Heterociclos com Nitrogénio (N)

<p>Applications 2-oxo-2,3-dihydrobenzo[d]oxazol-6-ylboronic acid pinacol ester (cas# 1105710-32-4) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is used in the synthesis of morpholinothiazoles as alpha 7 position allosteric modulators.<br>References MacDonald, G., et al.: PCT Int. Appl. (2011), WO 2011064288 A1 20110603<br></p>

<p>Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent.<br>References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>

<p>Applications 1-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethanone is used as a reagent in the synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles which exhibit neuroleptic activity.<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985)<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.<br>References Arava, V., et al.: Pharma Chemica, 5, 232 (2013)<br></p>

<p>Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.<br></p>

<p>Applications 4-[5-(4-Pentyloxyphenyl)isoxazol-3-yl]benzoic Acidis used to optimize the side chain of the natural product FR901379.<br>References Tomishima, M., et al.: Bioorg. Med. Chem. Lett., 18, 2886 (2008)<br></p>

<p>Applications Pyridinium Formate is used as a doping agent to study different form of EHD processing for use ewith viscous surface tension solutions.<br>References Larsen, G., et al.: Adv. Mat., 16, 166 (2004);<br></p>

<p>Applications 2-(3-Fluorophenyl)pyrrolidine<br></p>

<p>Applications 2-chloro-1H-benzimidazole (cas# 4857-06-1) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-cyclopropyl-4-oxazolecarboxylic Acid Ethyl Ester, is a heterocyclic building block used in the chemical synthesis.<br></p>

<p>Applications Tris(4-pyridyl)-s-triazine is used in the preparation of metal-metallite coordination polymers as well as porphyrin prisms.<br>References Youm, K. et al.: Chem. Comm., 29, 3375 (2008); Li, M. et al.: CrystEngComm., 15, 1225 (2013);<br></p>

<p>Applications 6-(Ethylamino)pyridine-3-carbonitrile<br></p>

<p>Applications 5-Boronopicolinic acid<br></p>

<p>Applications 1-(Phenylmethyl)-2-imidazolidinone (cas# 2385-38-8) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Tosylpyrrole (cas# 17639-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-hydroxy-1H,2H-pyrrolo[1,2-d][1,2,4]triazin-1-one (cas# 50269-88-0) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-N-[1-(methylsulfonyl)-4-piperidinyl]-4-quinazolinamine, is a building block used in chemical synthesis.<br></p>

<p>Applications Reagent used in Guanidino transfers.<br></p>

<p>Applications 1-(2-chloro-5-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (cas# 313069-92-0) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-pyrazole 4-pyruvic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications N-Chloropiperidine is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.<br></p>

<p>Applications 2-(2-Aminophenyl)-1H-benzimidazole is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins. Also used in the synthesis of pharmaceutical agents targeting leishmania related parasites.<br>References Keurulainen, L. et al.: Bioorg. Med. Chem. Lett., 25, 1933 (2015); He, Y. et al.: Bioorg. Med. Chem., 23, 2798 (2015);<br></p>

<p>Applications 5-Hydroxy-4,6-dimethyl-3-pyridinemethanol is used in the study of sphingosine-1-phosphate is a major chemoattractant and stem cell mobilization factor.<br>References Ratajczak, M.Z., et al.: Leukemia, 24, 976 (2010)<br></p>

<p>Applications 4-Ethylpyridine is a general chemical reagent used in the synthesis of substituted pyridines as well as diverse azacyclic compounds.<br>References Gandhamsetty, N. et al.: J. Am. Chem. Soc., 137, 15176 (2015); Chen, X. et al.: J. Coord. Chem., 68, 2835 (2015);<br></p>

<p>Applications N-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]Amine (cas# 147225-68-1) is a useful research chemical.<br></p>

<p>Applications 4-Chloropyridine is used to synthesize Thrombin inhibitors, compounds that have potent anticoagulant activity. 4-Chloropyridine is also used as a reagent to synthesize Botryllazine A, a pyrazine alkaloid that exhibits cytotoxicity against human tumour cells.<br>References de Candia, M., et al.: J. Med. Chem., 56, 8696 (2013); Kodimuthali, A., et al.: Tetrahedron Lett., 50, 1618 (2009); Singh, P., et al.: J. Org. Chem., 78, 2639 (2013)<br></p>

<p>Applications 2-Aminomethyl-3-nitropyridine is a derivative of 2-Methyl-3-nitropyridine (M320425).<br></p>

<p>Applications 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.<br>References Burger, M.T. et al.: ACS Med. Chem. Lett., 2, 774 (2011); Heffron, T.P. et al.: J. Med. Chdem., 55, 8007 (2012);<br></p>

<p>Applications Ethyl Imidazole-2-carboxylate is an intermediate used to synthesize tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). It is also used to prepare imidazoindenopyrazinone carboxylic acid derivatives as AMPA antagonists with anticonvulsant activities.<br>References Miyashiro, J., et al.: Bioorg. Med. Chem. Lett., 19, 4050 (2009); Pratt, J., et al.: Bioorg. Med. Chem. Lett., 10, 2749 (2000)<br></p>

<p>Applications [1,2,4]Triazolo[1,5-a]pyridin-8-ol can be used to prepare aminopyridine derivatives as glucokinase activators useful to treat diseases.<br>References Aicher, T. D., et al.: PCT Int. Appl., 145, (2008);<br></p>

<p>Applications (4S)​-4-​Carboxy-​5,​5-​dimethyl-​α-​[[(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​carbonyl]​amino]​-2-​thiazolidineacetic acid is a useful reactant for organic reactions.<br></p>

<p>Applications 5-(trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione (cas# 2145-56-4) is a useful research chemical.<br></p>

<p>Applications 1-ACETYL-2-PIPERIDINEACETIC ACID (cas# 25393-20-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Dichloropyridine-5-boronic acid<br></p>

<p>Applications 5-(Aminomethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one Hydrochloride is a useful research chemical.<br></p>

<p>Applications 3-amino-6-cyanopyridazine (cas# 340759-46-8) is a useful research chemical.<br></p>

<p>Applications 1,2-Benzisoxazole has therapeutic uses. It could be useful for treating parkinsonism.<br>References Panza, F., et al.: Expert Opin. Pharmacother., (2020)<br></p>

<p>Applications 6,7-Dihydro-Imidazo[1,5-a]pyrazin-8(5H)-one is a useful research chemical.<br></p>

<p>Applications N-[5-(4-Bromophenyl)-6-[2-(2-pyrimidinyloxy)ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 3-Amino-5-ethyl-5-phenylimidazolidine-2,4-dione (cas# 1139-11-3) could be useful for biological studies. An anticonvulsant.<br>References Lange, J., et al.: Pol. (1982), PL 123138 B1<br></p>

<p>Applications 2-Ethyl-3,5,6-trimethylpyrazine (cas# 17398-16-2) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5-N-t-BOC (CAS# 1523606-18-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-​Pyrrolidineacetic Acid is a useful reactant and reagent in organic reactions. It can be found used in cosmetic products such as wrinkle-​preventive​/ameliorating products.<br>References Londregan, A.T., et al.: ACS Comb. Sci., 18, 651-54 (2016); Tsunenaga, M., et al.: PCT Int. Appl. (2007), WO 2007013662 A1<br></p>

<p>Applications Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate is used as a reagent in the synthesis of imidazopyridines as Syk inhibitors. Also used as a reagent in the synthesis of quinoline, quinoxaline and naphthyridine derivatives as antibacterial agents.<br>References Blomgren, P., et al.: PCT Int. Appl. WO 2011112995 A1 20110915. Sep 15, 2011; Daines, R.A., et al.: PCT Int. Appl. WO 2007016610 A2 20070208. Feb 8, 2007<br></p>

<p>Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.<br>References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)<br></p>

<p>Applications N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (cas# 1219957-27-3) is a useful research chemical.<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxamide<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);<br></p>

<p>Applications Used in the preparation of 2-naphthyl substituted diarylpyrimidines (DAPY) analogues.<br>References Liang, Y. et al.; Bioorgan. Med. Chem. 18, 4601(2010).<br></p>

<p>Applications 4,6-Diamino-2-chloro-5-pyrimidinecarbonitrile is an intermediate in the synthesis of 2,4,6-Triamino-5-pyrimidinecarbonitrile is a photodegradation product of two isostructural pesticides in aqueous solution: Cyromazine (C989300) and Dicyclanil.<br>References Kimbrough, R., et al.: Environ. Sci. Technol., 30, 908 (1996), Root, D., et al.: Pesticide Sci., 48, 25 (1996), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000),<br></p>

<p>Applications 2-(5-Ethylpyridin-2-yl)prop-2-en-1-ol is a key intermediate in the synthesis of pioglitazone hydrochloride.<br>References Mohanty, S., et al.: Org. Process Res. Dev., 18, 168 (2014)<br></p>

<p>Applications 5-Amino-3,4-dimethylisoxazole (cas# 19947-75-2) is a compound useful in organic synthesis.<br>References Tellew, J., et al.: Bioorg. Med. Chem. Lett., 13, 1093 (2003),<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications Ethyl 4-aminopiperidine-1-carboxylate is a reagent used in various biosynthetic reactions.<br>References Fang, R.Q., et al.: Bioorg. Medn. Chem. Letters., 22, 5134 (2012);<br></p>

<p>Applications 1-Ethyl-3-piperidinone Hydrochloride used in preparation of Aminoimidazoles.<br>References Sabbasani, Venkata R., et al.: Angewandte Chemie, 58, 18913-18917 (2019);<br></p>

<p>Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications N-[1-[1-(4-Methoxyphenyl)-1H-tetrazol-5-yl]-1-methylpropyl]-1H-indole-3-ethanamine,<br></p>

<p>Applications Pyrimidin-4-ylboronic Acid is an intermediate used to prepare aldosterone synthase inhibiting pyrimidinylnaphthalenes via Suzuki cross-coupling reactions. It is also used in the synthesis of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine as a potent, orally active Src kinase inhibitor with antitumor activity.<br>References Voets, M., et al.; J. Med. Chem., 48, 6632 (2005); Noronha, G., et al.: Bioorg. Med. Chem. Lett., 17, 602 (2007)<br></p>

<p>Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A pyrolopyrimidine derivative used in the preparation of the antibiotic tubercidin (7-deazadenosine).<br>References Ektova, L.V. et al.: Bioorg. Khim., 4, 1250 (1978);<br></p>