Building Blocks

2-Chloro-1-(4-nitrophenyl)ethan-1-one is a precursor to the phosphonate herbicide, 2,2-dichloroethyl dimethyl phosphate. This compound reacts with halogenated compounds to produce various reaction products. It has been detected in rainwater samples as an intermediate in the production of hydrogen chloride and chloride gas.

1-BCP is an inorganic compound of formula BF4. It has been shown to have potentiation effects on glutamate induced excitotoxicity in hippocampal neurons and also enhances the activity of aniracetam, a nootropic drug. 1-BCP is effective at nanomolar concentrations and may be a potential treatment for neuronal disorders.

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzyl (cyano)methylamine is an anti-hypertensive agent that belongs to the group of propionyl chloride. It is a benzene derivative with a methyl group attached to one of the rings. Benzyl (cyano)methylamine can be used as an intermediate in the synthesis of other compounds, such as cyclohexanone, phenoxyacetic acid, and acetophenone.

Versatile small molecule scaffold

4-Bromobenzaldehyde oxime is an antibacterial agent that binds to the surface of gram-positive pathogens and inhibits their growth. It has been shown to inhibit the biosynthesis of bacterial cell walls, which may be due to its ability to form a covalent bond with serum albumin. This functional group is also responsible for the antiinflammatory activity 4-Bromobenzaldehyde oxime displays. The carbonyl group on this molecule reacts with abscisic acid (ABA) in a dehydration reaction, producing a chloride and an oxazolidinone.

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(4-Nitrophenoxy)propane-1,2-diol (3NPPD) is a nitrophenol that inhibits the growth of bacteria. 3NPPD has been shown to be an effective antimicrobial agent against Pseudomonas aeruginosa and other pathogenic bacteria. This compound binds to the cellular target at physiological concentrations, thereby inhibiting their growth rate. 3NPPD inhibits the synthesis of proteins by binding to the ribosomes in the bacterial cell wall. It also inhibits protein synthesis in eukaryotic cells by binding to ribosomes in rat liver microsomes and may cause damage to DNA. 3NPPD has been shown to inhibit the virulence factor production of P. aeruginosa.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methylpteridin-4-ol is a molecule that belongs to the group of bifunctional molecules. It is a component of the mitochondrial respiratory chain and has been shown to inhibit radiation-induced DNA damage in human cells. 2-Methylpteridin-4-ol has also been shown to have anti-cancer activity, but it does not cause any cytotoxic effects on normal cells. 2-Methylpteridin-4-ol is synthesized from glycinamide ribonucleotide (GAR) and pteridine in vivo and has been shown to inhibit glucose uptake in vitro. This compound binds to the active site of ATP synthase, inhibiting its function and leading to cell death.

1-[4-(2-Propynyloxy)phenyl]-1-ethanone is a quinine derivative with a bathochromic shift. It has been shown to undergo cycloadditions, photophysical, and supramolecular reactions in the presence of other molecules. 1-[4-(2-Propynyloxy)phenyl]-1-ethanone shows luminescent properties under optical microscopy and shifts from red to blue when it is irradiated. The compound can also be used as an optical probe for studying the mechanism of drug release in vitro.

Versatile small molecule scaffold

2-(1H-Indol-5-yl)acetic acid is a lipogenic agent that is used in the treatment of cancer. It binds to nuclear hormone receptors, which regulate lipid biosynthesis. 2-(1H-Indol-5-yl)acetic acid has been shown to inhibit the growth of human bladder cancer cells and increase the uptake of fatty acids by these cells. This agent also has anti-inflammatory properties and causes an increase in reactive oxygen species in microglia, which are immune system cells found in the brain. 2-(1H-Indol-5-yl)acetic acid has been shown to have cytotoxic effects on mammalian cells, but not on bacteria or yeast. 2-(1H-Indol-5-yl)acetic acid may be administered intravenously or intraperitoneally.

5-Oxaspiro[2.4]heptane-4,6-dione is an organic compound that has been synthesized by irradiating styrene with light. It has a molecular formula of C7H12O3 and a molar mass of 150.17 g/mol. The compound exists in two isomers, the cis and trans isomers, which have different optical properties that can be observed when it is irradiated with light. 5-Oxaspiro[2.4]heptane-4,6-dione has been shown to be reactive in many different ways; for example, it can modulate the activity of other compounds or transfer hydrogen atoms from one molecule to another. The compound also participates in stereospecific reactions, where the orientation of bonds affects the reactivity of the molecule. 5-Oxaspiro[2.4]heptane-4,6-dione has a five membered ring that resembles the

Mal-PEG2-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, mal-PEG2-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Biphenylyl)-2-propanol (BPP) is a crystalline compound that has a density of 1.3 g/cm3 and a melting point of 189°C. It has a nonplanar conformation with the hydrogen bond forming dihedral angles of 36° and an asymmetric shape. The functional theory predicts that BPP will have high reactivity, which is confirmed by gas phase experiments.

2-Phenylpropane-1-thiol is a molecule that is used as an intermediate in the synthesis of other compounds. 2-Phenylpropane-1-thiol can be used to measure mitochondrial membrane depolarization, which is a characteristic of bioenergetic dysfunction. This compound has been shown to inhibit the growth of ges-1 cells, which have been shown to have a high level of resistance to apoptosis induced by chemotherapeutic drugs. 2-Phenylpropane-1-thiol may also act as a ligand for proteins, although it has not been confirmed. The diameter of this molecule is 1.69 angstroms.

Versatile small molecule scaffold

5-Chloro-2,3-dihydrobenzofuran-2-carboxylic acid is a hypocholesterolemic agent that has been shown to lower plasma cholesterol levels in the rat model. This compound is an analog of propionate, a known hypocholesterolemic agent. 5-Chloro-2,3-dihydrobenzofuran-2-carboxylic acid is converted by esterases to its active form, 1,4-benzoquinone dioxane 2 carboxylic acid (BQDCA). The structural similarity of BQDCA with propionate suggests that it may have similar biological activities. 5-Chloro-2,3-dihydrobenzofuran-2-carboxylic acid also possesses some antihyperlipemic activity and has been shown to inhibit the synthesis of triglycerides in rat liver cells.

Versatile small molecule scaffold