes.</p>

<p>(+/-)-E-Homocamptothecin is a novel anticancer agent that is structurally related to camptothecin, a topoisomerase I inhibitor. It has shown inhibitory properties against human colon carcinoma cells and prostate carcinoma cells. (+/-)-E-Homocamptothecin inhibits the growth of cancer cells by preventing the production of proteins needed for cell division. The drug also has sequence specificity, inhibiting only cancer cells with the appropriate DNA sequences. Clinical development of (+/-)-E-Homocamptothecin has been reinforced by its ability to selectively kill leukemia cells in culture without affecting normal white blood cells.</p>

<p>Please enquire for more information about Oleic acid-2,6-diisopropylanilide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fb23 inhibitor is a drug that inhibits the growth of cancer cells. It has been shown to inhibit the development of cancer in mice with urothelial cancer. Fb23 inhibitor may work by altering the epigenetic landscape of cancer cells, thereby preventing them from progressing through the cell cycle and inducing apoptosis. Fb23 inhibitor also interacts with urothelial cells and prevents transformation into non-urothelial cells. This drug has shown some success in preventing mutations associated with neoplasia, including cancers such as lung, breast, or prostate.</p>

<p>2-Cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide is a Chinese compound that has been found to be an effective inhibitor of kinases. Specifically, it has been shown to inhibit cyclin-dependent kinase (CDK) 4 and 6, which are important regulators of cell cycle progression. This compound also exhibits potent anticancer activity against a variety of human cancer cell lines. It induces apoptosis in tumor cells by inhibiting the activity of protein kinases that play a critical role in cell survival and proliferation. The analog of this compound has been found in urine samples from cancer patients and may serve as a potential biomarker for the diagnosis and monitoring of cancer progression. Overall, 2-Cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-</p>

<p>Lesinurad sodium is a prodrug that is hydrolyzed to form ethyl formate, which inhibits the acid transporter (NT) in the kidneys. It is used for the treatment of chronic gouty arthritis and hyperuricemia associated with the use of xanthine oxidase inhibitors or allopurinol. Lesinurad sodium has been shown to be effective in reducing serum uric acid levels and pain symptoms in patients with chronic gouty arthritis. The drug has a plasma concentration-time curve that follows first-order kinetics and an elimination half-life of 15 hours. Lesinurad sodium has been shown to inhibit NT activity by structural formula, reaction yield, introducing techniques, and pharmacodynamics.</p>

Asmi is a biomarker that may be used for the diagnosis of bowel disease. It is a monoclonal antibody that binds to the protein albumin, which is found in the blood, and has been shown to be associated with congestive heart failure (CHF) and inflammatory bowel disease. Asmi has also been shown to have high sensitivity and specificity for detecting inflammation in patients with Crohn's disease. The levels of Asmi were found to be higher in patients with active Crohn's disease than in those with inactive Crohn's disease or healthy controls. This biomarker could be used as a measure of disease activity, which can help physicians manage their patient's condition.

<p>Arjunglucoside I is a compound that belongs to the group of triterpenoid saponins. It has been shown to have anti-inflammatory, anticarcinogenic and anti-mutagenic properties in experimental models. Arjunglucoside I inhibits inflammatory bowel disease by regulating the immune response of T-cells and natural killer cells. The compound also has beneficial effects on skin conditions such as eczema and psoriasis, as well as collagen production in skin fibroblasts. Arjunglucoside I can be found in food products such as cereal grains, wheat, oats and rye.</p>

<p>MS402 is a biological control agent derived from a naturally occurring entomopathogenic fungus, which targets specific agricultural pests through a parasitic mode of action. Upon application, this microorganism adheres to the host insect’s cuticle, penetrating it and proliferating within the body. Subsequently, the pest is incapacitated, which results in its death, thereby mitigating pest populations in crop environments.</p>

<p>Abh hydrochloride is a medicine that inhibits arginase activity. It is used as a treatment for symptoms of chronic liver disease and other diseases in which high levels of ammonia are produced. Abh hydrochloride works by inhibiting the production of ammonia, which is toxic to the human body.</p>

<p>HLY78 is a monoclonal antibody that targets the prostate cancer cell surface antigen, Prostate Specific Membrane Antigen (PSMA). This antibody has been shown to inhibit growth of prostate cancer cells in vitro and to suppress the growth of prostate tumors in vivo. HLY78 has also been shown to inhibit signal pathways, such as the phosphatidylinositol 3-kinase (PI3K) pathway, which may lead to decreased tumor progression and metastasis. HLY78 has been shown to bind to PSMA on prostate cancer cells with high affinity and specificity, thereby blocking the interaction between PSMA and its receptor. This binding inhibits the activation of PI3K and other signal pathways, leading to decreased tumor progression and metastasis.</p>

<p>2-Bromobutane-d9 is a high purity, commercially available research tool that is used as an activator for a number of receptors and ligands. It has been shown to be an inhibitor of ion channels. 2-Bromobutane-d9 has also been used in the study of protein interactions.</p>

<p>SGC0946 is a methyltransferase inhibitor that inhibits the methylation of DNA by inhibiting the activity of DNA methyltransferase. It is being developed for use in regenerative medicine to inhibit transcriptional regulation and pluripotent cells. SGC0946 has been shown to be effective in inhibiting cell factor and human serum methyltransferase, which are responsible for the production of monocytes. SGC0946 also inhibits the production of cytokines, such as IL-1β, IL-6, and TNF-α, as well as chemokines such as RANTES and MCP-1. This drug also inhibits the growth of infectious diseases such as HIV-1 and HCV by disrupting dna methylation.</p>

<p>AMG 1694 is a cytosolic inhibitor of the glucose-6-phosphatase enzyme, which has been shown to act as an antidiabetic drug in animal models. AMG 1694 has been shown to have a potent inhibitory effect on gluconeogenic enzymes in vitro and in vivo. In addition, AMG 1694 has a high uptake by cells, with minimal systemic pharmacokinetic effects. This molecule also inhibits the regulatory protein phosphofructokinase (PFK), which is involved in the metabolic pathway for glycolysis. AMG 1694 also inhibits the enzyme fructose-1,6-bisphosphatase, which regulates glucose metabolism. This agent is currently being studied for its use as an antidiabetic drug in humans.</p>

<p>CIL62 is a molecule that has been shown to induce ferroptosis, a form of programmed cell death. Ferroptosis is triggered by oxidative stress and characterized by the formation of lipid-rich, iron-containing organelles called lipidosomes. CIL62 induces ferroptosis by inhibiting the activity of the protein caspase-8, which is an enzyme that activates other caspases. CIL62 also inhibits the activity of caspase-9 and -3, two proteins involved in apoptosis, or programmed cell death.</p>

PD128907 HCl is a dopamine D3 receptor antagonist. It has been shown to have an inhibitory effect on the neurotransmitter dopamine, which is responsible for regulating mood, movement, and cognition. PD128907 HCl is a non-selective antagonist that can bind to both dopamine D1 and D2 receptors as well as serotonin 5-HT2A receptors. This drug has been tested in animal models of hyperactivity, and it has been shown to reduce symptoms of this condition by blocking the dopamine D4 receptor.

<p>[Pyr1]apelin-13 (human) (CAS: 217082-60-5)</p>

<p>2-Aminoacridone is a fluorescent chemical that can be used to detect the presence of α1-acid glycoprotein in human serum. 2-Aminoacridone is used as an analytical tool for measuring the activity of enzymes that catalyze nucleic acid synthesis, such as polymerases and transcription factors. It is also used to measure the activity of enzymes involved in polysaccharide synthesis, such as glycosyltransferases and glucuronidases. This chemical reacts with basic fibroblast cells and macrophages, which are white blood cells that play a role in inflammation. 2-Aminoacridone is also effective at detecting the presence of acidic oligosaccharides in polymers. The fluorescence detector is used to measure the intensity of this reaction by measuring the emission spectrum. The enzyme substrates are added to provide energy for this reaction, while trifluoroacetic acid removes any water molecules that may interfere</p>

<p>ITIC is a low energy dye with a wide absorption band in the visible region. ITIC has been used to detect fatty acids and cholesterol, as well as other molecules like human serum albumin, hemoglobin, and proteins. The molecule can be detected using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICPMS) and x-ray absorption spectroscopy (XAS). The detection sensitivity of ITIC is much higher than that of other dyes. The chemical stability of ITIC has been shown by its photostability, which means it does not degrade when exposed to light. ITIC can be used for many applications such as for detecting fatty acids in milk or for determining the concentration of cholesterol in blood samples.</p>

<p>Br-PBTC is a potentiator of the effects of estradiol. It has been shown to have allosteric modulating activity on α subunit nicotinic acetylcholine receptors, which are involved in the pharmacological effect of Br-PBTC. The sequence analysis of the receptor revealed that Br-PBTC interacts with 17β-estradiol and enhances its binding affinity to the receptor. This interaction may be due to an increase in the number of estradiol molecules bound to the receptor, or by increased conformational changes induced by Br-PBTC at the receptor site.</p>

<p>SU10944 is a drug that belongs to the class of slow-release drugs. It is used as an antiangiogenic therapy for prostate cancer and other diseases. SU10944 inhibits angiogenesis by binding to the stem cell factor receptor, which prevents the growth of new blood vessels and reduces inflammation. SU10944 also blocks prostaglandin synthesis and has chemotactic activity on monocytes and macrophages, which can be used in combination with other treatments to reduce or prevent metastasis. The drug also has biofunctional properties, such as promoting the release of epidermal growth factor (EGF) and angiogenic process.</p>

<p>DDP-38003 dihydrochloride is a research tool for the study of ion channels, ligand binding and protein interactions. DDP-38003 dihydrochloride has been shown to be an inhibitor of voltage-gated potassium channels with IC50 values in the micromolar range. This compound also binds to the beta2-adrenergic receptor and acts as an agonist.</p>

<p>Dgat2 inhibitor 122 is a research tool that can be used to inhibit the activation of the Dgat2 receptor. This inhibitor binds to the ligand binding site of Dgat2, preventing the activation of Dgat2 by its ligand. The structure of this inhibitor was solved using X-ray crystallography and it is a potent competitive antagonist with high purity. It has been shown to inhibit ion channels, which may be due to its ability to block protein interactions at the membrane level.</p>