Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

JNJ 37822681 is a novel, potent, and selective small molecule inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the degradation of anandamide, a cannabinoid receptor ligand. The compound has been shown to be efficacious in animal models predictive of antipsychotic activity.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Chloroisoquinolin-4-ol is a phenylpyrimidine with anti-inflammatory properties. It is used in the treatment of sensitivity and mediated diseases, such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. 1-Chloroisoquinolin-4-ol inhibits the enzymatic activity of matrix metalloproteinases (MMPs), which are enzymes that break down collagen and other proteins in the body. The inhibition of MMPs by 1-chloroisoquinolin-4-ol leads to reduced inflammation and pain. This compound is also an effective inhibitor of the activities of chloride channels involved in acid secretion by cells in the stomach lining, thus inhibiting acid production. 1-Chloroisoquinolin-4-ol has been shown to have anticholesterolemic effects on liver cells due to its ability to inhibit cholesterol synthesis through inhibition of HMG CoA

Versatile small molecule scaffold

2-Methyl-2-phenylmorpholine is an industrial chemical that has a c1-c4 alkyl group. It can be used in the production of antidepressants, such as Tofranil, and other drugs. 2-Methyl-2-phenylmorpholine is also used in the industrial production of polymers.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Benzothiophene-5-carbonitrile is a heterocyclic compound that is formed by condensation of ethyl azidoacetate with indole under catalysis. It can be used in the synthesis of heterocycles. The yield of 1-benzothiophene-5-carbonitrile is about 56%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(2-Methylprop-2-en-1-yl)piperidin-4-amine is an inhibitor that blocks the activity of ion channels. It is a competitive antagonist at the NMDA receptor and has been shown to inhibit the binding of glutamate, which is a neurotransmitter involved in synaptic transmission. 1-(2-Methylprop-2-en-1-yl)piperidin-4-amine also inhibits β 2 -adrenergic receptors and has been shown to be a potent activator of G protein coupled receptors. This chemical may also be used as a research tool for studying the effects of ligands on cell biology, peptides, pharmacology, or life science. It has high purity and CAS No. 1082454-34-9.

The Opn4 antagonist is a chemical that blocks the activity of the protein melanopsin, which is involved in regulating circadian rhythms. It has been shown to inhibit melatonin synthesis and muscle fiber contraction when applied intravitreally. These effects may be mediated by membrane channels that are activated by chloride ions. The effect of the Opn4 antagonist on photoreceptor cells is not yet known.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methylbenzene-1,3-dicarbaldehyde is a divalent hydrocarbon that has an oxidation catalyst. This compound is used as an intermediate in the production of drugs and pharmaceuticals. It has been shown to have cardiovascular disorders, such as vasodilatation and hypotension. The mechanism of action is not fully understood but may be related to its ability to act as a nitrovasodilator by increasing nitric oxide (NO) release. 2-Methylbenzene-1,3-dicarbaldehyde also produces psychotic disorders when long term exposure occurs. This compound has been shown to have neurotoxic effects in animal models with long term exposure.

3-Phenylbut-2-enoic acid is a prochiral, carbonyl compound that can be used in the synthesis of chiral pharmaceuticals. Mechanistic studies have shown that 3-phenylbut-2-enoic acid is a catalytic hydrogenation reagent that converts prochiral substrates to their corresponding chiral products. When combined with binap and butenoic acid, 3-phenylbut-2-enoic acid can catalyze the asymmetric synthesis of butenoate. The reaction yields high enantiomeric excesses and good yields.

Versatile small molecule scaffold

2-Bromo-6-methylnicotinonitrile is a reactive heterocyclic compound that has been used as a palladium catalyst. It undergoes substitution reactions with halides and polyhalogenated compounds. The yield of this reaction depends on the substituents and functional groups present. 2-Bromo-6-methylnicotinonitrile can also be used to form alkynes, alkynes, and heterocycles.
2-Bromo-6-methylnicotinonitrile is an alkyne that has two functional groups: a nitrile group and a bromine group. It reacts with nucleophiles such as ammonia or amines to form the corresponding amide or amine in good yields.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

BrettPhos Pd G4 is a versatile polymer used in various research applications. It is commonly used in the field of organic chemistry as a catalyst for reactions involving epoxy chloropropane, clofarabine, iminostilbene, glycine, kavalactone, phenylboronic acid, carbamazepine, and other compounds. This polymer acts as a powerful catalyst and facilitates the synthesis of complex molecules by promoting efficient chemical transformations. Additionally, BrettPhos Pd G4 is known for its inhibitory effects on certain enzymes and can be used as an inhibitor in biochemical studies. Its unique properties make it an essential tool for researchers in the field of organic chemistry and beyond.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-ethynylpyridine-2-carboxylate is a ligand that binds in the active site of many enzymes. It can enhance the activity of these enzymes and also change their conformations. Methyl 5-ethynylpyridine-2-carboxylate interacts with four subunits to form a tetradentate framework, which is responsible for this molecule's ability to bind to any type of ligand. This enhancement effect is reversible, and it can be reversed by oxidizing methyl 5-ethynylpyridine-2-carboxylate with nitric acid. The yield of methyl 5-ethynylpyridine-2-carboxylate depends on the reaction conditions and the type of arylacetylene used. Methyl 5-ethynylpyridine-2-carboxylate has been shown to be an effective ligand with a high emission yield when using 1,3

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

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1-Hydroxycyclopentane-1-carbonitrile is a monomer that is hydrolyzed to form benzoin and cyanohydrins. It can be used in the production of scifinder as a monomer or dimerizer.

3-Hydroxy-5-methylpyridine (3HMP) is a chemical substance that has been classified as an amine. It is a product of the metabolism of purines, which are nitrogenous bases found in DNA and RNA. 3HMP is produced by aerogenic bacteria (such as Enterobacter), and can be used to estimate the number of these bacteria present in water samples. 3HMP has been shown to have antiviral properties against influenza virus, and can be used as a biomarker for the presence of other viruses in animals. 3HMP also has mineralization properties, which have been studied extensively, particularly with regards to pancreatic disease.

Versatile small molecule scaffold

4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Piperyline is an alkanoic acid that has shown to be effective against skin cancer. It also has antimicrobial properties, which may be due to its ability to bind metal ions and form polymeric compounds. Piperyline inhibits microbial growth by inhibiting the synthesis of proteins and nucleic acids. The antimicrobial activity is related to its cationic polymerization with hydroxyl groups, which forms a structure that can inhibit microbial enzymes and disrupt microbial cell membranes. This compound also interacts with the skin's natural lipids, making it difficult for microorganisms to attach and grow on the skin. Piperyline is synthesized in organic chemistry laboratories as an amide precursor of other pharmaceuticals such as penicillin.