Heterociclos com Nitrogénio (N)

<p>Applications tert-Butyl 4-(6-ethylthieno[3,2-d]pyrimidin-4-yl)piperazine-1-carboxylate is an intermediate for the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.<br>References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012)<br></p>

<p>Applications 4-(3-Fluorophenyl)pyrimidin-2-amine (cas# 56875-59-3) is a useful research chemical.<br></p>

<p>Applications Piperophos is a pesticide used in agriculture for prevention of fungal diseases and insect infestation.<br>References Li, K. et al.: Fenxi Shi., 34, 236 (2015);<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-6-methyl-3,4-pyridinedicarboxylic Acid is used in studies to identify 4-pyridoxic acid dehydrogenase gene in pyridoxine catabolism of Mesorhizobium loti MAFF303099.<br>References Mukherjee, T., et al.: Bioorg. Chem., 35, 458 (2007)<br></p>

<p>Applications Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents.<br>References McLean, A., et al.: J. Chem. Phys., 72, 5639 (1980), Watts, J., et al.: J. Biol. Chem., 276, 43197 (2001),<br></p>

<p>Applications 6'-Amino-1,6-dihydro-2-methyl-6-oxo[3,3'-bipyridine]-5-carbonitrile is a reagent used in the preparation of cardiotonic agents.<br>References Yamanaka, M. et al.: Chem. Pharm. Bull., 40, 666 (1992);<br></p>

<p>Applications 5-Phenyl-1H-tetrazole (cas# 18039-42-4) is a useful research chemical.<br></p>

<p>Applications 5-(Aminosulphonyl)-1-methyl-1H-pyrrole-2-carboxylic acid (cas# 306936-62-9) is a useful research chemical.<br></p>

<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>

<p>Applications 2-chloro-6-(piperidin-1-yl)pyridine (cas# 19946-28-2) is a useful research chemical.<br></p>

<p>Applications 5-methyl-1H-pyrazole hydrochloride (cas# 119760-62-2) is a useful research chemical.<br></p>

<p>Applications 1-(3-Bromopropyl)-4-(4-chlorophenyl)piperazine is an intermediate in the synthesis of 2-​[3-​[4-​(4-​Chlorophenyl)​-​1-​piperazinyl]​propyl]​-1,​2,​4-triazolo[4,​3-​a]​pyridin-​3(2H)​-​one Hydrochloride (C433100), which is a related compound of Trazodone (T718500), which is an antidepressant.<br>References Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970), Brogden, R.N., et al.: Drugs, 21, 401 (1981), Gorecki, D., et al.: Anal. Profiles Drug Subs., 16, 693 (1986),<br></p>

<p>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br>References Liu, Y. et al.: Guang. Huag., 39, 54 (2011);<br></p>

<p>Applications 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors.<br>References Robichaud, J., et al.: J. Med. Chem., 46, 3709 (2003); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 702 (2007)<br></p>

<p>Applications 5-Acetyl-2H-pyrazole-3-carboxylic Acid Ethyl Ester (cas# 37622-89-2) is a useful research chemical.<br></p>

<p>Applications 5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.<br>References Koyama, M. et al.: J. Med. Chem., 30, 552 (1987); Upadhayaya, R. et al.: Bioorg. Med. Chem., 17, 2830 (2009);<br></p>

<p>Applications 1H-Pyrrole is a five membered heteroaromatic ring that is used as a synthetic intermediate to create products for the pharmaceutical, chemical, food and cosmetic industries. 1H-Pyrrole has the ability to undergo electrochemical polymerization, producing a durable, conductive film that can be used to coat biosensors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diaz, A., et al.: J. Chem. Soc. Chem. Comm., 14, 635 (1979); Kaneto, K.: Curr. Appl. Phys., 5, 178 (2005); Lipshutz, B.: Chem. Rev., 86, 795 (1986)<br></p>

<p>Applications N-[4-(Aminocarbonyl)phenyl]-2-methyl-4-oxazolecarboxamide (cas# 1119444-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine is used in the preparation of a pluripotent stem cell inhibitor.<br>References Furukawa, Yusuke. et al., Jichi Medical University(2019);<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 2-Pivaloylamino-3-(α-hydroxybenzyl)pyridine (cas# 86847-67-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Isoxazolo[5,4-b]pyridin-3-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.<br>References Gonzalez C., et al.: J. Med. Chem., 55, 11022 (2012); Cooper, A. B., et al.: Bioorg. Med. Chem. Lett., 27, 4471 (2017)<br></p>

<p>Applications 1-(3-(5-Oxo-2-(trifluoromethyl)-2,5-dihydrooxazol-4-yl)propyl)guanidine is an intermediate in the synthesis of δ-Guanido-α-ketovaleric Acid (G412100), a useful flavouring ingredient and a component of Cheddar cheese flavour.<br>References Van den Ouweland, G., et. al: PCT Int. Appl. WO 9610927 A1, 19960418 (1996); Ney, K., et, al.: Eur. Food Res. Technol., 146, 337 (1971)<br></p>